Conserved Protein Domain Family
EIF4E-T

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pfam10477: EIF4E-T 
Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E
EIF4E-T is the transporter protein for shuttling the mRNA cap-binding protein EIF4E protein, targeting it for nuclear import. EIF4E-T contains several key binding domains including two functional leucine-rich NESs (nuclear export signals) between residues 438-447 and 613-638 in the human protein. The other two binding domains are an EIF4E-binding site, between residues 27-42 in Q9EST3, and a bipartite NLS (nuclear localization signals) between 194-211, and these lie in family EIF4E-T_N. EIF4E is the eukaryotic translation initiation factor 4E that is the rate-limiting factor for cap-dependent translation initiation.
Statistics
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PSSM-Id: 371079
View PSSM: pfam10477
Aligned: 8 rows
Threshold Bit Score: 420.957
Threshold Setting Gi: 1005953686
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
ACY70537       10 YSRSDLLALRHEGSSRERPHCANRTELQTLNFWKinviqsnnns------nsygnktglsPERESSSLTIS--------- 74   Drosophila vi...
XP_015032358   10 YSRADLLALRYEGSARQRPSCSNQTELQTLGFWKngvlsvgsgssgcgisggtygnsclsPETDNSSLSSSn-------- 81   Drosophila wi...
Q8IH18         10 YSKVDLLALRYEGKSRQRPQCSTRLELQTLGFWKinlntaaltvss---aysnqnknrlsPEADNSSLICSn-------- 78   fruit fly
EDW25266       10 YSRADLLALRYEGSSRQRPQCANRNELQTLNFWKvnasanvpsn------yanpnkislsPETDNSSLSSSn-------- 75   Drosophila pe...
EFX87805       43 YSRDLLIKLKNHPSSKEKPAIFDDLDRVKNGMWD--------------------------PEHWHSRTAKEpkr------ 90   common water ...
PNI98010       30 YTKEELLDIKELPHSKQRPSCLSEKY-DSDGVWD--------------------------PEKWHASLYPAsg------- 75   chimpanzee
XP_005987194   28 YSKEELLEIKEGPHSNLRPLCLLGKY-DSDGVWD--------------------------PEKWHASLYPSsg------- 73   coelacanth
XP_015785233   41 YSKEELIEISKQPYCGKRPKFLDPDYVNKSGLWD--------------------------PDLWMNYKNPSnkpipsslp 94   two-spotted s...
ACY70537       75 -------------NGLLSSRRALRNRERAHNYYQRFSSSDQIGGedvqvslasatgnlcasykspkidhrsissshlmpa 141  Drosophila vi...
XP_015032358   82 -------------NGLNSSRRALRNRERANTYYQRFAPNDSQLGcddrerdrdrerdrdrererdtqsannittisfkss 148  Drosophila wi...
Q8IH18         79 -------------SSSISSRRAMRNRERANNYYQRFVPTDSLLIsgedkdkdalshgqpyklniidhrsiss-------- 137  fruit fly
EDW25266       76 -------------NGLISSRRAMRNRERANNYYQRFAPSDSHSMciedkdkdtqstqsvlggppfkssiidhrsissshl 142  Drosophila pe...
EFX87805       91 -----------snSGTVVGAGNKEDQQEKK-------------R------------------------------------ 110  common water ...
PNI98010       76 ------------rSSPVESLKKELDTDRPSLVRRIVDPRERV-------------------------------------- 105  chimpanzee
XP_005987194   74 ------------rSSPVEGFRKDQDSDRAILKRRIADPRERV-------------------------------------- 103  coelacanth
XP_015785233   95 strdhdlsapgltNKNIRGPPKRVNGESESSLRNRKDPRDRVK------------------------------------- 137  two-spotted s...
ACY70537      142 fakkrfviasgeridqnesqnektnasvnyedgkmnakentatpahanidlknHLRAINSSLGSPIRRGSpirraPAPge 221  Drosophila vi...
XP_015032358  149 sidhrsissshlmpafakrrfaaaaesseltsnnansddyisgvernvtptllNKESKRNSLVSPVPKGS-----GGC-- 221  Drosophila wi...
Q8IH18        138 -------------------------shlmpafakrrfviskgsnseesneginTCASKGKAASSPSRKGSeldtaETCln 192  fruit fly
EDW25266      143 mpafakr----rfavvncgngtenepintncddiavgenvtveldhthvstptHNQSQSKGMSSPIRKASew--gESCer 216  Drosophila pe...
EFX87805      111 -----------------------------------------------------GKEEGDEFCFTPQRRSFv----SGChv 133  common water ...
PNI98010      106 ------------------------------------------------------KEDDLDVVLSPQRRSFg----GGC-- 125  chimpanzee
XP_005987194  104 ------------------------------------------------------KEDDLDVVLSPQRRSFg----GGC-- 123  coelacanth
XP_015785233  138 ------------------------------------------------------EESQDDIVLSPQRRSFg----TGChi 159  two-spotted s...
ACY70537      222 wergekhsnpqENEQTLALSPTFSSGRqvgs---------lnvQ--------ERRIGSGRLLPRtdnwEYKNKD--ADIL 282  Drosophila vi...
XP_015032358  222 -----------DHEHSLASSPTYSSAR----------------H--------ERRIGSGRLLPRndnwEFKKQEtdTDSA 266  Drosophila wi...
Q8IH18        193 f-------vqpDHDQCMSSSPTFSTSR----------------Q--------ERRIGSGRLLPRsdnwDYKNEK--TVEA 239  fruit fly
EDW25266      217 rsn----nvqqDHDQSLASSPTFSTTR----------------Q--------ERRIGSGRLLPRadnwDYKGQQ--QSSS 266  Drosophila pe...
EFX87805      134 v--------rrQDAEPAVPPVVTESVRest--------------------lpARRVGSGRLTGR----DVEPAPvpAKEP 181  common water ...
PNI98010      126 ---------------HVTAAV--SSRRsgsplekd-sdglrllG--------GRRIGSGRII------------------ 161  chimpanzee
XP_005987194  124 ---------------HVIASAGPSSRRagspqenkenenlrglG--------GRRIGSGRLS------------------ 162  coelacanth
XP_015785233  160 v--------pvRNEQPVATGTQAQRSSvgkadnhahqqdrreeQllhrndnvNRRIGSGRLL------------------ 213  two-spotted s...
ACY70537      283 LNNHEKDRPENGSLA----------NQQRQRTSSGKHSERTSdyvgerDRDRDRRlnerkgidnRDQNDGKKMVQT---- 348  Drosophila vi...
XP_015032358  267 VVEREKDRERPHNGSmlq-----ssNQQNQRTYSGRQNDREF------GGDRDQR---------RSQYEGKRPLDRptgv 326  Drosophila wi...
Q8IH18        240 SIENEKETSPNGSGStssln-qhnqSQHRSRTFSGRLVERVPe-----VTDR------------RFQYDSKKSFDRqg-- 299  fruit fly
EDW25266      267 GIEKEKERSQNGSGSinqqnqsqnqNQQRPRTFSGRHGDRLTe----hIGDR------------RFQYDNKRSVDRqg-- 328  Drosophila pe...
EFX87805      182 RDRREPLRAPAPQRErtfdrepqrnERGNERNDRHDRNER----------NERSErngrtfqpsRADPRDKDPAEK---- 247  common water ...
PNI98010      162 --------------SartfekdhrlSDKDLRDLRDRDRER----------DFKDKrfrr--------------------- 196  chimpanzee
XP_005987194  163 --------------SsrgyerdgrpGDKDTRDARDR--ER----------DFKEKrfrr--------------------- 195  coelacanth
XP_015785233  214 ---NQRDKSNLEWSKsrdreeeienRRSNLRYTNGNSNNSGRy-----DYDRRSSmnnr--------------------- 264  two-spotted s...
ACY70537      349 -------------GRRTSNKDKFNFGdsniqSRGKRMNIYQTHD---RPEPEWFSAGPTSQHETIDLHGFDD-------- 404  Drosophila vi...
XP_015032358  327 gnttgsgavgglsGRRISNKDKFSFNd---vGRGKRGSSYHQMQdrhHKEPEWFSAGPTSQLETIDLHGFDDl------- 396  Drosophila wi...
Q8IH18        300 -----------inNRRISGKEPFSTQ-----SRSKRGNSYLIHE-----EPEWFSAGPKSQLETIDLHGFED-------- 350  fruit fly
EDW25266      329 -----------vsSRRSSNKDSGCIQ-----GRGKRTNMYHQHDr--HEEPEWFSAGPTSQLETIDLHGFDD-------- 382  Drosophila pe...
EFX87805      248 -------------DRRNFDRSGYDRDysgrgDRGDRYNSRRKNE---DDTPEWFFGGPSSQHDTIELRGFDE-------- 303  common water ...
PNI98010      197 ----------------------------efgDSKRVFGERRRNDsytEEEPEWFSAGPTSQSETIELTGFDDki------ 242  chimpanzee
XP_005987194  196 ----------------------------dfnDGKRGYGDRRRNDsytEEEPEWFSAGPTSQSETIELIGFDDkl------ 241  coelacanth
XP_015785233  265 ---------------------------------rygHHDRRDSRnheEEEPEWFTGGPTSQHDTIELKGFEEempedevs 311  two-spotted s...
ACY70537      405 --FEGESSANLKIVKEDASKELDLKTNQAATPTSRS-----SSIASLNVVESNSNNKKDSDSDITMSNVapsiqnh---- 473  Drosophila vi...
XP_015032358  397 --ENSNESRTSESKKDRACNALPVDTDKQIDHETMSk---nSSSVSLNLLETKTGDDVKDVDMNTLEAVnfrlsqkesd- 470  Drosophila wi...
Q8IH18        351 --LEKNEERSVTEDKNNQIQQLDKNLDAQASKDEASm---rNSNDSLNFREVIPSDEKKHTDENVVTSIqnstdlghpnk 425  fruit fly
EDW25266      383 --HDHNDERSEFEDKANRFPSKPSQLAEPIVVDGASt---sSSMSSLNVVDVKTKDDNKDTGESVIQPQleptqqsknhq 457  Drosophila pe...
EFX87805      304 --EKDRKQNSKAPIRKESNKERQQSSGAKKSEEPSTsssrpGSGLSGKVVKEDQPPKTEAPKRKSPVNQ----------- 370  common water ...
PNI98010      243 -lEEDHKGRKRTRRRTASVKEGIVECNGGVAEEDEV-----EVILAQEPAADQEVPRDAVLPEQSP-------------- 302  chimpanzee
XP_005987194  242 -iEEDRRRFKRSRKRTDSFKD--LECNGGVVEE-EV-----EVAISPDAVADQEVPQATVLPEPAP-------------- 298  coelacanth
XP_015785233  312 kgRQNHHRPQNQHVEPESRGQGSLINNGDVKEHFEN-----HNHYKSNGVEEHESGSKEI-------------------- 366  two-spotted s...
ACY70537      474 ----nvqaipkTDVEFNFDAFLNMDPMDHALMGNDSE-------------VQGDVKGTSRFSQWFAPK------------ 524  Drosophila vi...
XP_015032358  471 -qliklqhasnPEVEFNFDAFLNMDPLDNSLIGNDADmp----------gAEISGFGKSRFSRWFGPN------------ 527  Drosophila wi...
Q8IH18        426 nkpiqmqpsqnPESEFNFDAFLNMHPLDNSVLSNDET-------------GKSDSKGTSRFSRWFRQK------------ 480  fruit fly
EDW25266      458 -qsgrlpctsnSEGEFNFDAFLNMHPLDPTLMSNDGD-------------EQDETKGTSRFSRWFRPK------------ 511  Drosophila pe...
EFX87805      371 -----------DKMDFNIEDFLKMDGDLNGLGLGPTE--------------SEETSRGSKASRWFGK------------- 412  common water ...
PNI98010      303 -------------GDFDFNEFFNLDK-VPCLASMIEDv------------LGEGSVSASRFSRWFS-Npsrs-------- 347  chimpanzee
XP_005987194  299 -------------GEFDFNEFFNLDKSVPGLASMIEDv------------LGEASVSASRFSQWFSSNlsqs-------- 345  coelacanth
XP_015785233  367 -------------QDFDINEMFKFEGWKNIVSMSPENvtsipgftdpnvsGQNQNGGTSRFAQWFNVSrtetespidrll 433  two-spotted s...
ACY70537      525 -----EPA--NTNDQLYFGH-----ASTPDTQEI-----------------------P---------------------- 547  Drosophila vi...
XP_015032358  528 -----ESTknNNEESPKRRE-----ANTPDIHGI-----------------------P---------------------- 552  Drosophila wi...
Q8IH18        481 -----EAA--NNNEFPGFRE-----SHAQEKRGI-----------------------P---------------------- 503  fruit fly
EDW25266      512 -----EAA--NNNEPSGLRE-----SGAQETHDI-----------------------P---------------------- 534  Drosophila pe...
EFX87805      413 -----TSDlpEASKPPATENvkpdhSTNQDAAR----------------------------------------------- 440  common water ...
PNI98010      348 --gsrSSSlgSTPHEELERL-----AGLEQAILS-----------------------Pgqnsgnyfapi----------- 386  chimpanzee
XP_005987194  346 --gsrSSSlrSTPHEELERL-----AGLEQGISS-----------------------Pgqscgnffapiq---------- 385  coelacanth
XP_015785233  434 qnvtfSSSynAAPHDSRR-------SSVQEIERTlfnhnhlgngshridptvlglrnPetynghhhhngghintngteng 506  two-spotted s...
ACY70537      548 -------------SVKDLeAQMRKVDLRpendiinaTANAHPTI-------HTEQRDKAV-------------------- 587  Drosophila vi...
XP_015032358  553 -------------SVKDLeAQMTKVDLN--------TAMAMPPQ-------AVSDVEKPV-------------------- 584  Drosophila wi...
Q8IH18        504 -------------SVKDLeAQMIKVDMR--------TDLINPIAgs---lcQTVQMEKPI-------------------- 539  fruit fly
EDW25266      535 -------------SVKDLeAQMTKVNLR--------SEYTNPIAvay--ggQQAQVEKPV-------------------- 571  Drosophila pe...
EFX87805      441 -------------SLLEM-LQKGSQQQQ---------------SvehkkivTAEELERssgkys---------------- 475  common water ...
PNI98010      387 ---pledhaenkvDILEM-LQKAKVDLKpllsslsaNKEKLKESshsgvvlSVEEVEAGLkglkvdqqvknstpfmae-h 461  chimpanzee
XP_005987194  386 --sesteksenkvNILEM-LQNAKVDLKpllsnltaNKEKLRESthsgvvlSVEEVEAGLkglkveserkiatpfmaeql 462  coelacanth
XP_015785233  507 ahghndspvnkgkDLLNL-LQKANININdl----mqQQSSLPTLpkfeharSVEEIEAGLrsfpisgsn----------- 570  two-spotted s...
ACY70537      588 ----------------TKDTEAFKRLL-QQLGSQNISHPGTESSNPMNAVVRSGQSSNtqdrqqhiirvqenqike---- 646  Drosophila vi...
XP_015032358  585 ----------------TRDTEAFKKLL-QQLGAQNMQQGHEQEAATDLFQMMRGPNAIpqnahqlnhphlmdgqqnfavr 647  Drosophila wi...
Q8IH18        540 ----------------ARDTEAFKKLL-QQLGSQARQHHPCNDDCRTINLSNIANHVH---------------------- 580  fruit fly
EDW25266      572 ----------------ARDTEAFRKLL-QQLGSQSNQHQLGNDVYHMINTSNAHQCANqnthrphlidpqqnilrdh--- 631  Drosophila pe...
EFX87805      476 ----------nnerssDDGMTVFNKLL-AQVQESTTKPHSVMNSAPTEQDILANLLGKqmkie----------------- 527  common water ...
PNI98010      462 leetlsavtnnrqlkkDGDMTAFNKLV-STMKASGTL------------------------------------------- 497  chimpanzee
XP_005987194  463 eealtsvagskpvrkrDGDMSAFNKLV-NSMKESGTL------------------------------------------- 498  coelacanth
XP_015785233  571 -------qhdgnqqdkNVEHSDFNRLLlKAMSRRGTQ------------------------------------------- 600  two-spotted s...
ACY70537      647 -----delqlyqqqhskkidtaPQRHIEMISQNQMHPVLTPGVHDSNIsgllplQAHKRME------------------- 702  Drosophila vi...
XP_015032358  648 tdvevqpflqqqhqqqrlklleNLPPHRIVESLAPQQPNSVHGPTPNIh----vQTQKRME------------------- 704  Drosophila wi...
Q8IH18        581 ----------------------LESKLHQKINDGHLQQPELSVNVPTMptsshvFLQKRLE------------------- 619  fruit fly
EDW25266      632 ---spqikeedtelfqqrfkhsDCMPKRINEAMVQQQHTIQGVHTPNIa-----LAQKRME------------------- 684  Drosophila pe...
EFX87805      528 ------------------aqppQPVQYHAQQNHQDALAKFLQQQQNNQ------MHHPNTQ------------------- 564  common water ...
PNI98010      498 ------------------------------------------------------PSQPKVS------------------- 504  chimpanzee
XP_005987194  499 ------------------------------------------------------PMQPNVHrnseprllppnevraqplp 524  coelacanth
XP_015785233  601 ------------------------------------------------------FVNPNSK------------------- 607  two-spotted s...
ACY70537      703 IQQLLQGVVRGDVSIEFLNKELNN--------PNTTHQ-------------SREVI-----------------AAVLHEC 744  Drosophila vi...
XP_015032358  705 IQHLIQSIFRGDISLEFLEKELSN--------PNTTAH-------------TKDVI-----------------AAVFREC 746  Drosophila wi...
Q8IH18        620 IQHLIQRLHCGDVSHDFLEKELDN--------PSTPAA-------------TKDVI-----------------ATVLNEY 661  fruit fly
EDW25266      685 VHHLIQGIARGDVSVEFLEKELSN--------PSTVPH-------------TKDVI-----------------ATVLREY 726  Drosophila pe...
EFX87805      565 QHNTHQMLQQPQINHLHQQQQQSHlfsmhgeqPHSDVH------------------------------------SLMRDL 608  common water ...
PNI98010      505 ------ELLGQPVQRPASSNLLSGlmgsleptTSLLGQrapspplsqvfqtRAASAdylrpripspigftpgpQQLLGDP 578  chimpanzee
XP_005987194  525 QKNLLQEILGPQIPRSISPNILSSlmgnadhtAALLGHrglsppvsqlfqhQPRSPdyltgrip-spigfvpgHPVLADQ 603  coelacanth
XP_015785233  608 APVVIPLNVRPPIHLPGKPQFVN--------------------------------------------------------- 630  two-spotted s...
ACY70537      745 SNSGRNTVQHLPytndihPHNLVKNHQLFNKNIGP----------EDVFTQN-----------TPSQGINQHQR------ 797  Drosophila vi...
XP_015032358  747 SNARRNSMPPKQt----yQNDVIGGHSNLNAGLPPyhqtlgpnisEELFTPNl----------PSNPNMNHHIR------ 806  Drosophila wi...
Q8IH18        662 SHSKRNPVVt-------gDPNIFTQQSFLQPqsvh------qhysQELHSQN-----------TANHTINQLIS------ 711  fruit fly
EDW25266      727 SSSRRNSLAYKPaypnemDHHSLAHLSFHQAqpqh------qnysDDLFPQN-----------SSNHGISQHIR------ 783  Drosophila pe...
EFX87805      609 ANGHPQTLN---------QLHMMTMQKQHQQQQQHlqqqqqqqlqQYQQQQQ--------------QQRQAFVGspqqsv 665  common water ...
PNI98010      579 FQGMRKPMSPIT--------AQMSQLELQQAALEGlalphdlavqAANFYQPgfgkpqvdrtrDGFRNRQQRVTkspapv 650  chimpanzee
XP_005987194  604 FHGMPKAMSPVP------PQQVLSPLEMQQAVLEGlsfpqelalhSGNFYHPgfskyyldkgrDGYRNRQLRMNrspgpv 677  coelacanth
XP_015785233  631 -------------------QNFVGPQFVNQNFVQPvv------------------------------------------- 648  two-spotted s...
ACY70537      798 ---HSNSPTP---------LAFTPTSVLRKMTADKES 822  Drosophila virilis
XP_015032358  807 ---HSNSPTP---------LAFTPTSVLRKMTADKDT 831  Drosophila willistoni
Q8IH18        712 ---HGNSPTP---------LAFTPTSVLRKMTADKDT 736  fruit fly
EDW25266      784 ---HSNSPTP---------LAFTPTSVLRKMTADKDT 808  Drosophila persimilis
EFX87805      666 akqSASSSSP---------LSFTPTAVMRKMGAEKDK 693  common water flea
PNI98010      651 hrgNSSSPAPaasitsmlsPSFTPTSVIRKMYESKEK 687  chimpanzee
XP_005987194  678 hrgNVPSPAPasit-smlsPSFTPTSVIRKMYESKEK 713  coelacanth
XP_015785233  649 -----------------ipLNFTPTSVIRKF-AEKDK 667  two-spotted spider mite
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