Conserved Protein Domain Family
Cohesin_load

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pfam10345: Cohesin_load 
Cohesin loading factor
Cohesin_load is a common cohesin loading factor protein that is conserved in fungi. It is associated with the cohesin complex and is required in G1 for cohesin binding to chromosomes but dispensable in G2 when cohesion has been established. It is referred to as both Ssl3, in pombe, and Scc4, in S.cerevisiae. It complexes with Mis4.
Statistics
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PSSM-Id: 491093
Aligned: 48 rows
Threshold Bit Score: 306.165
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
EDK42881      360 KVSYFLQESTKFIHAAHEHLAYYHEKINLENYWKLIKAAIRCLLLVLKkyNRSMTDFQKVSAIYSLAWIYSEETENFDKA 439 
Q6CNT3         26 QLDLIYHLSKQYTLTAHDVVTEIETELELRQYYTLINQAIRCLRYLKDg-GFQLSLEQDFQITNDLVTLLIEETHRIDLA 104  Kluyveromyces...
XP_003647107    9 QRSLVYQRSRQYLAHAHSVASKVRSETQLRQYYTLIQEAIRGFEYLKN--ELQLTIAQDLQVTLDLVRVLLDETHEVELA 86  
XP_001646299   14 RPELVYGLAHEYLEQAYKLSGKVSDEVQLQQYYTLISMGIKCLQRLKL--EYSLTVEQDAKITLELVHVLLNETNNLSLA 91  
Q6FQF3          4 SAQELWELHEEYVTCAHNCVSKVQNRDQLRQYYQLIGAGVTCLVTIKE--KYSLSMEHDAQVTLALVSLLVDETADYDAA 81   [Candida] gla...
CCE79525       85 IVDLLLTNSDFYLKKAHQTVPHSNTPQGVSTYQKFVKLSIKSLLILIRryDKALNPYLESVIYLKLASIYYEETDNLNRA 164 
XP_001387408   10 VVENLFMTSDFFLQKAHKIVLNIYSEQGMNEYFKMIKISIKSLVIIARkyAQHLTPRKESILYYKLARLFLFETENIDKA 89  
Q6BID2        149 VVNNLVISSDYFLNRAHETVLDTNSMNGSKTYFKMIKISIKSLLLLIRkySKCLNPYLELIIYFKLARIYFIETENINRA 228  Debaryomyces ...
EMG49796      170 RFEYFIELSDYFRNRAHKD----VSTLPLDTYYKFIKLSLKCLTILDK--RHSLDMNQKFLVYYKLAQIYIEETENLEIG 243 
KAL1232129      8 YYLGLLSMAEDFRTRSPPE----------------IVNALRCLLSIF---EFSPPIGIEARLHFQVGHMYWSFTENIDHA 68   Trichinella p...
EDK42881      440 QEYANKAIQICRSQG-PSMIkyEFYCQLLLILII----VKTGGt--ASALDYLAEITN-LYETRGKQ---E---FVDCLL 505 
Q6CNT3        105 EQYFSALRERLQSTT-WVNE--KMYVDYVLLCKIp--lYKNDPshnKIALRNLSKLIS-KLDTSL---------WKVLFQ 169  Kluyveromyces...
XP_003647107   87 EQYLNGIRTRLQPTT-LTDD--KYLVDFYLLYHIp--mLKRDPg-nKLLLKNLGRLIG-TFNKSD-----P---WRLVFQ 151 
XP_001646299   92 EDYLSSLRERLKNHK-LGVLneKLHCEFIALYEIp--mKYSSEyyyKMSTRSCDSLLE-YLKTLESTqevQe-fWVPLFS 166 
Q6FQF3         82 EMYISSLQERLKNDK-YSDDleVYRLVCHFMNFYtiplKRKSQfhmNIALKNCNELVTyMENALESGsmqPyseWLVVFK 160  [Candida] gla...
CCE79525      165 DDYANKAIAITTRNN-FSSL--KFAAEVLAAKVL----ERSRP---GLALNYLSDKIK-SYNSSGSM---H---LGNLLA 227 
XP_001387408   90 DENIYKSGTIAKRNK-FTDL--IFVSDYLSAQIK----ERNNK---TVFVNFINERVT-YYENLELH---H---YVTMLQ 152 
Q6BID2        229 DDYVNKAISIATRNN-LIKV--KFICEFLAAQIL----EKSNP---KLSLNYINERIS-NFKMIGLH---S---LGSLFA 291  Debaryomyces ...
EMG49796      244 EKYLNQAIALSSN---LNDLknMFNCELMVCHLI----EKVNP---KTLINYLIAKIQ-FYQEKRLN---E---LVDCLE 306 
KAL1232129     69 RQHLERAITLARSHHaFEDV--LSDAAYSLAQLY----FKTNEs--ALGRNLLYQTIEtLKNCQGMF---C---WQIKLV 134  Trichinella p...
EDK42881      506 LMRIHYLLAT----DYSIALVNLQRMLKRQNKM------HPILYTVASIYLAGLLTyRGDP----KNAIMVLTNIK---Y 568 
Q6CNT3        170 YFRLQLIPGN------ERKLADYRDILFVIKNHe-----QFHFVVMCSFINYCLde-------giSIPADMW-------V 224  Kluyveromyces...
XP_003647107  152 YCRIAILDMNkssrNISSITADYAEMLNSTTSLepgaegEINGFLLCSYVTFLLNRtLLVSnddlEKLKLLKTKSDr--I 229 
XP_001646299  167 FINIWLNIKIg---KKNLIRSKFNNLLEKSSKLn----hEWEAFIILAYVSFLLDErYTVPpdviEKLNEInt------- 232 
Q6FQF3        161 FVVLTLSILTn---KHGRLHERYKELIEYENVPk-----IWKYILVLHYVDYRLKQrKPIEqdilSSLSEITVETAg--- 229  [Candida] gla...
CCE79525      228 ILKTGILLQE----DYSAGLVALQSLSALDIV-------DPATKVFCLLLQANLHLtd-----asPVVAISLCNEEs--T 289 
XP_001387408  153 LLKIESLLTY----DANTAVIILQSLAQSEKI-------DELTKVHCMLSLSNLHLyRGSPsislSIVNEIDKILDslg- 220 
Q6BID2        292 LLKIDNLLSQ----DPNTGLIVLQSLCQDPQI-------DNTTRALCFIYQSNLHLyRGSPkhslELLNHAEKLMYghe- 359  Debaryomyces ...
EMG49796      307 LIKIKYNLVH----NPDTALSSLTLLIGKTQ--------NQTIKAFCLIQSANLHLhRASPvtalDLINHAGKIIEd--- 371 
KAL1232129    135 FQLAQHLVNDr---DYITAREVLQLGYQAAVNEn-----CIYIRIMILLSISQLYMfes----rvKELHQTLSKVSqliD 202  Trichinella p...
EDK42881      569 NFE----PNSPLHALFLLNKLLAVMC-TNDYYGATKVMSKLYDLKNRSdaLKWRNWHPDGD----IELNITERdetnfns 639 
Q6CNT3        225 YFSemdtAHVKLKIWKILLELLVLI---FKDINITDKLTELKSFFDNN--KD----KIDSP-----LESIHLF------- 283  Kluyveromyces...
XP_003647107  230 SVK--------IKIWAMLLELLIAI---YQDENITLLLYDFKEFFGRH--KETLNTGRDSIl---LQIK----------- 282 
XP_001646299  233 -----nrFSPTLVAWRMVLELMMQIY---KEENITNKLNEFKEFFNQQ----KSNLENRDN----YCIKFD--------- 287 
Q6FQF3        230 ---------AKLYAWRLISELLMDIY---NDRNITEQLNRFKLFFKEC--KD----KLDGS----LEVNVD--------- 278  [Candida] gla...
CCE79525      290 LFEhl-qSYPQLMAMCLLHKLCGHLQ-AGYLKQGKEMINKISDFVQNQqnTGWRWWSEDGIi--nITIGITFD------- 358 
XP_001387408  221 -----neTPRQMAAMSAITRYYGEIQ-MNNVDEASKIMKSINSLIANEqnLSWSSWREDGKf--kIEIPIQPE------- 285 
Q6BID2        360 -----enYPIQLQAILFLLKYSVYIH-TDDSAGSKDVMQFISNFILTEqlKHWNSWKEDGTfkikIDIPSSNG------- 426  Debaryomyces ...
EMG49796      372 ------nNIESLKLSLLMAQFVAYIHlNKDSKKIIGKVSKFVGRDDNA----NGKIe--------LSIDVPKL------- 426 
KAL1232129    203 SWQgssiRRAHLRAWFFVIQICYFMS-EGKAKSSKACLIELQQLVQMI----THTVHQEQK------------------- 258  Trichinella p...
EDK42881      640 nFNSGFKFIVP-WLRVNDLLAVAYFINGLMFIGHKRD----Y-AEKNFHRATRQLERVKEDLks-----nrNPSFTVQTL 708 
Q6CNT3        284 -DTVSLKLDFP-VFGYKDVKNLLLFFQSVSYLPNCFDkrsnF-SVKFLPKTISTTGKLLSSL---------DEKCSLSKL 351  Kluyveromyces...
XP_003647107  283 -PGLKLKVEVP-FFNSADCKNILLLFQSVSYLPTCYSkssnF-STKFLPKVLRTSEELKQNV---------ARKASLSKL 350 
XP_001646299  288 -DSNRINITLPlIFNYKDLKNILLLLQSISYLVNCYDknanF-STKFLPKVQSTTKKLIDSLndk---stsEN--SLSYW 360 
Q6FQF3        279 -SKAKLQLKLEpIFHYKDLKNILLLLQSVSYLLNGYDkk-aNfSIKFLPKVQTTTQLLLEGIr-------nDSANSILTV 349  [Candida] gla...
CCE79525      359 -ETYSARYGIP-WINSDEFVILFYMLSGVLLLRTNNKk--rK-AKQIFEKCLEMVSNKLSETgernqhkttMIAFSMWHY 433 
XP_001387408  286 -ANTLIPTYLS-WLNSDEFVIMFYFLTGIHYMSEAANgk-kK-SKKVFDRCLQIVEKQLLELgsv----nnKRNLSITDL 357 
Q6BID2        427 -LNSDLSYRVT-WLNSDEFVIMFYFLTGVHFLPEIYNkk-yK-SKKVFQKCLQILDNQLHELrgm---gntERCFPLNQL 499  Debaryomyces ...
EMG49796      427 --DHTFRIDFD-WITTGELAILAHLLTGVALLSDSRN----K-AKICFEKALKNLSKVEKSNk--------LGSMSLDEY 490 
KAL1232129    259 -DEQQQYEYFQ-WISDEHLCILVYAMTVMQALHCGKFn---K-ARQYAERALAHVEKLRRLNeed--------------n 318  Trichinella p...
EDK42881      709 KEQYVKVRYFKFIIRYYLQY-------HAFVVDNWDATc-lNEFTtVARNALESKMEHTC-LKVQHPLVYYLQALWYLKK 779 
Q6CNT3        352 NSLHKFYHTLLDLVKFYQTCesi--ilHGMVADDNTTS---------PYQDLLQAWNAQL-RGQVKTASAIYYSILHNDL 419  Kluyveromyces...
XP_003647107  351 YSIGSIYDHIKELCQFYQAWeqm--ilNGPIENNLPQL---RNSDyYDLLESMNSHLLIP-RKSIKHVYNLYESLLKSKD 424 
XP_001646299  361 DAKINWYKSIISYCNFYQLWeqliltpQKLINNDFSEIsntSQNSfDSYHTLMEGITSQI-KGDGTLSLDQYSTVVRSKN 439 
Q6FQF3        350 DNKVSWYTTILKYVSFYKLWdyv--llKGITHEYKRNC---LEIPqKDHQLFLELIGRQS-KLTSTGGSEELQQLTEQYT 423  [Candida] gla...
CCE79525      434 YEKILFLETVRYKINFYETF-------MDFLEGRFSSTg--FTELrNVYHNLRFVSTDVInYSIHNTEVYYTYALFFQYY 504 
XP_001387408  358 SNKIIRLKFIKYSTKIYQAW-------IGFLNGEFKDInylNEFMsDYNNRRFSDEEFCE-YSLLLPKTYYLFALYYHYK 429 
Q6BID2        500 TKKIIRLSFIRYYINYYQVW-------MNFLDKNFTNIdplNEFLeNYNNSKFSDEELCY-YKLLIPNIFYLFGIFFQYK 571  Debaryomyces ...
EMG49796      491 VRKSKKLKYLRVLIKYYQTI-------NNFVISKYTIDp-lNEFM-QSTHKEMDESDYII-IKGFYRMIYYCFAMYYHHN 560 
KAL1232129    319 vAQSLWLLLLEHSIL------------SQLNTGHYVSA---VKEI--SLLKSACHCSPRL-FYQYGSRLHMLLGLYAVSM 380  Trichinella p...
EDK42881      780 GD----IQAAKYHFvkVRNLTRDvcledekqaLQQMRCGVGCesfmp------------qgkfNELYLYSSLHL--VIll 841 
Q6CNT3        420 GNrelkLLSLLHLY--AITLAEI-----------SECDTGNDdlht--------------lttKANQLVSQLDL--LLnt 470  Kluyveromyces...
XP_003647107  425 SEv--rLIAFMHCFilTISQLSQ---------CNEEPDQFSRliqq--------------annTWNQIIKNMEH--TP-- 475 
XP_001646299  440 AT----VEIRMISLlnSFIIKSS---------EGIKNEQSHQsvsd--------------shnIWQQVEKLLEE--SD-- 488 
Q6FQF3        424 DL----AGDSSVHY--EVKLSSLlncyiilssLVSEDIDKAKnisr--------------cndVWMSIQSIFDN--CD-- 479  [Candida] gla...
CCE79525      505 GK----ISRSKYYY--LKILSEVlngksspktTLSFSKMASKgetqn-----------rkwlhSEIYGFSLINLksIIdf 567 
XP_001387408  430 GD----IQAAKYYYlkVKNLTSEfnsaansdvVSSNCSVVGLgnvamv----------pksefSELYVFSSVHL--LVlv 493 
Q6BID2        572 GD----LKAAKYYYmrVRSFTLY---------EQEPSNTIEYssilqsslgvggetfqskgqfSELYIYSTLHL--VM-- 634  Debaryomyces ...
EMG49796      561 AD----LQAAKYYYlkVIESNKAvnpryaaeqLSLGIPCESispv---------------gkfDELSVYANLNL--VI-- 617 
KAL1232129    381 DQ----AQAAEAQFaaALRFNRD----------------------------------------PKLSFYLNLNL--AV-- 412  Trichinella p...
EDK42881      842 eYeVADIMRQGD---KQLRTFCD-------KLIGLrnsiadeiela------kggskgkgkssDMF--------Q----A 893 
Q6CNT3        471 sVfSASTVWRST---KLLLVIMG-------RFEPF----------------------------TKN-------------P 499  Kluyveromyces...
XP_003647107  476 -M-VNNNTWLCT---IATLWVLS-------KFEPF---------------------------------------SnhplP 504 
XP_001646299  489 -L-KENSIWECT---LTILWVTT-------HFKPFt---------------------------DQP--------L----P 517 
Q6FQF3        480 -L-RDNSLWNVT---ILMVWIIS-------HFEPF---------------------------------------TanplP 508  [Candida] gla...
CCE79525      568 eI-YRIPEDSRKvgsSSLNRLLElkdivdnDLNSI----------------------------VMNnnsnlsnkFlsnfT 618 
XP_001387408  494 qFeLSQLMKQAP---GQSTDAIN-------DCFKL----------------------------CNRlhnelngaF----G 531 
Q6BID2        635 -L-TEFEVYQITk--SSHTNIIN-------DRDDTyrfrshlyldltkifdqkdkktsnsfnmNLA--------G----S 691  Debaryomyces ...
EMG49796      618 -L-LHFETDKLK---QNTPSYLP-------DIKNQ----------------------------CLN--------N----L 645 
KAL1232129    413 -LyLQCGRESEF-------YNLM-------DINPE----------------------------RLA--------E----Q 437  Trichinella p...
EDK42881      894 NFMMTNTLALMTT-------DLilciLQDTSNIIPSNELRKMLTAISHKSA----FYFIYF-----LITFALATEMVASV 957 
Q6CNT3        500 QASNQNTLLLNEL-------EQ----YFAGNSLLPADDL--PTSKAPVKIK----KSLLLH-----IWLNYIAGSMSINE 557  Kluyveromyces...
XP_003647107  505 NDNDEERQLYLKK-------LEn---YYTANSLLSSDQSAQPSSFKLK-------KCLLLH-----FLLNFLGGTIFVSD 562 
XP_001646299  518 CTDEERSHYLEK--------LRvyynSNKIQGLNDVEISVLKEEGKYLKLK----KGLLLR-----ILLNYLGCSLFEHD 580 
Q6FQF3        509 STDEEKSSKLEAFk------------GYYQNNKYNVIDKKDAGMHNNLKVK----RGLLLH-----VLLNYIGARLFEQD 567  [Candida] gla...
CCE79525      619 NSYFSGTYHVLNQ-------IQa---YQQNDSLASLENRIFHGSDLKNHLAyvdnNEFVPS-----FLSALVKFTMYIIS 683 
XP_001387408  532 DRSTSNSFTSNFAkcndllkMThsilVNISDEEQQNSTFLQELSQVYNKYE----LKVCFP-----FVFNVVKHLLFVST 602 
Q6BID2        692 SQTLIITYNLLLS-------IYdnnySGSGKVNAESSEYPQILYDAMKGSN----SMHSFP-----YLISLIHYVTYLLS 755  Debaryomyces ...
EMG49796      646 EEAFKQSETTTSNt------FNlnftSNSDILFVTYNFILKIVLSSGIDLNfqtkIEQLLSklgpkSSFAFLGIILMYVL 719 
KAL1232129    438 SINLRAASLFVRG-------MH----LMLQRRYSEAKKVLCDALEVTSKED----LNHLVS-----FCFVLIGQMLLGVN 497  Trichinella p...
EDK42881      958 dqetILHEGMRVLPPSQTkvieendenlqqsesspssvtttigtststststknnvganetssisqsfSKSETADSC--R 1035
Q6CNT3        558 ----LDQRCVLSSTCFKLakq--------------------------------------------qylPYLRYLVGI--W 587  Kluyveromyces...
XP_003647107  563 ----IQERCNLSASCFQMckq--------------------------------------------qhmPVIRYIGGI--W 592 
XP_001646299  581 ----LESICKISEVCFNLskl--------------------------------------------qdmPVIRYIIGL--W 610 
Q6FQF3        568 ----LEEMTKISERCFRManisiedasyskksskqprvgsln---ttdieeseldhptnmnvegnqgiWAIRYIMGL--W 638  [Candida] gla...
CCE79525      684 ktieEKMKWLEHSLAEVQ--------------------------------------------------INSASHNSLivH 713 
XP_001387408  603 tsleEKNKYLSEFLTLIS--------------------------------------------------IPAKTDFERivF 632 
Q6BID2        756 tslaDKELALKMCLSLVSm------------------------------------------------eNCSDNERIV--N 785  Debaryomyces ...
EMG49796      720 n---FKNQDHLSVFKDRL--------------------------------------------------KDEDTEDIC--K 744 
KAL1232129    498 prpeHLQEALKLFTSSLH--------------------------------------------------LAQNNADAT--A 525  Trichinella p...
EDK42881     1036 VFLLRSIHVIMMQ-NGEHY 1053
Q6CNT3        588 NLMNNTIAMNSKEvALTKA 606  Kluyveromyces lactis
XP_003647107  593 HLINCTVAMKNKEvAVTRA 611 
XP_001646299  611 HLISCTSAMKSKEvTITRA 629 
Q6FQF3        639 SLMNYTVGMRQKEvIYTRN 657  [Candida] glabrata
CCE79525      714 TFILSEYY-NLLLiRNELD 731 
XP_001387408  633 TFILKSLLLH-FKsTGEND 650 
Q6BID2        786 LFILKDYSLQLHE-EGDYD 803  Debaryomyces hansenii
EMG49796      745 LLISKGFMKHFKEv-GEHD 762 
KAL1232129    526 QLWSSGALKNLYAiCQNAD 544  Trichinella pseudospiralis
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