3JD5


Conserved Protein Domain Family
MRP-S23

?
pfam10484: MRP-S23 
Mitochondrial ribosomal protein S23
MRP-S23 is one of the proteins that makes up the 55S ribosome in eukaryotes from nematodes to humans. It does not appear to carry any common motifs, either RNA binding or ribosomal protein motifs. All of the mammalian MRPs are encoded in nuclear genes that are evolving more rapidly than those encoding cytoplasmic ribosomal proteins. The MRPs are imported into mitochondria where they assemble coordinately with mitochondrially transcribed rRNAs into ribosomes that are responsible for translating the 13 mRNAs for essential proteins of the oxidative phosphorylation system. MRP-S23 is significantly up-regulated in uterine cancer cells.
Statistics
?
PSSM-Id: 402213
View PSSM: pfam10484
Aligned: 30 rows
Threshold Bit Score: 131.594
Threshold Setting Gi: 761910530
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
?
Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
3JD5_BB        2 AGSRLETVGSIFTRTRDLIRAGVLK--EKPLWFDVYNAFPPLREPVFRRPrL--RYgka--ksPTQDIYYHEDQIRAKFY 75 
2_pfamImport   1 AGSRLHRLGSVYSRTKDLIQSKVLPyeERPIWYDVYKAFPPHREPVYKPQsSpnQFglvdvedTVRPILYNEDWVRANVY 80 
XP_002120130   4 AGSRLHRLGSVYSRTKDLIRSKVLPyeERPLWYDVYEAFPPIREPVYEADtPpdKLglvdvedNVREVLYEEDWVRANVN 83  vase tunicate
Q8IP62         2 AQSRLEKIGTIFTRVQGLLRGGAMKteDKPIWYDVYAAFPPKLEPRFDRPaP--EI-------PVRQIFYAEDVVRAKLH 72  fruit fly
EFA07822       2 AQSRLERIGTIYTRAQGLIKSGGVRweDRPLWFDIYEAFPPKEEPNYDRPaP--NI-------PIKQIFYEEDKIRAIFH 72  red flour beetle
XP_003425757   2 AQSRLEKVGTIYSRLTSLIKSGGIPeeNKPIWLDLYKAFPPKYEPTFSRPaSg---------pPVRKIFYTEDLIRAQFH 72  jewel wasp
XP_011260048   2 AQSRLEKVGTIYTRVISLLKGKAMKeeDKPLWLAVYEAFPPKYEPRFDRQlP--KK-------NIKNIFYKEDLIRARFL 72  Florida carpent...
XP_002641727   4 fiTRAERSGNIFSRVTGLIRAGQLSwaDRPLWYDVYISSPPLSPPDWNVKlP--KFd-----qPIRPIFYEEDVLRAKFY 76  Caenorhabditis ...
PDM67811       4 fvTRSERAGNIFFRITALIRSGQLQwaDRPAWYDVYVAHPPLTPHDWNVQlP--KYn-----ePVKKIFYEEDIVRAQFY 76  Pristionchus pa...
XP_002108327   2 A-SRNFKVGTVYTRVLGLLKSGAIK--QKPLWFDIVETFPPILPTMHNRApVpgRA---------RKLQYWEDEVREKFY 69  Trichoplax adha...
3JD5_BB       76 aaygsGPKAFDLFNPNFKST----------------CQRFVEKYIELQK-L--GETDEEKLFVEAGKALLAE 128
2_pfamImport  81 -----GNPAFSNLNGKKISSlfvgpqaknyqeganfCHRFILKFEELKKtH--CDLNNEDLFRLAEKEMIEI 145
XP_002120130  84 -----GVNFYSSLNNKTISSlfteltgk-hkerknfCYRFVKKFQEIQKlN--NGLNNEQLFRMTEQEMKDa 147 vase tunicate
Q8IP62        73 ke-nkPQETISLFDHRRSTQ----------------SQQFVQIYQDLKG-Q--GALDEQRIYETALDLLAEQ 124 fruit fly
EFA07822      73 rn-nkKIGATHLLDTKYKTL----------------TQKFIESYTTIQA-QygESATEEQIYKEAIDLLKKS 126 red flour beetle
XP_003425757  73 kh-hrRYSNVNLLDNKSVSR----------------TESFILIYRQLEK----DGVPQDEIYNKAIEEFLEK 123 jewel wasp
XP_011260048  73 kd-qdFIPAINLANESVPSA----------------TQNFLSIYKTIKE-Q--EKLSGNETYKKAMQQYTse 124 Florida carpenter ant
XP_002641727  77 ktyrsTAGIQ--VDSSRTSV----------------SQQFINEYKLVKSeN--ASATPEELFELTTKRLNEN 128 Caenorhabditis briggsae
PDM67811      77 knhrnVGHVS--MDKEGDSI----------------SQQFINEYQALSKeE--PNLPMEEMFAKTEKRLEDV 128 Pristionchus pacificus
XP_002108327  70 ke-fkFIEPVNLYETDNKPTi---------------CDRFIMHYEQFSQ----EETDGDVAFAKSKEALEQE 121 Trichoplax adhaerens
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap