Conserved Protein Domain Family
Peptidase_U49
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pfam10463: Peptidase_U49 
Peptidase U49
This family contains Lit peptidase from Escherichia coli. Lit protease functions in bacterial cell death in response to infection by bacteriophage T4. Following binding of Gol peptide to domains II and III of elongation factor Tu, the Lit peptidase cleaves domain I of the elongation factor. This prevents binding of guanine nucleotides, shuts down translation and leads to cell death.
Links
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Statistics
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PSSM-Id: 402201
Aligned: 3 rows
Threshold Bit Score: 270.688
Created: 23-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
P11072  61 IVLTVASLEYIWAFSNFFWVFTQE---YSKSQKNNDEHFDLTGKNRLKKSDELLKWARKNLQTTGCESW---------PK 128 Escherichia coli K-12
Q5HXY2  68 ITMKWWALEVLWLTAFVFQNLGAR---LWRHAEDGNTSSTLEDEVHLRKGRDALAHAANLIENRESRNW---------PE 135 Gluconobacter oxydans
Q31IR0  52 IQFTQRSLEQLWLFGFAGLYALHSlsgIIFFVKCKGLKLDLEEIDGVPKQKEENERFSKIIETIKGLNSaeseydfnwPA 131 Hydrogenovibrio cruno...

P11072 129 KCPKPEAYLQGSed---sQVASEIFLCAIAWILHHEISHVVLQHPLV--TTAFSTQEEREADSHATKWILGNLYESAPel 203 Escherichia coli K-12
Q5HXY2 136 NIPHPAENKKDS------ERTNKVFLKALGWIELHEVAHITVDESIFsgAVNPSIAEEEYCDSYATNWVLAGNGKKLP-- 207 Gluconobacter oxydans
Q31IR0 132 GLPKPE---DGKpkdteqAAVFDLVLMATAYVFLHELKHVIFESEGN--SPEDRLREELECDSFALEMMLSKIQDYSAks 206 Hydrogenovibrio cruno...

P11072 204 --------kKRALGIATAVLCiqsLEVENYFCLQN--THPAAYERIYSNis-cYPVGNEELIEALC 258 Escherichia coli K-12
Q5HXY2 208 ---------SQREGVAVATFF---LVLREVLRGRTgpTHPNSQSRVAAS----QISDRHGGWLAII 257 Gluconobacter oxydans
Q31IR0 207 gypegqvlmKRSISIALGSVFlavATPRHNLGGTT--THPAVHDRWSATlgkiELEENDFYWLYFA 270 Hydrogenovibrio crunogenus XCL-2
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