Conserved Protein Domain Family
Peptidase_S68
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pfam10461: Peptidase_S68 (This model is not part of the current CDD release)
Peptidase S68
This family of serine peptidases contains PIDD proteins. PIDD forms a complex with RAIDD and procaspase-2 that is known as the 'PIDDosome'. The PIDDosome forms when DNA damage occurs and either activates NF-kappaB, leading to cell survival, or caspase-2, which leads to apoptosis.
Links
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Statistics
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PSSM-Id: 519393
Aligned: 9 rows
Threshold Bit Score: 32.4569
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_023199782 456 WSTLPTELRRGSEEHCCYpggrparlACSSVSHFSWFMAVSR 497 
3_pfamImport   1 WSPLPTALRRGSKHRSAY--------HRGRVPRFSWFMVVSR 34  
XP_008106536 409 WSELGTRVKHKGKMH--F--------ACCSVPHFSWFVVVSR 440 
ELV12606     364 WSDLETYLEEQVPKRL-W--------AHCRVRHFSWFHVVSR 396 
Q9ERV7       426 WNDLETQLEEEAPKRL-W--------ARCQVPHFSWFLVVLR 458  house mouse
5_pfamImport   1 WSDLKTRVKRKRKSKKCV--------AHCCVLHFSWFLVVSR 34  
1_pfamImport   1 WSTLPTFLRKGSPSHS-L--------ACCAVSQFSWFMAVSR 33  
XP_004941519 412 WSDLRTQVEKKRKSKKHV--------AHCSVLHFSWFLVVSR 445  chicken
XP_011605894 475 WSTLPTVLRRGrkhrsgsqsrrpprlacctVRQFSWFMVVSR 516  torafugu
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