Conserved Protein Domain Family
PACT_coil_coil
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pfam10495: PACT_coil_coil (This model is not part of the current CDD release)
Pericentrin-AKAP-450 domain of centrosomal targeting protein
This domain is a coiled-coil region close to the C-terminus of centrosomal proteins that is directly responsible for recruiting AKAP-450 and pericentrin to the centrosome. Hence the suggested name for this region is a PACT domain (pericentrin-AKAP-450 centrosomal targeting). This domain is also present at the C-terminus of coiled-coil proteins from Drosophila and S. pombe, and that from the Drosophila protein is sufficient for targeting to the centrosome in mammalian cells. The function of these proteins is unknown but they seem good candidates for having a centrosomal or spindle pole body location. The final 22 residues of this domain in AKAP-450 appear specifically to be a calmodulin-binding domain indicating that this member at least is likely to contribute to centrosome assembly.
Links
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Statistics
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PSSM-Id: 519412
Aligned: 74 rows
Threshold Bit Score: 59.5337
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
EMR63401      1225 RWEREAKLRNDAAFAKRFLGLQLEVAEACNKADLRILRGIHKQLgisspdsllsasrqkqqqersallygggggggggdn 1304
2_pfamImport     1 KYLRVESRRRALAFQKRYLLCILGSYQYCAENTLYVLAQLTRDQrsy--------------------------------- 47  
XP_011059726  2847 KYLRVESRRKALAYQKKYLLCIVGSYQYCEENTLCVLAQLTQDQrsy--------------------------------- 2893
XP_015793348   629 QYRRCLSHRNSLIYQKKYLLNVLGGYQLTERATLALLANPNVTTn----------------------------------- 673 
EDS26952       889 KYLRSESHRKALVHQKRYLQIVLATNEENELKALQLLTAQGLTPnp---------------------------------- 934 
16_pfamImport    1 KYLRSESHRKALVHQKRYLQIVLTTYEENEARALALLNAQLPPGqlevlala---------------------------- 52  
XP_002068917  2650 RYLRVESHRKALVYQKRYLKLTLESYQASEQMAMQAIAGGQGAT------------------------------------ 2693
Q400N1         918 RYLRVESHRKALVYQKRYLKLTLEGYQASEQLALQNLRGga--------------------------------------- 958  fruit fly
XP_009019651   774 NWIRSESQRQSLVYQKFYLTTLLSAYQKNEDDYTELLSAMLGCDyendes------------------------------ 823 
4_pfamImport     1 KYLRAESFRKALIFQKKYLLLLLGRFQECEDATMGLLARMEGYPglrd-------------------------------- 48  

EMR63401      1305 hnkkdssnrkkkpayHEVRAKAQHNLRVFATVLRAAARMRVDASRW 1350
2_pfamImport    48 ------------trlPHG----KVRLKIIVLVVISTLRMKWLIQRW 77  
XP_011059726  2894 ------------arlSRNR---KVRFRIAVFAIISIHRMKWLIQRW 2924
XP_015793348   674 --------------eSSLPNPGRLRFKSMVIAVIAIHRIVHIRLKH 705 
EDS26952       935 --------------pEPTSPKNRRSFRAVVTAVIAIERMRFIVRKW 966 
16_pfamImport   53 --------sgprsldSTTSRPRRKSFRSIVTVVVAIERMKYLVRKW 90  
XP_002068917  2694 ----------------VQKRPKKKLFKTVALAIIAIQRIKYIGRIW 2723
Q400N1         959 --------------eQPPQRNIKKKFKTVALAIIAIQRIKYIGRIW 990  fruit fly
XP_009019651   824 ---------vrrnknTILISSYKRKFKKIFVVIVFVVRVVKLAKVL 860 
4_pfamImport    49 ------------hemVPGRTEGLTRFRTAIRVSIAITSAHFARYVL 82
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