Conserved Protein Domain Family
Borealin
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pfam10512: Borealin (This model is not part of the current CDD release)
Cell division cycle-associated protein 8
The chromosomal passenger complex of Aurora B kinase, INCENP, and Survivin has essential regulatory roles at centromeres and the central spindle in mitosis. Borealin is also a member of the complex. Approximately half of Aurora B in mitotic cells is complexed with INCENP, Borealin, and Survivin. Depletion of Borealin by RNA interference delays mitotic progression and results in kinetochore-spindle mis-attachments and an increase in bipolar spindles associated with ectopic asters.
Links
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Statistics
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PSSM-Id: 519425
Aligned: 32 rows
Threshold Bit Score: 89.3258
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
EFA07677            102 RQSRTKNRVPKtTRIsrsqslrtknvtevyktpAQRvpanSYGTVTPKVKPNTPQVLLRRPKQGEVALSLQGSPLLTGnv 181
NP_001266370        150 RRSRSVYRTPAcNKN------------------AST----YYPAITPKVTPQTPLTVLRQPRQGEMVVSMSGSPVMVPtc 207
XP_001964860         95 SIGRLRLRTPRtQSQrdq------------aqsVDR------MKTRSRTMKDISMTFQRWPRPGERVLSTSGSPLAVQah 156
EDW35113             99 STARGRSRTPQtSLLprsl-----------iqsMDR----GNFNRGRTPQKVPPMPFLRFPRAGELVLSSGGSPLAVQtd 163
WGS:AAQB:GK15971-PA 138 HVARQKTRTPM-ASKlks-------------lsADR----NDSPTTSPLA------FLRYPKPGEIALSKFGSPILTQvm 193
XP_049540169        200 RTSRAKHKTPM-IGRpka-------------isADR----GYGVITPKVQPYTPLALIRHAKLGESVFSLTGSPVVTSnm 261
XP_039442896        208 RHSRSKFRTPNaAAGrlq------------tvsTDR----GLSLITPKVQPNTPMALLRHARAGESIYSMTGSPVITAam 271
Q16QC7              203 RLSRSKFRTPVpGSRlkq------------tvsADR----GMTMITPKVQPNTPMAIMRHARLGESIYSITGSPVITAam 266 yellow f...
Q7PSN3              219 RISRPKLRTPLpDGSrkgrt--------tqavsADR----GMSQIMLKVEPNTPLAFIRYPRAGESVYSLTGSPVVNTvm 286 Anophele...
ETN66209            209 RLSRLKMRTPM-QETtkrar--------gqavsTDR----GISQITLKVNLNTPITFLRHPRVGESVFSQSGSPVVNAta 275

EFA07677            182 ---vtDNVANINIPLEDGRLFSIQPQRG----LRvs-qIPELDLETKRQLETLRDNLNKVCSL 236
NP_001266370        208 ytmqpDEMANCNILLQDGTMLSLQPKQLr--qSQayipFSLMDTNVLNQLKTLKDNLDKVVKL 268
XP_001964860        157 ----aELHADVHIPTRKG-VITVKPHKIk--nIEre-vLMEMDQNTLNQVKTLNDNLEMIVDM 211
EDW35113            164 ---rrEDCADVHIPTKKG-VFMVKPLKMk--qVNre-vLMQLDANVLNQVKTLKSNLEVIVDM 219
WGS:AAQB:GK15971-PA 194 ----tDSFANVNIPIQDG-VLCLTSKKLvegeVNkd-lLKSLDENKLKEIKVLHANLQKIVNA 250
XP_049540169        262 ----lEATANVNIPVANG-MLSIRPTEMd--vVDet-lVRKIDANVLMEIKQLQSNLEKILNT 316
XP_039442896        272 ----vEETANVNIPVANG-MLSIRPTDMe--sFDag-lLQRIDPGTLEHLKKLQRNLNKIMQI 326
Q16QC7              267 ----vEEMANVNIPIQNG-ILSLRPTEMd--sIDtg-lVQKIDSDTLEHLKKLQMNLNKIMQM 321 yellow fever mosquito
Q7PSN3              287 ----sKNTANVNIPVPDG-MLSLQPTDLe--dMDre-lLPKIDYATLEHLKKLQANLNKVMQY 341 Anopheles gambiae str. PEST
ETN66209            276 ----yRQTRHINIPVPNG-MLALQSDELhd-eMVpe-mMPHLDSDTMDYLKG-RSRLQMVAYK 330
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