Conserved Protein Domain Family
Syntaxin-18_N

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pfam10496: Syntaxin-18_N (This model is not part of the current CDD release)
SNARE-complex protein Syntaxin-18 N-terminus
This is the conserved N-terminal of Syntaxin-18. Syntaxin-18 is found in the SNARE complex of the endoplasmic reticulum and functions in the trafficking between the ER intermediate compartment and the cis-Golgi vesicle. In particular, the N-terminal region is important for the formation of ER aggregates. More specifically, syntaxin-18 is involved in endoplasmic reticulum-mediated phagocytosis, presumably by regulating the specific and direct fusion of the ER with the plasma or phagosomal membranes.
Statistics
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PSSM-Id: 519413
Aligned: 64 rows
Threshold Bit Score: 58.5677
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_003224195   3 VDITLLFKASVKTVKtrnkalGvplGGgggsdssrDDA----LLLLKRSRPRS---DFSSRAREVVNNIGKLKDFLLQHR 75 
XP_003036686   4 MNITSEFRELLREKek-----------------lyPDAkrrkLSRREPPRPTGidkEYLREACTILDHINTLTRMLASIR 66 
XP_067521886   2 SNITIQFRQLVEQKa-------------------nSISpkksKEKKHEKYTYD---LFTKEAYRIYRHVDSLRHFLLSIR 59 
XP_011386238  13 TDLTADFQSLIAQRRq-----Ey--PPsasssaqgFGRlkrkDPPENVVKALK---QWLAQAYIIRKHIISLLGFLYSIR 82 
XP_012189145  13 TDLTADFHSLIAQRRq-----Ey--PPssss-aqpSRAlrrkDPPENVVKAHK---QWLRQAYIIRKHIISLLGFLYSIR 81 
XP_007414590   5 TSRTLEFKEILQQH-------K---KNqnlskpinPKSpiskTKPPSNLSETQ---TWSKEAKVVNHNIQDLLEFLKTIK 71 
XP_045284405  39 TDITPLVNELLKTHgtta--------------iqsRSLartrEAQRPSTETVD---EFLKEAYRINSHITSLLTYLKSIR 101
XP_001275273   2 TDLTPTLRRLLKEKh--------------------AITtarpEPRLPSSETTD---EFLKEAYRINFHITSLLSYLHSIR 58 
XP_054120041   2 TDLTPSVQELLREKrk-----------------elATDteipQTPPRDPKNVN---EFLKEAYRINSHIQSLLHYLQSIR 61 
XP_001240704   4 ADITLIVNGLLESHg--------------------VSGipniEDRRAKYQTVD---EFLKEAYRINSHISSLLTYLKSIR 60  Coccidioides im...
XP_003224195  76 KDYINT--YSHAmsefvrMTDTERDQI 100
XP_003036686  67 KPYLNVdaRPSP------LSRKGTRNI 87 
XP_067521886  60 PVYLSTsnRPRT------TRTQITQNT 80 
XP_011386238  83 RKYLALgrRHAV------HLGQGVHGA 103
XP_012189145  82 RKYLALgkARTH------QLRADQDGT 102
XP_007414590  72 RAYLDPtpSR--------SSTTHHNST 90 
XP_045284405 102 QSYLSTttPRA-------PFPHNGRSH 121
XP_001275273  59 PAYLALnpSTST------SSTSPSQPN 79 
XP_054120041  62 HSYLSIhtTKKK------PDTTPAATA 82 
XP_001240704  61 QAYLSTapRRPP------VSRRDTHRS 81  Coccidioides immitis RS
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