Conserved Protein Domain Family
TMEM65

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pfam10507: TMEM65 (This model is not part of the current CDD release)
Transmembrane protein 65
MEM65 is an intercalated disc protein that interacts with with connexin 43 (Cx43) and is required for correct localization of Cx43 to the intercalated disc. It is essential for cardiac function in zebrafish.
Statistics
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PSSM-Id: 519420
Aligned: 44 rows
Threshold Bit Score: 116.435
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_002292869   29 QSIPFVGFGIMDNSILLLAGEAIDTTLGVTLGISTMCAAAIGNIISDVVGVAFGTVIEDAIARwsgrierlsngkVKLpP 108 
ESS30998      570 SSLPFVGFGLVDNCIMIVAGDLFDTTLCVTLGLTTMAAAALGNWISDLMGLWLGSRIEALSSRi-----------LPI-P 637 
Q84X76        164 AAIPFVAFGFLDNAIMLVAGEEIDHMFGLRLGLSTLASAGLGNAVADVIGVGAAKYIEQAVRW------------LPFvK 231  Chlamydomonas...
Q38AF3        147 AGLPFVGFGFLDNAMMILAGDAIDNSFGLYFNCSVLTCAAMGNIFSGVLGMQLHGVIEKAVQR------------FNF-R 213  Trypanosoma b...
2_pfamImport    1 -FIPMFVYGVLDEAFLIIGGESINNIFSVYNGMSMLASAAVANIICN---LFLQLPAERCAEI------------LGF-R 63  
XP_001463428  669 AAPPFLAFGMLDNSTLVLAGGAIDNALSGSLGLSQMAAASLGGVVSGVAGIQVHGLAERYTRA----------------A 732 
Q57ZW2        304 ASVPFMAFGILDNSIFVTAGDAIDRRCAEAFGLTSMTAAALGGVVSGVAGVQMHGVAERFTQR------------VRLaR 371  Trypanosoma b...
Q4CY30        293 SAVPFMAFGMLDNTIFITAGDAIDKRFAEAFGMSTMAAAALGGVVSGTAGIQMHGLAERMAQR------------SRLaR 360  Trypanosoma c...
XP_010703630  166 AALPFVGFGFLDNSTMILAGDMIDGSLGFYLNCSVLASAAMGNVCSGVLGMQVHGLIDNTVQK------------LNL-N 232  Leishmania pa...
XP_002370181   49 SGAPFLGFGFMDNCLMLLCGDLIDSYLGAFLGVTTLTAAALGNLFSCTSGVVTGRCVEQLAYRt-----------VWF-P 116  Toxoplasma go...
XP_002292869  109 LPKLSHEQRNLRSVRLASQLGCAIGLTVGCIIGMFPLLFF 148 
ESS30998      638 KPSLTPEQRESPICRKHYYIGTGIGISIGCLLGMAPLLFL 677 
Q84X76        232 EPKLNKYQNAMPATQRAKLAGAMLGVFCGCMLGLTPLFLs 271  Chlamydomonas reinhardtii
Q38AF3        214 VPTLTENQMKGKRVFFAGHIGGTVGIMTGLLLGMIPLLLL 253  Trypanosoma brucei
2_pfamImport   64 KPVLSNDQRNTAEYRYASFSAKLSGLWLGLTLGILPLFFI 103 
XP_001463428  733 PPRLTMEQQRSDAYSRATQAGNTLGMVFGLILGMIPLLFM 772 
Q57ZW2        372 VPVLTAAQQKSKARGSATRVGNTAGMLVGLLLGMIPLLFV 411  Trypanosoma brucei
Q4CY30        361 PPTLTPSQSASASNGSATRVGSTLGMILGLLFGMTPLLLL 400  Trypanosoma cruzi
XP_010703630  233 TPVLSEEQLKDRRVFLAGHLGGTLGIMLGLILGMLPLLFL 272  Leishmania panamensis
XP_002370181  117 RVTLNAGQVGSRRALRAHTIGAVAGVCIGCTLGMFPLLFL 156  Toxoplasma gondii ME49
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