2RAW


Conserved Protein Domain Family
Nbl1_Borealin_N

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pfam10444: Nbl1_Borealin_N 
Nbl1 / Borealin N terminal
Nbl1 is a subunit of the conserved CPC, the chromosomal passenger complex, which regulates mitotic chromosome segregation. In Fungi and Animalia, this complex consists of the kinase Aurora B/AIR-2/Ipl1p, INCENP/ICP-1/Sli15p, and Survivin/BIR-1/Bir1p. In Animalia, a fourth subunit (Borealin/Dasra/CSC-1) is required for targeting CPC to centromeres and central spindles. Nbl1 has been shown in budding yeast to be essential for viability, and for CPC localization, stability, integrity, and function. The N-terminus of Borealin is homologous to Nbl1. This family contains both Nbl1, and the N terminal region of Borealin.
Statistics
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PSSM-Id: 402188
View PSSM: pfam10444
Aligned: 70 rows
Threshold Bit Score: 46.355
Threshold Setting Gi: 0
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2RAW_B         5 SFLKDFDREVEIRIKQIESDRQNLLKEVDNLYNIEILRLPKALREMNWLDYFAL 58 
KJE89396      30 RQLQQFELEVQSKVDKMNTLKKMQLLSLSNNFKFPMLQVPRAIKQMKLREYLER 83  Capsaspora owczarzaki ATCC 30864
Q5KIJ8        36 GLLQNFDLEVQDKLQYFRSMLKQTLDSFSLRGETEILSIPRELRTMTLGELEEK 89  Cryptococcus neoformans
XP_006558582  22 LLIKDFERQAHLRISKMEAESKMAIKSIETFVDVTLSRLPAEIRQMTLSEILNy 75  honey bee
Q0V9F7        41 LFMQDFVQQGKDRLAELKKDLESLSTTADKALEVELLKMPLAIRHMKVQDYLSL 94  tropical clawed frog
XP_008112117  37 LFLQDFDHQAKGNLQEMKKELASLLHTAEKAFRVELLALPVVMRKMRRKDLMHl 90  green anole
P86345        35 LFLSDFDQQAKESIREMKKELDLLLQMAEKAFMVELLKMPTAIRKMKRKDLLNL 88  chicken
NP_001189357  35 LFIQQFEKEAQDRINEMEANLNKLLATVDRVFKIELMKMPLSLHTTLIKDLMNd 88  zebrafish
XP_015223858  32 LFMQQFQKEAQERTKEMEEKLEQTVATVEKAFKVQILKMPPSLQRKSVKELTSe 85  spotted gar
TNN83913      29 LFIQQFEKEAQERMNEHEARMENMLATVDKVFKVELMKMPPSLQKTRIGDLITE 82  Tanaka's snailfish
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