1J2F


Conserved Protein Domain Family
IRF-3

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pfam10401: IRF-3 
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Interferon-regulatory factor 3
This is the interferon-regulatory factor 3 chain of the hetero-dimeric structure which also contains the shorter chain CREB-binding protein. These two subunits make up the DRAF1 (double-stranded RNA-activated factor 1). Viral dsRNA produced during viral transcription or replication leads to the activation of DRAF1. The DNA-binding specificity of DRAF1 correlates with transcriptional induction of ISG (interferon-alpha,beta-stimulated gene). IRF-3 preexists in the cytoplasm of uninfected cells and translocates to the nucleus following viral infection. Translocation of IRF-3 is accompanied by an increase in serine and threonine phosphorylation, and association with the CREB coactivator occurs only after infection.
Statistics
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PSSM-Id: 402154
View PSSM: pfam10401
Aligned: 28 rows
Threshold Bit Score: 166.276
Threshold Setting Gi: 193083009
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1J2F_A        34 EFEVTAFYRGRQVF-QQTISCPEgLRLVG-SEVGDRTl----------------PGWPVTLPDPGMs-LTDRGvMSYVRH 94  human
Q4H3B1       349 QYSLRVKYQQHEVLeRDLMEMNLgYRIHY-GDPDQQCylmkidepqrselivdfERPAISLPQVKT--IGGKG-TNGFQK 424 vase tunicate
NP_001122338 313 MYKVTLKYNGMVVK-SEKLSLAKgVRFMF-GSPLLQKnvveafr---sgerelvDLQTWEFPEQQM--LSSN--SANIDS 383 vase tunicate
AAI53603     194 RLELRVFYYGRVVE-SVLSCSPDgCFLLQgCAPVGSEriy-----------gpcAATQLFFPPPNAamLPT-GiCEAMTR 260 zebrafish
Q15306       251 RLHICLYYREILVK-ELTTSSPEgCRISH-------Ghty-----------dasNLDQVLFPYPE-----DNGqRKNIEK 306 human
XP_005163709 248 RLHVSLFYRESLVK-ELTTSSPEgCRISSsASPGSPSspssps-----eerlygGAEPVLFPFPY-----PQSqRRGAEK 316 zebrafish
Q5PNN7       230 RLHVMVFYRDALVR-EVTVSSPEgCQLGP---SREGQaya-----------spgAPELVELPHADG--VP---------- 282 zebrafish
CAF98086     259 RLHVSVFYRDSLVR-EVTISSPEgCHLTP-CSPDEKPypq------------agSPEVVPLPVDSL--SPPRRtDDGPPS 322 spotted green p...
NP_001350836 214 QMVISFYYGGKLVG-QATTTCPEgCRLSLsQPGLPGTkly-----------gpeGLELVRFPPADA--IPSERqRQVTRK 279 human
EOB03518     148 QMVINFFYGGKLVG-HITTSYPEgCRISLsQPSGPNEkly-----------apdALEHVRFPSAEA--IQNDRqKQITKK 213 mallard
1J2F_A        95 VLSCLGGGLALWRAGQ-WLWAQRLGHCHTYWAVSEELLPNsghGPDgEVPKDKEGGVFDLGPFIVDLITFTE-GSGRSPR 172 human
Q4H3B1       425 VLKNTDAGLVFTQDEDhNLFCKRLCQSRVFAFSRYGEDNDd-kHPI-KLEREATVLLFNLNLFITDWINCLKtSRKREAI 502 vase tunicate
NP_001122338 384 ILKSTDLGIVLQAQQN-GLTAKRLCQSQIFYFDQSNQGGH----SV-KLERKVAIEVLSHAKWVRSLLEQQRgSNTISPN 457 vase tunicate
AAI53603     261 LLPHLEKGVLLWVAPD-GLFIKRFCQGRVYWDGPLAEHRH---KPN-KLERERTCKLLDMKIFSQELLNYRQ-GIGPEPQ 334 zebrafish
Q15306       307 LLSHLERGVVLWMAPD-GLYAKRLCQSRIYWDGPLALCND---RPN-KLERDQTCKLFDTQQFLSELQAFAH-HGRSLPR 380 human
XP_005163709 317 LPNVLERGVLLWLSPD-GLYAKRLCQGRVYWEGPLAPYAD---KPN-KLEKEQTCKLMDTQQFLTELQGFIH-HGRPMPR 390 zebrafish
Q5PNN7       283 ----LERGVILWMAPD-GLYARRCCPCRVYWTGAHAPPTD---KPN-KLEREQNCKLLDTHLFITELQSYTL-HARPAPC 352 zebrafish
CAF98086     323 PPSTLEKGVFLWMGPD-GLYARRLCQSRVYWQRGSSQYAD---KPN-NLERGVSYKLLHTQDCLAEIQSYGL-HGRPPPR 396 spotted green p...
NP_001350836 280 LFGHLERGVLLHSSRQ-GVFVKRLCQGRVFCSGNAVVCKG---RPN-KLERDEVVQVFDTSQFFRELQQFYN-SQGRLPD 353 human
EOB03518     214 LFGHLERGVLLHSNKQ-GIFIKRLCQGRVFWSGNTMVYKD---RPN-KLDRDEVVKIFDTNLFFRDLQQYYN-NQGRYPD 287 mallard
1J2F_A       173 Y-ALWFCVGESWp-qDQPWTKRLVMVKVVPTCLRALVEMAR 211 human
Q4H3B1       503 DhSIHLSLGKKP---ETRRCKTFIGLKLIPKVAETLLALLT 540 vase tunicate
NP_001122338 458 EgSVKLVIGTKPs---SIRSVGLVSLTIQSACADILIKQFs 495 vase tunicate
AAI53603     335 Y-IVELCFGEEFpdpTQPKNKKLIRAQVTPMFAVDALRKLK 374 zebrafish
Q15306       381 F-QVTLCFGEEFp--dPQRQRKLITAHVEPLLARQLYYFAQ 418 human
XP_005163709 391 S-QVILCFGDEFp--dPQRQSKMITAQVEPMFARQLLYFAS 428 zebrafish
Q5PNN7       353 S-QVLLFFEDESt--eGQRPRRTYTVQVEPLFARQLLILTH 390 zebrafish
CAF98086     397 F-QILLSFGDECl--dPQRLRRTLTVQVEPLFSRQLLYYAQ 434 spotted green pufferfish
NP_001350836 354 G-RVVLCFGEEFp-dMAPLRSKLILVQIEQLYVRQLAEEAg 392 human
EOB03518     288 S-RVTLCFGEEFp--dPTLRCKLILVQVeqlflrqvvedte 325 mallard
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