Conserved Protein Domain Family
Cactin_mid

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pfam10312: Cactin_mid 
Conserved mid region of cactin
This is the conserved middle region of a family of proteins referred to as cactins. The region contains two of three predicted coiled-coil domains. Most members of this family have a CactinC_cactus pfam09732 domain at the C-terminal end. Upstream of Mid_cactin in Drosophila members are a serine-rich region, some non-typical RD motifs and three predicted bipartite nuclear localization signals, none of which are well-conserved. Cactin associates with IkappaB-cactus as one of the intracellular members of the Rel (NF-kappaB) pathway which is conserved in invertebrates and vertebrates. In mammals, this pathway controls the activities of the immune and inflammatory response genes as well as viral genes, and is critical for cell growth and survival. In Drosophila, the Rel pathway functions in the innate cellular and humoral immune response, in muscle development, and in the establishment of dorsal-ventral polarity in the early embryo.
Statistics
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PSSM-Id: 402090
View PSSM: pfam10312
Aligned: 107 rows
Threshold Bit Score: 110.721
Threshold Setting Gi: 89306013
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
EEC47384                      213 RMKELENYDDWARKEEEFHLHQQKQRSAIRLVEGREKPIDVLAKNLLL-----FGlseEDKkkrsslkyqerynalealq 287 Phaeodactylum tricornutum CCAP 1055/1...
EFC48828                       92 REREAERFDEYEKKESEFHLKQENLASFIRLRERRAKLIDFVTNNLKYlrfkdkllgddyds--------hlilsseher 163 Naegleria gruberi...
EGC35882                      237 RMKDMSNNEELEKKEEEFHFLQACKRCETRLFDNRPKPIDFLYKTLNMlhlpdHRenrE--------------------- 295 Dictyostelium purpureum...
A0CV63                        157 KERQMENYKQWIDNEDAFFEKVEKLRPLIRIQQQRELPFDKFVRIC---------------------------------- 202 Paramecium tetraurelia...
WGS:AAGF:cds.TTHERM_00459380A 194 QEREEEQYQQWKEKEEKFHAYQARIRALVRITQGKETTVDKINKIF---------------------------------- 239 Tetrahymena thermophila SB210...
EGR28681                      106 KEREYETYMQWKQKEESFHKFQSKIRALVRITQGKEEFVDKISKIY---------------------------------- 151 Ichthyophthirius multifiliis...
Q8IAN8                        296 KQKNQINIKEYMEKEHLFFFNQEIHFSNKRIKHKDIQPIDIFRTAIQI-----MKgeeDVQks----------------- 353 Plasmodium falciparum 3D7...
Q7RRC6                        244 KQKNQINIKEYIEQEELFFINQQIQSSDNRISHNHIQIVDIFRIATKI-----ESge--tVrn----------------- 299 Plasmodium yoelii yoelii...
EDL42918                      293 KQRNQINIKEYLQKEQLFFINQQIKSSDSRIDHNLLQLPDVFRLAAKI-----VNre--qVkr----------------- 348 malaria parasite P. vivax...
XP_002257640                  281 KQRNQVNIQDYLKKEQLFFIDQQIKSSDSRIERNFLQLPDIFRLAAMV-----VNre--qVkk----------------- 336 Plasmodium knowlesi strain H...
EEC47384                      288 tleAELED-P-HIMLKML--KLNELEELLVEIDMFRSL------ER-------------DalstvgvkSTQPnq------ 338 Phaeodactylum tricornutum CCAP 1055/1...
EFC48828                      164 iygVEYKK-P-YEVFHDR--KLQDLLDSQEDLETMIEC------DI-------------Dy------------------- 201 Naegleria gruberi...
EGC35882                      296 ---------P-VSMIQSIy-DPKILEELIEGIRDFTYL------DT-------------D--------QDNL-------- 329 Dictyostelium purpureum...
A0CV63                        203 ------------CIYKGQigHQKQLEQIMHNPSQFIKTlg---hED-------------QkvilneskKQFAieidnksn 254 Paramecium tetraurelia...
WGS:AAGF:cds.TTHERM_00459380A 240 ------------YIYRRKikYSEHLDPIMSNVQAFIKKqdeeelEKilaqainhhnqlqDpvaindqqYKDEseiv---k 304 Tetrahymena thermophila SB210...
EGR28681                      152 ------------YIYKQKiaFNPHLEPLMMDLISQIKIqettilQKl------------HelskncqlEEDFpaenelen 207 Ichthyophthirius multifiliis...
Q8IAN8                        354 -vgINNYTmPfNKILEGL--REKELVNCERQIKLFQMH------DK-------------Mfy-----eEKYE-------- 398 Plasmodium falciparum 3D7...
Q7RRC6                        300 -vhLENYRtPfYYMLEDL--SEHDLENCAKQIKLLISH------DR-------------Lfn-----eNKYH-------- 344 Plasmodium yoelii yoelii...
EDL42918                      349 -vrPALYRvPfHVLLEGQ--TERELENCAKQIKLLLQH------DE-------------Len-----gGKFR-------- 393 malaria parasite P. vivax...
XP_002257640                  337 -vrPALYRiPfHVLLEGQ--TEGELENCAKQIKLLLQH------DE-------------Lnn-----gGKFR-------- 381 Plasmodium knowlesi strain H...
EEC47384                      339 vlQYWDALHKVAQDEIKY--LKS---------GGDQG-S-HAKI---VVEVQKVFKGQSFADLAKMKDEVASRIRvnren 402 Phaeodactylum tricornutum CCAP 1055/1...
EFC48828                      202 -qDFWRALSVIVKDEINL--AKEyekkkvgkeEERTK-DiHASV---VAEIKELLSDKNLDELLEMEQLINETLD----- 269 Naegleria gruberi...
EGC35882                      330 --EFWEAALELSNYQLgvrn--------gedpANSDSsAlHHSL---TNDIRNILQGKSFKDLVSLETDILQKLE----- 391 Dictyostelium purpureum...
A0CV63                        255 fqDYWASIISIAQAEVEWreQKEkdpk-------cpkfGiQSEF---KQDIKKMFQGKSREGLDELEGEINQMLNy---- 320 Paramecium tetraurelia...
WGS:AAGF:cds.TTHERM_00459380A 305 fsQFWESIRSITQYYLDE--FRKrdqq----------kevLPEF---EEEIKAIFEGKNLEELLELEKGINQSIQl---- 365 Tetrahymena thermophila SB210...
EGR28681                      208 lnQFWVNMQHVTYFFLEEk---------------------HKQFeefQNEIQSIFINKKLPELSELEKTINSTLKn---- 262 Ichthyophthirius multifiliis...
Q8IAN8                        399 --KFWNALLFFCKYYLDKieLKGk----------eNN-YiDDNT---DIKIESFFLNKTYDELVKYEYKIKEKILm---- 458 Plasmodium falciparum 3D7...
Q7RRC6                        345 --KYWNSLYFFCEHYLSK--LNGdee------pykTK-EiDEKT---NKKIEEFFKNKDYDELITYENKIKNKIIt---- 406 Plasmodium yoelii yoelii...
EDL42918                      394 --RYWESLLFFCEHYLGQ--LHHkeqpaseaeEREVK-NvLSKT---ERQIQAFLEHKNYDELVTYEEKIKEKVVs---- 461 malaria parasite P. vivax...
XP_002257640                  382 --RYWNSLLFFCGYFLDQ--MREkeeptkdekAFDQN-NlQSKT---DKQIHTFLENKNYDELVTYEEKIKEKVVs---- 449 Plasmodium knowlesi strain H...
EEC47384                      403 sgsRGT-AFDVLYWQSVMEQLDVYLAKCELSDLH 435 Phaeodactylum tricornutum CCAP 1055/1
EFC48828                      270 ---NRDaSTDVEYWEGLKKYLQIYKARNIVSQIH 300 Naegleria gruberi
EGC35882                      392 ---SGS-AMNVEYWETLLKHLKIYKSSAFLKEKf 421 Dictyostelium purpureum
A0CV63                        321 ---GAEyKIDFDYWEKILKKLKVIKAKTILKNYY 351 Paramecium tetraurelia
WGS:AAGF:cds.TTHERM_00459380A 366 --tKYGsQEDQQYWQNMHKRLQLYKGDAILKNFY 397 Tetrahymena thermophila SB210
EGR28681                      263 ---PSLdKTDQLYWQNVQDRLLLYKASLIFQAly 293 Ichthyophthirius multifiliis
Q8IAN8                        459 ---EEStDNDVNYWNMILCKIPYYKSKYILKCFQ 489 Plasmodium falciparum 3D7
Q7RRC6                        407 ---NDIeNFDSIFWNTILLKIPFFKAKYILDDFr 437 Plasmodium yoelii yoelii
EDL42918                      462 ---QCEeVTDQVYWNRVLLKIPFFKAKNVLVHFH 492 malaria parasite P. vivax
XP_002257640                  450 ---QSEdHADEVYWNRVLVKIPYFKAKNVLLHFH 480 Plasmodium knowlesi strain H
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