3D85


Conserved Protein Domain Family
IL12p40_C

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pfam10420: IL12p40_C 
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Cytokine interleukin-12p40 C-terminus
IL12p40_C is the largely beta stranded C-terminal, D3, domain of interleukin-12p40 or interleukin-12B. This interleukin is produced on stimulation by macrophage-engulfed micro-organisms and other stimuli, when it dimerizes with interleukin-12p35 to form a heterodimer which then binds to receptors on natural killer cells to activate them to destroy the micro-organisms. This domain contains two disulfide bridges, one of which serves to bind p40 to p35 and the other to hold the beta strands within the domain together. The cupped shape of the p35 binding interface matches the elbow-like bend between D2 and D3 in p40. The domain is often associated with family fn3, pfam00041.
Statistics
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PSSM-Id: 402170
View PSSM: pfam10420
Aligned: 36 rows
Threshold Bit Score: 68.5743
Threshold Setting Gi: 972952843
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
3D85_D       104 KTFLRCEAKNYSGRFTCWWLTTI-S--TdLTFsVKSSRGsSDPQGVTCGaatlsaervrgdnKEY-EysVECQEDSACPA 179 human
XP_019219593 124 gGHIHCSAPNYTGSFHCSWKRTAlRsdAsVVL-VKAER---FTEDISCE-------------LDGdAsgVRCQD-AHCPY 185 Nile tilapia
XP_003971100 122 EGHIHCSAPNYTGPFRCSWTRADsRsnAaVLL-LQATR---NGQQIPCE-------------LDAgGsgVLCQD-NSCSY 183 torafugu
Q6UAP2       120 EGYIQCSVPNYSGPFRCSWSRTAsRsnAaVLL-LNATR---NGREIPCE-------------LDAdGsgIQCEE-DNCPY 181 spotted green p...
XP_014326861 126 qGHIHCSAQNYKGSFHCTWKKTYhRshAaVLL-VKAHR---NTDEISCV-------------LDAdGsgVQCQD-VDCPY 187 southern platyfish
XP_004076195 126 EDHIHCSAPNYKGSFHCTWKKTKyRshAsVLL-VKAER---YLDSIPCV-------------LDAdGlgVHCQD-AACPY 187 Japanese medaka
XP_007232947 122 KGFIHCSTKNYSGSFQCSWTWDDkRagK-VAL-VKAVRA-HSGGNISCS-------------LNSsGhgITCYDHEYCPY 185 Mexican tetra
CAJ44438     121 KGYIHCATNNYGGLFQCSWSWGEnRhgH-ITH-IEAIRP-DGGSNISCS-------------LDPgGksITCLDQDYCPY 184 zebrafish
XP_022531969 117 KEFITCVARNYSGPFHCFWKWDSkRngV-VVF-FKASR---NSQLMNCS-------------LDAdNngLTCEE-QQCPS 177 Mexican tetra
XP_021324894 118 KEFVSCSARNYNGQFHCSWKWHHeRthKaVVY-FAAIR---NSTDLNCT-------------LDSnIseLTCIDKDYCPY 180 zebrafish
3D85_D       180 AEESLPIEVMVDAVH 194 human
XP_019219593 186 KEEQHRISVTVYIRS 200 Nile tilapia
XP_003971100 184 KEEQHHILFTIHVHS 198 torafugu
Q6UAP2       182 KEEQHRIFLTTHIRR 196 spotted green pufferfish
XP_014326861 188 KEETHPIQFTIYMHS 202 southern platyfish
XP_004076195 188 KEEQYRISLTVYIHS 202 Japanese medaka
XP_007232947 186 SEELDNINLTIYFRS 200 Mexican tetra
CAJ44438     185 AEELERINLTVYFRS 199 zebrafish
XP_022531969 178 SEEVNRISLTLMVRS 192 Mexican tetra
XP_021324894 181 SEESLSINLTLLVRn 195 zebrafish
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