Conserved Protein Domain Family
MENTAL

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pfam10457: MENTAL (This model is not part of the current CDD release)
Cholesterol-capturing domain
Human meta-static lymph node (MLN) 64 is a late endosomal membrane protein, and carries this MENTAL (MLN64N-terminal) domain at its N-terminus. The domain is composed of four trans-membrane helices with three short intervening loops. The function of the domain is to capture cholesterol and pass it to the associated START domain pfam01852 for transfer to a cytosolic acceptor protein or membrane. In mammals, the MENTAL domain is involved in the localisation of MLN64 and MENTHO in late endosomes, and also in homo-and of hetero-interactions of these two proteins.
Statistics
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PSSM-Id: 519391
Aligned: 21 rows
Threshold Bit Score: 205.232
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_046451203  70 SAVRRFFCLFVTFDFLFTTLMWIICLVISGE-NIQEMLIDQIVHYT---IHGSLFDIVMASAGRFVILLLFYALLCINHW 145
4_pfamImport   1 SPIRRFFCLFVTFDLLLTCLIWLITLVLTGEfNFYTVIHKEILHYT---IRTSSFDIVMASAARFIILLLFYALLRLNHW 77 
EEC17164      46 SPVRRFFALLATFDVCFCSFLWILSAMLQYK-SVKLVYQSEILNYA---MSSSLFDMAVLAALRFLVLLLAYIVLRMKHW 121
Q19819        18 SKDRKRFIVITFFDTSITILLWLLCTVTRDD-DWDKVFFNEINIFNpkfIRISLFDIVLLAVLRMLILGVVYGICLVKQW 96  Caenorhabditis ...
XP_012060883  55 SNVRRFFCLFITFDLLFTFLMWLICTMIAGE-SLRTAFTDQVIHYH---IKTSLFDIVMAAICRFTVLLLFYALLYLNHW 130
2_pfamImport   1 SNVRRFFCLFVTFDLLLTFLMWLICTMIAGE-SLESAFMNQIVHYH---IKTSLFDIVMAAICRFTVLLLFYALLHLDHW 76 
XP_025161393  55 SHVRRSFCLFVTFDLLLTFLMWLICTMIAGQ-SLKAAFIDQVVHYH---IRTSLFDIVMAAICRFTVLLLFYALLYINHW 130
XP_049541004  77 SVVRRFFCLFVTFDLVFISLLWIICVVIKGQ-NVLSALEAQVVHYT---VQSSLFDVVAVAFIRFIVLILCYGLLGISHW 152
XP_002427212  69 SSIRRFFCCFVLFDLLLISLIWLICITIIDSnNIIKVIKMQILNYN---ISTSLFDLVGAAIIRFIILLLFNGILQLNTK 145
XP_008196392  60 STVRRFFCMFVTFDLLFTGLMWLICVMLKGE-NIMKALNEQIYHYN---VQTSLFDVVLAALCRFVVLLLFYALIYMNHW 135
XP_046451203 146 WVIAITTAGSCGFLIIKVFFFEWAK--ATNYTL--DVFLVLSSFVLSWGEAWFLDFRVLPQESLARD-FFRAi--SSDDE 218
4_pfamImport  78 IIVAITTASTCFFLVAKVCLFDWDT--TGNQVL--QVMLILSSFILSWSEAWLLDIRVIPNERNAENgWFVLnttTNFDE 153
EEC17164     122 LLVALMTTLSGSLVICKTFLYDWQAqlAVNSGVlaGVLLLVTSFVLPWGQAWFLDFRVVPSENRASQ-LLAR---IVNDA 197
Q19819        97 YTVAFTTLASSAYILMKVLFY---FnhSSSAVP--PLLLIITSFTLCWSEFYLMPFQILPRERRYARrELDGi------- 164 Caenorhabditis ...
XP_012060883 131 IIVAISTATTCAFLIAKVFLFDWTS--ANQPVF--QVLLILTSFVLAWAEAWFFDFRVIPQETQARN-WILS---FPDTE 202
2_pfamImport  77 IIVALTTATTCAFLIAKVFLFDWTI--CNQPVF--QVLLILTSFVLPWVEAWFFDIRVLPQETQARN-WFRN---FIDNE 148
XP_025161393 131 IIIAISTAATCVFLIGKVFVFDWSS--TNQPVF--QVLLIIISFVLAWAEAWFFDFRVIPQEIQARN-WFRN---HSATE 202
XP_049541004 153 VVIALSTTSSCGLLICKVILYDWTA--TSQPVF--EVLLIVVSFVLAWSEAWFLDCRVIPQERYISN-YLTAtgpTSVDA 227
XP_002427212 146 FFIGLTTFATLLFLVFKVIYYSWSS--EGQPTF--AVIIILMSFIVAWLEAWFFDCRVIPQELFALH-YVQTtgrLSESL 220
XP_008196392 136 IIVSISTTLTCVFLTAKVFLYDWPH--STQPVF--EVLLVLTSFVLSWGEAWFLDFRVLPQESHARR-FLIT---NTDSE 207
XP_046451203 219 ---------RAPLLQNQAPSVRS---------HNLDD----------------FYSPIDS 244
4_pfamImport 154 ---------RTPLLRNYPNIHSRlda----lsESIYS----------------FYSPAES 184
EEC17164     198 ---------FPPVPSAAARLRSE---------DGGTS----------------FYSPDsg 223
Q19819       165 ---------ENPEFSTDDEARSNnrhrrgrrqQNSGNqseaptavpsrvssgvFIASDYD 215 Caenorhabditis elegans
XP_012060883 203 ---------RTPLLQGIVTESR----------QHAANvdhmstfftpvespthsddedis 243
2_pfamImport 149 ---------REPLLRGVISESRQyt-----nnEHAGT----------------FFTPMDS 178
XP_025161393 203 ---------RSPLIQATSESRQNv--------DHMST----------------FFTPMDS 229
XP_049541004 228 ---------NTPLLQPYMTIAAGg--------ESVGN----------------FYSPFES 254
XP_002427212 221 nnlmtdrdfRNPLLKSFRARFADfe-----egASFKN----------------YYSPLEs 259
XP_008196392 208 ---------RAPLIQSYVRGLPSmy------tESVGN----------------FYSPLAS 236
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