2QIZ


Conserved Protein Domain Family
Ufd2P_core

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pfam10408: Ufd2P_core (This model is not part of the current CDD release)
Ubiquitin elongating factor core
This is the most conserved part of the core region of Ufd2P ubiquitin elongating factor or E4, running from helix alpha-11 to alpha-38. It consists of 31 helices of variable length connected by loops of variable size forming a compact unit; the helical packing pattern of the compact unit consists of five structural repeats that resemble tandem Armadillo (ARM) repeats. This domain is involved in ubiquitination as it binds Cdc48p and escorts ubiquitinated proteins from Cdc48p to the proteasome for degradation. The core is structurally similar to the nuclear transporter protein importin-alpha. The core is associated with the U-box at the C-terminus, pfam04564, which has ligase activity.
Statistics
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PSSM-Id: 519360
Aligned: 149 rows
Threshold Bit Score: 296.79
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2QIZ_A        238 LGPILSLSPI---Ea-----------aVAIRNYgd-nlLRSKQ--QTAM---IHESLQAEHKVVIDRLFFIVDKLVRGSL 297  brewer's yeast
XP_001566746  275 LGVLFGLGPKpmaAarapn----gnwlEVLELFpyqkkDEHQQ---------TVYTMQQEVKALAKMNVQLLQSLLRVN- 340 
Q4DG09        271 LGALLGVSTQirsHrllppysmsseraQLMSMFs----------tEVDDhskQISDLQFQMQASCAGNKRIILALLQAK- 339  Trypanosoma c...
Q584R0        275 LGAILGVGVFsraSrplppllrmvewrGYMDMFp----------tESEDhsqKISDLQSSMETACDANKRIVLVLLQNK- 343  Trypanosoma b...
XP_002141583  248 fGGFISPNPIdksLqskd-----nlnpIIQKYF------SGILmkTQTQitqCKLSIKNELSLIHEQSLILFRNILKSNI 316 
ESS33345      260 LGRLLAQTLLdgpTlkng-----rqesLSMKYF------AGNQalTTQYlqaTVQTLRHDEQNHQEVFLQIVKNLCRGGS 328 
XP_001614898  302 LGRLLSPTVItmpNvtnk------eeiAMYKYFyn-saTNSLNkmTLGAlksTYVMLRRDTDWILENCVETIKNLLKGGV 374 
Q7RS47        324 LGRLISPTIItmpNiknk------eeiAMYKYFyn-ntTNSLNkmTLASlknIYTVLRGDTNWILENCVEIIKNLLKGSN 396  Plasmodium yo...
XP_002808880  360 LGRLISPTIInmpNilkk------eeiAMYKYFfn-snTNSLNkmTLNGlknTYTLLRKDTDWILENCVEIIKNLLKSSS 432 
XP_002258056  284 LGRLLSPTVItmpNitkk------eeiAMYKYFyn-stTNTLNkmTLGAlknTYVMLRRDTDWILENCVEIIKNLLKGSG 356  Plasmodium kn...
2QIZ_A        298 NSRTDMISYFAHIANKNHLRRADH-----------------PPFK---------ELSSNGFMSNITLLLVRFSQPFld-- 349  brewer's yeast
XP_001566746  341 MTRNATLRYLGQALQLNEDYLKTM-----------------HHDS---------PISSRYFMIQLQSVLIELALPIfqar 394 
Q4DG09        340 VSREPTLRYIGTALRLNAGYTKTV-----------------HHNL---------PLSSRYFMTQLNDVLLEAALPLfek- 392  Trypanosoma c...
Q584R0        344 LSRFHTLRFMGSALRLNAGYTRTM-----------------HHDL---------PLSSRFFMCQLNDVLMEAALPVftk- 396  Trypanosoma b...
XP_002141583  317 NNRRKVLKWIGLVCCSNEGRTKLFnaisslsslrnnsntrsLQSSiqslilrtsGQTTNGFSLNVLELILKLLEPV---- 392 
ESS33345      329 DCRHRVVQWYGQILGSNELRAKMShmlrmtq----qqaaesLDPMhsml-lkvqGQTSYGFTLNAFWSLLGLAEPI---- 399 
XP_001614898  375 ESKKRVLLWLACIIISNEKKTKIMyhyst--------ypqsLDASyglf-lkllGENSYGFCLNMFWVLLCLCEPI---- 441 
Q7RS47        397 ESKKRVLLWLNCILISNEKKTKIMyhyst--------ypqsLDNSyglf-lkllGENSYGFCLNILWVLLCLCEPI---- 463  Plasmodium yo...
XP_002808880  433 DSKKIILLWINCILISNEKKTKIMyhyst--------ypqsLDTSyglf-lkllGENSYGFCLNMFWVLLCLCEPI---- 499 
XP_002258056  357 ESKKRVLLWLACIIISNEKKTKIMyhyst--------ypqsLDASyglf-lkllGENSYGFCLNMFWVLLCLCEPI---- 423  Plasmodium kn...
2QIZ_A        350 ---iSYKK-----IDKIDANYFnn------------pSLFI-DL-SGETRLNs----------DFKEADA-----FYDKN 392  brewer's yeast
XP_001566746  395 tnkeDMSSgcsydYRQIPAHYLldrl--------ygpHGVVvSFgSDVERVAhydndnplplvPSNRGAY---------- 456 
Q4DG09        393 ----------aydPTTIPPFYVled----------naDNTVvDFgEDVERIVhydeshplppfPALSEPF---------- 442  Trypanosoma c...
Q584R0        397 ----------gcdASSIPPAYLled----------pgEETVvDFgESVERIThydenrplpsfPSLQEPF---------- 446  Trypanosoma b...
XP_002141583  393 ----KIEK-----VLDLDYFYIlwgkldengdignevKSILgDLiNEATLG------------DKEKIKQwtdiiEAKKI 451 
ESS33345      400 ----KMDK-----LSDLCYFFClrgd--------avaREVLgDLaKDAKLG------------NEASVSAaekfcNAKGV 450 
XP_001614898  442 ----TMNK-----ISDFDFFFFlrd---------dpfSKFIlKNiTNQSSFE-----------EKSNVEKikekvKNEQS 492 
Q7RS47        464 ----TINK-----INDLDLYFFlrd---------dpfSGFIlKNiTNQSSFE-----------EISNVEKiknkvKNFES 514  Plasmodium yo...
XP_002808880  500 ----TVNK-----INDLDFFFFlrn---------dpfSKFLlKNiTNQSSFE-----------DKSNVEKikknvERSEC 550 
XP_002258056  424 ----TMNK-----ISDFDLFFFlrd---------dpfSKFLlKNiTNQSSFE-----------EKSNVENikqkvKNSEG 474  Plasmodium kn...
2QIZ_A        393 rktADSKP--------NFISDCFFLTLTYLHYGLGGTLSFEEKMGSEIKALK-------------------------Eei 439  brewer's yeast
XP_001566746  457 ----------------KPFIHLFFLAARAVTLCAAVLIDEHDRDERQATHPQasqqqrdf---------ftaekllvE-- 509 
Q4DG09        443 ----------------KPSVHLFFLVARSIMLSAGVMIETHQRVEQDLAHPQlppeqrav---------yvaeksliE-- 495  Trypanosoma c...
Q584R0        447 ----------------KPTVHLFFLAARSMMLSVSVLIELHERVEHESSRPNtstqqral---------civekslvE-- 499  Trypanosoma b...
XP_002141583  452 ---DIENKkleyndiiRFPTQIFWLSCKAIIVFMHPILSEYENKIHELNEYRnnstsmgllrqdteferltaelllyD-- 526 
ESS33345      451 ---LKAET--------KFPSEVFWLALKAVRVLFNPCMAEFTRILQKFQSVHdqgasptspey----rflvaeilswR-- 513 
XP_001614898  493 ---FQKEP--------KFITSIFWVTFKSLSVFFKPAIDEFIRIVQEVPNAKdkniyy-------------mnihtwK-- 546 
Q7RS47        515 ---FKKEP--------KFITCIFWMTYKALSVFLKPSIDEFIRIVHGVSNAKdkniyy-------------mnihtwK-- 568  Plasmodium yo...
XP_002808880  551 ---FQKEP--------KFITCIFWMTFKSLSVFFKPAVDEFIKIVQEAGNAKdkdfyy-------------mnihawK-- 604 
XP_002258056  475 ---FSKEP--------KFITCIFWITFKSLSVFFKPAIDEFMRIVQEVPNAKdknfyy-------------mnihtwK-- 528  Plasmodium kn...
2QIZ_A        440 ekvkkiaanhdvfarfitaqlskmekalktteslrfalqGFFAHRSLQLEVFDFICGASTFLIRVV-----------DPE 508  brewer's yeast
XP_001566746  510 ---------------------------------------GLLGSNELSASRLEFLNHLAHWLLTVMqvddq--------- 541 
Q4DG09        496 ---------------------------------------GLIGSENLGRKRVQVLNGIAAWLVRLMnvspg--------- 527  Trypanosoma c...
Q584R0        500 ---------------------------------------GLIGSHSLGQKRVRLLNGIAGWLVKVMgtled--------- 531  Trypanosoma b...
XP_002141583  527 ---------------------------------------CTLFHTNIMTTYWHFLSIFCHFIIRSIynfdeygnkikEWD 567 
ESS33345      514 ---------------------------------------TVILHPKFCSLYWHLVHLGLSWLLRAVycfnldgscrlDEE 554 
XP_001614898  547 ---------------------------------------IFLYSSRFIQLLFKFLHLSMAYFLHVAylfdmegnaclDMM 587 
Q7RS47        569 ---------------------------------------IFLYNSRFAQLLFKFLNLCMSYILNVVylydrdgnldaSMK 609  Plasmodium yo...
XP_002808880  605 ---------------------------------------IFLYNTRFNQLLFKFLHLCMNYFLHVAyvydingninnSMK 645 
XP_002258056  529 ---------------------------------------IFLYSSRFIQLLFKFLHLTMAYFLHVAylydmegnpcmDMM 569  Plasmodium kn...
2QIZ_A        509 HE-FPFK------------------------------------------------------------------------- 514  brewer's yeast
XP_001566746      --------------------------------------------------------------------------------     
Q4DG09            --------------------------------------------------------------------------------      Trypanosoma c...
Q584R0            --------------------------------------------------------------------------------      Trypanosoma b...
XP_002141583  568 DLiHSKQgkllnam------------------------------------------------------------------ 581 
ESS33345      555 TLsVKHPrlatlvmqscppplqverqra---------------------------------------------aranasg 589 
XP_001614898  588 NLlSEHSgsfthlvlrscpppnernyvrrgrtfgslsfsanlp---------------gggaekrdeeeppvevpqgvpq 652 
Q7RS47        610 SYlDEHKgnysqlvlkvcpppnesnnektks---------------------------------------anhrntgtni 650  Plasmodium yo...
XP_002808880  646 TClNEHNnslvhlvlkccpppnekyynntkegttegtnivshmrenekvernepigenkrienndgvvennqmnesgrng 725 
XP_002258056  570 NSlREHNgnfthlvlkscpppneknyfrrgktfgslslcen------------------dpggqgeeaeedaekrdeegr 631  Plasmodium kn...
2QIZ_A        515 -------------QIKLPL-----IpdqigvenvdnadflrAH-------------------APvPFKYYPEFVVEGPVN 557  brewer's yeast
XP_001566746  542 -------------------------------------gvlpAE-------------------PPaEWGYLPQCLVNCVI- 564 
Q4DG09        528 -------------------------------------gvlsKE-------------------PPeEWKYLPQQLVDLVI- 550  Trypanosoma c...
Q584R0        532 -------------------------------------gtllPE-------------------PPeTWKYLPQQLVEVVI- 554  Trypanosoma b...
XP_002141583  582 ------rnfgqpsSSL----------------------------------------------SP-QFSVLPSRIVDDIMT 608 
ESS33345      590 sqspnhaanasqdVTT----------------------------------------------PP-QFAALPSALVEDLFS 622 
XP_001614898  653 dvpqdvpqdapqdVPQdapqdapq---------dapqdvppMEvpqnvgeaqsrggsdhlfaSP-QFSIIPTFFLNDIFD 722 
Q7RS47        651 esntteedtsnndRSGnt----rnDnelerengd-------------------tnsennlcaSP-QFSIIPTFFLSDIFE 706  Plasmodium yo...
XP_002808880  726 sldedlnrderegINISNEsnnrvSlginnneentpmvispLDgsdd-----------rlyaSP-HFSIIPTFFLSDIFE 793 
XP_002258056  632 raelpqedglddrTQGqr-----gSdniernpq---------------------dredhlfaSP-QFSIIPTFFLNDIFD 684  Plasmodium kn...
2QIZ_A        558 YSLYISKYqt------spIFR-----NP-RLGSFVEFTTMVLRCPELVSNPHLKGKLVQL----LSVGAmpltdnspgFM 621  brewer's yeast
XP_001566746  565 ------------------RATsmaplDGlYSDGMISLMLVLMGNTKYFPKPHTHALFPAYllrlQENYT----------T 616 
Q4DG09        551 ------------------LGVkmaplEYfDLEHIVSLMLVLMGNTTYFPKPHTHALFPSFltrlLQNEE----------T 602  Trypanosoma c...
Q584R0        555 ------------------RGMqlaplDYpDVENVISLMLVLMGNTVYFPKPHTHALFPDFllrlLRNED----------T 606  Trypanosoma b...
XP_002141583  609 TTELILR-----------IKGndesiIGfDFDSYISLCISLISFGNYFNNPHSRCQKGVGsihyLLQLP---------QY 668 
ESS33345      623 SIRRMLELqsvylsvrssQGFeqppiAAmDAELVASACIAVMTASDFFRNVHLRCDGACKtlyfMFLTE---------GV 693 
XP_001614898  723 IIYLLYELdt------fkSPGnenflSYlNVDLFLSFCIFTMLSENHIKSIHLRCEAAPKtftyLYRSD---------SL 787 
Q7RS47        707 IIFLLYELdt------fkTQNhetfmSYiNLDLFLALTIFTMLSEKHIKSIHLRCESAPKtftyLYKSD---------NL 771  Plasmodium yo...
XP_002808880  794 ILYLLYELdl------fkSPNnetlmNYlDIDLFLAFSIFTMLSENHIKSIHLRCESAPKtfsfLYKLD---------NL 858 
XP_002258056  685 IIYLLYELda------fkNPGnenflSYlNTDLFLAFCIFTMLSENHIKSIHLRCEAAPKtftyLYRSD---------TM 749  Plasmodium kn...
2QIZ_A        622 MDIFEHDELVNKNLLYALLDFY--VivekTGSSSQFYDKFNSRYSISIILEELYyKIPSYKNQLIWQSQNNADf------ 693  brewer's yeast
XP_001566746  617 RKVLEQHPWFSTHIVRACMECY--IavekSS-----YERVEVRYELSYAIKTFL-----KSNLLCDPVREEMEsqanntm 684 
Q4DG09        603 KRALTSHRWFTQHIVRSCVLCY--IavekST-----YEKVSVRYMLSYCTKSFL-----MFDSLCQPVREEFEvdg--ti 668  Trypanosoma c...
Q584R0        607 QQALMAHRWFSQNIVRSCVLCY--IavekST-----YEKVSVRYTLSRCTKSFL-----LHESLCQPVRAEFEagg--tl 672  Trypanosoma b...
XP_002141583  669 RQKIETNEDCIEFILPNLISLFndV------QKSPYFDRFSLRLPIIILLENLI-GIESHRNRLYSFVKDRDEa------ 735 
ESS33345      694 RDRLESIPVVQEHLVRALTEVF--I----ASERGSYYDRITFRIPIVDLFQKLL-VVDNYKEALHRLGSSSPEk------ 760 
XP_001614898  788 KKIIEESELTRKYIIKSLTYVF--I----ASQKGEYTERMQTRVRIVENFNSLF-LNEIYVDQFTQLVIKNNNl------ 854 
Q7RS47        772 KSIIEESDLTKKYIIKSLTNVF--I----SSQKGEYTERMQTRLRIVENLNSFF-FNKIYVNQFTQLIINNNNl------ 838  Plasmodium yo...
XP_002808880  859 KKVIEESELTKKYIIKSLTNVF--I----ASQKGEYTERMQTRVRIVENFNSFF-LNKTYVNQFTQLVINNNNl------ 925 
XP_002258056  750 KKIIEESDLTRKYIIKSLTYVF--I----ASQKGEYTERMQTRVRIVENFNNLF-LNEIYVDQFTQLVIKNNNl------ 816  Plasmodium kn...
2QIZ_A        694 FVRFVARMLNDLTFLLDEGLSNLAEVHNIQNELD----NRAR-------------------------------------- 731  brewer's yeast
XP_001566746  685 LERFSHMAVAEVNEAVDQVIDTLTRMNEMVKAGAdlseNAVTssssqntadglhgqqq---------------------- 742 
Q4DG09        669 LERFSHMVTADVNEAVDQLVETLTQMNRMVKEGAdlsvSARAslsnngenirrgnaqrr--------------------- 727  Trypanosoma c...
Q584R0        673 LERFSHMVTAEVNDAVDQLIGTLTQMNRLVREGAdlseNPNPhrgdgggndgtagr------------------------ 728  Trypanosoma b...
XP_002141583  736 FTKFIHLLVSDLNYLLEEGMSMLAEIKKREISNNanrdNLQTnnniyndsn----------------------------- 786 
ESS33345      761 FIHMIHLLLNDVSTLVDQAMSALTEIRKRQHEGRdhdePPQPsattegaaaeaa-------------------------- 814 
XP_001614898  855 FVHLIHLLLNDVNFLVEEVVSYLSEIKRREDkk---rdDQERaisggvsggagsgatnggiaasaataattantssyana 931 
Q7RS47        839 FVHLIHLLLNDVNFLVEEVVSYLSEIKRREN--KkkakETSRmgsstirgerngnsqneegnsnqnnnidrrnrn---rr 913  Plasmodium yo...
XP_002808880  926 FVHLIHLLLNDVSFLVEEVVSYLSEIKRREENNKkkkdSQQEneqeansnsylnattrnnrtsngssnsvanln------ 999 
XP_002258056  817 FVHLIHLLLNDVNFLVEEVVSYLSEIKRREDkk---rdDQERgdtstggvtsglassatngqanggttntyana------ 887  Plasmodium kn...
2QIZ_A        732 -------------------------------GA-----PPTrE-EE-------DKELQTRLASASRQAKSSCGLADKSMK 767  brewer's yeast
XP_001566746  743 -----------------------pqvrhqrnnanrseeAVS-SeDDgeedeveNTDRSQTYHERGMSLRSHLMLFTASMD 798 
Q4DG09        728 ---------------qegmatsnsnnnnnqnNNfrsadGNV-NeEEaeadgddGE-APLTYHQLGLGLRERILLFEASMN 790  Trypanosoma c...
Q584R0        729 -----------------------------aatvnrgthrnteNeEEse---deTEGSPQSYHQLGLGLKQRILLFEGSVD 776  Trypanosoma b...
XP_002141583  787 -----------------------nninitnqSSnqnneDLE-HeSAyqnsdiqSSIEEMPLERLNQSCKGYMQLSHTSAS 842 
ESS33345      815 -------------------aaagaspsrsssSGtedeeDEE-EdDAgaslegnAQLRRETWSRLEATTRDLCSLGFNACS 874 
XP_001614898  932 trnsrvstgsashalnpsggsdledsapnanESynsenS---DnEEggggnvgTDITNESMRNLAARTKMIITYCYKSCI 1008
Q7RS47        914 dvedvdeddvlnefdgerdryensfninyenEEyneerE---DnGSgg----gSDISNESMSNLAARTKMIITYCYESCV 986  Plasmodium yo...
XP_002808880 1000 ysslnnnnnnnnnnnnnnnnnnnnnsnnfndSSfnsdnNSD-DgEEgg---mdYDLSNESMRNLAAKTKMIITYCYKSCI 1075
XP_002258056  888 arnsrvsntsassalnpygrsdfeesaanvnESynsdnS---DnDEggggnvgTDITNESMRNLTARTKMIITYCYKSCI 964  Plasmodium kn...
2QIZ_A        768 LFEIYSKDIPAAFVT-PEIVYRLASMLNYNLESLVGPKCGELKVKDPQSYSFNPKDLLKALTTVYINLse---------- 836  brewer's yeast
XP_001566746  799 MFIELSLQFPKGVSQ-NMVAGQISEMLARSLMAFAGPNSRNLKIQNADLYNFRPREVLMRLVDCFTHFrr---------- 867 
Q4DG09        791 LFIQLAISFSKGVAQ-NMVAQQISQMLARSLVSFAGAESKNLKIEYPERYNFRPREILNRLVDCLSQFrr---------- 859  Trypanosoma c...
Q584R0        777 LFIQLASSFPKGVAQ-NMVAQQISQMLARSLTSFVGADSKKLKIEHPERYGFRPREILGRIVECLVQFvr---------- 845  Trypanosoma b...
XP_002141583  843 LLQKITQYYPEEIIDsPLILPQIVTCLNSTLDRLVGPKCLELKVSNFESYNFNPRQLLANICLTYIKLsfknistmtnsv 922 
ESS33345      875 LFSLYAKECGAYIIRsSSILPQAVTTLDCCLDHLVGPRCLQLKVNNMESYNFQPKKWLMKVLESYVYLlqadp------- 947 
XP_001614898 1009 FLNLLCKSYPNSIVAsNTILTQIVTCLNCYFDYLVGPKCLNIKVKNMEQYNFRPQLWLTSIVESYLFLlnsdk------- 1081
Q7RS47        987 FLNLLCKNYPINIVTsNTILTQIVTCLNCYFDYLVGHKSLNIKVKNMEQYNFRPQLWLTSIVESYLYLlnlek------- 1059 Plasmodium yo...
XP_002808880 1076 FLNLLCKNYPNNILTsNTILSQIVTCLNCYFDYLVGPKCLNIKVKNMEQYNFRPQLWLTSIVESYLFLlnsdk------- 1148
XP_002258056  965 FLNLLCKNYPNNIVTsNTILSQIVTCLNCYFDYLVGPKCLNIKVKNMEQYNFRPQLWLTSIVESYLFLlnsdk------- 1037 Plasmodium kn...
2QIZ_A        837 ----------qsEFISAVAKDERSFNRNLFVRAVDILGRKtGLASPEFIEKLLNFANKA 885  brewer's yeast
XP_001566746  868 ----------skSFLRCLCHCSIPLSD--ISSVMRTIVDR-QLISEDLIWKVSEMKSAV 913 
Q4DG09        860 ----------fqNFMRSLCNCGVPLRE--ILQAIETVTER-GLVGEHLIWKLREIASTL 905  Trypanosoma cruzi
Q584R0        846 ----------leNFLRCLCNCGVPQKD--ILQAMKVISER-GLVGEHLVWKLNEIASSL 891  Trypanosoma brucei
XP_002141583  923 nlstnseqeicsQLISEIIEEQRFFKVATFAKAYHIVRRE-GLLNLVQLKQFGQLVKII 980 
ESS33345      948 --------eggdSLVAEILKDGRYFQKETVNKAYRIAKRE-GLMNLKLLEKFQELVKRL 997 
XP_001614898 1082 --------kneeLLTREIANEGRYYKPEVFNKAYYICKRE-GLLRKEDLNKFKIFCQQI 1131
Q7RS47       1060 --------dyqdLLIREIANEGRYYKQEIFNKAYYICKRE-SLLNKEDLNKFKLFCQNI 1109 Plasmodium yoelii yoelii
XP_002808880 1149 --------eheeLLIREIANEGRYYKAEIFNKAYYICKRE-GLLHKEELNKFKNFCQEI 1198
XP_002258056 1038 --------kneeLLTREIANEGRYYKPEVFNKAYYICKRE-GLLRKEDLNKFKNFCQQI 1087 Plasmodium knowlesi strain H
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