2GUW,1T8R


Conserved Protein Domain Family
AMNp_N

?
pfam10423: AMNp_N 
Click on image for an interactive view with Cn3D
Bacterial AMP nucleoside phosphorylase N-terminus
This is the N-terminal domain of bacterial AMP nucleoside phosphorylase (AMNp). The N- and C-termini form distinct domains which intertwine with each other to form a stable monomer which associates with five other monomers to yield the active hexamer. The N-terminus consists of a long helix and a four-stranded sheet with a novel topology. The C-terminus binds the nucleoside whereas the N-terminus acts as the enzymatic regulatory domain. AMNp (EC:3.2.2.4) catalyzes the hydrolysis of AMP to form adenine and ribose 5-phosphate. thereby regulating intracellular AMP levels.
Statistics
?
PSSM-Id: 402172
View PSSM: pfam10423
Aligned: 90 rows
Threshold Bit Score: 136.118
Threshold Setting Gi: 505212443
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
?
Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
2GUW_A              12 QALDRLEELYEQSVNALREAIADYVDNGTLPdPHARLnglfVYPSLSVSWDGATPNpPKTRAFGRFTHPGCYTTTVTRPA 91  Salmonell...
cebbi:cauri_0073    32 EAVARLCELYDKSCALAREALAs---------GDHDAyrhvVYPKITVHIRQWTPI-DRSEPFGYVDQEGRYSAVISKPW 101 Corynebac...
WP_015399545        12 EAIDRLAELYDHSADLARRILEn---------GNYDDyravVYPKVVVDVKEWRPI-ARTEPFGYVNEAGRYSATLSKPG 81  Corynebac...
CeBiTec:B841_00560  16 QAVDKLIDLYETSCATARRAIDt---------GDYAAyadvVYPRLVVDITQWRPI-DRTEPFGYVNEAGRYTTEVSKPA 85  Corynebac...
Q8NU52              11 DAIAKLIDIYDTSTKLAKETLNn---------EDYAAyadvVYPKLTVDVLEWKPI-DRTEPFGYVDRAGRYSATLSKPR 80  Corynebac...
Q8FUC1              24 EAIDRLKEIYTNSTDLAKRTLEd---------GDYAAyadvVYPKLVVEVLRWEPI-DRTEPFGYVDQAGRFSAVLSKPH 93  Corynebac...
ADL09561            10 DVVQQLEEIYAASISLAKEILEt---------GEYGRycdvVYPKLIVKILSWHPV-DRTEPFGYVDAAGCYSAVLSKPE 79  Corynebac...
WP_005287494        12 EAVDKLIELYRASCLLARESLDs---------GDVARyegvKYPKIAVEVKEWHPV-DRSQPFGYVDEAGVYSAVLSRPD 81  Corynebac...
WP_025251559         8 EAVGALIDIYESSTKRAHEVFEs---------GDYALysqvVYPKLTVEVKSWHPI-DRTQSYGYVDEEGVYSAVLSRPQ 77  Corynebac...
WP_012317461        17 TAIDRLVELYDDAAGALRTALERYLAGGPPPdATERLa--fRYPELRISYRPDGPLpRVRRATAKLQAAGTYATTVTHPG 94  Methyloba...
2GUW_A              92 LFRAYLLEQLNLVYHDYGAHIAVEASHHEIPYPYVIDGSa-LTLDRSMS-----AGLTRHFPTTELAQIGDETADGLFHP 165 Salmonell...
cebbi:cauri_0073   102 LIRDYLIEQLTRLSNNYPCDLYVGQSDERIPPEYI------RGTTHIPQ-------DRGNIPRPTLDAVHDGIVDGAWKA 168 Corynebac...
WP_015399545        82 LMRSYLHDQLTRLTGNYPCEIHVGPSDIRIPPEYI------RGVEGITEarragD-SADAIPRPTLDDVHDAIVDGEWEA 154 Corynebac...
CeBiTec:B841_00560  86 VMQEYLREQLERLTGNYESTILVGPGETRIPPEYI------ADMPDVSEarrtqDGSQDIIPRPTLDDVHDAIIDGKWEA 159 Corynebac...
Q8NU52              81 VIERYLREQLERLTSNYPCKIYVSESDIRIPPEYI------RGAPSATEarragD-VADIIPRPTLDEVHDAIIDGDWHA 153 Corynebac...
Q8FUC1              94 IMERYLREQLERLTGNYPCRIEVGPSDIRIPPEYI------RDAPSATEarragD-VAEIIPRPTLDEVHDAIIDGEWDA 166 Corynebac...
ADL09561            80 LIHDYLCEQLERLCANYECVITVEPSTVRIPPEYI------DGIEGVTEarragD-VAAEIPRPTLDDVDDAIIDGEWDA 152 Corynebac...
WP_005287494        82 IMARYLRHQLQCLVINYDCEIAVGYSDVGIPPEYI------RGLEGINEarrsrS--GTVIPRPTLDDVHDAIIDGDWDA 153 Corynebac...
WP_025251559        78 LMAAYLTSQLERLTSNYDCEISVAPSEVRIPPEYI------DGIEGLSEarragD-TGDFVPRPTLDDVDDAIIDGDWDA 150 Corynebac...
WP_012317461        95 FFRTYLTRQLEPLIADYGIAIEVGLSAQEIPYPYVLEAGldARGRTVDG-----ADLATYFPVPLLSLVGDEIADGTFDQ 169 Methyloba...
2GUW_A             166 GEF 168 Salmonella enterica subsp. enterica serovar Typhimurium str. LT2
cebbi:cauri_0073   169 FHG 171 Corynebacterium aurimucosum ATCC 700975
WP_015399545       155 FHG 157 Corynebacterium halotolerans
CeBiTec:B841_00560 160 FHG 162 Corynebacterium maris DSM 45190
Q8NU52             154 FNG 156 Corynebacterium glutamicum
Q8FUC1             167 FHG 169 Corynebacterium efficiens
ADL09561           153 FHG 155 Corynebacterium pseudotuberculosis C231
WP_005287494       154 FHG 156 Corynebacterium genitalium
WP_025251559       151 FHG 153 Corynebacterium vitaeruminis
WP_012317461       170 IAG 172 Methylobacterium
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap