Conserved Protein Domain Family
SR-25

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pfam10500: SR-25 
Nuclear RNA-splicing-associated protein
SR-25, otherwise known as ADP-ribosylation factor-like factor 6-interacting protein 4, is expressed in virtually all tissues. At the N-terminus there is a repeat of serine-arginine (SR repeat), and towards the middle of the protein there are clusters of both serines and of basic amino acids. The presence of many nuclear localization signals strongly implies that this is a nuclear protein that may contribute to RNA splicing. SR-25 is also implicated, along with heat-shock-protein-27, as a mediator in the Rac1 (GTPase ras-related C3 botulinum toxin substrate 1) signalling pathway.
Statistics
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PSSM-Id: 402225
View PSSM: pfam10500
Aligned: 13 rows
Threshold Bit Score: 141.974
Threshold Setting Gi: 82192703
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_007239762   5 RSRSRSRERKStsr--qgrERRTEKKRRKYSSSSS-SSSSASPSSQKKHG--------RVSnks------mskDRKTERK 67  Mexican tetra
XP_005989016   3 RSRSRERSRSRtktsscgkGLKRDGKKRSRSSSSSrRSTSLSKKCHHSTS--------PSK------------ERKPEKK 62  coelacanth
Q502P0         3 GSDSDSRSRSR---------NREENKSRSLSSSSA---RRPSPNHEKKH------------------------EHSSEKK 46  zebrafish
XP_604454      7 RKRSRSRSRSR---------GRGSEKKRKKSSKDVrRSCSASRSQSRKAS--------STSsg--------aeERSKHKA 61  cattle
Q66PJ3       191 RKRSRSRSRSR---------GRGSEKRKKKSRKDTsRNCSASTSQGRKAS---------TApgaeaspspcitERSKQKA 252 human
EGW14956       7 RKRSRSRSRSR--------GRRGSEKRSKKSSKDAsKNCSASKSPGHKAC--------STSe-----------ERSKHKA 59  Chinese hamster
Q4V8I5         7 RKRSRSRSRSR--------GRRGSEKRSKRSSKDSsRNCSTSKSQGHKAS--------STSgv---------eERSKHKA 61  Norway rat
XP_001521084   9 RSRSRSGSRGR--------PERSKEMRRKRGSKERrRSRSASGSRSRRPR--------AAShk---------pERSKDRG 63  platypus
XP_003761099  39 RSRSRSRSGSHg------pPEHGERRRRRRSSKDMgRSPSASGSQGQRIS--------LGSng---------eERSRDKA 95  Tasmanian devil
Q5F4A9         7 RKRSRSSSRSP--------SGSGREKGGARSS-------AASPGPRHRLS--------SAAar--------egRKKEGRK 55  chicken
AAI61359       9 RSRSRSPKVSQ---------SKSSKKKKKLSSRCR----SSSDSPVRKHS--------TLAkyra----evpdRRKKERR 63  tropical clawed...
XP_008516697   7 RKGSRSRSGTR---------ERGSEKRRKKSSKDApRSCSASRSQGRKAStvspgaeaSPSpc--------itERSKHKA 69  Przewalski's horse
XP_014730407   1 ---------mahsrsrkrsrsrsksnsrsrherkekkrrksskdsqrgssspprkrisgshghksslatareekkkegkd 71  Common starling
XP_007239762  68 KQKRRRSSSSSSSSSSSSSSSSISSSSSTSSSd----eEAKKKKKHRMTKKRLKKMK---AKKKKKEKKEKKr-lKKIKK 139 Mexican tetra
XP_005989016  63 KAKRKPSASTSSDSSSPASSTSTCSSSLSDSDtes-keSKQQKGKNKTKKSKKKSKKm-nRKSKKMKKKKAK---EAPTA 137 coelacanth
Q502P0        47 KMKRRRSSSSSSSSSSPSPS-------------------REKKAKKKKKRREAKKLKr-eKKKEKKEKKRQKklaLKAER 106 zebrafish
XP_604454     62 RRRPR-SSSSSSSSSSSSSSSSSSSSSSSSDG-------RKKRGKHKDKKRKKKKK-----KRKKKLKKRGK---E--KA 123 cattle
Q66PJ3       253 RRRTRSSSSSSSSSSSSSSSSSSSSSSSSSDG-------RKKRGKYKDKRRKKKKK-------RKKLKKKGK---E--KA 313 human
EGW14956      60 RRTAR-----SSSSSSSSSSSSSASSSSSSDG-------RKKRGKNKDKKRKKKKK------RKKKLKRKGK---E--KA 116 Chinese hamster
Q4V8I5        62 QRTSR--SSSSSSSSSSSSSSSSTSSSSSSDG-------RKKRGKHKDKKKRKKKK-----KRKKKMKRKGK---E--KA 122 Norway rat
XP_001521084  64 RKRRRPSSSSSSTSSSSSSSSSSSSSSRSSSG------GRKKRSKRKDKKRRKKKKK----KAKKKVKKKCR---EKGEA 130 platypus
XP_003761099  96 RKRRRPRSSSSSSSSSSSSSSSSSTSSSSSSGas--sgGRKKRGKRKDKKSTKKKAKkklRKKKKKKKKKEE---KAAKA 170 Tasmanian devil
Q5F4A9        56 KKKRKAKASSSDRSSSSRSSSSSSSTSSSDSDtrakqhSRRKRGKHKDKKKKKKMK--------KKLKKKSK---ERVKE 124 chicken
AAI61359      64 KKKRRRTVSTTSSSSSSSESSSSSSSSCSSSDdsvdssCKSKKSSHRKKKTKKQMKKkkaKKKSKKLKKKTSfklECQDA 143 tropical clawed...
XP_008516697  70 RRRPR--SSSSSSSSSSSSSSSSSSSSSSSDG-------RKKRGKHKDKKRKKKKK------RKKRLKKKGK---E--KA 129 Przewalski's horse
XP_014730407  72 kkkrkastsssgnssstsssssssssssssddssdsdskmkksqdskkkrmkqkdkkkrkkqkkkikkkskkktkERAKE 151 Common starling
XP_007239762 140 LA-AKAEKVATKApliipvpgsvqvektqsyLETWQNDDAAE-HGPVMTDEQKASFSTKRPMTKEEYEARQSVIRRVTDP 217 Mexican tetra
XP_005989016 138 AK-PKLSKMAGPS------------------VEQWQRETWVE-SGPVLTDEQKSRIQAMKPMTKEEWDARQSVIRRVVDP 197 coelacanth
Q502P0       107 AA-ALTASVPAPVpeek----------pqtyLKTWQSEETKE-HGPAMTDEQKAKLSTRRPLTKEEYEARQSVIRRVLDP 174 zebrafish
XP_604454    124 RM-QQTEALPGPS------------------LDQWHRAAKEEeDGPVLTDEQKSRIQAMKPMTKEEWDARQSVIRKVVDP 184 cattle
Q66PJ3       314 EA-QQVEALPGPS------------------LDQWHRSAGEEeDGPVLTDEQKSRIQAMKPMTKEEWDARQSIIRKVVDP 374 human
EGW14956     117 VVlHPAEALPGPS------------------LDQWHKSAGED-DGPVLTDEQKSRIQAMKPMTKEEWDARQSVIRKVVDP 177 Chinese hamster
Q4V8I5       123 VVvHQAEALPGPS------------------LDQWHRSAGEDnDGPVLTDEQKSRIQAMKPMTKEEWDARQSVIRKVVDP 184 Norway rat
XP_001521084 131 GT-QSPQGMPGPS------------------LDQWQKEPLEE-SGPVLTDEQKSRIQAMKPMTKEEWDARQSVVRKVVDP 190 platypus
XP_003761099 171 KA-KAVEEMPGPS------------------LDQWRKEPPVE-SGPVLTDEQKSRIQAMKPMTKEEWDARQSIIRKVVDP 230 Tasmanian devil
Q5F4A9       125 ER-GVSEALPGPS------------------LELWQKEPLAD-SGPVLTDEQKSRIQAMKPMTKEEWDARQSVIRRVVDP 184 chicken
AAI61359     144 KG-TAKEVLPGPS------------------INPCQKESPED-TGPALTDEQKSRIQAMKPMTKEEWDARQSVIRKVVDP 203 tropical clawed...
XP_008516697 130 KV-QQAEALPGPS------------------LDQWHRAAEEEeHGPVLTDEQKTRIQAMKPMTKEEWDARQSVIRKVVDP 190 Przewalski's horse
XP_014730407 152 EK-AKGEEVPGPS------------------LEQWQKESGVD-PGPVLTDEQKSRIQAMKPMTKEEWDARQSVIRRVVDP 211 Common starling
XP_007239762 218 ETGRTRLIRGDGEVLEEIVSKERHKDINK----------------------------QSTKADGTTFQKRLG 261 Mexican tetra
XP_005989016 198 ETRRTRLVKGDGEILEEIVSRERHKEINR----------------------------QATVGDGVSFQTRMG 241 coelacanth
Q502P0       175 ETGRTRLIRGDGEILEEIVSKERHKDINK----------------------------QSTRGDGDAFQKRLG 218 zebrafish
XP_604454    185 ETGRTRLIKGDGEVLEEIVTKERHREINK----------------------------QATRGDGLAFQMRAG 228 cattle
Q66PJ3       375 ETGRTRLIKGDGEVLEEIVTKERHREINK----------------------------QATRGDCLAFQMRAG 418 human
EGW14956     178 ETGRTRLIKGDGEVLEEIVTKERHREINKvgvtalamlcprcvytqylmlltcflpqQATRGDGLAFQMRAG 249 Chinese hamster
Q4V8I5       185 ETGRTRLIKGDGEVLEEIVTKERHREINK----------------------------QATRGDGLAFQMRAG 228 Norway rat
XP_001521084 191 ETGRTRLIKGDGEILEEIVTKERHKEINK----------------------------QATRGDGLAFQLRAG 234 platypus
XP_003761099 231 ETGRTRLIKGDGEVLEEIVTKERHKEINK----------------------------QATRGDGLTFQLRAG 274 Tasmanian devil
Q5F4A9       185 ETGRTRLIKGDGEVLEEIVSKERHKEINK----------------------------QATRGDGLAFQVRTG 228 chicken
AAI61359     204 ETGRMRLIKGDGEVLEEIVSKERHKEINK----------------------------QSTQKDGLAFQMHSG 247 tropical clawed frog
XP_008516697 191 ETGRTRLIKGDGEVLEEIVTKERHREINK----------------------------QATRGDGLAFQLRAG 234 Przewalski's horse
XP_014730407 212 ETGRTRLIKGDGEVLEEIVSKERHKEINK----------------------------QATRGDGLAFQVRTG 255 Common starling
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