Conserved Protein Domain Family
Peptidase_M66

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pfam10462: Peptidase_M66 
Peptidase M66
This family of metallopeptidases contains StcE, a virulence factor found in Shiga toxigenic Escherichia coli organisms. StcE peptidase cleaves C1 esterase inhibitor.
Statistics
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PSSM-Id: 287440
Aligned: 10 rows
Threshold Bit Score: 342.116
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q54CP8   98 EDNGERYSTKHHSVLLPKEWIRPNMKIKFtlteskdnSSLNIDSSNFFY--PDVSQDYTLKMWTLPFYLFGANDTNTQPF 175  Dictyostelium disco...
Q54CQ0  100 EDNGEKYSKVHHSGMIPKEWVRVGMKIQFss----fgGINGTEVSDILS--PDVGQDYTLKMWILPFYLFGANDTNTQPF 173  Dictyostelium disco...
Q54CP9   99 EDKGEKYSTVHHSIMLSKEWVKVGMKIQFftigndgnGSSVVKSSDFFY--PDVGQDYTLKMWTLPFYLFGANDTNTQPF 176  Dictyostelium disco...
Q54CP7  130 ESNGEQYSNEHHSIMIPKEWVKPGMKLQFfe-----nSNSFIKSSKFIF--PNVGQDYTLKMWTLPFYLFGANDTNTRPF 202  Dictyostelium disco...
Q54J86  100 ESNGTKYSTVHHSIRIPKDWMKPKMKIQF---------STMLLKSEFFF--PNIGHETNLNMWLLPFYLFGANDTNTQPL 168  Dictyostelium disco...
Q6LPV2  268 ENNKLVYADNTWSLKLPPNWIQPDIKMQF---------THGNLSGELSG--IKVGAPSELLIHTIDIGML------TEPR 330  Photobacterium prof...
Q9KN18  439 GRMKVVFSHLAWSLPLQWDWMKPGLSLRL--------TDNLGREGVLSQgeIQFGGAPELVIQNIDIGML------MPPR 504  Vibrio cholerae
P0C6Q7  232 nNKVVSYSNSYWSAEIPWNKMKSGMSLHF--------EDENGNLGIIESerIKFSAPSELIIQNIDLGML------YKPR 297  Vibrio cholerae O1 ...
Q2SFU6  136 EGDDLPYSDDAWSAVIPSDDMSKGVNIRV--------VAQGKSASEIVT--PALHPELDLTIQSLPFLIYGANESNI-PF 204  Hahella chejuensis ...
Q63KV4  192 ESGGRAYANDRWSAVVPAAWMVPGVSFSV--------SASNYTSSVAQA--PVFGTDADVQLTILPFYLFGADDTNSPPL 261  Burkholderia pseudo...
Q54CP8  176 S----VTNGIG--SEITKELMERWSCSDIIAVNHPIQRIDWPYLVMEP-R-----NGNPAMLITNSDQKKDGYA---IMN 240  Dictyostelium disco...
Q54CQ0  174 S----KTKGID--SGISKELIEKWSCSDLQADNHPIQKIDWPYFVMEP-R-----SGNPAMVITNSDQKKDGYA---IMN 238  Dictyostelium disco...
Q54CP9  177 S----KTKGID--SEITKELIEKWSCSDLQAINHPIQKIDWSYFVMEP-R-----NGNPAMVITNSDQKKDGYA---IMS 241  Dictyostelium disco...
Q54CP7  203 N----QTKNID--DSISAGLSQVYSCSNILSLNHPIQRVDWPYLVLGP-R-----NGLPGMLITNSDQKKDGYA---IME 267  Dictyostelium disco...
Q54J86  169 S----VTGSIS--KDVSDELIQKWSLSSLNALNHPISRIDWSYLILPAgR-----NNLPGLRITNSDQKRDGYE---IMS 234  Dictyostelium disco...
Q6LPV2  331 D----AFNFAKd-TSAQREYFQTVPVSRMTVSQYESLYLPE---VMLP-NgtlltDFDPSTGGWHSGTMRQRIGkelISI 401  Photobacterium prof...
Q9KN18  505 D----RNTMIQnlPTLAADYFQKIPASKLVMADYTPAHFPV---VTMP-NgvvytDKSASTGGWHSGDMREAIGkamVST 576  Vibrio cholerae
P0C6Q7  298 G----RNIVIKelERTAVDYFQKVPVSKLIFSDYTPIHFEK---ITLP-NgtvytEKSADIGGWHQGDMREAVGkalVST 369  Vibrio cholerae O1 ...
Q2SFU6  205 KiddlKVMFAD--PDTAGQGFAGMPFSKTHIVNHPLGVFESDYLIAPP-S-----GSAPAKKVESAADPDYSKP------ 270  Hahella chejuensis ...
Q63KV4  262 S----TTQAPD--AATQQEIFAKWPTAELKVRTHPAGRFSLATVVVGP-RadrtgAAQPAYPVTALDQQKDGYG---VMS 331  Burkholderia pseudo...
Q54CP8  241 GVLNILTEIREAFGESTSSIQIYSPLL---HLGANGKYTNP---------GGGLGGGSRG--TGDHKYTFTFFHEQGHAM 306  Dictyostelium disco...
Q54CQ0  239 GVLSILWLLRGMFGESSSSIQIYSPLL---HLDAKGRYADT---------YGGLGGSSAG--TGNHRFTGIFIHEQGHAM 304  Dictyostelium disco...
Q54CP9  242 GVLNILTQIRKVFGESSSSIQIYSPLL---HLDSKGKYADP---------YGGLGGGSRG--TGDYTYKGIFIHEQGHAM 307  Dictyostelium disco...
Q54CP7  268 GVLNILTGIRVAFGESTSSIQIYAPLL---HLGANGKYADT---------YGGLGGSSRG--TGDYRYSDTFVHEQGHAM 333  Dictyostelium disco...
Q54J86  235 VVLGILSGIRGANGEGPSSVLYYAPLI---HLGANGKYADP---------WGGLGGGSVG--TGDYSYTGIFIHEAGHSY 300  Dictyostelium disco...
Q6LPV2  402 GIDNANYGINSSIGEGESGHPYLASQLa--AHNSRGNYENGiv------tHGGSGGG--GivTLDASLGNEFSHEVGHNF 471  Photobacterium prof...
Q9KN18  577 GINNANVGIVSSAGYSQ-QYNRRFNHIt--AHTNVGIYTKKdtdlpqvvvHGGSGGG--GivTLEATTGNEWSHELGHNY 651  Vibrio cholerae
P0C6Q7  370 GINNANLGIVASSGYSQ-QYNRLTNHIt--AHTNIGYYNNGvv------vHGGSGGG--GivTLENTLHNEWSHELGHNY 438  Vibrio cholerae O1 ...
Q2SFU6  271 -ILDMVWHIEYATGDMALNKITFAPSMlidHSKAGPIKTRG---------FGGMAYTGSGasMG-YPSLGLLWHEGGHAL 339  Hahella chejuensis ...
Q63KV4  332 AMLTLITNMRTANGDGPLNNQYYAPLI---ALNSNGQFANL---------GGGLGGVGSGaaVGDHRYTGIFIHEQGHAF 399  Burkholderia pseudo...
Q54CP8  307 GLPH--AGEAFAAG-SYPYVNGSLLGSEWGYDANHNELLGTFIPPTSDqFKNCRRN-----SVFDS---KGRCVKQSVMQ 375  Dictyostelium disco...
Q54CQ0  305 GLPH--AGEAYDNKrKYPYKQGSLSGSEWGFDANHNEFLGTFIPPTAElYKTCKKN-----SIIDS---KGRCVKQSVMQ 374  Dictyostelium disco...
Q54CP9  308 GLPH--AGEAFDKG-TFPYQKGSLSGSEWGFDANHNEFLGNFLPPTAEyYRNCQKS-----FLIDN---KGRCIKQSVMQ 376  Dictyostelium disco...
Q54CP7  334 GLPH--AGEAFASG-SYPYVNGSLLGSEWGFDINHYEFLSITLSNTSKnYKGCEKK-----NVKDT---QNRCVKQSVMQ 402  Dictyostelium disco...
Q54J86  301 GLPH--AGDSYKSG-NYPYVDGSLLGSEWGFDMNHNEFLSVNIPSNIGaYKNCNKS-----FILDQ---NKNCVKQSVMQ 369  Dictyostelium disco...
Q6LPV2  472 GMGHypGGFSGS-----VHRQADAVNSTWGWDADLNKFIPNMSAKKNN-QSACLNG------ECQAp-fDGRKFGSDSMA 538  Photobacterium prof...
Q9KN18  652 GLGHwpYM--AS-----IH----DLESGWGWDAFHQRFIGNLHWKGDV-YTQQQGD------DIVPpfkDAFRFLRDAQN 713  Vibrio cholerae
P0C6Q7  439 GLGHyvAG--GT-----SH----GPDTSWGWDGYYKRFIANFDWKRSP-QSNIRPDn----QEVVKpfmDKYTYLWDAMS 502  Vibrio cholerae O1 ...
Q2SFU6  340 GLPHslSGSKDLRGpYYPYAEGSLSGSAWGYDQHKGYFRSPLTAPTSR-YFVCNGErgggvFQKTP---EGRCYRFDPMH 415  Hahella chejuensis ...
Q63KV4  400 GLNH--AGDEYAKG-AYPYAGGSLSGSVWGYDPNHREFLDVLVPTTASsYAKCASS-----HQLDA---QGRCYKQDPMQ 468  Burkholderia pseudo...
Q54CP8  376 GGAGDYSS-KYRYSMFADFEMTTIQNYFKNSIY 407  Dictyostelium discoideum
Q54CQ0  375 SGAGDQSS-KYRYSMFADFEMTTIQNYFKNSIY 406  Dictyostelium discoideum
Q54CP9  377 GGAGDQSS-KYRFSMFADYEMTTIQNYFKNSIY 408  Dictyostelium discoideum
Q54CP7  403 SGAGDRSS-NYLFSMFSDFEMSIIQNYFKNSIY 434  Dictyostelium discoideum
Q54J86  370 GGAGNQAQ-GYRYSMFADYEEVTIQNYFKDSII 401  Dictyostelium discoideum
Q6LPV2  539 GGAPMST--INRFTLYTPYTAANIQRNLESKIV 569  Photobacterium profundum
Q9KN18  714 GGEQEYVGtISRFTLEHPAQSRKAQRWMNNGFN 746  Vibrio cholerae
P0C6Q7  503 GGYDHQNGiISRYTLHHPYVARIIQDWLKNGAV 535  Vibrio cholerae O1 biovar El Tor str. N16961
Q2SFU6  416 SADEQKDP-DAAFPLFSDFNAGKMQRWVRNRAR 447  Hahella chejuensis KCTC 2396
Q63KV4  469 GGAGDQSS-GYKFATFSDYNTGRMQAWIASRVl 500  Burkholderia pseudomallei K96243
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