Conserved Protein Domain Family
BMT5-like

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pfam10354: BMT5-like (This model is not part of the current CDD release)
rRNA (uridine-N3-)-methyltransferase BTM5-like
This is the N-terminal domain found in proteins from plants, yeast and humans, including 25S rRNA (uridine-N(3))-methyltransferase BMT5 from S. cerevisiae and the poorly characterised Ferredoxin-fold anticodon-binding domain-containing protein 1 from human and Heavy metal-associated isoprenylated plant protein 41 from Arabidopsis. This domain has a characteristic Rossmann-like fold of S-adenosyl-L-methionine (SAM) binding domains. BTM5 is a SAM-dependent methyltransferase that specifically methylates the N3 position of uridine in 25S rRNA.
Statistics
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PSSM-Id: 519328
Aligned: 140 rows
Threshold Bit Score: 114.573
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
EPS27353        84 LLVGEGDFSFARSLA------KQY-KCrkLCATCYDSKETLFSKY---PQAEQHIQEILDSatskskktdqenahdekdq 153 
16_pfamImport    1 LLVGEGDFSFSLCLAsafgsaTN------ITATSLDSEDELSKKY---MDAMVNVSMLARF------------------- 52  
15_pfamImport    1 LLVGEGDFSFSLSLArafgsaTN------LIATSLDSQAELERNY---KNGKANVEELERL------------------- 52  
18_pfamImport    1 LLVGEGDFSFSLCLAkafgsaTN------ITATSLDTREELEQNY---KDAKNNVEELERH------------------- 52  
17_pfamImport    1 LLVGEGDFSFSLSLGrafgsaSN------ITTSSLDSRVDVNRKY---TYGKQNVEELERL------------------- 52  
XP_002874236    19 LVVGEGEFSFSLSLAkafgsaTN------ITAISLDIREELGRNY---NNGKVNVEELERL------------------- 70  
19_pfamImport    1 LLVGEGEFSFSLSLAkafasvAK------ITAVSLDVRVGLGRQY---SNGDANVKELESL------------------- 52  
XP_020431423  3218 LIVGDGDFSFTMALInkhkstHP------LLANSL-TTSELSMSPfksHEINSRMEQLNEL------------------- 3271
XP_004366742    51 LLTAEGNFSYTKSLLdryshlKGFgES--ITATEY--TKQLDASI------IPVTKQLEEK------------------- 101 
XP_002258201   126 LCVGEGNLSFSTLLQkelrpcQ-------VVATSMESPNVLQRNYg--SIFSKNLKILESC------------------- 177  Plasmodium k...
EPS27353       154 qtssqsqsqtqssstqkpAPKVLFSVDARKLGtpagggkeirngyprkerkiaawklaqqaqaqaqaqaraqssgsaaye 233 
16_pfamImport   53 ------------------GCDVQHEVDVHTMS------------------------------------------------ 66  
15_pfamImport   53 ------------------GCNVVFGVNVHSMT------------------------------------------------ 66  
18_pfamImport   53 ------------------GCTVIHGVNVHSMG------------------------------------------------ 66  
17_pfamImport   53 ------------------GGTVIHGVNVHSMS------------------------------------------------ 66  
XP_002874236    71 ------------------GCTVVRGVNVHSMA------------------------------------------------ 84  
19_pfamImport   53 ------------------GCTVVRGINVHTMT------------------------------------------------ 66  
XP_020431423  3272 ------------------GVRTIVGLNSNDISnv---------------------------------------------- 3287
XP_004366742   102 ------------------GVKIMLGVDGREIGqi---------------------------------------------- 117 
XP_002258201   178 ------------------GGIYVPEVDVEKIGeh---------------------------------------------- 193  Plasmodium k...
EPS27353       234 lrMslsggggggGGGpWDVICFNFPHV-----------GGLSTDVNR----QVRANQ--------ELLVAFFQACVPLLS 290 
16_pfamImport   67 --Fdns----lsLRR-YDRIVFNFPHA-----------GSRFFGREFss-kAIEGHR--------VLVQGFLENAKEMLE 119 
15_pfamImport   67 --Tkhn----lgCSAtYDRVIFNFPHA-----------GFDYG--REheikTIMRHQ--------ELVRGFMKSARLLVK 119 
18_pfamImport   67 --Kdhr----vlRSVvYDRVIFNFPHA-----------GFHFG--REfdsyTILQHQ--------RVVKGFFLSARELVD 119 
17_pfamImport   67 --Sdnr----laR---YNRIVFNFPHS-----------GLGFG--SEhesfYIMQHQ--------ALVRGFFESARKMLE 116 
XP_002874236    85 --Sddr----laH---YDIIIFNFPHA-----------G---------------KRD--------KVFGGFMESAREMMK 121 
19_pfamImport   67 --Sdyr----lsR---YDRIVFNFPHA-----------G---------------KHK--------DVVTGFMQSAPEMMN 103 
XP_020431423  3288 ----------fqGQR-FKRIQWNNPWPfw--------------------slSIYKNYi------sSVLPSFYVSASQLQQ 3330
XP_004366742   118 ----------fkGER-FNIIQCNCPFG-----------GSSERDRDEf----------------kTFTLEFFQSASELQK 159 
XP_002258201   194 ----------flHNT-FDVIIFNFPFVlpsddfiqtkwNIQKEKLHSdrniFLKYYKkseylllnKILYWLFKNGSLLLK 262  Plasmodium k...
EPS27353       291 KApppvdeddeeeewgedeedeeeddsepfdfenketsgkgmrtgpGQILVSLFEGEP---------YTLWNIK-DLARH 360 
16_pfamImport  120 EN--------------------------------------------GEIHITHKTTYp---------FSDWEIE-RLAKA 145 
15_pfamImport  120 DEdk-----------------------------------------gGEIHVVHKTEYp---------FSEWKLK-TLGEK 148 
18_pfamImport  120 AS--------------------------------------------GEIHVTHKIAYp---------FTNWNIK-TLGEE 145 
17_pfamImport  117 DEd-------------------------------------------GEIHLTHKTTRp---------FSEWEIE-TLAQE 143 
XP_002874236   122 DEd-------------------------------------------GEIHITLNTLPp---------FNKWDIK-ALAEE 148 
19_pfamImport  104 EG--------------------------------------------GEMHFTNMTMYp---------FNKLDIK-SLAGE 129 
XP_020431423  3331 PG--------------------------------------------DRIHMTLVQGSe--------dFKFRQMEnPLVRA 3358
XP_004366742   160 PG--------------------------------------------DRIHFALDQSKGywkerktfiYIERQREnPIVKG 195 
XP_002258201   263 DG--------------------------------------------GFLHLRLNDK-----------YLTC----DFANT 283  Plasmodium k...
EPS27353       361 ---AGLQVVTSFKFPWTEYEGYSHAR 383 
16_pfamImport  146 ---EGLKLAKESKFERSHYPGYNNKR 168 
15_pfamImport  149 ---EGLELVSEIEFCLNHYPGYSNKR 171 
18_pfamImport  146 ---EGLYCVREINFETCQYPGYSNKR 168 
17_pfamImport  144 ---KGLRLIGLMVFDQLAFPGYSNKK 166 
XP_002874236   149 ---KGLRLIQRMQFTKWAFPTYSNKR 171 
19_pfamImport  130 ---NGLRLIKQMQFKKWIFPCYSNKS 152 
XP_020431423  3359 sfrANYRLIRKRRLSNTRYPGYFHHY 3384
XP_004366742   196 sinANYKLIRKRRF-GERYPKYRHKK 220 
XP_002258201   284 ---FSLSLVEKIDFSASYFI-YKSLR 305  Plasmodium knowlesi strain H
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