Conserved Protein Domain Family
Pga1

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pfam10333: Pga1 
GPI-Mannosyltransferase II co-activator
Pga1 is found only in yeasts and not in mammals. It localizes in the ER as a glycosylated integral membrane protein. It binds to the GPI-mannosyltransferase II subunit of the GPI and it is responsible for the second mannose addition to GPI precursors. The GPI-anchoring complex is a glycolipid that functions as a membrane anchor for many cell-surface proteins.
Statistics
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PSSM-Id: 370985
View PSSM: pfam10333
Aligned: 13 rows
Threshold Bit Score: 150.162
Threshold Setting Gi: 598070943
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_007376300  10 FMAVLCLANTETYLIRTPYYFDIvshpraienrfNFHREIVEINQTHSLIEDypiqtidtfnvvdiSNVLNLDYN---SK 86  Spathaspora pas...
XP_002498238  10 LFVATVSANTESFLLHVPSDFPL-----------RKNSDEPSSYPRYISLHN--------------SNLAKTTFF---SG 61  Zygosaccharomyc...
CDF88623      10 FWVHWVWANTESFLLHVPRDFPTk----------QSSSTELIQYPRSISLQD--------------TNINKATFS---CG 62  Zygosaccharomyc...
XP_002552051  12 FYICFSLANTESIVFKVPDTFSP------------APQPIADENEPLISLEG--------------TNRALKTFD---AP 62  Lachancea therm...
P53896        16 FFIGFVHANTESILYKVPHNFPLkkp------rdSSTYARDVNLISSISLSG--------------EAMSQITIEantTD 75  Saccharomyces c...
EJT42225      18 LCFGFVQANTESILYKVPHNFPLskl------rdRVASTNDVNFIPFISLLG--------------EAMEQTTIKvntTN 77  Saccharomyces k...
Q6CIB6        14 SLCHLALGNTETYQFHVPKDFPE----------------LSPSYVP--KLPY--------------INARNTTFRtitTH 61  Kluyveromyces l...
Q754M6        30 ALCRVCLANTETFNIYIPGDFPVst-------vgAQQDGGIESGLPRMVLHN--------------INYKMQRFD---VV 85  Eremothecium go...
XP_003647581  12 TVLKCIVANTEAFNLHIPRDFPLhptevsssndgRVGRQLGTHYFPSMSLYN--------------INHKLQVYP---VP 74  Eremothecium cy...
Q6FP82        12 WLCAIVSANTETLRIRIPRQFKTs----------ELTRQVHDSYSILKNLED--------------TAIVSGNIN----- 62  [Candida] glabrata
CAR65887      17 FLVS---ANTETYLLQVPHYFNIpshpnvinphdLHHRSVHNLNKTHSVLLDfpiknt--ppssniSNTISLVYN---PL 88  Debaryomyces ha...
EDO15443       9 FLINFVIGNTESFLLHVSNEFPSissr----qldYSNVTTLSSPIDYISLKN--------------VNIAKKVIN---TN 67  Vanderwaltozyma...
CCE90604      14 SLFVLVIANTESFLVKVPKDFPV-----------GTSNHIDDQFPLRISLNN--------------SNHAKETIE---TH 65  Torulaspora del...
XP_007376300  87 VKpkKTLLVRINNygdslFQPDDLLNIKLCWPATTPYDFW-ISHTYL--------H-SNELLSTENDNFDlYLKIDYQFI 156 Spathaspora pas...
XP_002498238  62 IE--GPTYIELKS-----LQVDETYQIKICWTALDPVSITdIDWIVI--------P-HSTEFQNTKSDEA-RIFIKFNVV 124 Zygosaccharomyc...
CDF88623      63 IN--HSSFVELTH-----LQQGEAYQIKVCWTALDPISIDhMDWFVV--------P-HSTLFQGTTSDAA-RIFVRFDLR 125 Zygosaccharomyc...
XP_002552051  63 VD--SQFDIELRD-----LSPGDTFFAKICWTAVDPIDITsLGYSIK--------P-DYTARGGHWQDAPlRFFLSFEAK 126 Lachancea therm...
P53896        76 LElhNTTYIELAD-----LQRDETYQIKVCWSAIHPISINnLQTITI--------P-RFTEFQGTKSDYA-RILVTFQVL 140 Saccharomyces c...
EJT42225      78 LQlrNTTYIELTD-----LQADETYQIKVCWSAIHPISISnLQTVVI--------P-RFTEFRGTTSDYA-RIVVMFQTL 142 Saccharomyces k...
Q6CIB6        62 LQpeAKTFVELTG-----LKKNENYMVKICWTGIDPISLKsIRHQFI--------P-HGTVFKGTLSTQT-RAVILIETR 126 Kluyveromyces l...
Q754M6        86 PG--EMFYVQVDE-----LRQNENYQVRISWTAADGVGVAdMGHVVV--------P-HGAAFRGTVDERA-RVAVHFRVE 148 Eremothecium go...
XP_003647581  75 LN--DTFYIQLTD-----LKQDETYQIRICWTAMHPVNVEgLGYQIV--------A-HDVNFQGTVADDA-RIFVHFKVV 137 Eremothecium cy...
Q6FP82        63 -StsPFHVIEVRS-----NWSGTTLDVRVSWTAADGYSINdLGYLLItkehevvtPwSNETFEGLHE----KLYVYFKVV 132 [Candida] glabrata
CAR65887      89 VHpaKKLLVRLNNyhdetFKSDDLLYVKLCWPATTPINFR-FDHSFH--------RlSDFLFEHTEDTFDiYLEVEISSD 159 Debaryomyces ha...
EDO15443      68 ISasDPNYIELLH-----LSKDETYQIKICWSAIHPISIDdMDWFIV--------P-HSTLFQDTISDEA-RIFITFNTN 132 Vanderwaltozyma...
CCE90604      66 IGevNPTYIQLQH-----LQIDEVYQVKICWTALDPVSIDeMGWFIV--------P-HSTSLQGTTSEEA-RIFIKFTIT 130 Torulaspora del...
XP_007376300 157 GETYDPekyLHDNDNLQFQLYINKLPnnwLPIPLELYTYLLYLIDLV-ILTVWH 209 Spathaspora passalidarum NRRL Y-27907
XP_002498238 125 ADSWPP---LNQLTKIPINVSVINTK---LGIPVDLYKIIIYIGLVM-TITFWI 171 Zygosaccharomyces rouxii
CDF88623     126 ADSYPP---LEPMTRIPINVSVINTK---LAIPVDLYKLIVYIVLVT-AGVFLV 172 Zygosaccharomyces bailii CLIB 213
XP_002552051 127 SNSYP----LFSKPTVPINISVSAMR---MGVPVDLHATIIFMTLLT-GLIFII 172 Lachancea thermotolerans CBS 6340
P53896       141 SDSYP-----SEHAMVPIQVSLITTR---LGIPVDIYPTLIVMVLLV-AGLVVT 185 Saccharomyces cerevisiae S288C
EJT42225     143 PDSYP-----SEHTMVPIQVSLITTR---LSIPVDIYPILVVMVLLV-TGLLVT 187 Saccharomyces kudriavzevii IFO 1802
Q6CIB6       127 ADSYPI---LQDKVKVDVSLAVIK-----LGIPVDMYSILFYLACVL-ICAISF 171 Kluyveromyces lactis
Q754M6       149 AEAYPA---LAA-ARVPVNVAVVNIK---MGIPVDLYSIALYVLAVV-GAAAYV 194 Eremothecium gossypii
XP_003647581 138 PQCYPP---INADT-IPINVSVVNIK---MGIPVDLYSVVFYILLVL-GAVSYL 183 Eremothecium cymbalariae DBVPG#7215
Q6FP82       133 PDSYPL---LEDGQVFNVAINIKETF---LGLTSDLYVMIAYLIVLAsISRLVV 180 [Candida] glabrata
CAR65887     160 IHTYSTk-yNDSIEEIQFQLYITKMPskwIPIPLELYSYIVYVVDLC-ILLVSi 211 Debaryomyces hansenii CBS767
EDO15443     133 NDSYPV---MNDNQLVPINVSIINVK---LGIPVDLYRVLVFIIVVL-ISIFIL 179 Vanderwaltozyma polyspora DSM 70294
CCE90604     131 NDSYPT---MKPGTMVPINVSVINCK---LGVPVDLYKTIVYIIAVA-VSAVLL 177 Torulaspora delbrueckii
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