Conserved Protein Domain Family
Vps54_N
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pfam10475: Vps54_N 
Vacuolar-sorting protein 54, of GARP complex
This is a family of vacuolar-sorting proteins 54, from eukaryotes. Along with VPS52 and VPS53 this forms the Golgi-associated retrograde protein complex GARP. VPS54 is separated into N- and C-terminal regions each of which has a different function. This N-terminal family of is important for GARP complex assembly and stability, whereas the C-terminal domain, pfam07928, brings about localization to an early endocytic compartment.
Links
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Statistics
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PSSM-Id: 431303
Aligned: 9 rows
Threshold Bit Score: 369.378
Created: 21-Aug-2024
Updated: 4-Dec-2024
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q54MU4         72 LKITPAGFFDP--KFDTTqFILDLLPPN---VNNSSsefsifLDSNVKQFTRAMDYVNSKLYNRVRENYTEFVQGMSQIH 146  Dictyostelium...
Q54NV0        113 IDSLDEVYFKE--DFDPA-FILQNIPKD---APIDT------IDALTVKISGYHEAVDSRFNDLIRKSYNGFVQGMSQVY 180  Dictyostelium...
Q336V4        131 VDELEEVFFQE--EFDPIkYILQSIPAEg-dSSY--------FDKQSTLRLAQLDKIAERLSHHVMGHHEEMVKGMQLVM 199  Japanese rice
Q8RXC2        132 VEELEEGFYEE--DFDPVrHILENVPDDeseLAY--------FEKQATLRLVQLDKVAETLSHHVMEHHEVMVKGMNLVR 201  thale cress
Q18602         76 INSIDAAYFIDndEFDAIdYELKKLCDIe--MCYED------IQRERFRLKSQHTVVSKKISTLIMQKSSSYTAQVGEME 147  Caenorhabditi...
XP_002642305   80 IDSIDASYFIDndEFDAIdYELKKLCDId--MCYED------IQRERFRLKSQHTVVSKKISTLIMQKSSSYTNQVGEME 151 
Q5ZKV9         54 INSIEEVYFSNd-AFDIVkYELERLPPV---LSLQE------LEEYRDKLKQQQ------------------AAELERVT 105  chicken
Q7QF78          6 LESTEAIYFDG--GSNTGlHELRKLSESgqlLDCGS------IEQSMGVLRRQHRVISKKVLQLILEQRAACDGEFQRIR 77   Anopheles gam...
NP_611258      75 LESIEQCYYNP--DSNPQlYELKKVLNDg--IDNEL------IEVTIAQLRTQQKVLTKQVLQNILEQRNACSSEFAAIN 144 

Q54MU4        147 EIGVELQRSTVMCSNGRRTLSQTKKNLTQTAFIIMSKYTKRNLLTKMYMDLSQIREIVHLERLLKQTLSDGDYPATIKYY 226  Dictyostelium...
Q54NV0        181 EIEKDLTHSARMCTSGKEYLDGIQKNMTLFGFRLLAKHRIRQLSKFMYQESHIIKEISDAAKKIDMLLNMNEFSQALDLL 260  Dictyostelium...
Q336V4        200 ELEQDLKVANVICMNGRRHVSSSKNEVSR-DLVVNVKSKKKQALLDVLPILTELRNAQDMQMELESFVEKENYFQAFQLL 278  Japanese rice
Q8RXC2        202 ELEKDLKIANVICKNGRRNLTSSMNEASR-DLIVHTHSKKKQALLDMLPILTDLRHARVMQSNLEDLVEDGNYCKAFQVL 280  thale cress
Q18602        148 KIRDEVGSVINEILTIRKALALATSQ-TRTCLGLIAYKNKKIVLNQLKMTLTTIKGFHETEQHIRETIEEGNFPLAIQML 226  Caenorhabditi...
XP_002642305  152 NIREKVNGVVDEIISIRKALALATDQ-TRTCLGLIANEYKKASLHKLKTTLTTIKSFHEAETRIRETIQEGNFPLAIQML 230 
Q5ZKV9        106 SLQNGLQLAAVICADGRRHLNIAKEGFTQTSLGLLANQRKRQLLIGLLKSLRTIKTLQRTDVRLSEMLEEEDYPGAIQLC 185  chicken
Q7QF78         78 DTERLLRDTVTMCRAARTKLDTSKLLLTTTNLEILAAYKKRQTLVNLLRTLNALKSMRSIDQRLQRRLTDADYGGAIAIL 157  Anopheles gam...
NP_611258     145 DTQKKLEESLWTCQKARSYLNFARTNLTTTSLEILASYRKREVLKEVLDTLVAIKRLRTTDVEVQKLLADHNYSAAIALL 224 

Q54MU4        227 LECRRTITQHLHYNCVPDLDKNLQEIYHVVQERIDKDFLISCRDFNSTTYSRVFQAYKLLGRANRILDKLQSYFVDPIEP 306  Dictyostelium...
Q54NV0        261 NQWNQVITKYSKYTCIKDISSSIQVNADSVLDKIDSSLHSVCHNFDPKQFDIIMNSYFKLKKFQRIKDKIHQNFILNIED 340  Dictyostelium...
Q336V4        279 PEYLQILENYSGLSSVQEMGRGIEAWLARTIQKLDTHLLGVCQTFHEESYLTVIDAYALMGDIGGMAEKMQSFFLQEVLS 358  Japanese rice
Q8RXC2        281 SEYLQLLDSLSEFSAAQEMTRGVEVWLGRTLHKLDSLLLGVCQEFKEDSYVMVLDAYALIGDVSGLAEKIQSFFMQEVIS 360  thale cress
Q18602        227 IETQIKAGGYAHFTCVNEVISKLAGMSCLLEAELSAQLSTIAVVFDSEKYRFVYTAYEMLEKTEQVAEKLLTAFVEAIET 306  Caenorhabditi...
XP_002642305  231 IETQIQATGYGQFNCVNDILSKMMELSTLLETELATQLSTIAVVFDSEKYRFVFTAYEMLEKTDHVAEKLLNVFTDAIET 310 
Q5ZKV9        186 LECQKAASTFKHYSCISELNSKLQDTLEQIEEQLDVALSKICKNFDINHYTKVQQAYRLLGKTQTAMDQLHMHFTQAIHN 265  chicken
Q7QF78        158 LENKNLSQRFHQYRCVESLSHKLQDTLLLTEVQLESVLGEMPSEFEPARYQKLQEAYQLLGKQLIAMDQLHMNFVSSVHT 237  Anopheles gam...
NP_611258     225 LQCKSSAEAYMQFNCVQSLSKKLQETMLLMEFQLDTVLNEMVLGFDGRKYAKLQEAYKLANKSLMAMDQLHINYISAIHS 304 

Q54MU4        307 ETRNIVYSHVLLAEEnimNPERVKGLGYKELCRELKDDHFVNCLLAVFEYLCDLMASLYLMNQF 370  Dictyostelium discoideum AX4
Q54NV0        341 HSKKILKTHLNLTYS---KPEELLHMKFVDMCQHLKEDQYIPSLMGILEHLSDLMWSHYMMKQW 401  Dictyostelium discoideum AX4
Q336V4        359 QTHYVLKEMLEEEVG---NNTQRNRFTYSDLCAQVPEPKLRPCLLRTFQSLFSLMCSYYTIMSF 419  Japanese rice
Q8RXC2        361 ETHSVLKSIVGEDNS---AATQYSRLTYSDLCLQTPESKFRQCLLRTLAVLFQLIYSYHEIMSF 421  thale cress
Q18602        307 TTSAVVLSKLK-------EEDRLEDSSYTSLCLKLDSEQASITFREMGFVLCRSFQAFHKILNF 363  Caenorhabditis elegans
XP_002642305  311 TTTAVVMDKMK-------EEDRKDDATYTSLCLKLDGEQASTTFREMGFVLCRSFHSYHKVLQY 367 
Q5ZKV9        266 TVFQVVLGYVELCAGn--TDTKFQKLQYKDLCTHITSDSYIPCLADLCKALWEVMLSYYRTMQW 327  chicken
Q7QF78        238 AAFTVLRQHMEV------SVEESKKLTYEQMCECVPMDRYVHCLTELCRAFWKILVSYHQIRCW 295  Anopheles gambiae str. PEST
NP_611258     305 SVNAVLRGYSDP------GQDDQAKPLYEQLCEQLSVDKLLPCLISLCKTFWTILASYYQVVMW 362
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