3J4Q


Conserved Protein Domain Family
AKAP7_NLS

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pfam10469: AKAP7_NLS 
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AKAP7 2'5' RNA ligase-like domain
AKAP7_NLS is the N-terminal domain of the cyclic AMP-dependent protein kinase A, PKA, anchor protein AKAP7. This protein anchors PKA for its role in regulating PKA-mediated gene transcription in both somatic cells and oocytes. AKAP7_NLS carries the nuclear localization signal (NLS) KKRKK, that indicates the cellular destiny of this anchor protein. Binding to the regulatory subunits RI and RII of PKA is mediated via the family AKAP7_RIRII_bdg. at the C-terminus. This family represents a region that contains two 2'5' RNA ligase like domains pfam02834. Presumably this domain carried out some as yet unknown enzymatic function.
Statistics
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PSSM-Id: 402204
View PSSM: pfam10469
Aligned: 33 rows
Threshold Bit Score: 132.395
Threshold Setting Gi: 81875160
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
3J4Q_A        90 PNYFLSIPITNKK-ITAGIKVLQNSILRQDNRLTKAMVGDGSFHITLLVMQLLNEDEVNIGT------DALLELKpfv-e 161 human
CAM70801      72 PTHFLSLPLPSRCtLRVRVKEMHESMIFANQSIEPLLIPASKLHVTLGVMTIGGETATAEAAsaaaapDVLAAIQdcv-d 150 Leishmania infa...
Q4DBB7        71 PTHFLSLRLPVRNvLRTRVNEMHNQILFSHQQHAPLLVPLEKLHITLGVMAISEREETERLA-------SIYDCVsev-f 142 Trypanosoma cruzi
EDV25697     141 PNYFISLRLYNRN-IRQELSKIQGEMIAQDERLKFAAVSPAKIHITLFVMALNTDEEITKAE------VALKSVEmel-q 212 Trichoplax adha...
XP_002594647 482 PNYFVAIRVSNEE-IHRGLEAVQQAVLEQEKSLLPAMIPLINMHITLLVTHL-REEQVDRAK------EALRLAKapefl 553 Florida lancelet
XP_002602510  17 PNYTVAIRVTNDE-IRRGVRKIQEAVLAHEPNLEPAIIPLSNLHVTLLMLHL-REGQVQAAK------EALRQAKari-t 87  Florida lancelet
EFA86753      62 PNYFLGLQITEPT-ITDQLSQAQKHIANTVPLIRRDVTAAEKFHLTVFVMTLTDVQVQLPLV------KSLLQQAkli-s 133 Heterostelium a...
Q55E02        13 MNYFFGLQITELL-IYNQLKQIQNSMKKSCKYVEKDLIPSEKFHVTVFVMEL-TDEQLSIVK------STLMPQTkll-a 83  Dictyostelium d...
XP_002259684  50 PNYFVCIPLSGNKgLVEELIKVQNHVASKFEMLKECAIERNKFHISLLILHVKKSQMVASK-------EAFREAIeei-- 120 Plasmodium know...
Q7RFS5        43 PNYFICIPLNDNKiIINELLNIQKFVVSKFDLLNECIIEKEKFHISLLILYVKNKTQIDLSK------EAFNEAInei-- 114 Plasmodium yoel...
3J4Q_A       162 eiL-EG--KHLTLPFHGIGTF-QGQVGFVKLadg---dhVSALLEIAE----TAKRTF-QEKGILAGESRT--------- 220 human
CAM70801     151 qaChDTckEPLQLRFRGLGTFgHGRVLFAGCite---ahFTTLDTLVR----RIRKDLgLGLGVDMKGNPHd-------- 215 Leishmania infa...
Q4DBB7       143 svI-----HPLQLRFRGLGTFgFGRVLFIRVvpe---adFGILETAVS----KIRRRVgGELKVDMKGNPHd-------- 202 Trypanosoma cruzi
EDV25697     213 eyV-SQreQSSSISIESISHF-NQGVVFAQVkdd---vgFDMLKTIRA----KVHKLF-LEKNLANCDSKP--------- 273 Trichoplax adha...
XP_002594647 554 rpE-----NRLVLTFQGLGTF-RNDVVFAKIqen---dhLTSLRELAE----TVQTCF-VEKEVCSKKDKG--------- 610 Florida lancelet
XP_002602510  88 pqL-LQpfNKVVIPFEGLGTF-ADTTVFAKVaeg---ghLATLRQIAD----TVRTCF-AEKNLYPTDDNT--------- 148 Florida lancelet
EFA86753     134 neI-FGenTPSS-TIKGIGSFn-DRVLWSGLkdd---enSARLTEFQS----RLVKLF-EENNINIDKR----------- 191 Heterostelium a...
Q55E02        84 teI-FGenNKPSSSIKGIGSF-KDRVIWAGVnen--hdgYSKIVDYRN----RLYKLF-KDQNIKVEEDRD--------- 145 Dictyostelium d...
XP_002259684 121 -----kklNHQAISFDTLETF-RNDVLYAGLkedsrkyvVNMIALLRDaftkRDIHIFsNHKGKEEAREKTrpsgaidkg 194 Plasmodium know...
Q7RFS5       115 -----kkiNKKNLYFKSLDTF-HNDVLYLSLne----esNDYIILLAN----IFRKCF-EKRNIKIVYNSRkhvnnhkne 179 Plasmodium yoel...
3J4Q_A       221 ------------------------------------FKPHLTFMKLSKAPMLWKKGVrkie--pglyEQFIDHRF---GE 259 human
CAM70801     216 -----------------------------------sYVPHVTVAKIRPSQIGQFGRQlpi----smwADHQHHDF---GD 253 Leishmania infa...
Q4DBB7       203 -----------------------------------sYVPHVTIAKIRSKQQTQFGSKipi----smwVEYQHHDF---GD 240 Trypanosoma cruzi
EDV25697     274 ------------------------------------FKPHVTIFKLSKNPKKLKKLGiakld-pktyESWKDHHF---GI 313 Trichoplax adha...
XP_002594647 611 ------------------------------------FEPHLTLMKTSRNFGKLRSKGikkid-pklyEEFNDQRF---GE 650 Florida lancelet
XP_002602510 149 ------------------------------------FLPHLTLMKITDNNQGKLKSKgiqrispslyEGLREREL---GS 189 Florida lancelet
EFA86753     192 ------------------------------------WNPHITLAKGRggq--------------hfvDAFNDTEF---GL 218 Heterostelium a...
Q55E02       146 ------------------------------------WHPHITIAKGKNIQRNYLQIKkh---------mdENIEF---GF 177 Dictyostelium d...
XP_002259684 195 ignrtdk--------------gaavpstyqcsekeqITPHVTIMKNSYLRKIYANRKpqi-----faDYYADFNLsklQT 255 Plasmodium know...
Q7RFS5       180 pnnknepnnknepnnknepnnknepnnkkeqneqnkITPHLTLMKNSHLSRIYMNRKpki-----fpDYYSNFDLtklLT 254 Plasmodium yoel...
3J4Q_A       260 EILYQIDLCSMLKKkq-sNGYYHCESSIVI 288 human
CAM70801     254 VTFNRVDLCSMKGEg--kNGYYHVVSSAAV 281 Leishmania infantum JPCM5
Q4DBB7       241 VTFSQVDICSMRGSk---DGYYHTEGSVHL 267 Trypanosoma cruzi
EDV25697     314 EKMRGLQLCSMLLPpe-nDGFYRCISTIDF 342 Trichoplax adhaerens
XP_002594647 651 QVVEGLQLCSMLKKke-tDGYYHTEEQVMF 679 Florida lancelet
XP_002602510 190 QSVEGFQLCSLRKKrq-aDGYFHVEEQVKF 218 Florida lancelet
EFA86753     219 QKFQSLQLLRIGSSdp-iTKYYKIEESYAL 247 Heterostelium album PN500
Q55E02       178 QNFSKLQLMKIGTTdp-iTKYYFVEDTIDL 206 Dictyostelium discoideum AX4
XP_002259684 256 ERVVPNKIQFLEMDtdsaTSYYRVIDECGL 285 Plasmodium knowlesi strain H
Q7RFS5       255 EHITPNKIQLLEMDidpkTSYYKIISEFSF 284 Plasmodium yoelii yoelii
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