Conserved Protein Domain Family
SR-25
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pfam10500: SR-25 (This model is not part of the current CDD release)
Nuclear RNA-splicing-associated protein
SR-25, otherwise known as ADP-ribosylation factor-like factor 6-interacting protein 4, is expressed in virtually all tissues. At the N-terminus there is a repeat of serine-arginine (SR repeat), and towards the middle of the protein there are clusters of both serines and of basic amino acids. The presence of many nuclear localisation signals strongly implies that this is a nuclear protein that may contribute to RNA splicing. SR-25 is also implicated, along with heat-shock-protein-27, as a mediator in the Rac1 (GTPase ras-related C3 botulinum toxin substrate 1) signalling pathway.
Links
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Statistics
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PSSM-Id: 519416
Aligned: 10 rows
Threshold Bit Score: 145.85
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q66PJ3         7 RKRSRSRSRSR---------GRGSEKRKKKSRKDTsRNCSASTSQ----GRKASTAPGAEaspspcitERSKQKARRRTR 73  human
1_pfamImport   1 RSRSRSRERKStsrq--greRRTEKKRRKYSSSSS-SSSSASPSS----QKKHGRVSNKSms-----kDRKTERKKQKRR 68 
EGW14956       7 RKRSRSRSRSRg--------RRGSEKRSKKSSKDAsKNCSASKSP----GHKACSTSE----------ERSKHKARRTAR 64 
Q4V8I5         7 RKRSRSRSRSRg--------RRGSEKRSKRSSKDSsRNCSTSKSQ----GHKASSTSGVE--------ERSKHKAQRTSR 66  Norway rat
XP_028907899   9 RSRSRSGSRGRp--------ERSKEMRRKRGSKERrRSRSASGSR----SRRPRAASHKP--------ERSKDRGRKRRR 68 
Q5F4A9         7 RKRSRSSSRSPs--------GSGREKGGARSS-------AASPGP----RHRLSSAAAREg-------RKKEGRKKKKRK 60  chicken
XP_005989016   3 RSRSRERSRSRtktsscgkgLKRDGKKRSRSSSSSrRSTSLSKKC----HHSTSPSK-----------ERKPEKKKAKRK 67 
Q502P0         3 GSDSDSRSRSR---------NREENKSRSLSSSSA---RRPSPNH----EKKH---------------EHSSEKKKMKRR 51  zebrafish
XP_057348392   1 ----mahigsrkrsrsrsrsrgrwsgKRKRSSKDApRSCSASTSQ----GRKASTTSSGAe-------ERSKHKARRRPR 65  Chinese pangolin
XP_036777931   1 ----mahigsrkrsrsrsrsrgrwsgKRKRSSKDApRSCSASTSQgrkaSTTSSGAE-----------ERSKHKARRRPR 65  Chinese pangolin

Q66PJ3        74 SSSSSSSSSSSSSSSSSSSSSSSSS-DG-------RKKRGKYKDKRRKKKKK------RKKLKKKGK---E--KAEA-QQ 133 human
1_pfamImport  69 RSSSSSSSSSSSSSSSSISSSSSTS-SSde----eAKKKKKHRMTKKRLKKMka--kkKKKEKKEKKr-lKkiKKLA-AK 139
EGW14956      65 -----SSSSSSSSSSSSSASSSSSS-DG-------RKKRGKNKDKKRKKKKKr-----KKKLKRKGK---E--KAVVlHP 121
Q4V8I5        67 --SSSSSSSSSSSSSSSSTSSSSSS-DG-------RKKRGKHKDKKKRKKKKk----rKKKMKRKGK---E--KAVVvHQ 127 Norway rat
XP_028907899  69 PSSSSSSTSSSSSSSSSSSSSSRSS-SGg------RKKRSKRKDKKRRKKKKkk---aKKKVKKKCR---EkgEAGT-QS 134
Q5F4A9        61 AKASSSDRSSSSRSSSSSSSTSSSD-SDtrakqhsRRKRGKHKDKKKKKKMK-------KKLKKKSK---ErvKEER-GV 128 chicken
XP_005989016  68 PSASTSSDSSSPASSTSTCSSSLSD-SDtes-kesKQQKGKNKTKKSKKKSKkmnrksKKMKKKKAK---EapTAAK-PK 141
Q502P0        52 RSSSSSSSSSSPSPS--------------------REKKAKKKKKRREAKKLkrekkkEKKEKKRQKklaLkaERAA-AL 110 zebrafish
XP_057348392  66 -SSSSSSSSSSSSSSSSSSSSSSSS-DG-------RKKRGKHKDKKRKKKKKk----kKKL-KKKGK---E--KAKV-QQ 125 Chinese pangolin
XP_036777931  66 --SSSSSSSSSSSSSSSSSSSSSSSsDG-------RKKRGKHKDKKRKKKKKk-----KKKLKKKGK---E--KAKV-QQ 125 Chinese pangolin

Q66PJ3       134 VEALPGPS------------------LDQWHRSAGEEeDGPVLTDEQKSRIQAMKPMTKEEWDARQSIIRKVVDPETGRT 195 human
1_pfamImport 140 AEKVATKApliipvpgsvqvektqsyLETWQNDDAAE-HGPVMTDEQKASFSTKRPMTKEEYEARQSVIRRVTDPETGRT 218
EGW14956     122 AEALPGPS------------------LDQWHKSAGED-DGPVLTDEQKSRIQAMKPMTKEEWDARQSVIRKVVDPETGRT 182
Q4V8I5       128 AEALPGPS------------------LDQWHRSAGEDnDGPVLTDEQKSRIQAMKPMTKEEWDARQSVIRKVVDPETGRT 189 Norway rat
XP_028907899 135 PQGMPGPS------------------LDQWQKEPLEE-SGPVLTDEQKSRIQAMKPMTKEEWDARQSVVRKVVDPETGRT 195
Q5F4A9       129 SEALPGPS------------------LELWQKEPLAD-SGPVLTDEQKSRIQAMKPMTKEEWDARQSVIRRVVDPETGRT 189 chicken
XP_005989016 142 LSKMAGPS------------------VEQWQRETWVE-SGPVLTDEQKSRIQAMKPMTKEEWDARQSVIRRVVDPETRRT 202
Q502P0       111 TASVPAPVpeek----------pqtyLKTWQSEETKE-HGPAMTDEQKAKLSTRRPLTKEEYEARQSVIRRVLDPETGRT 179 zebrafish
XP_057348392 126 AEALPGPS------------------LDQWHRSAQEEeDGPVLTDEQKSRIQAMKPMTKEEWDARQSVIRKVVDPETGRT 187 Chinese pangolin
XP_036777931 126 AEALPGPS------------------LDQWHRSAQEEeDGPVLTDEQKSRIQAMKPMTKEEWDARQSVIRKVVDPETGRT 187 Chinese pangolin

Q66PJ3       196 RLIKGDGEVLEEIVTKERHREINK----------------------------QATRGDCLAFQMRAGL 235 human
1_pfamImport 219 RLIRGDGEVLEEIVSKERHKDINK----------------------------QSTKADGTTFQKRLGI 258
EGW14956     183 RLIKGDGEVLEEIVTKERHREINKvgvtalamlcprcvytqylmlltcflpqQATRGDGLAFQMRAGL 250
Q4V8I5       190 RLIKGDGEVLEEIVTKERHREINK----------------------------QATRGDGLAFQMRAGL 229 Norway rat
XP_028907899 196 RLIKGDGEILEEIVTKERHKEINK----------------------------QATRGDGLAFQLRAGL 235
Q5F4A9       190 RLIKGDGEVLEEIVSKERHKEINK----------------------------QATRGDGLAFQVRTGM 229 chicken
XP_005989016 203 RLVKGDGEILEEIVSRERHKEINR----------------------------QATVGDGVSFQTRMGL 242
Q502P0       180 RLIRGDGEILEEIVSKERHKDINK----------------------------QSTRGDGDAFQKRLGI 219 zebrafish
XP_057348392 188 RLIKGDGEILEEIVTKERHREINK----------------------------QATRGDGLTFQMRAGL 227 Chinese pangolin
XP_036777931 188 RLIKGDGEILEEIVTKERHREINK----------------------------QATRGDGLTFQMRAGL 227 Chinese pangolin
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