Conserved Protein Domain Family
Utp8

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pfam10395: Utp8 
Utp8 family
Utp8 is an essential component of the nuclear tRNA export machinery in Saccharomyces cerevisiae. It is a tRNA binding protein that acts at a step between tRNA maturation /aminoacylation, and translocation of the tRNA across the nuclear pore complex.
Statistics
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PSSM-Id: 402149
View PSSM: pfam10395
Aligned: 24 rows
Threshold Bit Score: 459.105
Threshold Setting Gi: 213407446
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q9P3A9         1 MASFGELSFLSEISNIHKSNKKHEIQSAGTVALdNGVESP-YYICVQVENQGIEVYHMKDE-RLFASCPLPEKTRFSCSP 78  Schizosaccharom...
EPY50902       1 MASFGELSLLGEISVSSNAEKKDEYRSSGTVALeNGQESS-SFIAVQIEKHGIEIYNLKEE-RLFASCPLPEKTVFSCKP 78  Schizosaccharom...
XP_002616815   5 IPGLGESYSLTELPRIPDL-SLPERVVVSESQNgKSYLST-ETIDLGISKSIISSYVLKPTpKLCWSYPLSPSTIVDSMD 82  Clavispora lusi...
EDK38524      13 GAFFEDSYPVHALSRLADL-SLSKKAVFATPTS----FKA-SQIDVGVSRSLISTFALKPTpKLVWSYPLPPSTIVECMD 86  Meyerozyma guil...
XP_001382358   5 VPSLSYNYPLSTLPRTSDL-KLHEKVVIPAISS----AEP-DSIDVGISKSIISSYIIRPTpKLIWSYALSPVTIVDCMA 78  Scheffersomyces...
EER30138       3 KPDLYDQYMITSLPRTPDL-QLSEKVVVPRISS----IDS-SIIDLGISKSIISSHITRPTpKLIWSYALNPTTLVDCMD 76  Candida tropica...
EMG45327       3 QPDLYDQYMITSLPRTPDL-KLSDKVVVPRISS----VDT-SIIDLGISKSVISSHITRPTpKLLWSYALNPTTIVDCMD 76  Candida maltosa...
CCE44174       3 SPQLTDQYHVLSLPRVNDV-PLPQKLVIPQINQtDVSSTS-SIIDIGVSNSMLASYITKPSpKLIWSYSIKPTVGIKCID 80  Candida parapsi...
XP_001527468   3 LPSFTNQFPVAVLPRVGDV-DLNERVAFPPLTSlASSSDDlTVVDFAVSKSMIASYLIKPSpKLLWSYALRPSAIVESID 81  Lodderomyces el...
XP_002770425   2 APSLSDSYSLVSLPRITDL-DLSHQVVIPTISS----TNT-THIDIGISKSIISSYILKPTpKLVWSFPLSPSTIVECMD 75  Debaryomyces ha...
Q9P3A9        79 IYIKEGNWH---YIWTCT-SLKsNgEWKILL-------WKFNDLEEESEVVYRDISNQ-QIFALHFISSTGq--LVIVFR 144 Schizosaccharom...
EPY50902      79 MYLHEGNSH---YIWACTsSARsKgEWKLLS-------WKYNDLKEHGEVRFRDLLNK-PVFSIHFIPSSGq--LVLVFV 145 Schizosaccharom...
XP_002616815  83 VKD---------SLYLVGlTERkK--SKLLMi---------qKTGDESVVTGEFSLSV-PAVAVKFSSTKS---AYVLLK 138 Clavispora lusi...
EDK38524      87 VHTVGDEE----KRFVVGlTDGrK--HKLVLi----------DRKGETSNVSEINVNG-KIVGVKFAGHGHgniIFVCMH 149 Meyerozyma guil...
XP_001382358  79 VCEKENN-----KLYIVGvTERrK--HKLLLlnrs----ltgSAEDSTTETMELKLEE-RLKDVKIFNDGAl--IVAVYE 144 Scheffersomyces...
EER30138      77 VIVKDDT-----KYYICGlTDRkK--SKLLLletkrtvTEDGNANYATSNEVELKLNN-KVVGVKFMGTQDl--ITILYE 146 Candida tropica...
EMG45327      77 VLVKDDL-----KYYVCGlTDRkK--SRILVlettstlTEDGNANYSTSKELELKVSK-SVIGVKFM-TAEl--IVVLYA 145 Candida maltosa...
CCE44174      81 VWHTTTTR----KLYIAGlEERkK--PRILVietengsTEDGSFSISTVGEMELAVGKdQVVAVKFLSTED---IVVVYQ 151 Candida parapsi...
XP_001527468  82 VLDQNADGK---KYYLVGiTERrN--YQILLvetdvgtTADGNVNITTSKEYTLTKTDdRILLVKFLSLQK---ILVSYA 153 Lodderomyces el...
XP_002770425  76 VQEVDGNGTdfiKNYVVGtTERkT--NKVLLi----------KRHNDSADHFEIKLDS-KVKGVRFSQCGKf--VYAILS 140 Debaryomyces ha...
Q9P3A9       145 NGKIAFLDPEDD-----------KVHMSASVNESATLLQSMYVPsQ-------------ANpiDAVRLASNeasgTNNNP 200 Schizosaccharom...
EPY50902     146 NGEISFLDPEDD-----------LIQTSASIKGNATLVKTGSVSnHvek-------diiSNstSEDKSAVVdgtgKDQSG 207 Schizosaccharom...
XP_002616815 139 NGDLELYNFSIEdsiiiekvpelTNLTQGTSKASSVMFSRFISDhNlkynhdlfffisrSNskLTYRLIAL------EGT 212 Clavispora lusi...
EDK38524     150 NGATKLYRKSVEgk-------lqEVSELSGAKGSKVIFNCFVAEkElgnehellitvecHGkeWAYRMISL------TET 216 Meyerozyma guil...
XP_001382358 145 SGSIDMFKTEANslvs----tvvEPITKKSKNAPKLLHSQFIDDlSitdrknfvvlafhDKthLHFKLVAL----NIASS 216 Scheffersomyces...
EER30138     147 NGSVEQVKFSGSeln------lgDNKLTTSKSKEKVVFNAFVNDlEeelll----avseNSknTIFRLVSI-----NPVK 211 Candida tropica...
EMG45327     146 DGSVESVKFVDDelt------ltGNKHGSTQKGETIVYNTFIQDlEedlll----visnNKknTIYRLISI-----NPAK 210 Candida maltosa...
CCE44174     152 SGSVQMVNYNEK-----------LTFGTKYQNEGNVIYSTFITDlDdllll----tvsrSKtlTTYNLISI------STS 210 Candida parapsi...
XP_001527468 154 SGTVEIISFDSEkded----alqSSTKIESKRREHVIYSTMVTDlEgtlllk-vskptsSKttLIYKLISIt---FDTTQ 225 Lodderomyces el...
XP_002770425 141 NGGIKLLKINEDsf-------edVSLDLKLKSGNELVYHKFISShEfkynndllltiesNErsLVYKLTSL------NYE 207 Debaryomyces ha...
Q9P3A9       201 KEIEMNsdttssvpksgSTSFSANVTSSTSMVYL---LYSVHVDKiiqyyVDSFSVSerrlvntravvlkevqapshilm 277 Schizosaccharom...
EPY50902     208 EDLSPS---------------SLSSLSTTTNIYL---LYALSVEKikqfyMSVFSTSekrilftkpieldsstspahvll 269 Schizosaccharom...
XP_002616815 213 KSFELY-----------QTSIPFSKPESLCFAYSdgtVYQFDKKTk---tISSSSLM----------------------- 255 Clavispora lusi...
EDK38524     217 RLLEVH-----------QVLVPGQ--KDCIFAYNcgqLFCLNISTk---eISLLDIP----------------------- 257 Meyerozyma guil...
XP_001382358 217 SFFEVN-----------SAKIEVADPASSKIAYAagfLYHLNPAAk---eITSYTIP----------------------- 259 Scheffersomyces...
EER30138     212 SIIQVS-----------SSSVPLV--EKAQYCYVsgtLYQYSNMK-----IASLPIS----------------------- 250 Candida tropica...
EMG45327     211 SIIEVT-----------SSVVPLV--QDAQYCYIsgtLYQYTDKK-----INSLSIS----------------------- 249 Candida maltosa...
CCE44174     211 KILPVQ-----------SYQTKPV--TGASYTYSsgiLYQYHDGV-----IDSFSIT----------------------- 249 Candida parapsi...
XP_001527468 226 SLAEV------------QNIQKEFKLDSCSFAYNagiLYQYYDSR-----IEAISIV----------------------- 265 Lodderomyces el...
XP_002770425 208 KSFEIN-----------Q--FSHFAECQCIFTYQsgvLYEFNIDKl---eISSRSII----------------------- 248 Debaryomyces ha...
Q9P3A9       278 skdstsiytisleglsiyslhdeskSYMLIK-ILHFQSI-------SKIEHIELISDNFLLIQHDSQLSLWDITFGTIQD 349 Schizosaccharom...
EPY50902     270 tkncekvfgffsnsvfvyasnestsSYQREK-SFQLENI-------PALSNVHLILDKFCLVQTKSQVSLWDLTYGTIQD 341 Schizosaccharom...
XP_002616815 256 -------------------------KPQETLkSFSLKNIigk-sssKSLFSMTSPSSERIILSHESSIFIISFKYESVLG 309 Clavispora lusi...
EDK38524     258 -------------------------SFSIVK-TISVAPLiqq-ktpLEAISLQVPAQNRLILGVKGTISLISFSFECLLD 310 Meyerozyma guil...
XP_001382358 260 -------------------------TFNSQR-TISVRALfpd-tfqAEEVSFFSPSIDRVLLSVANKIHLINFKFSCLLD 312 Scheffersomyces...
EER30138     251 -------------------------NFNIAK-TISVSSIid---neEQIVSLVAPAQDRILLGNASKLYLVNFQFASLLS 301 Candida tropica...
EMG45327     250 -------------------------NFTITN-TMSVEPIid----dEEPTSITAPAPDRILLGNSNKLYLLNVKFSSLLS 299 Candida maltosa...
CCE44174     250 -------------------------NFHIQK-SVSVLPIin----tEELVSIVSPAPDRILLGNANMIYLLNFKFEAVLS 299 Candida parapsi...
XP_001527468 266 -------------------------NFTNTKhTLALDSIie----pNFAVSLKAPAPDRVLLANGDKLYLINVKYGALLS 316 Lodderomyces el...
XP_002770425 249 -------------------------DFKVLK-SITVNSIidaptkaINDYSIICPSVDRLLLSWKSKLYLINFKFQSLLD 302 Debaryomyces ha...
Q9P3A9       350 V----YDLKQKPTILTFTCYKSSLKKMNQn--SQLTGYIAVLLKKGlaivPYTLPIKMLLADAVGKRTSKIGKLRGTNEl 423 Schizosaccharom...
EPY50902     342 V----LDTGNDTTFITVTINKNPSKRSSLklnSTVSGNIILLQKKTiasvPFTMPSVMSLADAIGKRKSKIGKILTKPEt 417 Schizosaccharom...
XP_002616815 310 E------HTNNSHNQVFLTFALPVAGNTTetrNSFALYLNFEEKTK-----TCKLKSIQIDVGLNLLSESLGKSLHNSS- 377 Clavispora lusi...
EDK38524     311 S--------FNMKGDIYLGSVVPTQGQRT-----FISFLHFNSDKN-----TTKIHMMNANVGRGTVAECLGKSMHRNE- 371 Meyerozyma guil...
XP_001382358 313 T------FESPNPDKVLINQVVKVKGSGRd-tKSLAVYLYLKNKDN-----NVYLNVINIDVGLNILSECLGKSIDKNS- 379 Scheffersomyces...
EER30138     302 TfkssSSSTHPVPDIVYINQVIQVKGNSTntcVSSAVYLNVKNKDN-----NVYLNVIDINVGLNKLSECLGKGLDKET- 375 Candida tropica...
EMG45327     300 TftssATSSHPIPDKVYINQVVPVKGNSTnsfISMAVYLNLKNKNN-----NVYLNVIDINVGLNKLSECLGKSIAKPK- 373 Candida maltosa...
CCE44174     300 QfksvSSTSNPVPDKVYLNQVAQVKGSSQstqSTRAYYVNLKNKDN-----NVYLNVIDVNVGLNKLNECLGKSIEGGN- 373 Candida parapsi...
XP_001527468 317 EyksvSSSSNPVADIVSICQVISVKGQSQntlNTTAFYLNLKNKDK-----NLYLNVVDVNVGQNKLSECLGKALTFAS- 390 Lodderomyces el...
XP_002770425 303 T--------YTRPDKIYIKQVVDVKGSSAntsSTFAVYLHYNARKK-----NTSLNIINVNTGINTLSECLGKSIVKRT- 368 Debaryomyces ha...
Q9P3A9       424 igegVlTKSKNGPSMRDQLLKNIQLQDHSL-------RDELISLRSlaEQKNTIEFDAKFLGVVERYQ------------ 484 Schizosaccharom...
EPY50902     418 iadgAlTKSKSSVTLCEQLLKNVQLQDHSL-------RDELHQLHTyvQNQDGESFDVKFLKFVEGFQ------------ 478 Schizosaccharom...
XP_002616815 378 ----E-IKWNGFPALEDENMIEANKKIVKe------lERTDKNLLQdqAQKNTSAFDSHVVEFLKNapleen-------- 438 Clavispora lusi...
EDK38524     372 ----A-VVSQGIPFILDEDLTESSKIGANe------fGAVLDKLRElrSQKSVEKWERVAVPFMKN-Eswesitkalnk- 438 Meyerozyma guil...
XP_001382358 380 ----NeDFFKGLVDLAKQDFETESESLSQe------lGEVFHHLQEakRTRDFNKWERILIPYLKN-Edwdvikkslksk 448 Scheffersomyces...
EER30138     376 ------NDFHVIPDLFNEDSTNNVNDDe--------vKEVFELLREakEAKDLNKWESILIPYLKNRKswasiknsiskk 441 Candida tropica...
EMG45327     374 ------LALREVPELFETKETPQSDe----------iEEVYQFLKDakESSDLNKWESILIPYLKNRKswtsikssiskt 437 Candida maltosa...
CCE44174     374 ----N-QDFSQVVDLYNGDDNEPTAPTSGe------lDQVYQTLEQacKAKDVNKWESILIPYLKTHKswqeinksk--- 439 Candida parapsi...
XP_001527468 391 ----G-KSLQNPKDLYDENSLKTTSHTDANghskselDEVYDSLKEaqEQKDIDQWESILIPYLKNKKswkeikqkqkqk 465 Lodderomyces el...
XP_002770425 369 ----N-DDFKGLTNVINDSFDKESTKISKe------lKEIYDELVElkTKKNINKWESIVVPYLKN-Eswtsikkalg-- 434 Debaryomyces ha...
Q9P3A9       485 --------------NQYANNCKilktsSVLPIPFAHAIESLLFSLDe-------ENELqvscAaSgTLNYLIRHRLF--- 540 Schizosaccharom...
EPY50902     479 --------------VQNSTNRKllktnSVLPIPFVHAIESILFSSNe-------EQDLdllcPaKaTLNYLLRNRLF--- 534 Schizosaccharom...
XP_002616815 439 --------ttykfsSL---TDR------VVDARFIESILAMIFEIDesesvqiiNEEFv---P-QtTLTYLFTHPLYpek 497 Clavispora lusi...
EDK38524     439 ----tkkhktypysAFDIDTDR------SLDPSFVEQIISIIVGgdq----fvlDPEFl---P-EhTVVYLLTHPLFpik 500 Meyerozyma guil...
XP_001382358 449 ---kktsekvykfkEFEVESDR------AVDVNFVTKVLSLIFKINtskvvefaDPEFi---P-EhTLIYLLTNPIFpve 515 Scheffersomyces...
EER30138     442 ---tkkadkvyefkEFEDNSDR------VVDIKFIDSVLDLIFTgnpp---efvDDGFv---P-EyTLMYLLTNPLFplk 505 Candida tropica...
EMG45327     438 ---skktdkvyefkEFEDNLDR------VVDINFVESVLDLIFTpsnp--pnfvNEGFv---P-EyTLMYLLTNPLFpik 502 Candida maltosa...
CCE44174     440 -----pksktyqfkEFDVENDR------IVDVNFINSIFDLIFTtepl---qfkDAQFi---P-EyTLMYLLTNPIYpka 501 Candida parapsi...
XP_001527468 466 nlksrkkdqvyqfkEFEVEHDR------IVNIEFVQSLFELIFVtsps--lqfkDADFi---P-EyTLMYLLTSPIFpss 533 Lodderomyces el...
XP_002770425 435 -----kntparefsVFEVEQDR------IIDPAFISKVLSLIFDe---------QSDFi---P-EyTLIYLLTHPLFpye 490 Debaryomyces ha...
Q9P3A9       541 ------------SYSTLVQkgfsGSVFDC----LYKFQKDIAFN-------------------------FLERTSDISAY 579 Schizosaccharom...
EPY50902     535 -------------TSSILRlhpsRSLFNC----IYKFQKESALL-------------------------LLERTLDLPAF 572 Schizosaccharom...
XP_002616815 498 yakgllmllsqlNQPDLLK----QAIDNCvgltIEELTQELINLvelldemdaeekedayyissflkatINRLSTDYSVG 573 Clavispora lusi...
EDK38524     501 ythglteelaklGNEDLLK----QALITCpnlpIDHLCRQLLDSdtgv-----------------faesASRLVAEKSIL 559 Meyerozyma guil...
XP_001382358 516 ytrgllklfsrsEQVTLLR----QAIITCpnltIHELLLQLFSShndev---------------ifsdlINRLIGVFATV 576 Scheffersomyces...
EER30138     506 ftpglvqlfndtGNTTLLR----QAINTCpgipCRDLVLQLVFEednet----------------msdlVNRIVGEFSRY 565 Candida tropica...
EMG45327     503 ftpglvqlfnntGNVTLLR----QAVNTCpgipCRDLLLQLVYDddket----------------lvdlVNRVHGEFSRQ 562 Candida maltosa...
CCE44174     502 yttnlvqllhdtGNITLLK----QAIKTCsnipLNDLLIQFVTTedmdi----------------fnelINRIVSDFAVT 561 Candida parapsi...
XP_001527468 534 yaqgliplfeqvNNKTLMR----QAIITCsnipLKDLVQQFVKEsdldv----------------ftdlIDRIVVNYSIS 593 Lodderomyces el...
XP_002770425 491 htkglltlftqlDKPRLLR----QAIITCpnlsIEEISLQLNNDnldi-----------------fqdvITRLISEFSVN 549 Debaryomyces ha...
Q9P3A9       580 EIACAIKTAinsskVKllrsalarlslfdsttsrealllafvpedFDslFKTLGNLVVDSNLASVKFnl--eTYIYCLSV 657 Schizosaccharom...
EPY50902     573 EVGCAIKKAlatmkTKllkigllrlsqfdcveaqeallltlgqedFDllFK-LICASITGKKTSVPLnldveILIYVASI 651 Schizosaccharom...
XP_002616815 574 EITSKLQEIlnieyES-----------------------------ANkkLEHLLNALIDINNNQ---------SWTLLQA 615 Clavispora lusi...
EDK38524     560 EITSSFKRVlqemnSS-----------------------------QG--LDTVLNRLLEWDSNK---------KWILVQA 599 Meyerozyma guil...
XP_001382358 577 DINKEFKKLlqneeSS-----------------------------VN--LNDLLNRLLQVKNNH--------KSWNLIEI 617 Scheffersomyces...
EER30138     566 EIADTIKDVlqnegEQ-----------------------------VD--IIELISKMLKLPGLN---------NWYIIEI 605 Candida tropica...
EMG45327     563 EITSTFKEIfqsdaKS-----------------------------ID--VVELIIKMIGLPGLN---------NWYIIEI 602 Candida maltosa...
CCE44174     562 EITTSLKDImpqysTD---------------------------------TIALINKVLSTSNDK---------GWILVEI 599 Candida parapsi...
XP_001527468 594 EITAVFNEVvksydGA-----------------------------ID--IIGLVNKLLAVKTYN---------NWNLIEI 633 Lodderomyces el...
XP_002770425 550 QITHQLNDIlqskqNN-----------------------------LN--LETILNNLIKLNNNQ---------SWYLIQS 589 Debaryomyces ha...
Q9P3A9       658 VLDAMGVggvasSSENLEAARILYNDLQEKLTNLTamslvlpaiseivkrkkdv---------haervqfyanpqpkaiv 728 Schizosaccharom...
EPY50902     652 VLDAMGVggiaaSTDNLTTAQELYSGLQSKITSLTamslalpavselikhkkka---------iaektfvhpnpqpkavv 722 Schizosaccharom...
XP_002616815 616 VIDVGGL-----FNWSLPTVNKLSEVIDAKVEALTqnsynltltsqaviglqnag------kkgakkstpkvvdnihein 684 Clavispora lusi...
EDK38524     600 IIDVGGL-----LNWPASTVDSLESIIARRITSLTtnsynltlvgqallsaqpsk------kskktkktakandiiesng 668 Meyerozyma guil...
XP_001382358 618 TIDAGGL-----FNWSLDTIEKLNELIETKVHALMensynltltnqvllfnepaskkk-skkkskptgksvtddivsnnv 691 Scheffersomyces...
EER30138     606 LIDVNGL-----FNWDMVDVNALNEIVTQKIEALTinsynltlsnqvl---------------------lhsekktskkv 659 Candida tropica...
EMG45327     603 LIDVNGL-----FNWDMIDINALSEIIDQKIEGLTvnsynltlsnqv-----------------------mlhnniskkt 654 Candida maltosa...
CCE44174     600 LVDISGL-----FNWSQENILRLNQIIDARLANLDinaynltlidq------------------------vqlkknqlkk 650 Candida parapsi...
XP_001527468 634 LININGL-----FNWTDENIERMESLVDSKIEVLDinaynvtlvdqvalkkn-------------qiansskkqkqkekq 695 Lodderomyces el...
XP_002770425 590 IIDVGGL-----FNWSMNTVNNLIEIIEDKLTSIMannynltltnqailinepirklnknkkagkkptdksnniiesnne 664 Debaryomyces ha...
Q9P3A9       729 dDMGDLATLLK---KDFLSEKRKGKSQRARGKEIDMaigkYTVERLEI 773 Schizosaccharomyces pombe 972h-
EPY50902     723 dDKADLATLLK---KDGLAEQRKNKSQRARGRELDItigrYTIERLEI 767 Schizosaccharomyces cryophilus OY26
XP_002616815 685 nQRLQLDAILTinnNTTN-KKLMVDEGIELAKKIPT----YSREKLVL 727 Clavispora lusitaniae ATCC 42720
EDK38524     669 fQQQQLDSILAmndLS---SKKVKDEALKLSQKVPS----YSVEKLVL 709 Meyerozyma guilliermondii ATCC 6260
XP_001382358 692 qQHSQLESIISvknGAK--NKRLDDPSIEISKKYPN----YTVDRLLL 733 Scheffersomyces stipitis CBS 6054
EER30138     660 kEPTQLDNLLTlanKDG--GKKASDET-DLQQKVPV----YSVEKLEL 700 Candida tropicalis MYA-3404
EMG45327     655 kDVTAANSLLTltsKST--SKKPLDDI-DAQRKVPV----YSIEKLE- 694 Candida maltosa Xu316
CCE44174     651 sKNTSVDGALTitdQTQL-NKRMES---DSNEKVPL----YSIERLEI 690 Candida parapsilosis
XP_001527468 696 iMDVEAMGLLKitdQTNLGGKKVES---VVDAKIPL----YSVEVLEV 736 Lodderomyces elongisporus NRRL YB-4239
XP_002770425 665 iQQQQLNSILSiqnNA---GRKLKDEGIEISKRIPN----YSIEKL-I 704 Debaryomyces hansenii CBS767
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