Conserved Protein Domain Family
Vps39_1

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pfam10366: Vps39_1 
Vacuolar sorting protein 39 domain 1
This domain is found on the vacuolar sorting protein Vps39 which is a component of the C-Vps complex. Vps39 is thought to be required for the fusion of endosomes and other types of transport intermediates with the vacuole. In Saccharomyces cerevisiae, Vps39 has been shown to stimulate nucleotide exchange. The precise function of this domain has not been characterized.
Statistics
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PSSM-Id: 371008
View PSSM: pfam10366
Aligned: 20 rows
Threshold Bit Score: 116.957
Threshold Setting Gi: 122049153
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q4GYA2    501 VDTAILRAYVFLgQEKELLNFLCTE-NACAPRDSEQCL--------LKGEQWVGLVALWYRQGLHSRSLELLKELAVtge 571  Trypanosoma brucei
Q6CEZ7    607 VDTSLLQCYIRV-SPGLIGPLLRVK-NYCDPTVVKTEL--------SKLSKWKELIDFYYGKGLHKDALELLVELKG--- 673  Yarrowia lipolytica
EGZ70789  652 VDTTLFRAFMYS-RPTLASSLFRIP-NFCDPQVVNERL--------VEHNRFNELVDFFYGKKLHRQALDLLRKFGSpde 721  Neurospora tetras...
Q4WGP8    620 VDTTLFRVYMYA-TPSLAGSLFRIA-NFCDPDVVIEKL--------EESGRQNDLIDFLYGKKMHRQALELLKKFGQaev 689  Aspergillus fumig...
Q0CIY1    618 VDTTLFRAYMYA-KPFLAGSLFRIA-NFCDPDVVMEWL--------EKAGRHNDLIDFLYGKKLHRQALELLRRFGQaes 687  Aspergillus terre...
Q6BS66    621 IDTALFLCYYYT-KPMLLGPLLRLPnNKCDTKIVHECLlanlhqhnKQPSFIKELLDFYYGRNLHKDALEMLYKLAHent 699  Debaryomyces hans...
Q6CWN0    564 IDTTLFEMYVKY-NRSMVGPLVRVD-NNCDFDTVEEIL--------NKENMVHELIDFYYFNNEHRKALDLLTEILDrt- 632  Kluyveromyces lactis
Q8L5Y0    502 LDTALLQALLHTgQSGAAIELLKGV-NYSDVKICEEIL--------MKSKNYSALLELFKSNSMHHEALKLLNQLADesk 572  thale cress
Q3UR70    448 IDTALLKLYAEA-DHDSLLDLLVTE-NFCLLTDSAAWL--------EKHKKYFALGLLYHYNKQDASAVQLWVNIVNgdi 517  house mouse
CAF99758  436 VDTALLKLYAEQ-DQDRLLELLSSS-NACLLADSVPWL--------EKYHKYFALGLLYHYNRQDATALQLWIRVADgdl 505  spotted green puf...
Q4GYA2    572 pt-csaigSSVNKEGEGidtvpnTIQDDNVIRDSFNDEFLSvlrrlLPKVMI 622  Trypanosoma brucei
Q6CEZ7    674 --------KNHEFTSES------IISYLQKLDAHNIDLILE-----FSKVPI 706  Yarrowia lipolytica
EGZ70789  722 p---deaaPTLHGPQRT-------VLYLQGLPPEMIDVILE-----FSEWTL 758  Neurospora tetrasperma FGSC 2509
Q4WGP8    690 d---eetaTQLQGPKRT-------VGYLQNLSPEHIDLIIE-----FAEWPV 726  Aspergillus fumigatus
Q0CIY1    688 e---eengSQLRGPKRT-------VGYLQSLPPDNIDLILE-----FAEWPV 724  Aspergillus terreus NIH2624
Q6BS66    700 ddhdddfdDFLRGPALT-------VQYLRKLDVNDLDLIFE-----FAEWVM 739  Debaryomyces hansenii
Q6CWN0    633 -------gDLKPGIKTL------VIEYLKNLEFTDLDLVFQ-----YSDYLL 666  Kluyveromyces lactis
Q8L5Y0    573 tn-qsqtdVTQIFSPEL------IIEYLKPLCRTDPMLVLE-----YSMLVL 612  thale cress
Q3UR70    518 ------qdSTRSDLYEY------IVDFLTYC--LDQELVWT-----HADWLL 550  house mouse
CAF99758  506 ------qdSTRSDLYEY------IVNFLCSC--SCLDLVWK-----YADWAL 538  spotted green pufferfish
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