Conserved Protein Domain Family
Stk19

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pfam10494: Stk19 (This model is not part of the current CDD release)
Serine-threonine protein kinase 19
This serine-threonine protein kinase number 19 is expressed from the MHC and predominantly in the nucleus. Protein kinases are involved in signal transduction pathways and play fundamental roles in the regulation of cell functions. This is a novel Ser/Thr protein kinase, that has Mn2+-dependent protein kinase activity that phosphorylates alpha -casein at Ser/Thr residues and histone at Ser residues. It can be covalently modified by the reactive ATP analogue 5'-p-fluorosulfonylbenzoyladenosine in the absence of ATP, and this modification is prevented in the presence of 1 mM ATP, indicating that the kinase domain of is capable of binding ATP.
Statistics
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PSSM-Id: 519411
Aligned: 46 rows
Threshold Bit Score: 137.767
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_007780254  78 RDRMFSDVPErGSGMNSTRTAEVLNYRLN-LP--------PIVTVAHIHSFT-N-SPTSIDREIAELIRSGKIRKLVIPG 146
EGV64875     121 EHLVFQ-----LKGLAMSTKAEIMKYRTThIPq-------GLVTTNQLYSIFdKeGNTFVDRNIELSIRKGQIRKFVITN 188
XP_002547448 117 EERILS-----LKGISQQVKIEILRFRRN-LPn-------GLITTTQLYSIFlNqNNTFVDKSLELNIRQGKLRRFVISN 183
EMG47184     110 EERIFS-----LKRLSSDAKVAILKFRKG-FPs-------GLVTVTQLYSIFlNqNNTFVDKSVELGVRQGKLRKFVINN 176
XP_036668023 116 EEKVFQ-----IKGLSSTLKAELIRYRHS-LPq-------GLVAITQLYAIFhNeGPTFVDKSLELNIRKGILRKFIITN 182
XP_001525879 139 EEVIFQ-----IKGLSLTSKAELVKFRSS-FPs-------GIVTINQLYSIFsAqGNTFVDKQVELNVRQGLLRKFVLNN 205
XP_002277335  22 esedydealsleqslTFSDTLVALRIMRAqFPqiekvsvqPFILRSQLYSSVk--DRTQVDRELESLRRDKVLRIFKLNT 99 
Q5XVE4        36 gavsedqclpledDLTFSDTSVALRMMRAqFPridqasipPFILQSQLYSSVn--DRTQVDRELECLRREKVVRVFKLNT 113 thale cress
XP_006005730  32 kramfQDVPDtKAALKYLASLFPRKLFNDsLP--------PVVLKHQLYSIVk--DKTTVDRQLNELKDQGEIRIFQLGF 101 coelacanth
EEQ41705     101 QDLLFS-----LRGLSMEVKAEILKYRNHqLPr------gGMVTVNQLYTVFeHrGNTFVDRSLEKCIRDGLVMKFVITN 169 Clavispora lusi...
XP_007780254 147 RNAGRAagrdAVG-----------DCLVLFSDWERLV----RSHPDLTDGLK--------------------EKYVTLLR 191
EGV64875     189 AAPIIQtsndQARngkitygyenvEVLVKTGVFYSKI----QETLSKLTDSFqik---------------vlQKFEKFTK 249
XP_002547448 184 ASPVISrslnRFEsgkvtygfenvDLIVKSKEYFKLI----MELKTKLEEELederlptslrnkkvtglsslVKFLNYLQ 259
EMG47184     177 ASPVISrssnKFQsgkvtygfenvDILVETETYFEMI----KSAINASQEDltatpeqr------klalsslTNFQNYLN 246
XP_036668023 183 ASPVISrshnKFQvnkvtygfediEVIAKVDYFHKLI----KKVMSGLDDKSssk--------------qalVKFNELIS 244
XP_001525879 206 ASPVISrsinRLQmrkvtygyenvELLVKTEDYYKNL----INIVESTDKENeklr-------------ltmSKFLNLAK 268
XP_002277335 100 GQDD--------------------HAIMFMDDYLNQIerviKRMAAKKQDELav-----------------fEWFKTHVI 142
Q5XVE4       114 GQDD--------------------HAIIFLDDYLNQVdrivKRMEEKKQSDLei-----------------fKLFKMHVL 156 thale cress
XP_006005730 102 ATDV--------------------FGIVFTDEYKNKV----LAATAGKEHSVv------------------tQKFLETVL 139 coelacanth
EEQ41705     170 ASPVISrsgkSGTyhkvtygyensEVVVKKEQYLRLI----DESMGKEKPEss------------------lVKFKEYVM 227 Clavispora lusi...
XP_007780254 192 ATQTSSIA------SSA----L----TH-SEAATLTSAGFLISTtasahsstadfflrpsvassgtlsslasagsraaag 256
EGV64875     250 ENPTTLFI--------StedsF----LE-SELTTLVELGFITLTsn---------------------------------- 282
XP_002547448 260 ESPSATSI-------TSmnsgL----AK-EELSHLMNLGFVTLSsn---------------------------------- 293
EMG47184     247 KSPSALYVtg---------dtF----ANqDEVSYLVKSGFLTLSsn---------------------------------- 279
XP_036668023 245 LHPTEMFIst---------ldF----TN-EEVSNLVQLGFITLTsn---------------------------------- 276
XP_001525879 269 SSPSQMFIst---------ssF----DD-YEVSMLIQMGYLTLTt----------------------------------- 299
XP_002277335 143 TSKLEPSIehqelcSLLs---FggnvKD-EHISLLINAGLLTRQ------------------------------------ 182
Q5XVE4       157 DSKLEPSIghhellSLLs---LggkvKD-AHITLLINAGLLTRQ------------------------------------ 196 thale cress
XP_006005730 140 MSCSDISFnkekmlKEFl---F----RD-KEITQLMNAGVITVR------------------------------------ 175 coelacanth
EEQ41705     228 SHPEALFVtt---------edF----SV-EEITKLVKLGFLTLTsn---------------------------------- 259 Clavispora lusi...
XP_007780254 257 tleavggvnalhnvggsgggtaisggarAAAASGAQYNFSLPNTGPYLRLLTTARSHLVTLLGKSsRYREAPVSLLRDRW 336
EGV64875     283 ---------------------------hKNEIESQQYALSFPNCGTYLKLVNNGRSWLVKTLNKC-KFHELLESELFNRW 334
XP_002547448 294 ---------------------------hLNEIESNEYAISYPSCGTYLKLVNAGRSWLVKVLNKL-KFKELLEDQLITKW 345
EMG47184     280 ---------------------------hLNEIEVSQYAISYPSCGTYLKMINAGRTWLVKLLNKG-KFKELLEDQIQSKW 331
XP_036668023 277 ---------------------------hFNEIE-HKYSISYPGCGTYLKLVNEGRTWLVKSLNRN-KHKEALEEELFRKW 327
XP_001525879 300 ---------------------------nFSSSEEAQLEISYPGCGRFLRLINEGRMWLVGTLNRN-THKEMLEDELFRKW 351
XP_002277335 183 ------------------------------LIDPNMYWFAIPNIGSLLKGLSQGRKELLSFLNRR-RYKEMMLAPLEKK- 230
Q5XVE4       197 ------------------------------LIDPDMYWFAIPSTGKLWKGLSQGRNELLSLIKRK-RHKEMFLAELEKK- 244 thale cress
XP_006005730 176 --------------------------------DAGSWWLAIPGAGRFVKYFIKGRKHVLGMIKKT-KYKEVLQSDLETR- 221 coelacanth
EEQ41705     260 ---------------------------hHNEIDIHDYALAYPKCGTFLKIVNSGRAWLVRILSKM-TYKEMLEDTIYEKW 311 Clavispora lusi...
XP_007780254 337 DGgvadd-statqAKKvrgefvgvlpgrtkKWRTFWGLRFEWVLEEAVGMGLVEAFQTgSVGLGVRV 402
EGV64875     335 EGidlndnskmsnFRK-----------------PFYGFDLNWILADALGAGIIEVFNT-PVGRGWKL 383
XP_002547448 346 QGinpqgnskmnnFRA-----------------PFYGYDLNWVLADALGAGVVEVFNT-PVGRGWRL 394
EMG47184     332 EGftpqgnskmnnFRA-----------------PFFGYDLNWVLADALGAGVIEVFNT-PVGRGWRL 380
XP_036668023 328 SGmnpegdpklnnFRK-----------------PFYGYDLHWVLADGLGSGIVEVFNT-PVGRGWRL 376
XP_001525879 352 MGvslegdlklnnFKK-----------------PFYGYDLHWVLADAFGGGIVEVFNT-PVGRGWRL 400
XP_002277335 231 -------------------------------RLRLSPLDMRFHLRDLIGSGHVKTVHT-PTGLVVRV 265
Q5XVE4       245 -------------------------------RLRFSPLDVRFHVRDLIGSGHLKTVQT-TSGLIVRI 279 thale cress
XP_006005730 222 ------------------------------KMVSAVKLGIQYHVHDIIGAELVTCIPT-TSGTLLRL 257 coelacanth
EEQ41705     312 EGkim------anFRR-----------------PFYGYDLTWILADSWGSGVVEPFNT-PVGRGWRL 354 Clavispora lusitaniae ATCC 4...
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