Conserved Protein Domain Family
NARG2_C
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pfam10505: NARG2_C (This model is not part of the current CDD release)
NMDA receptor-regulated gene protein 2 C-terminus
The transition of neuronal cells from pre-cursor to mature state is regulated by the N-methyl-d-aspartate (NMDA) receptor, a glutamate-gated ion channel that is permeable to Ca2+. NMDA receptors probably mediate this activity by permitting expression of NARG2. NARG2 is transiently expressed, being a regulatory protein that is present in the nucleus of dividing cells and then down-regulated as progenitors exit the cell cycle and begin to differentiate. NARG2 contains repeats of (S/T)PXX, (11 in mouse , six in human), a putative DNA-binding motif that is found in many gene-regulatory proteins including Kruppel, Hunchback and Antennapedi.
Links
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Statistics
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PSSM-Id: 519419
Aligned: 21 rows
Threshold Bit Score: 226.82
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
ETN66051     404 RQALDKRQHeNRFYQLWKLTDEQSd---------eEQAVLIDFRQDFYQTLRK-----TRLFMNLSvKLEHQPEFGAEQM 469
XP_001954923 384 SSGIVDSNS-NCALVSWILKSQDH-----------NFQMFSTLSIPAVRDSYGk----KLLGCHLI-KLENKPDCGCEIM 446
Q8IGQ6       104 PSDIEDGNC-NSALVSWTLRCKGEgdd------cnDFQIFSTLSIPAVKDSSGk----EPLGCHFI-KLENKPDCGCEIM 171 fruit fly
XP_001994515 382 VHPIKQARS-NGALVSWRLQTDEKd---------dALLIYSSLAIAAVRDTLGe----HPLGCHLI-KLENKPDCGCEIM 446
XP_002053561 384 VRPMPEAKS-NSALVSWRLRAGEAdte-----aepALLMYSSLPIAAVRDAAAn----QMLGCHLI-KLENKPDCGCEIM 452
XP_001998268 388 APVVTEMKT-NCALVSWRLRAAESt---------kSLSIYSSLSVAAVRDAAAk----QLLGCHLI-KLESKPECGCEIM 452
EDS41823     376 RKPSEPVQK-NVSLQLWNLQDGDE-----------QYRFLVRTRTDCYESLRK-----VKFYINISiKLEYQTEFGAEQM 438
EFN68808     338 GNETNNIKT-NVMYKLFTIGPTESlnqelgkhdvkEYQMLVRTKTDGTEVLPN-----KTQHVILTpKMEHQLGLGAEAV 411
2_pfamImport   1 NESVQDDYN-NYNYDKWMLKVSNVngv------dkSFNLLVRNKPHGIQQQIKp----QNTPVVIIpKVEYQPEFGFEKV 69 
3_pfamImport   1 EDYEAPAEG-NVFYKLYSLQ---------------ELLLLVRSSVSLTHSRHCgssqnQFVPVHVLpKLEFQLCHGVECL 64 

ETN66051     470 TKAELLHEWARQLLR-PNSKTLRIRLDPVTHRMISSHYLELRDIEEELLRLYGVKPRHLITSMWGTLRRLQLFPVGSYLL 548
XP_001954923 447 TKYELLKAWLQIKLL-QAESGHCTRISLRDFDPVLEEKLTLASLEQQLHDYYNTSMPQLLSNLFEFLKIFHTVPVGDYLL 525
Q8IGQ6       172 SKYELISAWVQLKLM-RAEMGHCTRISLRDFEPMLEEKLTLISLEQQLHDYYNTSMPQLLSNLCEFLKLLDTVPAGDYLL 250 fruit fly
XP_001994515 447 TKYELISAWLQLKLL-QANVGHCSRISLRDFAPLLEQQLKLEALEEQLYEYYHTSMPQQLCQLHEFLKLLRTVAPGEYLL 525
XP_002053561 453 TKYELLSAWLQLKLL-QTDIGHCSRISLQDLAPLLEEPLTLGALEQQLHEYYHISMPQQLSQLREFLKLLRSVTPGRYLL 531
XP_001998268 453 TKYEMLSIWLQLQLL-QSNVGHCSRISLQDMQPLLEQKVTLSTLAQQLHECYNINVAQLLSQLAEFLKMLSSISPGEYLL 531
EDS41823     439 TKSELIREWTRQRLR-PNSRTLRLRINASNHIILSHHYLELKDIEEELKRLYDIEPQNLLTNLWQTLRLIMQFPPGEHLL 517
EFN68808     412 TFEELSHQWASLIFR-PGTILGRVRIEVDSSEIIQIEKHTTASLSNEMRRLYNTKIEDSLSILHNIIEGLSSLTPGQYIM 490
2_pfamImport  70 SEEQLVEYWLDTSFRcPKTKLAL--VSVQHDMDLMQVKWTIEEVESLSS---NGKDQMYLQRLYLTLEKLTQLGKGEYVL 144
3_pfamImport  65 TSSEACQLWTESLLH-SNTVSYIAHINALTSKVALLRKLPDDWKHKMSC---WFKPSKSLNILHHLLKKLTGLQEGQYMV 140

ETN66051     549 HRDERtvqgwsvYTEVgrergqQLNPNAVVYDLRTRLHAieYDLPPLEq----YDWIPIDKCFITQVHREGSILPCSFPH 624
XP_001954923 526 RYSPK-------YKDKfllcttTKQASTQSFQLHQVLKD--AVPSDQNfl-sqSSYLPISATLCGRMHEELQLVPCSFPA 595
Q8IGQ6       251 RYSPK-------YKDKfllcivTKEATPQSFQLHQLLTE--SIPSDQAfl-tqSSYLPISPTLCGRLHEELHLLPCAFPA 320 fruit fly
XP_001994515 526 RYTTK-------YKDKfllcrpSLEATAQSFQLHDLLMS--KPPTDINfltqsNSYLPISTKLCSRLHEQLQLLPCAFPA 596
XP_002053561 532 RYTAK-------YKDKfllcqpTPEPTPNSFKLYDLLAG--TSPNDINfltqaASYLPISPKLCSRLHEQLQLLPCSFPV 602
XP_001998268 532 RYTSK-------YKDMfllcqpTADDTSMSFKLHELLMGt-SSPNNIDfltqsSTYLPITPLLCSRLHEQLQLLPCAFPA 603
EDS41823     518 QHDTKnpetvmiLSQS---------STTFTLDLHALYSNveYERCALEe----YDWVPIDATVITKLHREHTLLPGTFPH 584
EFN68808     491 RHVPQrgpfayiYKQV-------EEPGKNVFDLHTVCQSamLQTVPKT------PWPLIDTMLTTPAIRQFKKMPAMFNP 557
2_pfamImport 145 LHNPKkpfhvdvYQSS----------VYGGFNLLNMYFVlqQTEVSDS-----LVWNPIDREILCPIHNYFKVAPCMFRP 209
3_pfamImport 141 AHKAGepf-vtiLKAT----------KGGPHNLQQVHNGvpQPPSSGH-----MPWIPVDPAVVLPFHHNHGRVPCTFPP 204
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