Conserved Protein Domain Family
MCC-bdg_PDZ

?
pfam10506: MCC-bdg_PDZ 
PDZ domain of MCC-2 bdg protein for Usher syndrome
The protein has a high homology to the tumor suppressor MCC (mutated in colon cancer; or MCC1 hereafter) and was named MCC2. MCC2 protein binds the first PDZ domain of AIE-75 with its C-terminal amino acids -DTFL. A possible role of MCC2 as a tumor suppressor has been put forward. The carboxyl terminus of the predicted protein was DTFL which matched the consensus motif X-S/T-X-phi (phi: hydrophobic amino acid residue) for binding to the PDZ domain of AIE-75.
Statistics
?
PSSM-Id: 402230
View PSSM: pfam10506
Aligned: 27 rows
Threshold Bit Score: 49.2222
Threshold Setting Gi: 1632305619
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
?
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
XP_002407470 699 KLKARIDELLATLEKITKNSELRSQQSAEFVNDLKRANRQVPALVSAFEkakkkNLSKMKKIEQQTTAMT 768  black-legged tick
XP_001947508 399 QLQTRLDHVRSQMAVLELMFEQSAAQTDKLYLILGKYESNMIALKLEVE-----TSEEIMNCYSSLLSIy 463  pea aphid
EEB15263     451 RLNSKLEHVRAQNAVLALTLEECKAQCDKLSLLLGKYESNAVALKLALN-----YSDQALHVAESLVyll 515  human body louse
XP_002116317 555 sLTTKIDELTADNNALLLAIEECKEIASALTVLNGKYESNCAILRSALE-----YTDRSLEIYELLASLF 619  Trichoplax adhaerens
EFX90286     553 RLASRSEHLRAQNDVLSMTLAESRALGERLAVLLGKYESNCMALRMALE-----RADRVSEAFEVLAALV 617  common water flea
XP_011447473 881 KLKSRVQELVVALEKLSRNSEIRHQQSAEFVSDLKKAN---SALIAAFEktkkkYQGKLKKLEFQIQALT 947  Pacific oyster
EFX90286     851 RLQLKIQELTGALERITSSAEIRSQQSAELVSDVKKAN---ATLVQLLErtkkkYQSRLKRLEQQMVNMS 917  common water flea
XP_002428001 714 KLKERIEDLVNKLDQIARNSELRYQENAELVLDLKAAN---SALVSTLDrckkkYQGRLKKLEAQMMSMV 780  human body louse
TKC48028       3 KLKARVQELVSALERLTKSSEIRHQQSAEFVNDLKRAN---SNLVAAYEkakkkHQNKLKKLESQMMAMV 69   narwhal
XP_002603181 765 RLKARIQELVTTLETVQRNNETRHQQSAEFVNDLKRAN---SGLVAAYEkakkkHQSRLKKLESQMMAMV 831  Florida lancelet
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap