2LXE


Conserved Protein Domain Family
WIYLD
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pfam10440: WIYLD (This model is not part of the current CDD release)
Ubiquitin-binding WIYLD domain
This presumed domain has been predicted to contain three alpha helices. The domain was named the WIYLD domain based on the pattern of most conserved residues. It binds ubiquitin. In the Arabidopsis thaliana histone-lysine N-methyltransferase SUVR4 binding of ubiquitin to this domain stimulates enzymatic activity and converts its activity from a strict dimethylase to a di/trimethylase.
Links
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Statistics
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PSSM-Id: 519382
Aligned: 28 rows
Threshold Bit Score: 63.037
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
2LXE_A        45 KDEKVLKALERTRQLDIPDEKTMPVLMKLLEEAGGN--WSYIKLDNYTALVDAIYSVEDE 102 thale cress
XP_006606485  10 GESRMDAALDAMKPYGFPNRLVRTTVNSLLKVYGGNggWFFIEESAYSLLIETLLEKQAN 69 
XP_020525231  11 GSRRVDAAIDALLPFGFSKSTITCTVNKLLKVYGGDsgWLFIEEASYRLLIDTILEDQEK 70 
1_pfamImport   4 GERRIDAAIDHLAEYGFPKPRIRKIINNLLQLYGRDg-WVFLEEGSYKIVLDTLLEEQEQ 62 
XP_002464252   9 GERRIDAATDHLAQYGFAKPQIRNVIHDLLQVYGREg-WPFLEEGSYSLVRNRLLEEQAQ 67 
XP_015696649  10 GGGRIDAAIDHFTPMGYAKPDIRAVVKQLLKLYG-DdgWPFLEEGAYRVVQEALFEKQER 68 
XP_015696559  38 GERRIDAAIDHFIPMGYATSDIQTVIKQLLEVYG-KdgWRFLEEDSYRVVQEALFEKQEy 96 
PNT61089       7 RVGRMDAAIDHFTPMGYKETQVRSVVNSLLKVYG-NdgWPLLEGDCYEVVQQELFKQEEE 65 
XP_004956294  14 GDRRIDAAIDHFAAMGYAARDIRDAIADLLKVYGGPsaWPLLEEGSYQVVQDKLFEKEDE 73 
XP_002526881  10 GLKRIDAALDALRPMGFSPDLIRKTVQSLLKAYGGDegWPFLEENSYRLVIESILEELEk 69
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