7OKX


Conserved Protein Domain Family
ELL

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pfam10390: ELL (This model is not part of the current CDD release)
RNA polymerase II elongation factor ELL
ELL is a family of RNA polymerase II elongation factors. It is bound stably to elongation-associated factors 1 and 2, EAFs, and together these act as a strong regulator of transcription activity. by direct interaction with Pol II. ELL binds to pol II on its own but the affinity is greatly increased by the cooperation of EAF. Some members carry an Occludin domain pfam07303 just downstream. There is no S. cerevisiae member.
Statistics
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PSSM-Id: 519346
Aligned: 28 rows
Threshold Bit Score: 289.961
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
7OKX_M                11 EEQRYGLSCGRLGQD--NITVLHVKLTETAIRALETYQS----HKNLIPFRPSIQFQGLHGLVKIPKNDPLne------- 77   human
7_pfamImport           1 QQRRYGLSCGKNHGGpgNRTLFHVKLTDTALRALEAHRN----LKESLPGKPSICFKGNQGRLSYMRPITEv-------- 68  
XP_006629044           6 QEERYGLSCGKINKNipNKTLYHVKLTDTAIRALEAYQN----FKASIPHQPVICFKGSQGYIKIPVPSADssg------ 75  
XP_002116407           5 QSGNYTLSRNRSTDD--SIVAVQVKLTDSCLNALDSYIKf---ALKLNEDHPTLSCDGKTGRIFIPDKNGG--------- 70  
2_pfamImport           1 SNQNNGLMPKQRTGK--NKTLFFVKLTDSCLKAVEDYLRccqqGNSENLPKPRIQFKGNEGQLCVPSISKN--------- 69  
WGS:AAPU:GI13662-PB   17 SSGNYGMSQSHRYTDd-TKEYIFLKLTDSAYRAIEEYQRnenaKRLAPGQCAKIQCNGNTGFIHFPLPSSDssnsvnng- 94  
XP_014764500          16 STGNYGMSQRHRYTDd-SKEYIIVKLTDSAFRAIEEYQRddhaKRLPPGQRAKIQFTGNEGVIQFPRSSSDanghhnnps 94  
EDX11139              16 STGNYGMSQSHRYTDd-SKEYIIVKLTDSAFRAIEEYQRddnaKRLQPGQRAKIQFVGNTGVIHFPRPATDangipnang 94  
XP_011605154           6 QEHRYGLSCSKIHKNspNQTRFHVKLTDTAIRTLETFQN----LKASLSNQPAICFKGSQGYIKIPAPTHEspd------ 75   torafugu
XP_064422104           1 -----------------------------------myahspvaLPISLPKQSLISFRGNRGYIKIPDDNYPng------- 38   coelac...
7OKX_M                78 -----------------vHNFNFYLSNVGkdn----pqGSFDC--IQQtfsssGASQLNCLGFIQDKITVCATNDSYQMT 134  human
7_pfamImport          69 ------------------NMFSKNLSAISsilghnsahTRFCS--NXQfvssdGREQLEGQGVIQDKITVCATDDSYKMT 128 
XP_006629044          76 ----------------alRVFSFYLSSDSkdk----pqASFDC--IHQyvssdGREQLECQGSIQDKITVCATDDSYQMT 133 
XP_002116407          71 ------------------RDFQFSCTTLPed------rGPFECysMHQs----HSDKMIYEGSITTRMSIQATDEIYAKT 122 
2_pfamImport          70 ------------------YTFDFSLSNTTdaa---aprSSFEC--IRQn----TSRSLEYVGTLNRHIRVLANDDVYEAT 122 
WGS:AAPU:GI13662-PB   95 ----------sgsgmeagRKFGFTIDDLE---------GTLEC--IQQ-----QQQELDVLGALARRMRIHANDDVYDTT 148 
XP_014764500          95 tngngngngngnsgndpgRKFLFTINNME---------GTLEC--VQQ-----QQQNLGVLGAVTFRMRIHANDDVYDTT 158 
EDX11139              95 ng-----sdatgaggggsRKFGFTINNME---------GTLEC--VQQ-----QQRNLGVLGAVTLRMRIHANDDVYDST 153 
XP_011605154          76 ----------------afRVFSFYLSSDSkdk----pqSSFDC--IHQyvsgeGRDHLEGQGSIQDKITVCATDDSYQTT 133  torafugu
XP_064422104          39 -----------------lRVFSFDVSNDSkdk----phSGFDC--IRQns-cgGQCQLGFLGSIQDKITICATDDSYQAT 94   coelac...
7OKX_M               135 RERMTQAEEESRNRSTKVIKPG--GPYVGKRVq-iRKAP----------------------------------------- 170  human
7_pfamImport         129 RERMSRVKKDNWSRSVIEIKPG--ATHQIKGVkfhKRLA----------------------------------------- 165 
XP_006629044         134 RERVSQVEKETWSRAAIEIKPG--TTHPSKCVkiqKKHG----------------------------------------- 170 
XP_002116407         123 KIKMEKAEEERKESRAKLVNPVskATKGGRn---kSKPVl---------------------------------------- 159 
2_pfamImport         123 RHRMVAVEELHKKSCTREIELDs-KSALSRKIr--KNPAqiranrhn--------------------------------- 166 
WGS:AAPU:GI13662-PB  149 RSKMARVEETEKSKCIREIKPN--QSDIGRKV---KKPAsasshhsgnnnsnnnssnsnsfns----------------- 206 
XP_014764500         159 RTKMAIAEETEKSKCIREIKPN--QSDIGRKV---KKPPsmmsssnnnnnnnnassfssfnsssansgsmttttafhhhn 233 
EDX11139             154 RTKMAIAEETEKSKCIREIKPN--QSDIGRKV---KKPPttiqssastasafsssnssnsgltttafhhhsncnnsgnnn 228 
XP_011605154         134 RERMSQVEKDIWSRTAIEIKPG-----PSKCIkvqRKQA----------------------------------------- 167  torafugu
XP_064422104          95 RDRVTQVEKESWSRTAIEIKPG--ATYRSKGVnvaKKPG----------------------------------------- 131  coelac...
7OKX_M                   --------------------------------------------------------------------------------      human
7_pfamImport             --------------------------------------------------------------------------------     
XP_006629044             --------------------------------------------------------------------------------     
XP_002116407             --------------------------------------------------------------------------------     
2_pfamImport             --------------------------------------------------------------------------------     
WGS:AAPU:GI13662-PB      --------------------------------------------------------------------------------     
XP_014764500         234 nnnnnsginnnnnsssnsfnnnnnnnnhsrklasspfnglgvgmgggsnsatnsasssinsssaaaaayssrspnpsmlg 313 
EDX11139             229 nsissfnsfnsn-----------------------------------------nhsrklgsspfnglgvgssssssafas 267 
XP_011605154             --------------------------------------------------------------------------------      torafugu
XP_064422104             --------------------------------------------------------------------------------      coelac...
7OKX_M               171 --------------------------QAVSDTVP-----------ERKRSTPMNP------------------------- 188  human
7_pfamImport         166 --------------------------PLCASEN------------SFQRQSASN-------------------------- 181 
XP_006629044         171 --------------------------APMPGDSF-----------PSHKHSPTG-------------------------- 187 
XP_002116407         160 --------------------------LRPTRTIP-----------ASKPLLPSRSt------------------------ 178 
2_pfamImport         167 --------------------------------------nnsynnvNITNNVPKPIiskpipp------------------ 190 
WGS:AAPU:GI13662-PB  207 ---nnsrklvsspfngltsssvataaTAVAAAAT-----------SIASRSPNPNilgasgtvngsrstalantfangis 272 
XP_014764500         314 asgtvngttgggggryhhqyhggagaGAASSLAStfasg-isqgyNMSGSSPRDSaqgqmsggangr------------- 379 
EDX11139             268 rspnpstlgasgtvngsgvgggryggGAASSLAStfangisqgynNLSGSSPRDSmtagtsgatassaiss--------- 338 
XP_011605154         168 --------------------------LVTGSE-------------SSNKLSPSN-------------------------- 182  torafugu
XP_064422104         132 --------------------------LCSISKGL-----------NFRKSSPASP------------------------- 149  coelac...
7OKX_M               189 ------------------------------------------ANTIRKt---------------hSSSTISQRPYRDRVI 211  human
7_pfamImport         182 ----------------------------------------------RRn---------------sCIATATHKPFRERII 200 
XP_006629044         188 -------------------------------------------AGPKRs---------------sTPSPVAHRPLRDRII 209 
XP_002116407         179 ----------------------------------------------------------------nYVTTSSNKPYKDRVI 194 
2_pfamImport         191 ----------------------------------------------------------hiplptnHASDISKKPLRDRII 212 
WGS:AAPU:GI13662-PB  273 qgyalsgssprdsnsttagtvagtalggsfnsngrnkmlngsGSNSRSgntksggangngggngnKMSDVSRRSIRERLI 352 
XP_014764500         380 -------------------------------srmasgggnatGASSRSannks--------sggnKMSEVSRRNIRERLV 420 
EDX11139             339 --------------------------rnkmpsggltssnsnsSSSSRSannks--------sggnKMSDVSRRNIRERLI 384 
XP_011605154         183 ----------------------------------------------KRs---------------lVPSPVAHRPLRDRII 201  torafugu
XP_064422104         150 ------------------------------------------TQMPKKa---------------aATSTLTHRALRERLI 172  coelac...
7OKX_M               212 HLLALKAYKKPELLARLQKDG-VNQKDKNSLGAILQQVANLnsKDLSYTLKDYVFKELQRD-WPGYSEIDRRSLESVLSR 289  human
7_pfamImport         201 HLLALKAYRKPELLLWMEQEK-ASPRDKAELGGILEEVAKVnpKDGSYVLQDHFYRLVQKD-WPNYSEEERRLIGRLLAR 278 
XP_006629044         210 HLLALKPYRKPELILWLERDR-ASPKDKADLGSVLDEVAKLnpKNHSFTLKDEFYRHVHRD-WPGYTEDERQHIHRLLAR 287 
XP_002116407         195 HYLAIQPLNKLELLTRLHKDGrANKKDTNRLGSILKEVAVM--KNNKFYLHKHLYSEVQVDkFSSYTENDKRLVALNISK 272 
2_pfamImport         213 HLLALRPYKKPELISILNRDG-LKDKDRTQIMSVLSHVAQA--KDNAYYLLRHIWNEVQED-WPFYSSQDHIVLKRRKPQ 288 
WGS:AAPU:GI13662-PB  353 HLLALKPFKKPELYARLKNEG-IKDRERNLIGNILTDISTM--SHNTFNLRRQMWNDVDEN-WPFFSEQELQQLKRRKPQ 428 
XP_014764500         421 HLLALKAFKKPELFARLKNEG-IRDRERNQITNILMDISTM--SHNTYNLRRQMWNDVDEN-WPFFSEQELQQLKRRKPQ 496 
EDX11139             385 HLLALKAFKKPELFARLKNEG-IRDRERNQITNILMDISTM--SHNTYNLRRQMWNDVDEN-WPFFSEQEVQQLKRRKPQ 460 
XP_011605154         202 HHLALKPYRKPELLLWLERER-AGPKDKADLTSVLEEVGKLnpKDNSYALKDEFYRHVQRD-WPGYLEEEKQFVHRLLIR 279  torafugu
XP_064422104         173 HLLALKPFRKPELILWLEREG-AHPRDKTELPSLLDEVAKLnpKENSYSLKEELYRLVQTD-WPGYSKEDRQLLHRLLLR 250  coelac...
7OKX_M               290 KL 291  human
7_pfamImport         279 WV 280 
XP_006629044         288 KL 289 
XP_002116407         273 YC 274 
2_pfamImport         289 NL 290 
WGS:AAPU:GI13662-PB  429 NL 430 
XP_014764500         497 NL 498 
EDX11139             461 NL 462 
XP_011605154         280 KL 281  torafugu
XP_064422104         251 kq 252  coelacanth
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