Conserved Protein Domain Family
USHBP1_PDZ-bd
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pfam10506: USHBP1_PDZ-bd 
Harmonin-binding protein USHBP1, PDZ-binding domain
The protein has a high homology to the tumour suppressor MCC (mutated in colon cancer; or MCC1 hereafter) and was named MCC2. MCC2 protein binds the first PDZ domain of AIE-75 with its C-terminal amino acids -DTFL. A possible role of MCC2 as a tumor suppressor has been put forward. The carboxyl terminus of the predicted protein was DTFL which matched the consensus motif X-S/T-X-phi (phi: hydrophobic amino acid residue) for binding to the PDZ domain of AIE-75.
Links
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Statistics
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PSSM-Id: 491218
Aligned: 20 rows
Threshold Bit Score: 53.482
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
EEC12313      699 KLKARIDELLATLEKITKNSELRSQQSAEFVNDLKRANRQVPALVSAFEkakkkNLSKMKKIEQQTT-----AMT 768 
EFX90286      851 RLQLKIQELTGALERITSSAEIRSQQSAELVSDVKKAN---ATLVQLLErtkkkYQSRLKRLEQQMV-----NMS 917 
XP_002116317  555 SLTTKIDELTADNNALLLAIEECKEIASALTVLNGKYESNCAILRSALE-----YTDRSLEIYELLA-----SLF 619 
1_pfamImport    1 QLQTRLDHVRSQMAVLELMFEQSAAQTDKLYLILGKYESNMIALKLEVE-----TSEEIMNCYSSLL-----SIY 65  
2_pfamImport    1 RLNSKLEHVRAQNAVLALTLEECKAQCDKLSLLLGKYESNAVALKLALN-----YSDQALHVAESLVylletKQN 70  
7_pfamImport    1 RLQNRIDQYKMKNSVLSLTLRECKEHCDHLYLLCGKYESNALALQSALN-----CSDRAIEAYDVML-----ALL 65  
Q7KSI6        218 RLQRRVEQLEMRNTMLALTLDECKEHTEHLYLLCGKYESNAVALQLALN-----CSDRAIEAYDVML-----ALL 282  fruit fly
XP_046437911  591 RLASRSEHLRAQNDVLSMTLAESRALGERLAVLLGKYESNCMALRMALE-----RADRVSEAFEVLA-----ALV 655  common water flea
XP_038952771  934 KLKARVQELVSALERLTKSSEIRHQQSAEFVNDLKRAN---SNLVAAYEkakkkHQNKLKKLESQMM-----AMV 1000 Norway rat
XP_006001684  381 RLQRCIDQLKCQNDFLLVMLERHKNDSEKLSMLLGKHESNSTALQLALQ-----YSEECIDAYDVLS-----SLA 445  coelacanth
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