5Y5A,1YA0,8BH8


Conserved Protein Domain Family
EST1_DNA_bind

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pfam10373: EST1_DNA_bind (This model is not part of the current CDD release)
Est1 DNA/RNA binding domain
Est1 is a protein which recruits or activates telomerase at the site of polymerisation. This is the DNA/RNA binding domain of EST1.
Statistics
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PSSM-Id: 519339
Aligned: 50 rows
Threshold Bit Score: 103.64
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
5Y5A_A        220 PLRYLDIASTIVPSVGETFLQRGICYTHTKNFGNAAYQFVRSSLSRLP-S-DAGIPNFTNLLGDPNGSLFKKLLNSLDDL 297  Kluyveromyces...
Q6BIA6        250 ALNFYKFCILLLPALNEPYNHIGMIYNLMDSKYDACYWFLRSQFTRLP-DyKLGLTNLNTILRKDWFINHLISFNNPNK- 327  Debaryomyces ...
XP_002546674  226 AIQYYNLCIMLIPALSEPYNQIGVIYNSVDDKFNAIYWFLRSHFSRLS-EhQLGFANMSAILKKHWFTTALVDIVNGN-- 302 
XP_001382751  247 AIQFYKLCIVLIPALNEPYNHIGMICNTLNKQFEACIWFLRSTLTRIG-NfQVGMNNFKSIIRKKPFVAKLNRINSDRFD 325 
XP_001483583  253 SMNFYKLCIMLLPTLHEPYNHIGMIHNIVGNKVEACYWFLRSRFTRIP-NyDLGLKNLESIMVKSWFQDQLGDAFKSK-- 329 
EEQ37036      235 PLLYYSKCIQLFPNMTDPYNHIGVIYNSVQEKFLAVEWFSRAQLTSSR-KrDIAKYNMATIFTKPWLEETYSRVLKTP-- 311 
Q6FU90        234 SKEYFDLASLLLPSSGETYLQRGMVYIQTDNLGTAVQEFIKGSLAKSP-C-PAALSNFKTIILENDSTLHLRLDKLILDV 311  [Candida] gla...
XP_002554554  220 SMRYFNLATLVLPSVGEPYLQEGLIYVQARNFGFSTYSFARSALSRLP-S-AAGLPNFLSSVCDPNSKIFTQVMIAFQDI 297 
XP_001642519  222 SIRYFDMASLILPSVGETYLQKGMILISTENYGIASYEFIRSILSRIP-N-LAGFSNLTKLLCDDKSSLRKRFESILLDT 299 
8BH8_A        226 AIQYYNLCIMLIPALSEPYNQIGVIYNSVDDKFNAIYWFLRSHFSRLSeH-QLGFANMSAILKKHWFTTALVDIVNGN-- 302  Candida tropi...
5Y5A_A        298 -KV----QETikkRIINMEIMEFYILPLIGSHIFPQTW--------K----NNRHSDR--LKHFQTLLFDKIEIRYIKni 358  Kluyveromyces...
Q6BIA6        328 -K-----NKI---SVSKIDELNITLICLICYYYVPEYYhqsnntitKnfkhSKIEGDF--FKKLFESFDKYIRRYEEEdl 396  Debaryomyces ...
XP_002546674  303 -------SER---RFSNANVMNVFLVCLLGYIYCPERY--------Kn--gPNIVKKIp-FSKIETDLFKMISSDFDEq- 360 
XP_001382751  326 gGRsktePTM---EDDLNTMLACRVLYLYDPEEHQVDYkt----ikKtt-fSKLEDTL--SRHLKSSFSKLLSEGKDgs- 394 
XP_001483583  330 --------WQ---GGDLHLTSQIVLLNLIGYHYFPQRYrh----geLly-gNETYDNVe-REYLSFEFSQSHFQQLMSts 392 
EEQ37036      312 ---------S---KSWSISESQIILLRILGHLFYPQAYkk---------pmY-YDKTA--VDFLSTLFIQSNLWPYVRda 367 
Q6FU90        312 hSQd--lKGT---KIVNREIIELYFLAIFGSYFAPDVWtn----pkK----PGFLRNGlaVKTLELTLYEKIASRYIKni 378  [Candida] gla...
XP_002554554  298 fKQe---RDG---RVVNREIIEIYFLVLFCANFAPALWsg---------etGKCLLSGarLQHIREQYCQKTATRYAKnl 362 
XP_001642519  300 hNKd--iLST---RIVDKEITEYYFLALFSNKFTKCIQkd----ipQnt-dDTLLDGRlkLNHIELALYERISTKYMKni 369 
8BH8_A        303 -------SER---RFSNANVMNVFLVCLLGYIYCPERYk------nG----PNIVKKIp-FSKIETDLFKMISSD-FDe- 359  Candida tropi...
5Y5A_A        359 ----sMIFQDLILLIGSFH---MY-QMINGVSSNIRSI-------QSETKFLEFIFK-FFTHLIDKVIMKEFK-NCEMFQ 421  Kluyveromyces...
Q6BIA6        397 ----nLYVKQLVVLMSFNK---LLeRGSDKLISEQ---------------FIKFTFR-YINKLLESCVSMEFD-YQNKRV 452  Debaryomyces ...
XP_002546674  361 -----VVLKHLVVMFGIVR---LTrEDEQRDK------------------LLRFAFR-YVEKVLVYLKTGDGL--MVLRF 411 
XP_001382751  395 ----nFFLNQLVFLISI---------------------------------YYLFTYR-YIDQFCTHLLDVELN-EISATN 435 
XP_001483583  393 seyinHYVHSLLLLIMFSE---LLnENNNQK-------------------LFRLTKL-YISGFLALVESIDLK-TEGFEG 448 
EEQ37036      368 ----rIISDMLIVLMSFFI---LAeSEHSNEAST----------------KCGSLLTrFVVNYLKHVSRWHSD-TRDNTG 423 
Q6FU90        379 ----eTIYNDLIIGIGGFN---LLqLFGNMGPDSRVKIlksntltRNQLSYLSFVFT-YITRIITDVIKEAWNgNHEVYL 450  [Candida] gla...
XP_002554554  363 ----pLILQNEILLIAGFD---LLkTYNSANKDEKATQk-------VKNSFLGFSFD-LISHFIDNVVVKEIE-NQQEWV 426 
XP_001642519  370 ----hTIFVSLLTVIGGYEiisLNnTNSNDQLRIKKISlde--isEKQLAYLKFAFD-LISHIFNNVIAKGWEnNLEKYE 442 
8BH8_A        360 ----qVVLKHLVVMFGIVR---LTrEDEQRDK------------------LLRFAFR-YVEKVLVYLKTGDGL--MVLRF 411  Candida tropi...
5Y5A_A        422 YLAMARIMMCWIKSHKNVLKFAHRSTSFCQSMVNLTNELLSs-------------nDLSISFEHLHRPTRDYfYEEDIML 488  Kluyveromyces...
Q6BIA6        453 VLIILRLLSNWFKENKVILRNFQARKSLMVNIVTLLNGMTSdiygndslsqdinreKIIHLIKSNSRPVRDyyFKEDVYF 532  Debaryomyces ...
XP_002546674  412 ILNLLRENAPWLQVFT-------SRRNCVVYLTAVLKRFAS---------------------DSTTRPTRMffFEEDVNF 463 
XP_001382751  436 SLQCFRLILNWIKENKRAYRSLQDKHRTMSKIVQVSNKFLE-----------------DNSLNIPDKVh---yFQEDLMF 495 
XP_001483583  449 SLVFLRLALAYIKENKPFAKYFFRDAAMVVSLCSPFNEILSkc------------dWIHESVRTNLKPTRSyyYTEDVVF 516 
EEQ37036      424 VLQNIRTILAFCHEFPSSY-KYSKEDIVRALHQAIWAILSDedet--------sisNLLIAFSDNQVPVRSylFSEDVQF 494 
Q6FU90        451 YLAMLRIIGCWIFANESVLEFAKSNVAFCQAYADLLNDFLAs-------------gLVSYGPDNSVKPKRSylFEEDIQL 517  [Candida] gla...
XP_002554554  427 YLAFVRVVNCWLMSNKAALQFAHRDVRFCDAMMRLMNSVLKs-------------pTLTRPPELNHRPRRPyfFEEDVSL 493 
XP_001642519  443 YLAMVRIVICWIKSNKSVIQYSHRNRKFCDSFVNLLNNFLSs-------------kKFTEMTIPDVRPGRAyfFQEDIFL 509 
8BH8_A        412 ILNLLRENAPWLQVFTS-------RRNCVVYLTAVLKRFAS---------------------DSTTRPTRMFfFEEDVNF 463  Candida tropi...
5Y5A_A        489 KEFGPTKFTL 498  Kluyveromyces lactis NRRL Y-1140
Q6BIA6        533 RDFLIIKFQL 542  Debaryomyces hansenii
XP_002546674  464 RDCSLIKYQF 473 
XP_001382751  496 KDFIVIRNQF 505 
XP_001483583  517 KDFLPIKYQF 526 
EEQ37036      495 KDFVAIGSRF 504 
Q6FU90        518 RELGFIGDEL 527  [Candida] glabrata
XP_002554554  494 RDFKSVKFTL 503 
XP_001642519  510 KEFSPIKYAL 519 
8BH8_A        464 RDCSLIKYQF 473  Candida tropicalis MYA-3404
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