Conserved Protein Domain Family
ZGRF1-like_N

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pfam10382: ZGRF1-like_N (This model is not part of the current CDD release)
DNA helicase ZGRF1-like, N-terminal domain
This domain can be found in human 5'-3' DNA helicase ZGRF1 and similar eukaryotic proteins. ZGRF1 promotes repair of replication -blocking DNA lesions through stimulation of homologous recombination (HR). This domain can also be found in Mte1 (Mph1-associated telomere maintenance protein 1) from Saccharomyces cerevisiae, which is involved in telomere maintenance and in and fission yeast Dbl2, involved in meiotic chromosome segregation. However, there is no evidence to suggest that this domain, which is predicted to adopt an all-beta structure, is implicated in DNA damage resistance or nuclear focus formation.
Statistics
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PSSM-Id: 519342
Aligned: 74 rows
Threshold Bit Score: 50.5848
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_007409418  34 IKKYSCMYTSDVYKNKKVWHDGEVRLHHVNSKAYLYSDRSDRLAETFVKaAsrrsrltsqpnagpscqlpdTFALTEDDE 113
Q6BKR7         9 VHEYTILYSNRIIQKDKKWNDGKLKYYEFNNKLEVFNEDGNLIEVDFISeKf-------------------KHNLVERNE 69  Debaryomyces ha...
XP_002547401  12 IHEYEILYTARVIQKSKKWNDGKLKFYEFNRKIEIHNESGHLIATDFYKnKpvg--------------vilEKLFFENNE 77 
EMG47204      12 IHEYNILYTSRVRQKTKNWIDGKLTFYEFNQKVEIHNENNLLVATDFYKnRtvn--------------dllNNLLKEDQE 77 
XP_007374494   8 VHEYQVLYSNRVRQKDKKWNDGKLQFYELNSKLQLFNSDNHLISTDFIRdRpis--------------filANVLVEDNE 73 
XP_001385666   9 VHEYNVLYSSRIHQRDKRWSDGILRFYEFNSKLEVANEHGIIITTDFIKnKpns--------------htlSKTLVPDNE 74 
XP_002615758   7 VHDFKALYSTRVHQKDKRWVDGRLRYYEFNKKIEVLSEEGSLVMSDFYPqNakp--------------pleSGVFEDGNT 72 
XP_006683693   6 VHEYSILYSDRLVQKDKKWVDGFLRYYEFNNKVEILNEDEQLVKGDFK-----------------------NISFEVGKQ 62 
XP_001486902   9 VHEYRVLYSTRIVQKDKKWCDGILRYYEVNNKVELSNPTQLLLVSDFLSgSvgf---------------vmSEMLASGHE 73 
XP_011273926   9 VQEYTIMYTFNIVQKIKKWNDGKLKFFKFNNKVQVFNEDSILVTSQFLQnDk------------------mLQMDTWGSE 70 
XP_007409418 114 IEFNQveddhqlrascYLAQIVNLIE 139
Q6BKR7        70 FKLPNn---------rLLIEIDCKLS 86  Debaryomyces hansenii
XP_002547401  78 FKLPNa---------nFLIQIQGKLR 94 
EMG47204      78 FKLPNc---------gYLIQMLEKIG 94 
XP_007374494  74 FAFPSn---------kYIIQIQDKMG 90 
XP_001385666  75 FKLPNn---------kLILQISDKIS 91 
XP_002615758  73 YVLPSg---------kMVVEFSEYLG 89 
XP_006683693  63 YVINK-----------MLVDIIDFNG 77 
XP_001486902  74 FKLPNk---------sFLVMVDEKIG 90 
XP_011273926  71 FKLGS-----------VLVMIEEMVF 85 
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