Conserved Protein Domain Family
Syndetin_C

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pfam10474: Syndetin_C (This model is not part of the current CDD release)
Syndetin, C-terminal
The function of this domain is unknown but it is found at the C terminus of syndetin (VPS50), a unique component of the endosome-associated retrograde protein (EARP) complex. The EARP complex otherwise shares four of its five subunits with the Golgi-associated retrograde protein (GARP) complex. The EARP complex is localised to recycling to endosomes where it acts as a tethering complex for recycling of plasma membrane receptors.
Statistics
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PSSM-Id: 519400
Aligned: 37 rows
Threshold Bit Score: 175.079
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_001419490   81 LYGLKERGIALESLSRVADEFKR-IKARVKRSLPLKDAALADRFYSHTVAAVD-DLREHVY-KNVASLLLNIEfcaeaig 157 
EFJ24849      726 FFAIKERTVAAESLIFLATLIRN-SRQHLQSLLHQNALPFVDQFFARTVDASI-DLREHVY-KTGARLLLNIG------- 795 
XP_006833490  822 SFGLKERCIGPETLSHVAQILYR-SKAHLQSMLQQNNGAIVEDFYRNMVDSVL-DLVEHIH-RTTARLLLNIN------- 891 
XP_006591098  893 SLGLKERCVAVDTISLVARILNR-SKAHLQSMLLQSNSTILEDFYVHLVDAVP-DLTEHVH-RTTVRLLLHIN------- 962 
Q8RXC2        889 SFSLKERCAAVDTVSLVARVLHK-SKAHLQSMLMSRNGSLVEDFFGQLVGSVP-DLTEHLH-RTTARILLHVN------- 958  thale cress
XP_002952743  938 QWGLRERVVAVESLIYMAQELKA-AKQAIILALPGRCQRDVEQYFNRTVEAAA-DLREYLF-KAAARVMMQGVwdg---- 1010
XP_002683118  667 LFGLYERSIAAESLTFLYNAVEKiIEKRMEELIPKNKRSNASQFLKSMKSATE-EVKDCIYgRTVKYLLFDFPym----- 740 
XP_001317963  562 LRTLDQASAASDNMKGVAWYLRS-VRSFIEESLPENSLGALRRFFSDVVSIFLqSFASFCF-PFFGPSMVNLT------- 632 
XP_002906666  793 LYALAERSIACEAIVGQSRLLNA-IEDLARSYLPDRYLCLMDEVFERNRTMAR-ELRSFMY-STIAVRLVDVP------- 862 
XP_001019529  815 FKGISERIIAIESFDYLLFIYRS-LIPIIQYMYDKTFDQFEVDYYESIYN----ELKSLIF-VDYAPQFARSD------- 881  Tetrahymena t...
XP_001419490  158 dgdpnfALVNSTFVGKYNIRET-PSRHNKWVDDVQAELLQFTTKLAC---ADVAPEALDVLWQHAASVIQDSLVDGFSKV 233 
EFJ24849      796 ------SYVDRISNTRWELKEL-GMEHNGYVDSLLGEFKQYTVRLSN---AGVSRQVHELLLQYGVDILAETLVEGLSRV 865 
XP_006833490  892 ------GYVDRVANAKWEFKEL-GLEHNGYVDLLLGEFKHYKMRLAH---AGIRKEIQDVLLEYGLENVAETLIEGLSRV 961 
XP_006591098  963 ------GYVERVANCKWEVKEL-GMEHNGYVDLMLGEFKHYKTRLAH---GGIRKEVQDLLLDYGLEIVAETLVEGLSRV 1032
Q8RXC2        959 ------GYVDRIANSKWEIKEL-GMEHNGYVDLMLGEFKHYKTRLAH---GGIPQEVQNLLLEYGVEIFAEMLVEGLSRI 1028 thale cress
XP_002952743 1011 ----drGIPAAIGVTNYNVREP-AIKQSPWADFSVRALHTFREKVLA---ARLPLPLVVLLWDFAVAVVTEGLLTGLAGV 1082
XP_002683118  741 -----eKYPDKIANCKYHIQVM-GDQCNKFVFELRDDIKKFFSIKLQtiddrLPENSINCLWDLAVKYVIDVLVEGFSRV 814 
XP_001317963  633 ------EFDTQVKNTKWTINEP-PLDPHPFTKLWTENVSSFVKQVDE---MKLAQDHKDEILTSLWNYSSFSFINDLATI 702 
XP_002906666  863 ------ALMESVAAVSWDIPYI-SDQHNEYIVHLVQKCGEAWGGLQIladGSIPMDAREDIWAEMVQIIMDTLLQAFSTV 935 
XP_001019529  882 ------QIFSAIPNSKWELSSQeVGQTSNYVERFCQIIVDYKEQLRStggGSVPEQVQEEIFCLLIDFCYKELIEAYSKI 955  Tetrahymena t...
XP_001419490  234 KKCTDAGRALMALDVETLRGEFAKLAPS------QSlAF-DWRYVSTYINAFY-VPEKDVEKWMQIHp-EFSKKQKLALV 304 
EFJ24849      866 RRCNNEGRAVMSLDLQVLINGLQHLAPA------KL-KA-NLQIVDAYIKAFY-LPETEYLYWAKSHp-EYSKQQIINLI 935 
XP_006833490  962 KRCTNEGRALMSLDLQVLINGLQHFVSI------NV-KP-KMHIVESFIKAYY-LPETEYVHWARSHp-EYSKNQVIGLV 1031
XP_006591098 1033 KRCSDEGRALMSLDLQVLINGLHHFVSL------NV-KP-KLQMVETFIKAYY-LPETEYVHWARAHp-EYSKSQVVGLV 1102
Q8RXC2       1029 KRCTDEGRVLMSLDLQVLINGLQHFVPT------KV-KP-KLQIVETFIKAYY-LPETEYVHWARAHp-EYTKAQVVGLV 1098 thale cress
XP_002952743 1083 RKCSLEGRANMSFDLSHVERQIRAMGPP------NF-KPtALAIVDAYIKAFY-LPWEELPHWCRTHvaQYGKQRLFTLV 1154
XP_002683118  815 KKCNNEGRVLMQLDLQTFTTELQRMVPSslieknKGsVP-HVAIARSYIQAYYeQNESDLLEWVKKNvhHFTVKQMAAIA 893 
XP_001317963  703 QKVTAEGRTAMLSDFRNMAHDYVNVT--------KKrIQpDNSWVAGFVQAYF-LGIEDFKKWAVENakRYTQNHMMSIV 773 
XP_002906666  936 SKPTAQGRALMLLDLHALQNGLDLINHVs----sRT-VPrGREYVGNYIKAFY-YDEDELLEWVQANktLYSKVQFANLL 1009
XP_001019529  956 KKINEFGRLQMQRDFQMIQKKVQSLSKN------QTrEQlQRAFVEAYLKICQsQDIEEVQTFINTNkeRYSLEALIGLI 1029 Tetrahymena t...
XP_001419490  305 AHN--ASAdrdrrwTAKFRQDLLNAIE 329 
EFJ24849      936 NLV--ASMnn---wKRKTRTDLLERIE 957 
XP_006833490 1032 NLV--ASMnn---wKRKTRLEMLEKIE 1053
XP_006591098 1103 NLV--ATMkg---wKRKTRLDILEKIE 1124
Q8RXC2       1099 NLV--ATMkg---wKRKTRLEVIEKIE 1120 thale cress
XP_002952743 1155 EVS--AEFnk---vKRHQKNEVLEMIE 1176
XP_002683118  894 TLNfgANL------KKNELKQLTSQVE 914 
XP_001317963  774 ETGfsDNI------KRQDRKDLSNFVK 794 
XP_002906666 1010 KNGigSTL------EIKKLREIVLKID 1030
XP_001019529 1030 RISaaGSNiv---vKTKQKDQILTILN 1053 Tetrahymena thermophila SB210
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