Conserved Protein Domain Family
Peptidase_S26

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pfam10502: Peptidase_S26 
Signal peptidase, peptidase S26
This is a family of membrane signal serine endopeptidases which function in the processing of newly-synthesized secreted proteins. Peptidase S26 removes the hydrophobic, N-terminal, signal peptides as proteins are translocated across membranes. The active site residues take the form of a catalytic dyad that is Ser, Lys in subfamily S26A; the Ser is the nucleophile in catalysis, and the Lys is the general base.
Statistics
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PSSM-Id: 402227
View PSSM: pfam10502
Aligned: 77 rows
Threshold Bit Score: 92.2635
Threshold Setting Gi: 499623358
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q89AM6         51 VVQTFA---SFFPILIIV--FIIRTFICEPFQIPSESMMPTLLPGDFILVKKFSYGiknpfsnnvivfINTPKRGDIVVF 125 Buchnera aphid...
Q1QF78          3 RQRSLL----VVIATGAG--AVLCLALTGWCADLRINMTPSYPRGLWRIEAL----------------DRPADVGDRIFI 60  Nitrobacter ha...
Q44350          2 SKRAVI---RFLGVAGLVlsGATVMGLIGGYRV---NVTPSEPLGLWRVEKL----------------RRPVQSGDLVFV 59  Agrobacterium ...
P55417         14 RGKPLL---LGLATMTMAavGTISAAWFGGYRI---NLTPSEPLGLWRIVKI----------------DRPSAVGDLVFI 71  Sinorhizobium ...
Q2K2P6         16 TNAVVL---LALAASIVG--GGVAAATVGGFRI---NMTPSEPLGLWRIVAL----------------DRPAVAGDLIFI 71  Rhizobium etli...
Q1LIY3         18 RARLVL---AGLSACGLA--ALAWASFVHPLPRLTYNPSDSVEVGWYRIDPLDHRTss---------pPRPLSVGSIVLV 83  Cupriavidus me...
WP_011806074   26 RARIVL---SGLAACGLA--ALAWAYFVHPLPRLIYNPSDSVAVGWYRVDPLHHRPcs---------lPRPLSVDTIVLT 91  Acidovorax sp....
jgi:Ajs_2658   22 RARLVL---AGFAAVGLA--ALAWAAFVQPLPRLIYNPSDSVPVGWYRVDPIQHRAgs---------lARSLSVGSIVLT 87  Acidovorax sp....
jgi:Caul_5335   7 RRRLLViaaALAPAVLL---GALALVVQGPSLL--WNRSDSEPRGLYIRS------------------AAAPSRGQIIAF 63  Caulobacter sp...
Q3IUW1          3 LRDLAR---RSFMIGGSL--FVVAGFWLLHNGRLTLNASHSLPEPAYLMWAW----------------PKVIWKGAVISA 61  Rhodobacter sp...
Q89AM6        126 KHPNn-------------nAI------NYVKRIVGLPGDKINYNilTKRLTITpnninEQHTKnisinykyikpndftkh 186 Buchnera aphid...
Q1QF78         61 CPPDtavferafkrgyirrGLcagglsPLIKTVAAIGGQQIDV---AARVSID-----GRVLGh---------------- 116 Nitrobacter ha...
Q44350         60 CPPHnaffeeawlrgylrsGLcpgwfaPLIKSVLALPGQRVEI---ADRIVID-----GHPVSa---------------- 115 Agrobacterium ...
P55417         72 CPPRtsamrearmrgylraGLcpggiaPLIKSVIAVAGQRVEV---GVSVNVD-----GHPVPs---------------- 127 Sinorhizobium ...
Q2K2P6         72 CPPQttemrearergylrsGTcqggiaPLIKTVIAIAGQHIEI---GAGVTID-----GRPIAf---------------- 127 Rhizobium etli...
Q1LIY3         84 PLPAeaaalaa-qrgylptRI------PLLKRVGAVAPQEVCIA--DGKVRID-----GVPSA----------------- 132 Cupriavidus me...
WP_011806074   92 TLPPdaaalaa-qrgylpaRI------PLLKRVGAIAPQHVCVF--DALVWIE-----GVPVA----------------- 140 Acidovorax sp....
jgi:Ajs_2658   88 QLPAdgaalaa-qrgylpaHV------PLLKRVGAVAPQHVCIV--AGQVRID-----GVPVA----------------- 136 Acidovorax sp....
jgi:Caul_5335  64 PAPPsvlt-------yasgRMaymrhmPILKEVAAMSGDTVCTL--DGKLVIN-----GVWRA----------------- 112 Caulobacter sp...
Q3IUW1         62 DPPAayaa--------rfdGL------LFTKRVVGLPGDRIEHR--DGAVCVA-----GECYP----------------- 103 Rhodobacter sp...
Q89AM6        187 fklnNIILNNVHSLEssnnnllqlemyqekiekiayniffkkklidqkdlyfkqFSQKQGTWIVPKHKYFVLGDNRDNSL 266 Buchnera aphid...
Q1QF78        117 ---sNVRRMDAAGRP---------------------------------------LLPFAGGV-IPAGALFLHSD-FAGSY 152 Nitrobacter ha...
Q44350        116 ---sTVSATDSEGRA---------------------------------------IAPFAGGV-VPPGFLF-LHSSFASSY 151 Agrobacterium ...
P55417        128 ---sALALRDGQGRP---------------------------------------MKPFSGGI-VPTDYVFLHSP-FSGSY 163 Sinorhizobium ...
Q2K2P6        128 ---sELAERDGKGRP---------------------------------------MKPFPGGV-VPDESVFLLSPFR-SSY 163 Rhizobium etli...
Q1LIY3        133 ----AVLSADRWGRP---------------------------------------LPSRQQCHRLRHGELFLLSVTNPASF 169 Cupriavidus me...
WP_011806074  141 ----TVRPADRLGRP---------------------------------------LPSWPQCRQLRPGELFLLSSTNPASF 177 Acidovorax sp....
jgi:Ajs_2658  137 ----AALPADRLGRP---------------------------------------LPSLQLCRCLEPGELFLLSVTNPASF 173 Acidovorax sp....
jgi:Caul_5335 113 ----PVLAHDGESRP---------------------------------------LPHWRACRRLGEGEFFVFSNRIPNSF 149 Caulobacter sp...
Q3IUW1        104 -------LALKDGAP---------------------------------------FAPALAEGVIPDGHYAAFGSS-ADSL 136 Rhodobacter sp...
Q89AM6        267 DSRY--WGFVPEKNL----IGKVVFIWmhL 290 Buchnera aphidicola str. Bp (Baizongia pistaciae)
Q1QF78        153 DSRY--FGPIPASGI----LGLAR-PV--L 173 Nitrobacter hamburgensis X14
Q44350        152 DSRY--FGPIPDSGL----LGLAR-PV--F 172 Agrobacterium fabrum str. C58
P55417        164 DSRY--FGPIPAAGI----LGLAQ-EV--L 184 Sinorhizobium fredii NGR234
Q2K2P6        164 DSRY--FGPLPASGI----LGLAK-PV--L 184 Rhizobium etli CFN 42
Q1LIY3        170 DSRY--FGPVSAASV----IGVAR-PV--W 190 Cupriavidus metallidurans CH34
WP_011806074  178 DSRY--FGPVSASAV----IGVAR-PI--W 198 Acidovorax sp. JS42
jgi:Ajs_2658  174 DSRY--FGPVSASAV----IGIAH-PV--W 194 Acidovorax sp. JS42
jgi:Caul_5335 150 DSRY--YGPVRHEAI----VGVFR-PI--M 170 Caulobacter sp. K31
Q3IUW1        137 DSRYatVGLFARETIravgVGTTLVPH--W 164 Rhodobacter sphaeroides 2.4.1
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