7UGK,7UK3


Conserved Protein Domain Family
Q_salvage

?
pfam10343: Q_salvage (This model is not part of the current CDD release)
Queuosine salvage protein
Queuosine salvage proteins occur in most Eukarya as well as in a few bacteria possible via horizontal gene-transfer. Queuosine (Q) is a chemical modification found at the wobble position of tRNAs that have GUN anticodons, and it ensures faithful translation of the respective C- and U-ending codons. Most bacteria synthesize queuosine de novo, whereas eukaryotes rely solely on salvaging this essential component from the environment or the gut flora. This entry represents queuosine salvage proteins (Qng1, also known as DUF2419) which have been identified as a queuosine nucleoside glycosylases that play an essential role in allowing eukaryotic cells to salvage Q from bacterial sources and to recycle Q from endogenous tRNAs.
Statistics
?
PSSM-Id: 519323
Aligned: 109 rows
Threshold Bit Score: 256.66
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
?
Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
7UGK_A        58 LNPRa---ADE-AAVNWVFVTDTLNFSFWSEQdEHK-CVVRYRGKTYSGYWSLCAAVNRALDEGIPITSASYYATVTLDQ 132 human
XP_025264543  55 YHPDk---YDH-RAADWLFVLNTMNFALWNPK-GTKqWTV----NQLTGYQALCAAIKRAIDNNRPIWDPKYYTKLTRYG 125
XP_011134930  52 FHPKh---DDP-LAVDWIFILDTLNFSFWT-----QtGAKKWTVNGQTGYFALCAAVKRAIEEGKPILDPAYYSKITLSD 122
EGI61988      52 FHPKp---DDS-RAADWIFVLDTLNFSFWT-----EtDTKKWNVNGETGYFAFCAAVSRAIDEGKPMWDPKYYSQITQQD 122
XP_009012357  58 LLPQt---QDE-FAANWIFLSDLLNFCFWSS--PGKeYMVHYKSKNRTGYWSLCAALWRALDDGYDITNPAFYSKIDEST 131
XP_015786129  55 LHPKe---PTD-FAVNWIFLVDSLNFSFWPD--EDKeFGVTYKDIEYTGYWALCAIINRALDQGIPMCNPDYYSNLSLDQ 128
XP_015793048  54 LNPGi---SNE-FAINWIFLVNSINFSYWPD--PDQeFAVTYKQAEYTGYWAICAIINRALNQGIPMVSPEYYSNLSYDQ 127
XP_046438167 106 IHSYplpvTEDvSSIEWLFVADALNFSFWALE-ENVhYSVELHEKQYTGYMALCAAITKALEADIPITSSQYYATITKEE 184
EEC01060      53 LHPKa---LDN-STVQWIFFVDALNFCFWSQN-SEEkCEIEFDGRRHTGYWSLCAAVNRAIQASIPLLDAQFCRDISHEQ 127
9_pfamImport   1 LHPNf---ADD-AAIDFIFAVDTLNFCFWSDD-PEEtYKVKYKDTFYSGYWSIVAALKRAEDEGKPVFSAIFMSSVDLDE 75 
7UGK_A       133 VRNILRSD-TD--VS---MPLVEERHRI-LNETGKILLEKFGGSFLNCVRESENSAQKLMHLVVESFPSYRDVTL--FEG 203 human
XP_025264543 126 LENIFKSDdGE--TN---IPLIHERLEI-LHKVGTVLLRKFQGSFMRCIQLCNRNPVKLLQLIVHEFVSYNDAPLckDAG 199
XP_011134930 123 VESIFRGD-DE--VN---IPLVNERLQV-LHEAGKVLLSKYQGTFKTCIESCKGSAAKLLNLIVSEFKAYRDEAV--YEG 193
EGI61988     123 ADIIFRGD-NE--VK---IPLIHDRIKG-LHEAGKVLLDKYKGTFVECIKSCKGSAEKLLQLIVKEFESYRDEAY--YEG 193
XP_009012357 132 LKKIFRSD-SN--YD---IPKLHERHCImLKD-GEILLKNFNGSFLNVVKACNNSAENLVNLITKEFTSFTDQIN--FQN 202
XP_015786129 129 VKRIFAAHrKGkpNEpmdLPLLEERHAI-MRENGSVLVKKFSNTFVSMVIKAKNSAKTLLKMVHEYFPSFRDELL--YNG 205
XP_015793048 128 VQRIFRAHkKGkpNEpmeLPLLKERANI-MKDNGKILVKKFSSNFVTVVVKAKKSARSLLQLIYENFPSFRDECV--FNK 204
XP_046438167 185 VDKIFISS-TG--ES---IPLLEERWRI-LQECGKILNEKFDGKFYNCIKQSANSATKLLNLIISNFPSFRDEGV--IEG 255
EEC01060     128 VEHIFRSC-TP--VP---FPLLEERHRI-LRECGQVLCTSYGGEFANCILRSNRSCQKLLDELVTNVPSFRDEGI--FNG 198
9_pfamImport  76 FKHIVRSD-TI--VE---IPLLKERLKA-YNEAGRVLLEKYDGSFSNCIRRCNKDAVQLVNILAADFSSYRDESV--FDG 146
7UGK_A       204 KRVSFYKRAQILVADTWSVLEGKGDGCFK---DISSITMFADYRLPQVLAHLGALKYSDDLLKKLL-KGEMLSYGDRQEV 279 human
XP_025264543 200 K-VYLHTKAQILLSDIWVCFKGHELG-FDyniDVMYSMIFVDSRVSQILRHFKLLEYSTKLMNKLE-NNEPLEYGSTEEI 276
XP_011134930 194 QRVSFYKRAQILIGDIWSCFKGCGIGEFH---DINSITMFADYRIPQVFLYFKAFRYSDSLLKKLR-SDELLENGSREEA 269
EGI61988     194 HRISIYKRAQILIGDIWACFEGRGLGEFH---DIDSIAMFADYRIPQVLVHYGTMRYSDSLMSKLK-SDESLKQGSREEV 269
XP_009012357 203 VEVSFYKRAQILVADIWSCFGGKGYGRFH---DIDTITAFADYRVPQVLNWFGALKYSEELTSLLKkEGTTFAHGDRWEI 279
XP_015786129 206 ESIGFYKRAQLLIGDIYACHEGKGLGKFD---DIQDITMFADYRVPQCLYYLGVINYRDELLRRLS-AGEKFKYGDPDEV 281
XP_015793048 205 ERVGFYRRAQLLISDIYACHEGKNLGKFD---DIDYLTLLVDQRAPQYLHFCNVLSYSLELRKKLK-LGEVLKYDDPDVI 280
XP_046438167 256 KKVSFYKRAQILVADIWSIFKGKGFGNFT---DVDSITMFADYRVPQSLVHFGAMAYSDRLHGLLL-ANHMFLNGDREEM 331
EEC01060     199 VPVSFYKRAQILVADIWACFGGQGLGEFE---DIGTLTAFADYRVPQVLAHFGALRYSERLSSLLQ-SGVLLQNGDKEEM 274
9_pfamImport 147 RPIALYKRAQIAVADIWLCFEGRGLGEFS---NIDKLTMFADYRVPQTLEYFGILQYSKELKEKLQ-NRETLQSGCRLES 222
7UGK_A       280 EIRGCSLWCVELIRDCLLELI-EQKGEKpn--------gEIN-SILLDYYLWDYAHDHREDM--KGIPFHRIRCIYY 344 human
XP_025264543 277 EIRSCLIFIIKLVAKDLKFIY-NNNKMEnis------emNINfFVVVNNFLWDYR-QEYDQLlmETQPFPNIKCVYY 345
XP_011134930 270 EIRGCSIELVERLYAEVRRMI-EDPKSPvkspealntakHVN-AVLIDQFLWDYRRKHAAGIddQVVPFHKTRCIYY 344
EGI61988     270 EIRACSIEAVEQVRDEVRRLIaADSKLGlnp------ltDVN-AIVIDHYLWDYRREYAQEL--EHIPFHKTRTIYY 337
XP_009012357 280 EIRGCTIHCIELIVKKVNETL-ESLPSStt-------nlKVN-SIIIDHYLWDMRREKAKEL--ESVPYHRTESIYY 345
XP_015786129 282 EIRGVSIHAVEQIKNGVVRLA-EINNVTlp--------iPAT-SVIVDFYLWDLRRSRPDEId-ECITYHKTRSIHY 347
XP_015793048 281 EMRGVAIHAYELIKREVKRMQ-VRCGVKlp--------lPLT-PTIMEFYFWDLERNRRDEId-RQLPSHKIRAIHY 346
XP_046438167 332 EIRGCSIHSVELIKEELKSHQ-VNTTTNs---------lPMN-SAMIDYFLWEYRRRFAQTL--AKVPYHKVRCIYY 395
EEC01060     275 EIRGATIHACELVCEELKRRL-QGDAALg----------EIN-SILVDFCLWDYRRKRAADL--DHVPFHRVRSCYY 337
9_pfamImport 223 EIRGCSIEAVEKLKSETRKIL-LSNPETtky------akIVN-SITIDNHLWDFAASHRSKM--AHLEFHRVRTIFY 289
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap