Conserved Protein Domain Family
7TM_GPCR_Srz

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pfam10325: 7TM_GPCR_Srz 
Serpentine type 7TM GPCR chemoreceptor Srz
Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srz is a solo families amongst the superfamilies of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'. The genes encoding Srz appear to be under strong adaptive evolutionary pressure.
Statistics
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PSSM-Id: 402098
View PSSM: pfam10325
Aligned: 55 rows
Threshold Bit Score: 144.651
Threshold Setting Gi: 75028238
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q7YWQ3        18 ASLHWILLMMLLSYISLPFYIYVHKINKQREES---FPlIMKQFYKM-VKIAYFCFFMVIVIgsVILLTFFSNilsnpsf 93  Caenorhabditis ...
Q6A587        21 EFDLISYAFLLINLIIFPFYKYLYEINRDRDKKmllFP-TVQHFYEM-VQLAYFLFVFSIIL--HTLLHVIHE------- 89  Caenorhabditis ...
O45639        23 GLHSLFLISVVLYLFVFPFYVYVFKLNKRRDKKtllYP-TVHHFYKI-VKISYCLFVSSMMF--GKLAIHFSY------- 91  Caenorhabditis ...
O44460        23 GLVAIFYISTLLYLVIFPFYVYVFKLNRRRDRKtllFP-TVSHFYGM-VKITYCMFGILIFC--NIMILCNNPg------ 92  Caenorhabditis ...
Q5WRK6        19 GFIAMFLTFTLFYLITFPFYVIAFKLNRTRDRNtllFP-TVGHVYNM-VTITFYLFVSFIIC--MSLFMNSGP------- 87  Caenorhabditis ...
O44459        23 GLVAIFYFLMLLYLVIYPFYVYNFKLNRRKDKNallFP-TVNHFYHM-VNISYSLFVLLITV--ICLAGVAYYhlg---f 95  Caenorhabditis ...
Q9XU34        23 SLFLLSIFLVILFIIIFPIFVILNRANRRRDEKtaiYP-ITNYFYKS-LCVFYIFSTVCIII--TVLILIYGP------- 91  Caenorhabditis ...
O01838        20 IGAVLLIIYLISIIVIFPLYVYVYRLNRKTEKLayfYP-ITKHFYSViCSMQFYIYVTLSIG--AITWLFFDL------- 89  Caenorhabditis ...
Q6BET3        18 SLFIFSAIYLFSLFIMFPIYVYVYRYNDKNDKMalfHP-ITSHFYKM-IKWFHAIALFFIIF--LILVFISSN------- 86  Caenorhabditis ...
NP_001343611  20 GSNLITGIIILIYFLLFPFYVYVNKANRKRDQAvliYP-FTKHFFKM-TVVMSILYVIFIAG--MLSGVLFLV------- 88  Caenorhabditis ...
Q7YWQ3        94 eKFHIVLIIFLLFGGAVVTIqflaFIVTLQVFHVLIFLIAIQNLLRFFF-PL---RFSLLKNSTDRYVKQFYIFFVSKEI 169 Caenorhabditis ...
Q6A587        90 --IVIIRFLIVVIFYALCFT----MYHLTKAFYLTTFFLAFQQFLVFYF-PKlekQVSIIQKHFFKDVWYLYIIFLITEA 162 Caenorhabditis ...
O45639        92 -KNGLICALCFAIAVVFIFT----LYLLTEAFHLITFLLALQRFLIYFFpPGaekYVTAVQDFINKQIWKLYLVMFLKEV 166 Caenorhabditis ...
O44460        93 -RRFFFGFFVIVVAMCIVFT----LYLCTAAFHFITFLLAAQRFLIFFF-PNtekHVAVFQKFLFKHIWKVYLVIFVKEV 166 Caenorhabditis ...
Q5WRK6        88 ---ELSNLILFIIVALITFA----LYLSTEAFHFLIFLLAAQRFLVFYF-PStekHIALFQKFMSKKVWYVHLVSVVKEI 159 Caenorhabditis ...
O44459        96 vRSLPEQLTFVILVTFIIFA----QYLCAEAFHLTIFLLAAQRLLVFFF-PHtekQVARFQKLMAKHIWYLYLVCFIKEL 170 Caenorhabditis ...
Q9XU34        92 -PNAFTGTVNIIFVFCIVFP----LIIFVHVHHLIIFLMAVQRFLLVFF-PSfepLVTFGQKTTNKIIYTLHFLFILTHL 165 Caenorhabditis ...
O01838        90 ---TAAGCVFIVSLFFAYFV----AITVTSVQNVLLFILALRLFMILFF-PNfkkVISINQKSFQATRNLLYIVYSLIQI 161 Caenorhabditis ...
Q6BET3        87 --TKIITTAVPILILIVYLM----SSVITSIQNSLLFLLALYRFIIVFF-PSw---kSVASTNFKKLIKILYIFFILVQI 156 Caenorhabditis ...
NP_001343611  89 -RKSPYIAVSGLAIFFAIQA----LSLVTHVFNLLLSLLGIAKFILYFF-PSqekRVSSIQKSVYRRIWLLYVACSFEDA 162 Caenorhabditis ...
Q7YWQ3       170 ACFLLFAACDNDFLPRni-----------wETGHVVYLITFLIMNvLISQLSPLIYIPIIWRTRKNKTlMYSQQHAYLYR 238 Caenorhabditis ...
Q6A587       163 ILWVLSNGSTAAE-----------------AKFDTFSSATIIIPY-VLQLFSTLFYIPIMRSVRKNAY-VTSGHYYILQK 223 Caenorhabditis ...
O45639       167 VLIIVYSLTEFNKEEGl-------------THFGIYFITVVLVLY-ALLFLSTVFYIPIIISARRLSH-VDSAQQCMVQK 231 Caenorhabditis ...
O44460       167 TLFIIFNHNTSDSRRT--------------TNFGVYILTIFSLSY-ALLFLSTVFYIPIMISAWKVY----PAQKCAVQK 227 Caenorhabditis ...
Q5WRK6       160 TIICIVGSQMEIKRPNircipapgycqdtwSGIGFYTVGFILFFH-VLLFLSIPFYIPIMISAQKIS----SNQYCKVQN 234 Caenorhabditis ...
O44459       171 ALAIIFCTTISTEFLGie-----------gNPFGYYTMGFVALFY-VLLFLSTAFYIPIMIRTRKFA----SIQNCVVNN 234 Caenorhabditis ...
Q9XU34       166 GLLILDWANYQGSLS---------------QIPTLYYLCYFIFLN-IIQITSAILYIPMVMKIRSFAH-LASSRTYQPQN 228 Caenorhabditis ...
O01838       162 ISKLVKIFC---------------------GTESAAYGRIYVAGD-ILVMFAAIMYVIMFMKIRRWSK-MTGDQLNNPEK 218 Caenorhabditis ...
Q6BET3       157 IHKLLQNICIISS-----------------MIDENILLIIYITGD-VLVVTAAVLYGIMFFKIRKWSQ-LVGDSLNQPEQ 217 Caenorhabditis ...
NP_001343611 163 ILYVWVLRENE----------------------------MNIIKI-GLLVFTNDMYIDICFAIhsnidkcseacksrist 213 Caenorhabditis ...
Q7YWQ3       239 YVFWQNVLVFSFKTIALPYLMENPEidrILV--------GILYNDFSTLPLTIQLSYLWCNR 292 Caenorhabditis elegans
Q6A587       224 YIFWQAVTALIFESFPIIFSTIQL----LHGscgcsfvvIATLVSTLITPLTIQVPYLGSRK 281 Caenorhabditis elegans
O45639       232 YIYWQTLTVFICKLQSVFLCIYLF----IRAssitditfGIVLTDIVTTPLIVQIPYLGSNR 289 Caenorhabditis elegans
O44460       228 YIYWQTLTVFIFKSTAIVIFIYQSTfgaYSTvhy---tsGILATDVVTTPLIVQISYLGSNR 286 Caenorhabditis elegans
Q5WRK6       235 YIHWQTLTIFVCKLINIVVVIYNHTfgsLSIaey---tvVIVIIDIVTTPLIVQLSYLGSNG 293 Caenorhabditis elegans
O44459       235 YIHWQTLTVFICKSIAIVLFVYNNTygtFSTgky---tfCIACSDIVTTPLIVQISYLGSNG 293 Caenorhabditis elegans
Q9XU34       229 FILYQTLFISGSKSSHIWALGLVF----WADfsvihffiICGGFDLLSTPVLIQVSYLFCNK 286 Caenorhabditis elegans
O01838       219 YIFYQTVLIVVTKLLAINVILVMCYqdgYSDdwa---fgAFVVSDVLTTPFVIQGSYLLCNR 277 Caenorhabditis elegans
Q6BET3       218 YIFYQTLFIIISKSLAVTLISLSCLi--YGDcagqkifiILLFTDLTVTPAVIQGSYLLCNR 277 Caenorhabditis elegans
NP_001343611 214 rkqstkqlhllcl------------------------------------------------- 226 Caenorhabditis elegans
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