Conserved Protein Domain Family
Elong_Iki1

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pfam10483: Elong_Iki1 
Elongator subunit Iki1
This family is a component of the RNA polymerase II elongator complex. This complex is involved in elongation of RNA polymerase II transcription and in modification of wobble nucleosides in tRNA.
Statistics
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PSSM-Id: 402212
View PSSM: pfam10483
Aligned: 89 rows
Threshold Bit Score: 141.178
Threshold Setting Gi: 326426862
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
EPE02265      15 LLQKLLNLRDGvSPLTLVLDTPREPGTPLLEEMML-----RAK-TGaggaaR-TKVVYVCSN----LAPRr--------- 74  Ophiostoma pice...
EGD72432       2 MLADLLALRQTtTSL-IVQDELECRGDVILAQLAR-----QLR-SR-----G-GKCVVVCGErgadVFDG---------- 58  Salpingoeca ros...
XP_006627641   1 MLLEIIDGTEG-GGLVVIKDSVNCPGRCLLKSCVN-----AAL-RR-----K-ESVHVLGFD----VSEEelragldgea 63  spotted gar
CCE93439      11 LLKRVLSLADF-SPLVLAIDSIAQSSCKLIEEVYY-----NAKeSG-----D-FTIIYISFE----TANE---------- 64  Torulaspora del...
CCF56456      11 LLKRVLSLTEP-SSFILCLDSVSQSSSYLIEELVF-----NANkSA-----G-TNIIFVSFE----TNDK---------- 64  Kazachstania af...
CCK70022      11 LLKRVLNLTDN-SFFILCIDNLAQTSQGIVQEVIHyr-dsVE-----------GNVIFVSFC----TAEK---------- 63  Kazachstania na...
EJT41876      11 LFKRVLSLTES-SPLILCLDSMAQTSHRLIQEFIH-----QSKsKG-----NeCPVVYISFE----TVNV---------- 65  Saccharomyces k...
XP_003669258  11 LLKRILSLSEA-TPLLLCLDSIPQTANYLINEIVH-----HSRnTL-----N-LETIFVAFE----TLNK---------- 64  Naumovozyma dai...
XP_003677064  11 LLKRVLCLTES-SPLILCLDSVAQTSNHLIDEIIH-----NTKtNS-----S-LKVIYVAFE----TLNK---------- 64  Naumovozyma cas...
Q6FIL7        11 LLKRILSLTEP-APLLLVSDTLAQSSYFLVQEVIHnvqeyQKS-KN-----S-GVIVFVAFE----TVNK---------- 68  [Candida] glabrata
EPE02265      75 -----------qSPHVD----VYIER--RDEPsLEAFQARILKEVPPPPAPtssssspssssggtRCLIIIDSLG-PIaq 136 Ophiostoma pice...
EGD72432      59 ------------PVTSV----PWLDAtaSA-DfVTRIAEEAEAq---------------------QACVFVDSFG-SLaa 99  Salpingoeca ros...
XP_006627641  64 akslvfhngytdPLCWTgmgtGQLTAlhFS---AQEIRARISQSRGPe-----------------PVTLAVDSLSwVLrh 123 spotted gar
CCE93439      65 ------------PSYAD----IFIRAeaLS---LEKLSQTIQSYLPPSNRPtk-----------sKFLVVIDSINhis-- 112 Torulaspora del...
CCF56456      65 ------------PEYAS----NFIDAenMD---LAKIGQLVKSYL-PSSSEtr----------rsKNLVIVDSLNcis-- 112 Kazachstania af...
CCK70022      64 ------------PSYAT----HFIDVtaIG-G-LEKVVDQVHSYL-PSPRGtvk--------snkKFLILIDSLNymp-- 114 Kazachstania na...
EJT41876      66 ------------PSYCT----QFIDAaqMD---FVHVVRQITSYL-PAATAtqa---------kkH-MVIIDSLNyip-- 113 Saccharomyces k...
XP_003669258  65 ------------PSYAT----HFIDIneVS-GgLPKLIETLQSYL-PSPQQkhs---------nkR-LVIIDSLNyip-- 114 Naumovozyma dai...
XP_003677064  65 ------------PDYAS----HFIEVtnTSS--LTKTMEIIQSHL-PSPSSttth-------nnkKILLIIDSLNyip-- 116 Naumovozyma cas...
Q6FIL7        69 ------------PRYTD----IFIDAskVG---FTKLPEAISSFL-PTPQTpvn--------tscRNVIVIDSLNhvp-- 118 [Candida] glabrata
EPE02265     137 sd-plfVAAFVSSLV-SP-TTSVVGLYRTDNyassiql-plspelqGKPHPYKVLTHLATAVLRVN----------PLDE 202 Ophiostoma pice...
EGD72432     100 fageraALKFVQRLLqRK-GCSVYMCLHSNT---------------VSAFCARELEHLCRTHVRIQahsaalshagTAPH 163 Salpingoeca ros...
XP_006627641 124 np-tasVCQSLQELRrDGlLKRILVLLHSDL---------------HQHGMVDSVCHLASTVVTVA----------PFSG 177 spotted gar
CCE93439     113 ---tnhISQFVGSIAs-L-HSTLLAVYHADLpeyqe------ktlaHYPSSIELLNFMATTILKVQq---------VTSK 172 Torulaspora del...
CCF56456     113 ---rshLTQFVSSIAs-P-HATIVATYHKDVpevde------hgleNYPSAVELLKFISTTIMNINp---------ILPR 172 Kazachstania af...
CCK70022     115 ---rtkLAQFISSLGs-P-YAIILATYHREMleshmhvtqeynntsNYPSGLELLQFMATSIITTNp---------ILPS 180 Kazachstania na...
EJT41876     114 ---tdlITRFLSEIAs-P-HCTIIATYHKDItdddhav--ipggnnNYPDKLTLLQFMATTILDIEv---------ALAG 177 Saccharomyces k...
XP_003669258 115 ---ndkLAQFISAVAs-P-HCTLVGVYHKDTpevdi------paldNYPSSLELLQFMATTILNITp---------ALPS 174 Naumovozyma dai...
XP_003677064 117 ---ndkLAQFVSSIAs-P-NATLVATYHKDFpeven------paldNYPSSLELIQFMATSVINIYp---------KLSK 176 Naumovozyma cas...
Q6FIL7       119 ---raqLTKFIGSIAt-P-HATILATLHRDMhdspy-----ehgldNYPSAIELLHFMATTSLDVTp-----------AS 177 [Candida] glabrata
EPE02265     203 E--VARKRARDRAEELPQFGWAEG-EG-FPFAynnwrysktdlmataatpgtgafasdidrrgILVDMELRRRSGRAVVE 278 Ophiostoma pice...
EGD72432     164 ---VGRQLQQQHVVVADTIHMRTGgSKpTTSR-------------------------------ALVTINTLRNGQRAVSV 209 Salpingoeca ros...
XP_006627641 178 LggVVGETAPQ----------------------------------------------------GIAMTTQRIKSGKVLQE 205 spotted gar
CCE93439     173 N--ATEE-EIENDLSRFLIP--RGlNN-DIFK---------------------------------LTLTTRRKSGRSQSY 213 Torulaspora del...
CCF56456     173 S--LDRE-ELNISLNRFRMP--RGlNN-PTFK---------------------------------LEFTNRRRSGRALSY 213 Kazachstania af...
CCK70022     181 T--LDDSGELHDQLDSLRIP--RGlNQ-PRFE---------------------------------ITLVNRRKSGRSVTY 222 Kazachstania na...
EJT41876     178 N--LDTE-EVGELLNEFRIP--VGxNN-EIYQ---------------------------------LRFVNKRKSGRSLEY 218 Saccharomyces k...
XP_003669258 175 R--IDEE-SLKYELEKYSIP--RGlNN-PIFN---------------------------------LKLINRRRSGRSLSY 215 Naumovozyma dai...
XP_003677064 177 S--LDDE-TLKYELDKFNIP--RGlNN-QTFN---------------------------------VNLINRRKSGRSITY 217 Naumovozyma cas...
Q6FIL7       178 T--ISDDDELNQQLSKLQIP--RGlNN-TTFK---------------------------------VSLTYKRKSGRELTY 219 [Candida] glabrata
EPE02265     279 R------YVMVLGGAGGAg---------aKKEPSSSagTrgkmpwqkgatpctdITVMSDHPLFavpdlsegfkrpgd-- 341 Ophiostoma pice...
EGD72432     210 QpltaapTLLDALEHTPApitatatspasTATTTTAttE-----------------AVSTRGQGatasvsmpsttrtata 272 Salpingoeca ros...
XP_006627641 206 E------ECFTVGQDLSVqvygrpsqpglTEPEPEDsqA----------------------------------------- 238 spotted gar
CCE93439     214 S------FHINTKTHSYEtiia---sspaDGEGNEN--P---------------EML---QGLS---------------- 248 Torulaspora del...
CCF56456     214 E------FNVDTVNHNYSivme---agteDGV-VET--P---------------EML---QDLA---------------- 247 Kazachstania af...
CCK70022     223 N------FLVDTDTHQYDlatk----endTSAEQET--P---------------EML---QDLT---------------- 256 Kazachstania na...
EJT41876     219 D------FTIDSKNHEYElslstrqeeadGGNELET--P---------------DML---QGLT---------------- 256 Saccharomyces k...
XP_003669258 216 D------FQIDTNKHLYEhvin---npeeQENEIET--P---------------EML---QGLT---------------- 250 Naumovozyma dai...
XP_003677064 218 S------FQIDSTKHTYDliksalqqdeeQQV-NET--P---------------EML---QDLT---------------- 254 Naumovozyma cas...
Q6FIL7       220 D------FKVDYNTHQYYqimd---kkdvDENALET--P---------------EML---QGLT---------------- 254 [Candida] glabrata
EPE02265     342 ----gngndddsdedlptS-----TFNLGLTDKQRRDREGIVLPYF----DAQTDIGa---G--EGGRILYD 395 Ophiostoma piceae UAMH ...
EGD72432     273 aappqpqqvsagggggddDpltnlTFSLKLTEEEKAMRARTALPYAktreEKQRALA-------GTGAIYYE 337 Salpingoeca rosetta
XP_006627641 239 ------------------DpaanlTFNLRLSEHERQAKDNLALPFA----FSQEKKSallrPraGGGQILYE 288 spotted gar
CCE93439     249 ------------------------TFNLSTSAKQKMAKEQVELPFL----EAQ-SF-----N--TGGAIVYq 284 Torulaspora delbrueckii
CCF56456     248 ------------------------TFNLSTSAKQKEAKDQVALPFL----EAQ-SF-----S--AGGAIVYE 283 Kazachstania africana C...
CCK70022     257 ------------------------TFNLSTSTKQKQAKEQVNLPFL----EAQ-SF-----G--TGGAIVYE 292 Kazachstania naganishii...
EJT41876     257 ------------------------TFNLGTSNKQKLAKDQVALPFL----EAQ-SF-----G--QGGAIVYE 292 Saccharomyces kudriavze...
XP_003669258 251 ------------------------TFNLSTSTKQKMAKDQVALPFL----EAQ-GLE----S--HGGAIVYE 287 Naumovozyma dairenensis...
XP_003677064 255 ------------------------TFNLSTSAKQKKAKDQVSLPFL----EAQ-SLS----S--HASAIVYE 291 Naumovozyma castellii C...
Q6FIL7       255 ------------------------TFNLSTSAKQKAAKDQVELPFL----EAQ-SL-----T--AGGAIVYE 290 [Candida] glabrata
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