2GUW,7UWQ


Conserved Protein Domain Family
AMNp_N

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pfam10423: AMNp_N (This model is not part of the current CDD release)
Bacterial AMP nucleoside phosphorylase N-terminus
This is the N-terminal domain of bacterial AMP nucleoside phosphorylase (AMNp). The N- and C-termini form distinct domains which intertwine with each other to form a stable monomer which associates with five other monomers to yield the active hexamer. The N-terminus consists of a long helix and a four-stranded sheet with a novel topology. The C-terminus binds the nucleoside whereas the N-terminus acts as the enzymatic regulatory domain. AMNp (EC:3.2.2.4) catalyzes the hydrolyzis of AMP to form adenine and ribose 5-phosphate. thereby regulating intracellular AMP levels.
Statistics
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PSSM-Id: 519371
Aligned: 66 rows
Threshold Bit Score: 146.539
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2GUW_A             12 QALDRLEELYEQSVNALREAIADYVDNGTLpDPHARLnglfVYPSLSVSWDGATPnP-PKTRAFGRFTHPGCYTTTVTRP 90  Salmonella...
WP_015399545       12 EAIDRLAELYDHSADLARRILE---------NGNYDDyravVYPKVVVDVKEWRP-I-ARTEPFGYVNEAGRYSATLSKP 80  Corynebact...
WP_025251559        8 EAVGALIDIYESSTKRAHEVFE---------SGDYALysqvVYPKLTVEVKSWHP-I-DRTQSYGYVDEEGVYSAVLSRP 76  Corynebact...
gbufpa:Cp267_0072  10 DVVQQLEEIYAASISLAKEILE----TGEY-GRYCDV----VYPKLIVKILSWHP-V-DRTEPFGYVDAAGCYSAVLSKP 78 
WP_020933530       16 QAVDKLIDLYETSCATARRAID---------TGDYAAyadvVYPRLVVDITQWRP-I-DRTEPFGYVNEAGRYTTEVSKP 84  Corynebact...
Q8NU52             11 DAIAKLIDIYDTSTKLAKETLN---------NEDYAAyadvVYPKLTVDVLEWKP-I-DRTEPFGYVDRAGRYSATLSKP 79  Corynebact...
Q8FUC1             24 EAIDRLKEIYTNSTDLAKRTLE---------DGDYAAyadvVYPKLVVEVLRWEP-I-DRTEPFGYVDQAGRFSAVLSKP 92  Corynebact...
cebbi:cauri_0073   32 EAVARLCELYDKSCALAREALA---------SGDHDAyrhvVYPKITVHIRQWTP-I-DRSEPFGYVDQEGRYSAVISKP 100
Q9HX46             25 EAVDRLAELHRQATAALSQALKRYIKERIEpSEAERQn--fHYPQLRIGYRCQGE-VpSTTRAYAKVQVPGEYSVTVTHP 101 Pseudomona...
WP_011914750       16 AAVDYLAELHARATTALNQALKRYVTSRAEpSLQERSl--fRYPQLRLTYECHGE-VpASTRAYAKVQAPGVYSVTVTHP 92  Stutzerimo...
2GUW_A             91 ALFRAYLLEQLNLVYHDYGAHIAVEASHHEIPYPYVIDGsA--LTLDRSMS-----AGLTRHFPTTELAQIGDETADGLF 163 Salmonella...
WP_015399545       81 GLMRSYLHDQLTRLTGNYPCEIHVGPSDIRIPPEYI-------RGVEGITEarragD-SADAIPRPTLDDVHDAIVDGEW 152 Corynebact...
WP_025251559       77 QLMAAYLTSQLERLTSNYDCEISVAPSEVRIPPEYI-------DGIEGLSEarragD-TGDFVPRPTLDDVDDAIIDGDW 148 Corynebact...
gbufpa:Cp267_0072  79 ELIHDYLCEQLERLCANYECVITVEPSTVRIPPEYIDGI-E--GVTEARRA-----GDVAAEIPRPTLDDVDDAIIDGEW 150
WP_020933530       85 AVMQEYLREQLERLTGNYESTILVGPGETRIPPEYI-------ADMPDVSEarrtqDGSQDIIPRPTLDDVHDAIIDGKW 157 Corynebact...
Q8NU52             80 RVIERYLREQLERLTSNYPCKIYVSESDIRIPPEYI-------RGAPSATEarragD-VADIIPRPTLDEVHDAIIDGDW 151 Corynebact...
Q8FUC1             93 HIMERYLREQLERLTGNYPCRIEVGPSDIRIPPEYI-------RDAPSATEarragD-VAEIIPRPTLDEVHDAIIDGEW 164 Corynebact...
cebbi:cauri_0073  101 WLIRDYLIEQLTRLSNNYPCDLYVGQSDERIPPEYI-------RGTTHIPQ-------DRGNIPRPTLDAVHDGIVDGAW 166
Q9HX46            102 DAFRKYLLEQLRPLMDDFTVQVQVGPSQQDIPYPYVVEQ-GdeLAGSGVTA-----AELARVFPSTDLSAASDDIADGLY 175 Pseudomona...
WP_011914750       93 AAFRAYLLDQLKPLIQDFNVTVEVGLSDRNIPYPYVIEQ-GdeLAGTGVTA-----AELARVFPSTDLSAATDDIADGLY 166 Stutzerimo...
2GUW_A            164 HPGEFYP 170 Salmonella enterica subsp. enterica serovar Typhimurium str. LT2
WP_015399545      153 EAFHGEE 159 Corynebacterium halotolerans
WP_025251559      149 DAFHGPE 155 Corynebacterium vitaeruminis
gbufpa:Cp267_0072 151 DAFHGEE 157
WP_020933530      158 EAFHGKE 164 Corynebacterium maris
Q8NU52            152 HAFNGPE 158 Corynebacterium glutamicum
Q8FUC1            165 DAFHGEE 171 Corynebacterium efficiens
cebbi:cauri_0073  167 KAFHGKD 173
Q9HX46            176 EWERADQ 182 Pseudomonas aeruginosa
WP_011914750      167 DWEHADP 173 Stutzerimonas stutzeri
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