5MGC


Conserved Protein Domain Family
BetaGal_dom2

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pfam10435: BetaGal_dom2 
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Beta-galactosidase, domain 2
This is the second domain of the five-domain beta-galactosidase enzyme that altogether catalyzes the hydrolysis of beta(1-3) and beta(1-4) galactosyl bonds in oligosaccharides as well as the inverse reaction of enzymatic condensation and trans-glycosylation. This domain is made up of 16 antiparallel beta-strands and an alpha-helix at its C-terminus. The fold of this domain appears to be unique. In addition, the last seven strands of the domain form a subdomain with an immunoglobulin-like (I-type Ig) fold in which the first strand is divided between the two beta-sheets. In penicillin spp this strand is interrupted by a 12-residue insertion which forms an additional edge-strand to the second beta-sheet of the sub-domain. The remainder of the second domain forms a series of beta-hairpins at its N-terminus, four strands of which are contiguous with part of the Ig-like sub-domain, forming in total a seven-stranded antiparallel beta-sheet. This domain is associated with family Glyco_hydro_35, pfam01301, which is N-terminal to it, but itself has no metazoan members.
Statistics
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PSSM-Id: 402180
View PSSM: pfam10435
Aligned: 128 rows
Threshold Bit Score: 134.98
Threshold Setting Gi: 81355147
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
5MGC_A        398 ASPGNLTTS-GYaDTTDLTVTPLLGn-STGSFFVVRHSDYSSEESTSYKLRLPTSaGSVTIPQlggtLTLNGRDSKIHVT 475  Aspergillus n...
EFQ26803      398 TKTERVGNGtGYtTNTAISTSELRNvdNDAAFYVVRHAYTPSNTNEAFKLSVKTSqGSFTIPQhgssVAINGHQAKVLVT 477  Colletotrichu...
EGY16496      374 YKTERVGNStSYtNNPAIAASELRNidNDAGFYVVMHQTSSSGTRETFKLDVKTSaGDLTIPQhs-sITINGHQAKILVT 452  Verticillium ...
EEU37610      408 TKTERVENStSAsTNKEILVSELRNvdNDAAFYVTRHSYSPSGTKEQFKVKVKTSeGEFLIPQyadqITINGHQSKILVT 487  [Nectria] hae...
EXK29145      401 TKTTRVTNStSLsTNDAILISELRHeeNDAAFYVARHDHSPSGTKETFKLHVKTSeGKLTIPQnegsITINGHQSKVIPT 480  Fusarium oxys...
EKG09927      399 READRVGNStSYsTNSAVLATELRNaeTGGAFYIARHANSVTGEPVAFHLRVKTSiGNLTIPQregqIELNAREAKIVPT 478  Macrophomina ...
XP_007588655  384 READRLGNStSYsTNVEVTATELRSkgTGAGFYIARHADSVTGKPVSFKLHVETSlGNLTIPQkegeIELNAREAKILPT 463  Neofusicoccum...
EKD16411      406 TKVNLIRNSkLYaSDPAIFTSELRNpdTNAGFYVTVHFSSPSRDLTPFKLTVATTmGNLTIPMyaesIVLNGRESKIVVT 485  Marssonina br...
XP_008079294  346 TKVDRIANNtGLtSTPDIKTTELRNpdTNGAFYVTAHTLSPSRDKTSFKLSISTSaGNLTVPQyasdIVLNGRQSKIIVT 425  Glarea lozoye...
Q2UNR7         60 SKVERVGNStQYaTDQDIFTTELRNpdTGSAFYVTRHEYSPSTELTKFRLHVSTDiGNLTVPTkg-sITINGTESKVLVT 138  Aspergillus o...
5MGC_A        476 DYNVS-G-TNIIYSTAEVFTWKKFADGKVLVLYGGAGEHHELAIST-------KSN--VTVIEgseSgiSSKQtsssvVV 544  Aspergillus n...
EFQ26803      478 DFAFG-E-KTLLYSTAEVLSYTVLDGREVVAFWLPEGESGEFTVTGvns-aeiVRDanVADFNv--Y--PGEAn---vTV 547  Colletotrichu...
EGY16496      453 DFSFG-S-KTLLYSTAEVLTYAVFNEKEVLVLWLPEGESGEFVVNGvtd--aqSGEqgLGKIDf--Y--PGEDs---iTV 521  Verticillium ...
EEU37610      488 DFNFG-S-KKLLYSTAEVLTYSAFDKKEVLVLWLPEGETGEFTLQEhtk--vkSTSkaLKGLQv--K--AGKEn---vTV 556  [Nectria] hae...
EXK29145      481 DFHFG-K-KTLLYSTAEVLTYSIIDNKEVIVLWLPEGEQGEFTLKGnt---elKHDksLKGIKv--K--ASKKs---vTV 548  Fusarium oxys...
EKG09927      479 DFRFS-G-QRLIYSTAEVFTYVELDGKPTVALWVPDGESGEFFLEGkgn--vsATAspSDGVTf--H--QDARg---lIV 547  Macrophomina ...
XP_007588655  464 DFRFS-G-QKLIYSTAEVFTYVELDGKPTVALWVPDGEGGEFFLEGkgn--tsAKAtpSDNVTf--H--QDSHg---lIV 532  Neofusicoccum...
EKD16411      486 DFALG-K-QKLVYSTAEVLTVSTQDETPLLFLWLPASESGEFWLSGvrs-aslLKKdgCSNFQv--N--ETSGg---lVI 555  Marssonina br...
XP_008079294  426 DFTIG-K-QKLIYSTAEVLTVSVQDGVPVVLLWLPAGESGEFFLSGaqa-gqvKKSegASGVKf--S--PVDGg---tVV 495  Glarea lozoye...
Q2UNR7        139 DFPIGsSgKKITYTTLEILTVADLGDRQVVVFWAPEGEEGEFLLKDaksgkvmTGNadNKTVT------TTRYg---vVT 209  Aspergillus o...
5MGC_A        545 GwDVSTT-RRIIQVG-DLKILLLDRNSAYN 572  Aspergillus niger CBS 513.88
EFQ26803      548 A-YTQKKgITSVALGdGSRALLLDRSAAYL 576  Colletotrichum graminicola M1.001
EGY16496      522 S-YTQEKgIFNVELEdGSSVVLLDRKAAYH 550  Verticillium dahliae VdLs.17
EEU37610      557 T-YTQEKgLFTLGLEdGSTIVLVDRETAYH 585  [Nectria] haematococca mpVI 77-13-4
EXK29145      549 N-YTQQKgLFTLNLKdGSTIVLADRKTAYK 577  Fusarium oxysporum f. sp. melonis 26406
EKG09927      548 N-FANQTgTTVIDTDa-ARFVLLDRTDAWK 575  Macrophomina phaseolina MS6
XP_007588655  533 N-FANQNgTTIVDTEs-ARFVLLGRTAAWK 560  Neofusicoccum parvum UCRNP2
EKD16411      556 S-YKQLQgTCVVKFDnGYRVVLIDRSAAYg 584  Marssonina brunnea f. sp. 'multigermtubi' MB_m1
XP_008079294  496 S-YTQLAgSAVIDFe-GSKFVLVDRASAYK 523  Glarea lozoyensis ATCC 20868
Q2UNR7        210 S-VGAGNeKTVIDYNhDVQAVVVDRQSAYK 238  Aspergillus oryzae
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