3TV2,1VDK,4HGV


Conserved Protein Domain Family
FumaraseC_C
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pfam10415: FumaraseC_C (This model is not part of the current CDD release)
Fumarase C C-terminus
Fumarase C catalyzes the stereo-specific interconversion of fumarate to L-malate as part of the Kreb's cycle. The full-length protein forms a tetramer with visible globular shape. FumaraseC_C is the C-terminal 65 residues referred to as domain 3. The core of the molecule consists of a bundle of 20 alpha-helices from the five-helix bundle of domain 2. The projections from the core of the tetramer are generated from domains 1 and 3 of each subunit. FumaraseC_C does not appear to be part of either the active site or the activation site but is helical in structure forming a little bundle.
Links
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Statistics
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PSSM-Id: 519364
Aligned: 532 rows
Threshold Bit Score: 31.9177
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
3TV2_A        404 LVTALNPHIGYDKAAQIAKKAHKEGTTLKAAAL-ALGYVTDAQFDEWVRPEHMVG 457 Burkholderia pseudomallei 1710b
Q6LKW1        410 LATVIATLFGYKVGCRIAAKAFEQNLRVRDVVL-DEQLLTPEQADYLLDPMVMTN 463 Photobacterium profundum
WP_014455852  402 LITRVADDIGYDRAARIALQAQRERRSLRDVLMtDEGF-SAAECDRLLDPLTMLP 455 Spirochaeta africana
WP_006928125  407 ILTALVGRLGYEKIQQVAQKMQQTGQSVREIVI-SEGWLDESTFNELTSAEavnr 460 Caldithrix abyssi
ADO57007      394 maSALVAELGYDEAASIASAAIAQGRSPEDIAE-DRGQLTRARIDQLCHPYTVTK 447
WP_015232516  380 LITVFSPLIGYDNAKKLYERIRK-GEKLEDVAK-SLGL-DQETINKITDLNILVK 431 Caldisphaera lagunensis
WP_012185982  381 LITVISPVIGYDKAAEIGRRLTH-GLSIREALR-ELGY-TDEQINEILNLEKLTK 432 Caldivirga maquilingensis
19_pfamImport   1 LVTVISPIIGYDKASEIGKRLSK-GMSIREALK-ELGF-KDDEIDRILDLSKLVK 52 
Q4JCD3        381 LITIVSPVIGYDKASEIGKKLAK-GLSIREALK-ELGY-NDEQIDKILDLKKLTK 432 Sulfolobus acidocaldarius
jgi:Vdis_1363 387 LITMLTPMIGYEKAAELSRELMM-GRSIRDVLK-ELGF-SDDEIDNILNLKELTK 438
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