Conserved Protein Domain Family
CENP-F_N

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pfam10481: CENP-F_N 
Cenp-F N-terminal domain
Mitosin or centromere-associated protein-F (Cenp-F) is found bound across the centromere as one of the proteins of the outer layer of the kinetochore. Most of the kinetochore/centromere functions appear to depend upon binding of the C-terminal par to f the molecule, whereas the N-terminal part, here, may be a cytoplasmic player in controlling the function of microtubules and dynein.
Statistics
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PSSM-Id: 491197
Aligned: 9 rows
Threshold Bit Score: 377.259
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_014345462    1 MSWAIEEWKEGLPSKALQKIQDFESQLEKLKKERQQKQFQLESLEAAFQKQKQKVENEKSEVTALKRENQSLVESCDNLE 80  
XP_039770804    1 MSWAVEEWKEGLSTRALQKIQELESQLDKLKKERQQRQFQLESLEAALQKQKQKVENEKTEAATLKRENQSLMEMCDNLE 80  
XP_002934738    1 MSWVVEEWKEGLPTKTLQKIQELESQLDKLKKERQQRQFQLESLEAAFQKQKQKAESEKSEISALKRENQSLIESCDNQE 80  
2_pfamImport    1 MSWAVEEWKDGLPGKALQKIQEIESQLDKLKKERQQKQFQLETLEAALQKQKQKMEVEKNEVTALKRENQSLVESCDNLE 80  
XP_011607920    1 MSWAVEEWKDGLPVKALQKIQEMEVHLDKLKKERTQKQFKLDSLEAALQKQKQKADIERTESSALKRENQSLVESCDSLE 80  
XP_040023468    1 MSWAVEEWKDGLPGKALQKIQEMEVQLDKLKKDRNQKQFQLDSLEAARQKQKQKADSDRTETAALKRESQSLVESCDSLE 80  
XP_008124053    1 MSWVVEEWKEGLSTKVLHKIQELESQLEKFKKERQQKQFQLESLEAALQKQKQKVDQEKNEGSTLKRENQNLMELCDNLE 80  
1_pfamImport    1 MSWALEEWKDGLSTRALQKIQELEGQLDKLKKDRQQRQFQLESLEDALQKQKKKVEDQKNEGATLKRENQSLMETCENLE 80  
NP_001074832    1 MSWALEEWKEGLPSRALQKIQELEGQLEKLKKEKQQRQFQLDSLEAALQKQKQKVEDGKTEGADLKRENQRLMEICEHLE 80  
XP_014345462   81 KSKQKISHDLQVKELQVNFLEGQLATCKKQIEKLEQEMKRS------------------KCEIERSQQPLLL---GD--- 136 
XP_039770804   81 KTRQKISHDLQVKESQVNYQEGQLNSSKRQIEKLELELKRThlycgyllevwgwkdsrcKSELERGQQALLP---GDs-- 155 
XP_002934738   81 KAKQKITHEYQLKESQVNFLEGQLSASKKQIEKLEQELKRY------------------KSDLEKSQLSFNA---CD--- 136 
2_pfamImport   81 KTRQKVTHELQVKEQQVNYLEGQLAASKKQIEKLEQEIKRN------------------KVELDRSQQSVAA---GD--- 136 
XP_011607920   81 KSRQKLAHDLGIKEQQVSYLEGQLNSCRKTTECLEQELKKY------------------KNELERSQSAGSS---LSsss 139 
XP_040023468   81 KARQKAVHDLGVKEQQVCYLDGQLNSCRKTIERLEQELKKY------------------KSELDRSQSAGSSslsSSss- 141 
XP_008124053   81 NTRQKLAHDLQVKELQVNFQEGQLISSKKQIENLEQELKRY------------------KSELEKHQKIHVA---GDv-- 137 
1_pfamImport   81 KMRQKISHELQVKESQVNFQEGQLNSSKKQIEKLEQELKRY------------------KSELERNQLAVLP---GDvs- 138 
NP_001074832   81 KSRQKLSHELQVKESQVNLQESQLSSCKKQIEKLEQELKRC------------------KSEFERSQQVAQS---ADv-- 137 
XP_014345462  137 -LQPCATPEKNFAVPVA-PSRNYNDSKVEELQEKYNKEVEERKRLEAELKIM-QAKV-------VNQSqgNVNRRDIARQ 206 
XP_039770804  156 sLSVSSTPQKSFTAPLT-PSQYHNDAKYKELQEKYNKEVEERKRLEAEVKVM-QVQKmn---qaLPQS--TVNHREIARH 228 
XP_002934738  137 -MSVCATPQKSFVAPYT-P-NKYTDFRYEELQEKYQKEVEERKRLETEMKTLrNVPQpp---qaAAQS--TMTHRDIARH 208 
2_pfamImport  137 -QQSYGTPQKSFATPAT-PSQKLHDSKLEEIQEKYYKEVEERQKLEAELKVM-QIKKiivkfqlLNQS--SVSHKDIARQ 211 
XP_011607920  140 eLQPYTTPQKSIPTPLPvTANRHQDNRLEGLEEEYNLEVKERKKLETELKVL-QVKLe-----nQSSA--TVSHKDFVAR 211 
XP_040023468  142 eLQPYTTPQKTFSTPASvPACRQQDNRLDELQEKYNQEVEGRKRLETELKVL-QVKL-------LNHSsvTVSHKDIAAR 213 
XP_008124053  138 sFN--STPQRNLITSST-PS--DNDSKYEELQAKYSKEVEERRRLEAELKSL-KSQKtn---ttCPES--MISRREIARQ 206 
1_pfamImport  139 tLN--STPQKSSAPPVQ-SS--QSASRYEELQEKYSKEVEERKRLEEEVKAL-QIKKas---ktVPPN--NMSHREIARH 207 
NP_001074832  138 sLNPCSTPQKLFATPLT-PS-----STYEDLKEKYNKEVEERKRLEEEVKAL-HAKKvs---lpVSQA--TMNHRDIARH 205 
XP_014345462  207 QASSSVFPWQ-QEQTPSHAASNSLETPSRRGCTTSHFPWE-REETPSMYCqRSAkktaSNSSFNESSSNSPQNDLLKVQN 284 
XP_039770804  229 QTSSSVFSWQ-QEKTPNRFSANIQETPLKRGFSACHFPWE-QEETPNKPE-RKE----ANTSICDNSCNSQLMDQLKAQN 301 
XP_002934738  209 QTSSSVFSWQ-EDRTPSHPSSTSHDKRLKRSFASSQLLWD-QEETPSKRGvRSE----NLGKSASDSYTTQLNDQLKTQN 282 
2_pfamImport  212 QTQSSIFPWQ-QDQTPSRQSHSFLETPLKRGIGASSFLWD-HEETPYKRN--------SRSTLHDNAGSSQQSEQLKAMN 281 
XP_011607920  212 QAGSSIFPWQ-QDQAHSWQIQDAVETPVKRRGTS---LWDvHEETPIKPSqRMS-------SLQSPARSCQQMEQLKTLN 280 
XP_040023468  214 QAGSSIFPWQpPDQAHGRQSQDAMETPLKRRGTS---LWEsHEETPIKSSqRMS----SSRAAQSPCGSSHQMDQLKSIN 286 
XP_008124053  207 QASSSVFSWQ-QEKTPSRFSSSPQETPISSGSVTSHRSQE-FGATPSHRYlKSTkkgmSNSGIFSSKDSPLL--KMKAQN 282 
1_pfamImport  208 QSSSSVFPWQ-QEKTPTRHSANAQETPFRRGFTALHVPWE-QETTPNRMPsWQD----TNCSFHENPSDPHLLDQIKAQN 281 
NP_001074832  206 QASSSVFPWQ-QENTPSRLSSDALKTPLRRDGSAAHFLGE--EVSPNKSSmKTGrg--dCSSLPGEPHSAQLLHQAKAQN 280 
XP_014345462  285 QELNSKVTELELRLQAQEKE 304 
XP_039770804  302 QELRSEVSELERLLQGQEKD 321 
XP_002934738  283 QELKSRINELEMRLQVQEKD 302 
2_pfamImport  282 QDLKAKVSEMELCLQAQDKD 301 
XP_011607920  281 QELCGRVSELERILSTQQKD 300 
XP_040023468  287 QELRGRVLELEKSLSTQEKE 306 
XP_008124053  283 QELRSRIQELEHKLQSQTQD 302 
1_pfamImport  282 QELRFKVNELEHRLQGQEKD 301 
NP_001074832  281 QDLKSKMTELELRLQGQEKE 300 
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