3N0A,3V0J


Conserved Protein Domain Family
PTEN_C2

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pfam10409: PTEN_C2 
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C2 domain of PTEN tumor-suppressor protein
This is the C2 domain-like domain, in greek key form, of the PTEN protein, phosphatidyl-inositol triphosphate phosphatase, and it is the C-terminus. This domain may well include a CBR3 loop which means it plays a central role in membrane binding. This domain associates across an extensive interface with the N-terminal phosphatase domain DSPc (pfam00782) suggesting that the C2 domain productively positions the catalytic part of the protein onto the membrane.
Statistics
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PSSM-Id: 402161
View PSSM: pfam10409
Aligned: 49 rows
Threshold Bit Score: 31.8646
Threshold Setting Gi: 268554025
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
3N0A_A     185 HFKPLTIKSITVSPVPffnKQRNGc---------RPYCDVLIGETKIy-----TTCADFERMKEYr------VQDGKIFI 244 cattle
A0EHL3     170 PAKTVELIEVRLVGIPn-fGIFGGcskifkfiivEPFIRIQNENKQLi-----QQPTILTNQDQQk------QYSAIFKF 237 Paramecium tetrau...
A0CUG9     286 PNKQVELVKIRLIPVPn-vQVFGGc---------APWFRIQNKDKEY-------NSKNQFPVKEYk------LEPYIEFK 342 Paramecium tetrau...
A0BN98     247 PQPKIQILQIRLITIPs-mNYSNSc---------TPYILIQNYQNQA-------TFTKFQIVNDS-----------FILF 298 Paramecium tetrau...
A0DZJ0     242 PQNKIQISQIRLITIPi-mNCQNSc---------NPYILIQNNQSKI-------LVSKFQIVKDS-----------FIIF 293 Paramecium tetrau...
NP_954866  530 PKKVLVIKRLVVYSIHg-vGKGDGs---------DLEVQIIMWQETVfsfcnsRNCMIFHDPETD---------RAIINV 590 house mouse
Q6XPS3     392 PRRILFIKRFIIYSI-----RGDVc---------DLKVQVVMEKKVVfs---sTSLGNCSILHDIe------TDKILINV 448 human
P56180     410 PRRILFIKHFIIYSIPr-----yVr---------DLKIQIEMEKKVVfs---tISLGKCSVLDNIt------TDKILIDV 466 human
3V0J_A     193 PMKKLKVTGVTITAIQg-vGRGNGs---------DLSMQIVSERQEVll---cKFAEGYNCALQYd-----aTDDCVTCE 254 vase tunicate
KAE8627222 162 PEKQLKIRSIRIYSIQg-vGRSNGt---------DLKVQIIMKKEVVfqc-vcETQGN------CklffdagNNSIVISL 224 tropical clawed frog
3N0A_A     245 PLSITV-QGDVVVSM-YHLRSTigSRLQAKvtntqIFQLQFHTGFIPldTTVLKFTKPELDACDVP---EKYPQLFQVTL 319 cattle
A0EHL3     238 Q-GVYL-SGDVVVQF-FHKS----IVLEEK-----MFQAWLNTSFVImsPQLQIFKRDELDGVGKDkqfKKFPINFSLEI 305 Paramecium tetrau...
A0CUG9     343 LKDIIL-QGDVLLQF-LNQGF---WSRSEK-----LFQAWFNCDFFDy-TGVLMIDKFMLDKACKDksgKTFQKDFRIEL 411 Paramecium tetrau...
A0BN98     299 TVDIIV-EKDTRIIC-YNKT----LMGKEV-----MFQFWFHTGFIEs-NGLLVIDKYMLDRAVKDkkhKIFSPNFRVEV 366 Paramecium tetrau...
A0DZJ0     294 MTDAVV-EGDTRIIC-YNKS----LLSKQI-----MFQFWFHTSFLDd-TGLLIIDKYMLDKAVKDknhKVFSPNFRVEV 361 Paramecium tetrau...
NP_954866  591 FHCPAL-YDDVKVKF-LSPNLP--KYYDDC-----PFFFWFHTSFIK--NNRLYLPRNELDNTHKPktwKIYGEKFAVEV 659 house mouse
Q6XPS3     449 YDGPPL-YDDVKVQF-FSSNLP--KYYDNC-----PFFFWFNTSFIQ--NNRLCLPRNELDNPHKQkawKIYPPEFAVEI 517 human
P56180     467 FDGLPL-YDDVKVQF-FYSNLP--TYYDNC-----SFYFWLHTSFIE--NNRLYLPKNELDNLHKQkarRIYPSDFAVEI 535 human
3V0J_A     255 VKNCPVlAGDIKVRF-MSTSKSlpRGYDNC-----PFYFWFNTSLVE--GDHVTLKREEIDNPHKKktwKIYRDNFTVKL 326 vase tunicate
KAE8627222 225 D-GCPViSGDIKIRFeSSANIP--KGYDDC-----AFYFWFNTSFIE--NSRLYLSKNELDNPHKEksgKIYKENFAVEL 294 tropical clawed frog
3N0A_A     320 DVE 322 cattle
A0EHL3     306 LFD 308 Paramecium tetraurelia
A0CUG9     412 HVV 414 Paramecium tetraurelia
A0BN98     367 QTI 369 Paramecium tetraurelia
A0DZJ0     362 QTF 364 Paramecium tetraurelia
NP_954866  660 DFG 662 house mouse
Q6XPS3     518 LFG 520 human
P56180     536 LFG 538 human
3V0J_A     327 TFS 329 vase tunicate
KAE8627222 295 NFE 297 tropical clawed frog
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