4XZY,5JXF


Conserved Protein Domain Family
Peptidase_S46

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pfam10459: Peptidase_S46 (This model is not part of the current CDD release)
Peptidase S46
Dipeptidyl-peptidase 7 (DPP-7) is the best characterised member of this family. It is a serine peptidase that is located on the cell surface and is predicted to have two N-terminal transmembrane domains.
Statistics
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PSSM-Id: 519392
Aligned: 29 rows
Threshold Bit Score: 561.526
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
4XZY_A            21 ADEG-MWLMQQLGRKYAQMKE-RGLKMKEYDLYNPNGTSlKDAVVLfDGGCTGEVVSDRGLVLTNHHCGYDMIQAHSTLE 98  Porphyromon...
Q1GVV7            23 AEEG-MWTFDAVp--TDAIKAaYGWAPDQKWLDHTRAAA-----VRlTGGCSASFVSNEGLILTNHHCVVGCLQNLSSAD 94  Sphingopyxi...
Q2G546            56 ADEG-MWTFDAFp--SAKMQAdYGWAPDGRWLDRVQAAA-----VRlTGGCSASFVSPDGLILTNHHCVVECAQDNSTDE 127 Novosphingo...
Q7NHA9            34 AEEG-MWTYDNFp--SEQVAKkYGFKPDAAWLERVRLAS-----LRlAGGCSGSFVSPNGLVMTNHHCAATCIEELSTAQ 105 Gloeobacter...
jgi:Anae109_3411  37 ADEG-MWTYDAFp--ADKVEKkYGFRPSDAWLENARLSS-----ARlAGGCSASFVSEDGLVMTNHHCAHECIEQLSTAQ 108
Q2IEV3            18 ADEG-MWTYDAFp--SDRVARkYGFDPSRAWLDRARLAS-----ARlARGCSASFVSDGGLVMTNHHCVHECVEELSSAG 89  Anaeromyxob...
Q1IPC2            27 ADEG-MWLFTNPp--TAAIQKkYGFAITQEWLDHLRLSS-----SR-APGGSSEFVSPDGLLMTNHHVAQSCIHDLSSGG 97  Candidatus ...
Q7UKL5            28 ADEG-MYLFNDVp--RELLRDrHQFEPSEEWLKHLQLSS-----VRfNSGGSGSFVSSNGLVLTNHHVASDTLAKLSSKE 99  Pirellula sp.
Q2S133             5 SDAGrIWSLVAPp--ADRLVRrYGMEVDSAWAAHLRRSV-----LR-LPGCTGALVSADGLALTTARCVRRHLNSQGDT- 75  Salinibacte...
Q5QV86            17 ADEG-MWMPKQLPEIADKLKA-AGLTIDPNDISKLTEFP-AAAIVS-LGGCSASFVSPEGLVATNHHCAYNSIAHNSTPE 92  Idiomarina ...
4XZY_A            99 HNYLENGFWAMREADELPN-KDISVVFIDKIEDVTDYVKKELKaiKDPNSMDYLSPKYLQKLADK-KAGKNfsaknpGLS 176 Porphyromon...
Q1GVV7            95 SDLVAGGFNAADRARELKC-PGQQAEVVTAITDVTGSIRAAIGs-LTGEALVKARDARIAEIESAeCPDRD------TTR 166 Sphingopyxi...
Q2G546           128 NDLLKLGFVPVRREEELKC-PGQQAEVVTAIGDVTARVRAAIGt-ATGEALVKARDAEAARIEKEgCRDAA------TTR 199 Novosphingo...
Q7NHA9           106 QNYIESGFLARRPEAELKC-PDVELNQLTAIEDVTERVKKATAn-LSGQQFSDAQKAEFARIEKA-CADAT------GLR 176 Gloeobacter...
jgi:Anae109_3411 109 KDFVKSGFYAKTLPDEVKC-PTVEVNQLVQITDVTQRIRAATKg-LEGEAYHKALQGEMAKAEKE-CQTSD------ELR 179
Q2IEV3            90 RDLVASGYLARSGAEELRC-PAMQVDQLLRITDVTKRVHGALAg-LEGARFNAALQAQKAAIEKE-CQGGDa-----GLR 161 Anaeromyxob...
Q1IPC2            98 KDYMKDGFYAATREQEPKC-PGIEFLVLTDIKDVSEQIHSAVKarMASAESGKATRQAMSAAEKA-CSTE-------GFK 168 Candidatus ...
Q7UKL5           100 RNLIDDGFLAKSFDEELKA-PDLELNQLISIEDVTDRINQQITnaDDAEEAAKERRAAIATIEKE-SLDET------GLR 171 Pirellula sp.
Q2S133            76 ------AIVAARPADERAV-PALHADRLVRTSDVTAAVRTARQd-TAKAAAISAVQGRLQTEAES------------GRH 135 Salinibacte...
Q5QV86            93 NDLLANGFLAKGLDAEVPAaPGSRIFVTKAVDDVTNKVIDAKVteLTGKARLDAIEDNQKALVAE-CEEDE------GHR 165 Idiomarina ...
4XZY_A           177 VEIKAFYGGNLYLMFTKKTYTDVRLVGAPPSSIGKFGADTDNWIWPRHTGDFSIFRIYADKNGNPAPYSEDNVPLKPKRF 256 Porphyromon...
Q1GVV7           167 CQVVTLFGGGQYKLYKYRKYSDVRIAWAPEFQAAFFGGDPDNFNFPRYAMDAAFLRAYEN-----------GKPAATPAH 235 Sphingopyxi...
Q2G546           200 CEVVTLFGGGQYKLYTYRKYADVRLAWAPQFQAAFFGGDPDNFNYPRYALDAAFLRAYEN-----------GRPVKVKSF 268 Novosphingo...
Q7NHA9           177 CDVVNLYQGGLYNLYKYKRYQDVRLVFAPEFRIAFFGGDPDNFNFPRYDLDVTFLRAYDK-----------SQPVKTEHY 245 Gloeobacter...
jgi:Anae109_3411 180 CDVVTLYQGGVYDLYKYRRFQDVRLVFAPEFAIAFFGGDPDNFMFPRYDLDVAFLRVYQG-----------GKPAKMKNF 248
Q2IEV3           162 CELVELYHGGVYSLYQYRRYDDVRLVFAPEFAIAFFGGDPDNFMFPRYDLDVAFIRVYRD-----------GKPAPTAEH 230 Anaeromyxob...
Q1IPC2           169 CDVVTLYAGAMYHLYKYKKYTDVRLVFAPEFQMAFFGGDPDNFTFPRYDLDITFFRMYEN-----------GKPAHTENY 237 Candidatus ...
Q7UKL5           172 SDVVTLFGGAKYHLYRYKKYTDVRLVWAPETAAAFFGGDADNFEYPRYNLDATLMRVYED-----------GEPAKLEHF 240 Pirellula sp.
Q2S133           136 VEVAADGEGA-YTAYTYRRHEDVRVALLPDRRISAFGGTDAALTYPRSAFDVALLRIYTSE----------GQPLAPNHF 204 Salinibacte...
Q5QV86           166 CTVAAYYGSLEYYLIKQLEIKDVRLVHAPASGVGKFGGDTDNWMWPRHTGDYSFLRAYVSPEGESADYSEDNVPYKPDYH 245 Idiomarina ...
4XZY_A           257 FNISLGGVQENDYAMIMGFPGTTHRYFTASEVDEWKSIDNDIRIRMRDIRQGVMLREMLADPQIKIMYSAKYAASQNAYK 336 Porphyromon...
Q1GVV7           236 LKWNPRAPQEGEITFVVGNPGSTQRLLTETQRAFQRTERLPLTLLLLSEYRGRLIASMDESPEKAREGADELFGIENSFK 315 Sphingopyxi...
Q2G546           269 LKWNPRAPQVGEATFVVGNPGSTQRLFTSEQIAFQREVGLPLTTTILSELRGRLIGAMERSPQAKREGADELFGIENSLK 348 Novosphingo...
Q7NHA9           246 LPLSPTGPKAGELVFVSGSPGSTSRLFTVAQLEFLRDVVFPESLKRRAELRGVLTQFARQGPEQRRISQETLFGVENSFK 325 Gloeobacter...
jgi:Anae109_3411 249 FRWSAKGAEAGELTLVSGHPGGTDRGLTTAQLAMQRDVVLPDRLQSLAELRGLLTGYQLLGPEQKRTSNALLFYVENGYK 328
Q2IEV3           231 FTWSPAGAPAGALTFVSGNPGKTERLLTVAQLEYVRDRALPDSLERLAEERGLLTGFQLTGPEAKRVSTSRLFYNENSVK 310 Anaeromyxob...
Q1IPC2           238 LKFAKKGVKEGDLLFVSGHPGRTSRLLSIAELEYLRDVQYPWQIKNLTRRVNLLLAFSKEGAEQAREAEHDLFSFQNSQK 317 Candidatus ...
Q7UKL5           241 LKWNDQPAKDGDLVFVSGHPGRTQRIFTVEALEYLRDKRLPHVLDLLRRKEVLLQQYRLEGKEAARRGRDELFGIQNARK 320 Pirellula sp.
Q2S133           205 FDPSGQGARPGDAVFSAGLPTAPHRAESAAQLATRRDLVLPARRDRLETRAQAL-RARLDTTEASPPQRSALRDAKRALK 283 Salinibacte...
Q5QV86           246 LTIASEGLEEGDFVMALGYPGRTNRHRLPSEVKETFEWSYPKTVEQFQDSLDIIARETADDKDAELKYASRVAGLNNYLK 325 Idiomarina ...
4XZY_A           337 RAIGANWAIKTRGLRQNKQAMQDRLIAWGAKQGTPr--YEEAVHEIDATVAKRADLRRRYWMIEEGII----RGieFARS 410 Porphyromon...
Q1GVV7           316 ALSGQFRALNDPAFTAQMAAAEAELREKVRGNAEIg----DPWSEIDAAMAKRRDTYLDSVFLERGPA----SFstLAGY 387 Sphingopyxi...
Q2G546           349 VYVGRQKALNDPAFLKMLAEAEADLKAKSLGKPGIg----DPWADTARAVKAYRDLYVPWRFIV--------PWgsLMGY 416 Novosphingo...
Q7NHA9           326 AINGQQQALLDREFFGRKVAAEQKLRAAVARDPALerkYGKAWDEIALIEKRYETFYRPYLLVERGAA----FNskLFDI 401 Gloeobacter...
jgi:Anae109_3411 329 ALRGRHLALQDRAFFRSLVESEETLKAQLAKAPAGkdaL-AAFDAIAQAQQRLLQIRDEYNALEGGFR-----NstLFGM 402
Q2IEV3           311 ARRGQLAALRDPAFFASKVAEENRLRAALRRDPAKarkYLPAWDRIAAAQVRARALDVPYDWLELFPSgrtrIGgdLFWM 390 Anaeromyxob...
Q1IPC2           318 ALTGYNTFFANKEGWAKKQADEKQFRDYVKAHAERekeFGDPWTEVNQAEGTQRGMFFDYQYVEMLAG----LRgsLAAD 393 Candidatus ...
Q7UKL5           321 AYSGMLTGLQDPQTFVSKRGRQDRLLTALSKSPEHsglA-DAWKEIAEVQTEKAELLDRSVSLRs----------eLFQL 389 Pirellula sp.
Q2S133           284 QTRARLEALRNEYVRARLAQRDERLRRALRRDPALqrrFGGVLDSLAAIQNTKRTLGAGYRAFGAAEG----GPh-GSST 358 Salinibacte...
Q5QV86           326 NRQGMLDSFANSDLLERKQQEHKELTEWVNSDRTKkalYADGLNTIDTLLQQRHKKSRADYQLNNATP----R---LLSV 398 Idiomarina ...
4XZY_A           411 PIPTEDETKALQgn----daSARKEAIDKIRTRYSKFAnKDYSAEVDKKVAVAMLTEYLKEIPyeNLPLHLRLVKdrf-- 484 Porphyromon...
Q1GVV7           388 AQTLVRAAEERAkpnserlpGFTDSALPLTEKRLTDP--VPTYPWLEELAVAFWASKAREYLGtdN-DDIKALLGke--- 461 Sphingopyxi...
Q2G546           417 AQTIVQGTAEREkpdadrlpGYTESNLELTTKTLLDE--APVYPWLEQVEMAWSLSKAREYLGadD-ADTRLLLGre--- 490 Novosphingo...
Q7NHA9           402 ARTLVRAAQERPkpnekrlrEFRDSALPSLTQSLFSE--APIYGDLDEVTLTFSLTKLREYLGtdD-PLVRQVLGke--- 475 Gloeobacter...
jgi:Anae109_3411 403 ARDLVRGAVERPkpnpdrlrEFRESNLPALTQELFSQ--APIYPEFEALLLGHSLTKIRERLGtdH-PTVKKLLGke--- 476
Q2IEV3           391 ARHLVRAAEERKkpdgerlkEYRDTALPSLADSVTSS--APIDAAYETVRLGFWLEKVRERLGtdH-PAVKHALGta--- 464 Anaeromyxob...
Q1IPC2           394 ARFIVRAAQQRTlpndqrlrGYTDSALATREQELFSD--APAYKDLNKAMLADSLADMQEQEPk--nPSLLKVLAgk--- 466 Candidatus ...
Q7UKL5           390 ALQILILSEEDRkpneerlpGYTDSGRESLMAQLLSP--APIYDDLEMVKLADEIALLLESRGmnD-SIVQEVLAgr--- 463 Pirellula sp.
Q2S133           359 YRRLLReer---------qeSPTRTASSHASMTAADSL-QSSSGPVETALLAARLEALRRHLRpdT-AAVGRLLGgq--- 424 Salinibacte...
Q5QV86           399 ARAVHRLAQEGTkpdaerkaGYQERDVPRFQSYLAGMD-RNFDAKVEKALDLHNLSSYMAQPKseRDAAFDKAMGlrdgm 477 Idiomarina ...
4XZY_A           485 -agdVQAYVDDIFARSVFGSEAQFDAF--AAVPSVEKlAEDPMVLFASSV-FDEYRKLYNELRPYDDPILRAQRTYIAGL 560 Porphyromon...
Q1GVV7           462 ---sPEALAKRLVTGTRLADPAYRQQLwdGGAAAIAA-SDDPMIRFFARLdPRSREIKAAFDRDYDAPVTAAQARLAKAR 537 Sphingopyxi...
Q2G546           491 ---sPEALAERLVGGTTLADPAVRRALweGGRKAVEA-SSDPMIVYARAIdARERELKKLVDERYAGPLAEAGATLADAR 566 Novosphingo...
Q7NHA9           476 ---sPEEVARRLVQGTKLTNVALRKLLweGGAAAVAA-SSDPMIRFAVAVdPAARALRLRYEREIEGPVNQNSELIAQAL 551 Gloeobacter...
jgi:Anae109_3411 477 ---sPQEVAKRVVEGTKLRDVAVRKRLweGGEAAVKG-ANDPLLALAAAVdADARAIRRTFEDEVDSVVKKNHERIAEAR 552
Q2IEV3           465 ---sPAEIARKAVAGTALRDPAVRKALwdGGAAAVEA-SKDPLIALARATdADARAIRTRWEDEVDSVETRNQALIAQAR 540 Anaeromyxob...
Q1IPC2           467 ---sPKDRAAELIDGSKLDDAAYRKKLydGGLKAVEE-STDPLVVMMRSIePQALALRQKFDDEVDPKLRDGGAKIAKVR 542 Candidatus ...
Q7UKL5           464 ---sPKQVASELVTGTKIKDIETRKALidGGLDAVLA-SKDPMIRLARVIaPEYRRI-DKINEQLSEREKQAYAEITQAT 538 Pirellula sp.
Q2S133           425 ---sPAERAASVVEQLASASGDGTDAFp----------TDGPAADVAAVVgARARSFHEQW-RGLTRAERRLTRRLADAR 490 Salinibacte...
Q5QV86           478 sndeLSALIDGWYESTSLLDRDNRMALleFDPEQFEQ-SEDPFVKAAVAL-YPSDLEDEKKSEELSGKIQQAYADYMRAK 555 Idiomarina ...
4XZY_A           561 LEMDGD--QDQFPDANLTLRFTYGQVKG--YSPRDNVYYGHQTTLDGVMEK--EdPDNWEFVVDPKLKAVYERKDFGRYa 634 Porphyromon...
Q1GVV7           538 FAAYg---DALYPDATFTLRLSYGQVKG--WTERGK-PVPAMTRIGGTYDRa---tGQLPYKLAEAFVTAESRID----- 603 Sphingopyxi...
Q2G546           567 FLAYg---DRIYPDATFTLRISYGKVQG--WKERGI-DVAAVTTLGGAFERa---tGAEPFDLASAFAANEARID----- 632 Novosphingo...
Q7NHA9           552 FAQTg---TSVYPDATFSPRLSYGAVEG--YEHNGR-RVEPFTDMAGAFERa---tGKDPYALPPSWLAAKDRLN----- 617 Gloeobacter...
jgi:Anae109_3411 553 FAVQg---RTNYPDATFTLRLSYGAVEG--WLEKGT-PVEPFTVFAGAYERh---tGRDPYALPESWLTAKERLD----- 618
Q2IEV3           541 FAAYg---RSIYPDATFSPRLSYGQVKG--WKQDGR-EVPPFTTFAGAFERh---tGSEPYALPKSWLDAKPRLD----- 606 Anaeromyxob...
Q1IPC2           543 FAIFg---QTQPPDATFTLRLSYGPAKG--YEENGK-HIPWSTTMDGAYKHaaDhGNKSPYELPKSWMDAKGKFD----- 611 Candidatus ...
Q7UKL5           539 TAIEg---TGGYPDATFTLRLAFGVVSG--YEERGE-QIKPTTNFAGAFTHakEhEGQEDFDLPESWMSAKEKID----- 607 Pirellula sp.
Q2S133           491 RAARs---APVLTDGT-APRLTDGRVRG--YPYNGT-TAPPFTTVFGLYERnrAfGGETPWALPERWHKAGERMD----- 558 Salinibacte...
Q5QV86           556 IAFMQSkgEAVYPDANSTLRITYGNVAGrdHGTEDGNAWAPFTTLRGVTEK--A-TGEGEFNAPEEQLKAIEAGDFGPYe 632 Idiomarina ...
4XZY_A           635 -DRSGRMPVAFCATTHTTGGNSGSPVMNANGELIGLNFDRNWEGVGGDIQYLADYQRSIIVDIRYVLLVIDKVGGCQRLL 713 Porphyromon...
Q1GVV7           604 ----KNGVYDFVTTNDIIGGNSGSPVIARDGSVIGTAFDGNIHSLGGNFGYDGTLNRTVAVSTAAIQQALDVIWPAPALA 679 Sphingopyxi...
Q2G546           633 ----KAVPFDFVTTNDIIGGNSGSPVIDRSGTVIGAAFDGNIHSIGGNYGYQGDVNRTVVVSAAAVQHALEVIYPAPALV 708 Novosphingo...
Q7NHA9           618 ----LATPFNFVTTNDIIGGNSGSPVIDSRAQAVGLIFDGNIHSLGGAFGFDAALNRAVAVDSRALIEALRAVYGAGALV 693 Gloeobacter...
jgi:Anae109_3411 619 ----LRTRFNFVTTNDIIGGNSGSPMINEKAEIVGLVFDGNIHSLGGDYGFDPAVNRTVAVHSDAIVEALTKIYGAERVV 694
Q2IEV3           607 ----LATPLDFVTDNDIIGGNSGSPVFDRDLRIVGLAFDGNLASLGGDYGFDDSANRAVAVHSSAILHALARIYGADRLV 682 Anaeromyxob...
Q1IPC2           612 ----GNTPFDVVTTADIIGGNSGSPVVNTNGELVGIIFDGNIESLPLNFMYDDLQARAVHVDSRAILESLQKIYHADALY 687 Candidatus ...
Q7UKL5           608 ----LETQLNFVCTADIIGGNSGSPVVDRDGVLVGLIFDGNIQSLTSDYLYTNVQSRAVSVSGVAIPEALRSIYQANELA 683 Pirellula sp.
Q2S133           559 ----RSTPLTLVASVDGAVSNNGAPLLNQSLELVGVAAGPNIQGVAGAYLFLPERMRTVGTDVRGLREALTAVYGADALV 634 Salinibacte...
Q5QV86           633 kVDLNSVPVNYLATLDITGGNSGSAVLNHKGEFVGLAFDGTLDSIISDWDFNLENTRSIQVDTRYMLWQMQYVDHADNVL 712 Idiomarina ...
4XZY_A           714 DEM 716 Porphyromonas gingivalis
Q1GVV7           680 AEL 682 Sphingopyxis alaskensis
Q2G546           709 KEL 711 Novosphingobium aromaticivorans DSM 12444
Q7NHA9           694 DEL 696 Gloeobacter violaceus
jgi:Anae109_3411 695 QEL 697
Q2IEV3           683 SEL 685 Anaeromyxobacter dehalogenans 2CP-C
Q1IPC2           688 EEI 690 Candidatus Koribacter versatilis Ellin345
Q7UKL5           684 DQL 686 Pirellula sp.
Q2S133           635 DEL 637 Salinibacter ruber DSM 13855
Q5QV86           713 REL 715 Idiomarina loihiensis
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