5M4K,2Q8F,1Y8N,1Y8O,7EAT


Conserved Protein Domain Family
BCDHK_Adom3

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pfam10436: BCDHK_Adom3 (This model is not part of the current CDD release)
Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase
Catabolism and synthesis of leucine, isoleucine and valine are finely balanced, allowing the body to make the most of dietary input but removing excesses to prevent toxic build-up of their corresponding keto-acids. This is the butyryl-CoA dehydrogenase, subunit A domain 3, a largely alpha-helical bundle of the enzyme BCDHK. This enzyme is the regulator of the dehydrogenase complex that breaks branched-chain amino-acids down, by phosphorylating and thereby inactivating it when synthesis is required. The domain is associated with family HATPase_c pfam02518 which is towards the C-terminal.
Statistics
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PSSM-Id: 519379
Aligned: 262 rows
Threshold Bit Score: 73.7442
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
5M4K_A        31 PLSMKQFLDFGS-------------Sn---ACEKTSFTFLRQELPVRLANIMKEINLLPDRV----LSTPSVQLVQSWYV 90  human
Q4DWQ3        42 RQTLQSLLAFyssrpmqkmsnlneviyyclKTGYNAEIFCHMELPVLLARLIMAIDTLPCGL----NAMPSVLLVRNTYL 117 Trypanosoma cruzi
XP_002494198  39 KLSLKQIAQFGQ-------------Tps-tPQIFRSSVFLLDELPVRLSKRITLLRNPPEIIrergLQAPFLEW-ARTYE 103
XP_009022481  60 RLMPLTMLYSGK-------------SpdnsH-LVKSAQYLQRELPIRFAHQVSRFRKLPFIA----GVHPLILEVHDLYI 121
XP_002182780  14 PLRLADMYEYGR-------------Gid-pAQRLRNSQFLHRELPIRVAQRAYDLLTLPHGL----SNATPIRQVAATYI 75 
XP_001465865 125 DIFFENLLYInt-----------------pNDLMQHSETVFRQYLVRIARRVRHLNHAPYGL----SQMPGIQMLKKWYQ 183
Q4E0C6        89 RLPLRNMMHIrn-----------------vEDLYVHAKIIHREYLVRLAQRARALTLAPMGL----SQMPSIQELRRSYE 147 Trypanosoma cruzi
Q385U0        89 TLALRNMVHIrt-----------------hEDLYSHARLIHREYLVRVAQRARALSHACVGL----SQMPSIQELRRWYE 147 Trypanosoma brucei
XP_003970966  86 RLTLATLLYSGK-------------SpdghH-ILSSAKYLHKELPVRIAHRIKGFRSLPFII----GCNPTILQVHELYI 147 torafugu
XP_018638005 103 PMTIKRLLQLepa---------------ndASLLRGAEWIREELPVRLSHRLYDFHRLPFVA----VTNPLVHSVYETYL 163 Toxoplasma gond...
5M4K_A        91 QSLLDIMEFLDK--D--PED------------------------------------------------------------ 106 human
Q4DWQ3       118 DSFKKLIKCDFPdnDe---------------------------------------------------------------- 133 Trypanosoma cruzi
XP_002494198 104 KTFVQVLKFKRAfgF--MNNedeisrlvdrvhsehsysnvtpittelknrllkesdvsgtlmnkdidndgfsvfgliglk 181
XP_009022481 122 RSFHNLNNFPPv--DsdFKD------------------------------------------------------------ 139
XP_002182780  76 QYLQQFKSRPCPqnK--PQE------------------------------------------------------------ 93 
XP_001465865 184 WSFHDVRSTPVPttRd---------------------------------------------------------------- 199
Q4E0C6       148 WSFHGVNSTKPPidLe---------------------------------------------------------------- 163 Trypanosoma cruzi
Q385U0       148 WSFHDVRSTKAPvdAe---------------------------------------------------------------- 163 Trypanosoma brucei
XP_003970966 148 RAYHMLSDFPQ---IedQDV------------------------------------------------------------ 164 torafugu
XP_018638005 164 KTFDRMRRLPPLktVa---------------------------------------------------------------- 179 Toxoplasma gond...
5M4K_A       107 ----------------------------HrtlSQFTDALVTIRN-RHN--DVVPTMAQGVLEYKdty-----------gd 144 human
Q4DWQ3       134 ----------------------------Si--LHFRRVVADIEEa-HSkrDVLGTMAMGLLELkkllsrhr--qyvfsqn 180 Trypanosoma cruzi
XP_002494198 182 slasnsaevsglkkylqvayrshteihsYl--EEVATLFQLILKn-HS--NDILSFTKLLMEHTgkkqls----mnefdn 252
XP_009022481 140 ----------------------------E---LAYCGVLKTFLEe-HK--NDVSLLTKGLKDVrnf-----------vke 174
XP_002182780  94 --------------------------------EEFTDFVQSLVLdRAA--VPISIFREQPDRLQ---------------- 123
XP_001465865 200 ----------------------------Ec--YRCDRMVRRVFL-RHY--NVSSLITDGMVEFAsregwthvdeevmrty 246
Q4E0C6       164 ----------------------------Sa--QEFDSLMRCVFL-RHY--NVSSLLSEGMYELGqremwserdfsdkslv 210 Trypanosoma cruzi
Q385U0       164 ----------------------------Ga--LKFDTLVRRLFL-RHY--NVSALLSEGMHELGerqrwdehshsddllt 210 Trypanosoma brucei
XP_003970966 165 ----------------------------E---ARFCKLVQQLLDd-HK--DVVTMLAQGFKECrkh-----------mtd 199 torafugu
XP_018638005 180 ----------------------------Dm--NAFVQLVEKERS-THD--RTVDLMGQGVRQLRric------------- 213 Toxoplasma gond...
5M4K_A       145 DpvsnQ---------------NIQYFLDRFYLSRISIRMLINQHTLIFDGSTNp--------------------AHPkH- 188 human
Q4DWQ3       181 K----KpsgsafeltldealmDVTKPMDNFSLRMVNYNFISRMLLTLEEN--------------------------DdDm 230 Trypanosoma cruzi
XP_002494198 253 Q----Kq---------------IHRYLNMLFSSRIGTRVLLAQHLQLYKMSTGklrss------------vmkqLQHqGm 301
XP_009022481 175 K----Nv---------------LEDFLEKVLNSRIATELLCKHHIILQKE--------------------------IhGn 209
XP_002182780 124 ---------------------EMEDALYRFFTARVGLRFLTVHHVLSSRRPSAkalkdv---------tflfppDQSdDf 173
XP_001465865 247 D----E----------------LQNFFEAFCLGRVRLRFLVGNYMYLSTKILGvskeeyavndpdgltvpiffdHNAeDf 306
Q4E0C6       211 E----Tf-------------eELQVFFDEFCTGRVRLRFLVGNYMYLSTHILNvepkesek-----lttslffdHDPdSf 268 Trypanosoma cruzi
Q385U0       211 E----Tf-------------dELQRFFDEFCMGRVRLRFLVGNYVQLSTQILRveprysek-----ltapmyfdHDPeSf 268 Trypanosoma brucei
XP_003970966 200 E----Av---------------LRSFLDSTLCSRLGIRMLATHHLALHED--------------------------NpDf 234 torafugu
XP_018638005 214 ------------------rdvDLNSFLERFFYFRIGRRVMIDQLVHLQSK--------------------------QeGw 249 Toxoplasma gond...
5M4K_A       189 IGSID 193 human
Q4DWQ3       231 VGMVD 235 Trypanosoma cruzi
XP_002494198 302 TGVIG 306
XP_009022481 210 IGIIT 214
XP_002182780 174 LGCIQ 178
XP_001465865 307 VGQIC 311
Q4E0C6       269 TGMIC 273 Trypanosoma cruzi
Q385U0       269 VGQIC 273 Trypanosoma brucei
XP_003970966 235 VGIIC 239 torafugu
XP_018638005 250 QGIIH 254 Toxoplasma gondii ME49
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