4ME8


Conserved Protein Domain Family
Peptidase_S26
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pfam10502: Peptidase_S26 (This model is not part of the current CDD release)
Signal peptidase, peptidase S26
This is a family of membrane signal serine endopeptidases which function in the processing of newly-synthesised secreted proteins. Peptidase S26 removes the hydrophobic, N-terminal, signal peptides as proteins are translocated across membranes. The active site residues take the form of a catalytic dyad that is Ser, Lys in subfamily S26A; the Ser is the nucleophile in catalysis, and the Lys is the general base.
Links
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Statistics
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PSSM-Id: 519417
Aligned: 61 rows
Threshold Bit Score: 80.7728
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
4ME8_A          1 GAAVNGSSXEPTLHN---NDRLWVTSIKKPQRFDIIAFPSPRNGQRVAKR-------LIGLPGETVEYRDDTLy------ 64  Enterococcus f...
Q3IUW1          3 LRDLARRSFMIGGSL---FVVAGFWLLHNGRLTLNASHSLPEPAYLMWAW-------PKVIWKGAVISADPPAayaa--- 69  Rhodobacter sp...
WP_011801912    5 QLNLVPLYVTLLAMSataIFAIVAKSSGLVLNVTGSMPDLVy--------------kLGLGEKGSLVSFCSPIphps--- 67  Polaromonas na...
Q44350          2 SKRAVIRFLGVAGLVl-sGATVMGLIGGYRV---NVTPSEPLGLWRVEKL-------RRPVQSGDLVFVCPPHnaffeea 70  Agrobacterium ...
Q1QF78          3 RQRSLL-VVIATGAG---AVLCLALTGWCADLRINMTPSYPRGLWRIEAL-------DRPADVGDRIFICPPDtavfera 71  Nitrobacter ha...
Q1LIY3         18 RARLVLAGLSACGLA---ALAWASFVHPLPRLTYNPSDSVEVGWYRIDPLdhrtsspPRPLSVGSIVLVPLPAeaaalaa 94  Cupriavidus me...
2_pfamImport    1 CAHLVLAVLSTCGLA---AMAWASFAMPSAHVVYNPSNSVPVGWYRIESVts----pADSLHVGSIVLARLPAeaaalaa 73 
WP_011747828    3 RARYIM-VTVAALAA---VIVGSIPTAPRLV--WNASASVPIGFYTIAP--------VDRLAVPDLVAVMPPEpfagfmv 68  Paracoccus den...
1_pfamImport    1 RTTYLAATAAAVMVI---GAVSVTDITPRLI--WNASASLPIGLYRVEP--------PTTLTLGDLVAVDPPEplaqfvt 67 
jgi:Pden_0136   6 RTAYLAATGLAVLVI---GAVSVTEIAPRLI--WNASASVPLGLYAVQP--------VGNLTLGDLVAVTLPEplaqfiv 72 

4ME8_A         65 --------IN------GVSLSEDYLASAKRNVSKNENYTQDFTLE--TLEATQSLTVPegxyfvlgdnrPRSDDSRYFgf 128 Enterococcus f...
Q3IUW1         70 -----rfdGL------LFTKRVVGLPGDRIEHRDGAVCVAGECYP-----LALKDGAP-----------FAPALAEGV-- 120 Rhodobacter sp...
WP_011801912   68 -----ighGAcpdgsmPLIKRVVGVAGDLVTATDAGIDINGQPVPnsRPLDLDTKESA-----------LPHLRGSFS-- 129 Polaromonas na...
Q44350         71 wlrgylrsGLcpgwfaPLIKSVLALPGQRVEI-ADRIVIDGHPVSasTVSATDSEGRA-----------IAPFAGGV--- 135 Agrobacterium ...
Q1QF78         72 fkrgyirrGLcagglsPLIKTVAAIGGQQIDV-AARVSIDGRVLGhsNVRRMDAAGRP-----------LLPFAGGV--- 136 Nitrobacter ha...
Q1LIY3         95 -qrgylptRI------PLLKRVGAVAPQEVCIADGKVRIDGVPSA--AVLSADRWGRP-----------LPSRQQCHR-- 152 Cupriavidus me...
2_pfamImport   74 -qrgylppHI------PLLKRIGAVAPQDVCIVNGVVRIDGVPVA--AVLRTDRMGRP-----------LLSWQQCRA-- 131
WP_011747828   69 -argyvgrDV------PILKHVIGLPGQRICRDGAAITIDGRHLG--EARERDSQGRD-----------LPVWQGCRT-- 126 Paracoccus den...
1_pfamImport   68 -argyvgpGV------PLLKRVAALPGTRVCRTGATITVQGEAIG--EARERDRIGRP-----------LPTWQGCQV-- 125
jgi:Pden_0136  73 -argyvgpGV------PLLKRVAALPGTRVCRRGSTITGDGQVLG--EARERDRFGRP-----------LPTWQGCRL-- 130

4ME8_A        129 VKQASVEGVLTFRYYPLDKIG--FP 151 Enterococcus faecalis V583
Q3IUW1        121 IPDGHYAAFGSS-ADSLDSRYatVG 144 Rhodobacter sphaeroides 2.4.1
WP_011801912  130 LKQGDIWTAGEH-PNSFDSRY--FG 151 Polaromonas naphthalenivorans
Q44350        136 VPPGFLF-LHSSFASSYDSRY--FG 157 Agrobacterium fabrum str. C58
Q1QF78        137 IPAGALFLHSD-FAGSYDSRY--FG 158 Nitrobacter hamburgensis X14
Q1LIY3        153 LRHGELFLLSVTNPASFDSRY--FG 175 Cupriavidus metallidurans CH34
2_pfamImport  132 LAEGELFLLSVTNPASFDSRY--FG 154
WP_011747828  127 IAEGEVFLMNPAVADSFDGRY--FG 149 Paracoccus denitrificans
1_pfamImport  126 VGTDEVFLMNREVGDSLDGRY--FG 148
jgi:Pden_0136 131 IAEGEVFLMNQDAEDSLDGRY--FG 153
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