3DSH,5BVI,1ZOQ,5OEM


Conserved Protein Domain Family
IRF-3
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pfam10401: IRF-3 (This model is not part of the current CDD release)
Interferon-regulatory factor 3
This is the interferon-regulatory factor 3 chain of the hetero-dimeric structure which also contains the shorter chain CREB-binding protein. These two subunits make up the DRAF1 (double-stranded RNA-activated factor 1). Viral dsRNA produced during viral transcription or replication leads to the activation of DRAF1. The DNA-binding specificity of DRAF1 correlates with transcriptional induction of ISG (interferon-alpha,beta-stimulated gene). IRF-3 preexists in the cytoplasm of uninfected cells and translocates to the nucleus following viral infection. Translocation of IRF-3 is accompanied by an increase in serine and threonine phosphorylation, and association with the CREB coactivator occurs only after infection.
Links
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Statistics
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PSSM-Id: 519354
Aligned: 28 rows
Threshold Bit Score: 170.12
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
3DSH_A        16 LTDLEIKFQYRGRPPR-ALTISNPHGCRLFYsqlEATQEQVELFGPI-----------SLEQVRFPSPED-IPSdKqRFY 82  human
Q14653       201 EWEFEVTAFYRGRQVF-QQTISCPEGLRLVG---SEVGDRTL----------------PGWPVTLPDPGMsLTDrGvMSY 260 human
Q4JF28       197 DWEFEVTAFYRGCQVF-QQTVFCPGGLRLVG---SEAGDRML----------------PGQPIRLPDPATsLTDkSvTDY 256 domestic cattle
Q90643       283 PPLLDITIYYRGKMVY-QEQVDDSR-CVLAY---QPLDPAVA----------------EQRLVLFPSPAS-LPDpRqRRY 340 chicken
NP_001300708 169 NLDLEISISYRRTEVL-KTRLCSSL-IHFFY---QCDPSEL-----------------RGEQIRFPTTDC-LIDvKqIQY 225
Q4H3B1       347 LRQYSLRVKYQQHEVLeRDLMEMNLGYRIHY---GDPDQQCYLMKIDepqrselivdfERPAISLPQVKT-IGGkG-TNG 421 vase tunicate
1ZOQ_A         6 eWEFEVTAFYRGRQVF-QQTISCPEGLRLVG---SEVGDRTL----------------PGWPVTLPDPGMsLTDrGvMSY 65  human
XP_046755345  69 YSQMVITFFYSGRLVG-HITTSYPEGCRLSLs--QPSNHGEKLYTPD-----------SLEHVRFPSAEA-IQNdRqKQI 133 chicken
XP_003967453 215 IYDLEISIHYRKREML-RTTVKAPR-VQLHY---HSEAPELK----------------AHHHICFPPTEG-LLDrKqIEY 272 torafugu
NP_001122338 311 MLMYKVTLKYNGMVVK-SEKLSLAKGVRFMF---GSPLLQKNVVEAFrsge---relvDLQTWEFPEQQM-LSSn--SAN 380 vase tunicate

3DSH_A        83 TNQLLDVLDRGLILQLQGQ-DLYAIRLCQCKVFWSGPCASAH---Ds--CPN-PIQREVKTKLFSLEHFLNELILFQK-G 154 human
Q14653       261 VRHVLSCLGGGLALWRAGQ-WLWAQRLGHCHTYWAVSEELLP---NsghGPDgEVPKDKEGGVFDLGPFIVDLITFTE-G 335 human
Q4JF28       257 VQRVLSCLGGGLALWRAGQ-WLCAQRLGHCHVYWAIGEELLP---ScghKPDgEVPKDREGGVFNLGPFITDLITFIE-G 331 domestic cattle
Q90643       341 TEDLLEV--AGLRLEQRAG-QLLATRLKKCKVFWALSQQLEG---Ge--PPLnLLHRDQETTIFDFRVFCTELRDFRDsR 412 chicken
NP_001300708 226 TKRILDSIQRGLQLEVNQY-GIYGFRQDKCKVFVSTSDPCEI---Qk-pEPR-KLQQNSKEQLLSFDKYIRDLLDFKE-N 298
Q4H3B1       422 FQKVLKNTDAGLVFTQDEDhNLFCKRLCQSRVFAFSRYGEDN---Dd-kHPI-KLEREATVLLFNLNLFITDWINCLKtS 496 vase tunicate
1ZOQ_A        66 VRHVLSCLGGGLALWRAGQ-WLWAQRLGHCHTYWAVSEELLPnsgH---GPDgEVPKDKEGGVFDLGPFIVDLITFTE-G 140 human
XP_046755345 134 TKKLFGHLERGVLLHSNKQ-GIFIKRLCQGRVFWSGNTVVYK---D---RPS-KLDRDEVVKIFDTNLFFRELQQYYN-N 204 chicken
XP_003967453 273 TNRVLNSIQKGLLLEVRDT-GIYATRQDRCHVFASTSDPSVA---Hp--EPS-KLPQNNIVELLSFAKYAHELKLFKE-N 344 torafugu
NP_001122338 381 IDSILKSTDLGIVLQAQQN-GLTAKRLCQSQIFYFDQSNQGG---H----SV-KLERKVAIEVLSHAKWVRSLLEQQRgS 451 vase tunicate

3DSH_A       155 QTnTPPPF-EIFFCFGEEWpdRKP-REKKLITVQVVPVAARLLLEMFS 200 human
Q14653       336 SG-RSPRY-ALWFCVGESWpqDQP-WTKRLVMVKVVPTCLRALVEMAR 380 human
Q4JF28       332 SR-RSPLY-TLWFCVGQSWpqDQP-WIKRLVMVKVVPMCLRVLVDIAR 376 domestic cattle
Q90643       413 RE-RSPDF-TIFLCFGQCFssTKP-KESKLILVKLVPQFCEYWYEQVQ 457 chicken
NP_001300708 299 RG-GSPDY-TIYLCFGEKLhdGKP-LEKKLITVKVVPLICRELHERAQ 343
Q4H3B1       497 RK-REAIDhSIHLSLGKKP--ETR-RCKTFIGLKLIPKVAETLLALLT 540 vase tunicate
1ZOQ_A       141 SG-RSPRY-ALWFCVGESWpqDQP-WTKRLVMVKVVPTCLRALVEMAR 185 human
XP_046755345 205 QG-RFPDS-RVMLCFGEEFp-dTVpLRCKLILVQVeqlcvrqvmeeag 249 chicken
XP_003967453 345 NG-GSPEY-TINMCFGEKFpdGKA-LEKKLVSVKVVPLICQHLHEMAH 389 torafugu
NP_001122338 452 NT-ISPNEgSVKLVIGTKPs--SI-RSVGLVSLTIQSACADILIKQFS 495 vase tunicate
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