7WLD


Conserved Protein Domain Family
PIG-S

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pfam10510: PIG-S (This model is not part of the current CDD release)
Phosphatidylinositol-glycan biosynthesis class S protein
PIG-S is one of several key, core, components of the glycosylphosphatidylinositol (GPI) trans-amidase complex that mediates GPI anchoring in the endoplasmic reticulum. Anchoring occurs when a protein's C-terminal GPI attachment signal peptide is replaced with a pre-assembled GPI. Mammalian GPITransamidase consists of at least five components: Gaa1, Gpi8, PIG-S, PIG-T, and PIG-U, all five of which are required for function. It is possible that Gaa1, Gpi8, PIG-S, and PIG-T form a tightly associated core that is only weakly associated with PIG-U. The exact function of PIG-S is unclear.
Statistics
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PSSM-Id: 519423
Aligned: 92 rows
Threshold Bit Score: 266.834
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
7WLD_S        24 FFAAVAIVLGLPLWWKTTETYRASLPYSQISGLNA-LQLRLMVPVTVV-FTRESVPL----DDQEKLPFTVVHE-REIPl 96  human
XP_004365648   7 LYIVVIAGVGLPVWWRTTTIYRASLPCELLVAPTGsESDQLPLAIQVV-LDPALLLDaqkrPSAEFSVSDLERAlHSQAh 85 
Q9VC10        28 AFIVVIIGIGVPMWWRTTTVYRVNLPSTEILSLSK-IPIKTAVQVAIY-----TQQT----SRGQLLI---------AEl 88  fruit fly
XP_002430196   6 SFFVVLILIGVPLWWKTTEVYRFSLPYSQIDVLHE-HKLTIQMNIHVM-----TIDN----SRGTAIV---------EDl 66 
XP_026298010  32 SFAVLLLGIGVPLWWHTTAVPRVPLPYDGIEQLSN-LEINIKTKLIIL-----ALSR----DRAELLV---------HDi 92 
EGI69864      17 SFAVLLLGIGVPLWWHTTTVPRVTLPYTGIDELSK-LDIKITTKITVA-----ALSH----NRAESLA---------REi 77 
EEC14582      32 SFVLIFLFIGLPVWWKATTVYRVSLPYSEIEALSS-KKIVQRISVHVL-LVEKQYPE----GDLVNL--LDNATsAKRTa 103
XP_003135738  46 AFIVIVLIFGLPLWWQTTSTYRAPF-----RTFSSdQ--QIVLPVYISiASSHSSMK----SHIGRAITLLLNElSELPv 114
EGT37906      60 SFVILVFLIGMPMWYYTTSTYRAPFP-----TFSAnR--SVTVPIRVNvAIASSQIT----VDMEQLLSEIKQNmTTKEv 128
Q22496        51 SFVILVFFIGMPMWHFTTSTYRSNFP-----TFPSnQ--SITVPIRVIfVITSEDLR----NDVKTLMNELEVNmTKKEv 119 Caenorhabditis ...
7WLD_S        97 kyKMKIkc-rFQKAYRRAlDHEEEalssgsvqeae----------------amldepqeqaeGSLTVYVISEhSsl---- 155 human
XP_004365648  86 ehARTLss-kVAFRPVVSvITTQTneriahtieemaralnansnagdghlstqkiaeqidppYFFAANMTPG-Sgtvfvv 163
Q9VC10        89 qnAFSDne-iWSVEFKQLsPTP-Mtqeahtpaale----------------klllenhvqsvGDFMFIEWPK-Lq----- 144 fruit fly
XP_002430196  67 kkFFQIsk-iFNITFKQHtVDK-Qllgscktlaei-----------------enkikhpsyvGSLQLIEIPG-Lsrf--- 123
XP_026298010  93 keAFKNas-iCQVEIIYRvISN-Tfafthhqlek-------------------iasnfdvdvGQLLLFETTN-Ln----- 145
EGI69864      78 rrTFENae-iYQLNVEYQiVSN-Nllasaftyhel----------------ekvastfdldvGDLLLLEATN-Ln----- 133
EEC14582     104 qfTDGNey-vYEWAVRLAyQDETDlllsgktleeid--------------talhhmehlradNRLNVVVVPN-Gtf---- 163
XP_003135738 115 idRLRLifklNHEDMDALeFISRAnke---------------------------------vsNLFGVHVAVI-Netvw-- 158
EGT37906     129 vfPLKFdwttEFIGIKTFeELEQDhsvkv-----------------------------ednkDFFDVFIALV-Pekdwsh 178
Q22496       120 vaPLDFtwttQFIGLRSFeHLEQDhsiqi-----------------------------eenkEFFDVFVALV-Pekewth 169 Caenorhabditis ...
7WLD_S       156 -lpQDMMSYIGPKRTAVVRgIMHRE-AFNIIGRRIVQVAQAMSLTE---DvlAAaladHLPEDKws--------aeK-RR 221 human
XP_004365648 164 adaRLPRIVVGSSRLLIAN-LFPSAaATEPIETIVARVLFEQMADVgatSlsYDqpddTLAKQAeqnsg---dalrA-RR 238
Q9VC10       145 ---eE--LLLTTERSALMR--------SDTPSNKIAQLLHAKILQT---YriNQil---sTDer-----------mG-AK 193 fruit fly
XP_002430196 124 -vpYS--IVLGEKRTIYFA--------SNVDVVKLYDFINTKVLNE---DvlVDtt--leINLPvqsk----lnknS-RH 182
XP_026298010 146 ---nA--VLVGSERTIYFS--------TETTSSTLIQILSEWMLHE---NslALtk--naLTEPtlys----ldekN-RR 202
EGI69864     134 ---dA--VLVGSKRTLYFS--------TETSISTLIQVLSEWILRD---KslALtk--naLAEPtmys----ldeeN-RR 190
EEC14582     164 ----kgKVTIGLHKTIYFEgg----eGLQDLARSIANVVREDAIRE---DllKRlf--tsPKSQersr----pdkeR-MR 225
XP_003135738 159 pysGYTTYFDDQWTFILNc------eDESKLAQRMFEAITDVLLDTshlSaiVRrdlrQGIQSSkvsalssrqqkrLiWD 232
EGT37906     179 ysaTRIQLGIGKWNFVQWptk---eeEKRKASSRITELISEILIDIphlNsiVRrdlrQKMQPWqiaalplshqkrLvWD 255
Q22496       170 ysaTRIQLGIGKWNFIQWptk---seEKQKASTRVTDLVSETLIDVphlNsiVRrdlrQKMQPWqiaalplshqkrLvWD 246 Caenorhabditis ...
7WLD_S       222 PLKSSLGYEITFSLLNPDPKSh-----DvyWDIEGAVRRYVQPFLNALGAAGNFSVDSQILYYAMLG---VNPRF---DS 290 human
XP_004365648 239 TFSTASSFEVLFTLALGAGSSssasssY--WDPRAIYAA-LRPFLAAVSVDDAPTVSSQIIYEAQPL---VTPTFd--KK 310
Q9VC10       194 SEAPQPAYDVIVSVLNPKPRLth---aK--WNIAMAVKTYIEPWLAKVSGVSNYTVRSQWKYRVAIE---ADLK----QV 261 fruit fly
XP_002430196 183 KISLSESFDILFTILNPDPDLld---vT--FDIQKAIEDFVTPFKSDLNDMYEFHIKSQWLYYVDLQ---VQTKFl--NF 252
XP_026298010 203 RFPASSAYDILITVVNPDPEKlk---iD--WNLREMVEEYVEPFLDEVSILSNFSVKSQWLYLLPLD---VTPK----RV 270
EGI69864     191 RFPASLAYDVLVTLVNPDPEKlk---iV--WDLKTVTEEYVQPFLDELSILSNFSIKSQWLYLLPLD---MNPR----RV 258
EEC14582     226 PLSATTKFDVTFTLIVPEPQIld---vS--WKIQEAIHAYMGPFLDRVSTLATVNVKSQVLYLTDLK---VQPHF---DK 294
XP_003135738 233 SVALSARYIVQVIFLHAGYNEss---eH--YSAENIIL-HARRFAAKLAEVSDLIISSEHLWDFDLTa-wLKKDVqgrNT 305
EGT37906     256 SAPLATAYHIQIIHLHENTEVsm---dL--LGAQEKTAKAFRKFAEKVEGVTKVEVSFEHLWDFETTtqfLAKDVqerWT 330
Q22496       247 SAPLATNYHIQVIHLHENSEItp---eS--LKEQEKTARALRKFAEKVKEITNVEVSFEHLWDFEPTrgfLIKDVqerWA 321 Caenorhabditis ...
7WLD_S       291 aS------SSYYLDMHSLPHVINPVESRLGSSAaSLYPVLNFLLYVPELAHSPLYIQDKDgAPva----tnAFHSPRWGG 360 human
XP_004365648 311 -L------NAFVLRPDQLQHFVNSQDWGLGFST-HNNPVVNLLVFEPPPELRPLLLLDATgHPaa----qnGFLIPRWGG 378
Q9VC10       262 -RdqsklgRHYALQETALPHLLTSIAQNLSAST-TDKPAINLVVYIPPCHIAPLHIYNSKdQRltrn-dvdAFISPPWGG 338 fruit fly
XP_002430196 253 -Tdk---gPHFALPADLLPHVITPLEKKLASHV-SKYPCLNFILYIPPCATSPLFIYTKNgFKleg---anAFISPKWGG 324
XP_026298010 271 -PdssplgRHFALSEDVLPQLITPLEKKLASQV-SLRSTINFVIYVVPCDNAPLYIYTRSgHRskinanveAFLSPRWGG 348
EGI69864     259 -PdsspnrRHFALRENVLPQLVTPLEKKLASQV-SLHPCINLVVYMVPCDNAPLYIYTRSgHRsrtdsnveAFLSPRWGG 336
EEC14582     295 -Ek----gV-YSLTADKLPLIINPVEGSSGLHA-SVNPALNFMVYVVPRAHHPLYVYDERgQPle----tnAFLSPKWGG 363
XP_003135738 306 -I-----------QMDDISQIVTAIEQETSTVE-SSAPVMKLVVLD---APQPLALLDYMgDEs------nGLVVASWGA 363
EGT37906     331 -L-----------THSAMEELVKKVDAQMQTSL-EQGTVLRFVILE---TVEPVIFLDETgEDv------hGVAVASWGA 388
Q22496       322 -L-----------THSAMEELVKKVDSQLQTSL-QHGAVLRFVVLE---TVEPVIVLDDTgEDs------hGVAVASWGA 379 Caenorhabditis ...
7WLD_S       361 IMVYNVDSKTYNAsv---lPVRVEVD-MVRVMEVFLAQLRLLFGIaqpqlpPkc------lLSGP-----TSEGlmtwEL 425 human
XP_004365648 379 VLVVNPTADQAVE--------------LSEICSVLLAQLRLLMGL------RtqrsrmtelDTVHvllprQLAGltdfEH 438
Q9VC10       339 FIIANPPEHVCLAamsdqeAVPYHVS-TTDNMQVMLDQLHKLLDI------Sselq-megvKVVDi----EQLEprrwEY 406 fruit fly
XP_002430196 325 IQIYNHNRNFCSDgk----kVEVNID-SNYVMSVYLAQFRLLLGM------Pdiaevq---------dtknlnKvrlwEK 384
XP_026298010 349 VILINPPVETCMTvks-deLVTIVPE-QTIVVGTFLTQLKLLLGI------Pepkf-lngvTIVPl----PGLKlhnwEV 415
EGI69864     337 VILINPSSEVCEStre-neAITLVPE-ETAIVGTFLAQLRLLLGI------Pemks-ingvTAVPl----VGLKsrdwEI 403
EEC14582     364 FLFYNVPKF---PesgaalPARVDLD-MRSIFQVFLGQLRLLMGL------Pdtrp-keglHVM------EGSVcsdlEV 426
XP_003135738 364 LL-------------------SYAGQrRLAVNQSVIAAMRALFGL------Dtdlpvssdr---------splpvanwEI 409
EGT37906     389 VL-----------------------PrTELTESKAISAMRIQMGM------Daellpgwhr---------ppvavcqwEI 430
Q22496       380 VL-----------------------PrNEATESRAIAAIRIQMGM------Daelshgwhr---------ppvaicqwEV 421 Caenorhabditis ...
7WLD_S       426 DRLLWARSVENLATATTTLTSLAQLLGKISNIVIKDDVASEVYKAVAAVQKSAEEL-AsGHL---ASAFVASQEAVTSSE 501 human
XP_004365648 439 DSLLRSRWLEHLASARHSLKSFCQLLDTIPNMVVSDELQRKVDVARAAMGQANSAM-QrNAL---HEAYSLSKRTAHIAE 514
Q9VC10       407 EAYLRRSAIRHISTASSTLQSLIKLLDQISYIVIDDEVGAAITNSYADILAAKAAL-LeHRL---ADASVLAKRAFVASE 482 fruit fly
XP_002430196 385 DSLLRLRTVEQLTFTKLTLQSLSKLLGKINNIVINDQVGHAIYSALDNVYEASEAL-GkGDL---LTGYNLSKKAFLASE 460
XP_026298010 416 DALLRVRTIEQLTSAKLTLQSLARLLQEIGNIVITDIVGNRIKTALSLVEKSAQQL-TqGDL---ATGFLLSKEAFITAE 491
EGI69864     404 DSLLRYRTVEQLTSAKLTLQSLARLLKEISNIVITDVVGNRIKTALGLVHESAEHL-RrGDL---KRSFILSKEAFIISE 479
EEC14582     427 DFLLRRRTQDYLSMSVSSLFSLSQLLSTISNIVIKDEIGDLIYSSVHSAERSLELL-SkGDL---ETAFKEAEAAFLASE 502
XP_003135738 410 KRIKLRSFVDCSINGMSSVAAIHKLVSQIDNIVINEEMASKTNLAVELISQALLTVeKiGDI-----DVASVTQGRALAE 484
EGT37906     431 ARARLRASVDNAMRAASAIRALDQLAQKISNIAINDDVADRAKRAVSILDSTVKP----GRMldfEKLL----EARRLAD 502
Q22496       422 ARARLRASVDNAMRAASAVRALDQLAQKISNIVINDDVADRATRAVEILNDVVRP----GRMldfERLL----EARRLAD 493 Caenorhabditis ...
7WLD_S       502 LAFFDPSLLHLLYFPDDQKFAIYIPLFLPMAVPILLSLVKIFLETRK 548 human
XP_004365648 515 AVFFDSNALSLLYFPEDNKYAIYVPLFAPAGLPILVAVVKALRQWRA 561
Q9VC10       483 RGFFDASLLAQLYFPDEQKYAIYIPLFLPIMVPVLSSFNMLRGVLQA 529 fruit fly
XP_002430196 461 KAFTDPSLLSLLYFPDDQKYAVYIPLFLPIMIPVLISIKPILQWLNL 507
XP_026298010 492 AAFSDPTLFALLYFPADQKYAVYTPLFLPTMVPVLLSLKSIYRYYFV 538
EGI69864     480 AAFSDPTLLALLYFPEDQKYAVYIPLFLPAMIPVLLSLKNIRRYYFL 526
EEC14582     503 KAFFDPSLLALLYFPDDQKYAIYIPLFLPISIPVLLSLRYILTHYRQ 549
XP_003135738 485 SALNDKSLLSLLYFPNDQKFAIYLPLFLPTLLPLFGSILALNRYWMG 531
EGT37906     503 SANNDHSLLAMLYFPMDQRTAVLIPLAVPIVLPILKLMFEIAMVLIR 549
Q22496       494 SANSDHSLLAMLYFPMDQRTAVLIPLAVPIVLPICKLVYEIAKITVF 540 Caenorhabditis elegans
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