Conserved Protein Domain Family
Mei5

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pfam10376: Mei5 
Double-strand recombination repair protein
Mei5 is one of a pair of meiosis-specific proteins which facilitate the loading of Dmc1 on to Rad51 on DNA at double-strand breaks during recombination. Recombination is carried out by a large protein complex based around the two RecA homologs, Rad51 and Dmc1. This complex may play both a catalytic and a structural role in the interaction between homologous chromosomes during meiosis. Mei5 is seen to contain a coiled-coli region.
Statistics
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PSSM-Id: 371014
View PSSM: pfam10376
Aligned: 14 rows
Threshold Bit Score: 142.984
Threshold Setting Gi: 156113992
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_006630886  13 FCTPD--S----------TLNSTPHGLSVKQPMSASLKERLKRTRRSFHSPFTVAKRLKIDppEAEDDSKVQEVSPKSER 80  spotted gar
XP_008268702  50 PSTPQacA----------NPPSSLARSSGKQPMSATLRERLRKTRVSFNSCYSVVKRLKVD--NEENDQNLSEKPPSATE 117 rabbit
XP_004749372  12 PSTPRacA----------SPPSPRTSSLRKQPMSATLRERLRKTRSSFNSHYNVVKRLKVE--NEENDQTFPEKPASSTE 79  domestic ferret
Q86XK3        25 PSTPQasA----------NPSSPYTNSSRKQPMSATLRERLRKTRFSFNSSYNVVKRLKVE--SEENDQTFSEKPASSTE 92  human
XP_010587307  11 PSTPQacE----------IPSSPCTYSSGKQPMSATLRERLRKTRSSFNSCSSVVKRLKVE--NEESDPIFSEKPVSSME 78  African savanna...
XP_007479134  12 PATPKasE----------TVAVSQSHSSGKQLMSATLRERLKKTRSSFNSCYALAKRVKGD--TEENNSTVSKRATSSSD 79  gray short-tail...
XP_003218562  13 CSTPEtsD----------QKSCS---SSEKQPMSSTLRERLKKARRSFHSTLIVPKRLKID--EENNCSSTCKEESLPKG 77  green anole
Q9USV1        71 ALTPDlrDtkihtslpitTPFSKKRAREAKNILLKPFKSPLRQTASPQVADTNLKPSLAVTnlNSDETNTSSEPVTSPLR 150 Schizosaccharom...
P32489        15 VNEEEntC----------INHSYTKKDTNNYRVGKSGIKDLKKPTNQ--------KEIAIK-----NRELTKQLTLLRQE 71  Saccharomyces c...
EDO15526      21 VNDPDkrP----------LLT-----DLGKSSINKG-FNKVNANDSS--------KELRIL-----NNELSKELAEVSKK 71  Vanderwaltozyma...
XP_006630886  81 DLDSaGGNTVSINKGRPWESPEV---TDTSRQWDVCRTGTEsgneaaqssSSRERADPPAQI------------DLLQLR 145 spotted gar
XP_008268702 118 ENCLeFQESFKRIDSELEESTHL---KNTFQNVSACEATSLdtg----scSVLQNDFMKENLpi---------qGLKEER 181 rabbit
XP_004749372  80 ENCLeLQENFKHKDGEFKESTYL---KNTFKNISACESKSLdte----scSDLQSDFVNEELpk---------qGLSEER 143 domestic ferret
Q86XK3        93 ENCLeFQESFKHIDSEFEENTNL---KNTLKNLNVCESQSLdsg----scSALQNEFVSEKLpk---------qRLNAEK 156 human
XP_010587307  79 ENHLeFQGSFKHTDSESEKSTYL---KNTFKNISACESKSLdtg----scSALQNDFASENLpk---------qELKEEK 142 African savanna...
XP_007479134  80 GSCSgSSENCKNMEKA-EESLCL---KDPLKDVDVYRSE------------SLELSGLPDNLpvvseghsigkkELLEEK 143 gray short-tail...
XP_003218562  78 ESYCiSQSKDEDLEKVPDETSHL---KSTIQERDLCMSECTgysknaqgsTEVLLLGKDDRLw-----------ELMEEK 143 green anole
Q9USV1       151 TT----PNSIK------RQKRLF---KSPISNCLNPKSDpe-------------------------------itQLLSRR 186 Schizosaccharom...
P32489        72 NNHL--QQACKILS----ENKIIenrKSIEKWRTICEME-----------LSFILNSTLIKInrmggykdflekEMEAKK 134 Saccharomyces c...
EDO15526      72 IDQL--KQSIKILNRYEEQDKNL---KLIEKWRGVSKAG-----------MSYIFNSLRFRIdkmggyeefrrkEIEAEK 135 Vanderwaltozyma...
XP_006630886 146 DRLKKEVGE----------KEEMLRRLKMVRMYRTKNDLDKLQFLINKWRGSSQAVLYELKSAFC--------------- 200 spotted gar
XP_008268702 182 AKLVKQVQE----------KEDLLRRLKLVKMYRSKNDLSQLQSLIKKWRNCSQLLLHELHSAMS--------------- 236 rabbit
XP_004749372 144 TKLMKQIEE----------KEDLLRRLKLVKMYRSKNDLSQLQLLIQKWRSCSQLLLYELQSAMS--------------- 198 domestic ferret
Q86XK3       157 AKLVKQVQE----------KEDLLRRLKLVKMYRSKNDLSQLQLLIKKWRSCSQLLLYELQSAVS--------------- 211 human
XP_010587307 143 AKLVKQVQE----------KEDFLRRLKLVKMYRSKNDLSQLQLLIKKWRNCSQQLLYELQSAMS--------------- 197 African savanna...
XP_007479134 144 MKLLKQVQE----------KEELLRRLKLTKMYRSKNDLSHLQSLIKKWRNSSQLLLFELQSTLS--------------- 198 gray short-tail...
XP_003218562 144 ATLVKQVQE----------KEELLRRLKLVKMYRSKNNPTELQSLISKWRSSSQMMLYELQMALA--------------- 198 green anole
Q9USV1       187 LKLEKEVRN----------LQEQLITAETARKVEAKNEDKDLQTLIQKWKNAAQQAAEVLFKPMAerirlaggvtqsfri 256 Schizosaccharom...
P32489       135 RRLEYQIDNgmedqiceikESDDFRQLSEVEKQEWESQMNE---QLKELEKKKIAELEKLNKVLH--------------- 196 Saccharomyces c...
EDO15526     136 RKIEYQFDDglqneidnilDSEEFKALPIDDQIEYKEKMDE---KIQQAEEYKLKQFEKFDKELA--------------- 197 Vanderwaltozyma...
XP_006630886 201 -T-DGR--------QLSLTQLIDHYGLDDRILHYN 225 spotted gar
XP_008268702 237 -E-ENK--------KLSLTQLVDHYGLDDKLIHYN 261 rabbit
XP_004749372 199 -A-ENR--------KLSLTQLIDHYGLDDKLLHYN 223 domestic ferret
Q86XK3       212 -E-ENK--------KLSLTQLIDHYGLDDKLLHYN 236 human
XP_010587307 198 -E-ENK--------KLSLTELIDYYGLDDKLLHYN 222 African savanna elephant
XP_007479134 199 -V-ENK--------KLSLTQLIDSYGLEDQLLHYN 223 gray short-tailed opossum
XP_003218562 199 -T-DNQ--------KLSITQLIDNFGLDDQLLHYN 223 green anole
Q9USV1       257 eEgENKgqiqevrtEFTMSMFLNQFGVPVHLMSFD 291 Schizosaccharomyces pombe 972h-
P32489       197 -DsEGK--------DFGMAELCTRLKLDYSLIFPQ 222 Saccharomyces cerevisiae S288C
EDO15526     198 -NaSNK--------ELTMEELADRLKVEYKLIFss 223 Vanderwaltozyma polyspora DSM 70294
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