Conserved Protein Domain Family
Cytokin_check_N
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pfam10407: Cytokin_check_N (This model is not part of the current CDD release)
Cdc14 phosphatase binding protein N-terminus
Cytokinesis in yeasts involves a family of proteins whose essential function is to bind Cdc14-family phosphatase and prevent this from being sequestered and inhibited in the nucleolus. This is the highly conserved N-terminus of a family of proteins which act as cytokinesis checkpoint controls by allowing cells to cope with cytokinesis defects. These proteins are required for rDNA silencing and mini-chromosome maintenance.
Links
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Statistics
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PSSM-Id: 519359
Aligned: 36 rows
Threshold Bit Score: 80.6577
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q6FXK6         46 TRKFLHF-TKPENTLLQLADEIENRITKLYSNLniESFEILSLQDINHCDLDATYLVKDVFS-MDNTVLVILKNE 118  [Candida] glabrata
CCE85033       28 SRKFLHL-TDPETSLEKVCGELTRRFKRLYPFE--EEILIENLQDDDKCDLDAEFKVSDVLG-PGETLRVVIGND 98  
XP_001384256   28 TKRFLHL-ADPTIELGNIDKDIDSRYRKLYPDE--SPLNIEKLQDNDNCDLDPEFRIQDVLT-NGDVLRIVVRNI 98  
EEQ38280       25 YKKFLHL-TDPYCTIGQVCDASILRYNRLYPDA--DKLVVEGVQDNDCCDLDPEFVAEDVFS-SGDVLRILVDNv 95  
EMG47231       29 FVKFLYI-ANKEATIKSLEDGLVSRFSKRYPNE--RKLKILSFQDRDLCDLDPDFAVEDVFDdQNNEIRVLANNK 100 
XP_002548257   28 YLKFLYL-VDPNSTIDELEEGLCKRFKRRYPKE--DDLIVFSYQDHELLDLDPEFEISDIFDeQNNEIRILVDNT 99  
Q6CGH4         58 AKRFLYLvSDPDETIEELADKLKATFMELYPHH--AKPCIDSIQDEAALDLDRRFLLREVFE-DNSLVRMVLTQP 129  Yarrowia lipolytica
O74354         16 DNQFMIL-FDPSSSISLLKEKVQETYKSLYPFE--SNINIRNIKNEESYDIPNEYLVGEIFP-TNS--KVIVESf 84   Schizosaccharomyce...
EDO36987       15 DKKFLVI-ADEDWTVEDVKSCTEVIFSKLYPGE--PSLTVSKLQNEFHFDLPLDYCAGDALV-DSGLVFAIEDEv 85  
XP_036663364   28 AKKFLHL-IDPVKQIGELLDAVVAQFQRLYPEE--PAINVVKCQDKNQCDLDKDYQVEDVFE-SNDEVRVIVDNl 98
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