Conserved Protein Domain Family
Ilm1
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pfam10311: Ilm1 (This model is not part of the current CDD release)
Increased loss of mitochondrial DNA protein 1
This is a family of proteins of approximately 200 residues that are conserved in fungi. Ilm1 is part of the peroxisome, a complex that is the sole site of beta-oxidation in Saccharomyces cerevisiae and known to be required for optimal growth in the presence of fatty acid. Ilm1 may participate in the control of the C16/C18 ratio since it interacts strongly with Mga2p, a transcription factor that controls expression of Ole1, the sole fatty acyl desaturase in S. cerevisiae responsible for conversion of the saturated fatty acids stearate (C18) and palmitate (C16) to oleate and palmitoleate, respectively.
Links
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Statistics
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PSSM-Id: 519313
Aligned: 49 rows
Threshold Bit Score: 123.84
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
EPE04171       4 ISARTIITSLSFFHLTLGFFFLTSPVSLADQSLVYVVGDAMGMPTTPGFDVPS-PALAFLAVILAFMGISDIATL----- 77 
XP_002560159   4 ISSKTLIQAHAVFLVVIAGYLVKNPEVITDSDLVFMMGEALKIDF-PSLSSPQqSPFTFCAILIFIESLVDLVLLsnipf 82 
XP_049967852   4 LSSKTLIQAHAVFTVVIAGYLLKNPAVITDSDIVFMMGEALQIDF-PAPTTPTsSPYVICSVLLFVAAAVDIVLLtslpf 82 
XP_054122419   4 LSSKTLIQAHALFTFILSVYLVISPNAITDSDIIFIIGEAMQIDLDPAMTTFQ-YPLAICAILLTGEALVDLIIVrk--- 79 
XP_002485252   4 LSSKTLIQLHALFMFILAVYLITSPSSITESDLIFIIGEAMQIDLDPAMSTSQ-FPFSICAILLVSEALIDLIVVgk--- 79 
GAD96368       4 FSSKTLIKAHAFFLFVLAVYLTKSPEVITDSDLVFILGEAMKIDVSPTFARPQ-SPFALCGILLVADALVDLIVVtk--- 79 
2_pfamImport   1 LSSKTLIQAHALFLFVLAVYLTRSPEVVTESDLVFMLGEFLNLEATPSISRPQ-SPFALCGVLLVVDALVDLILVtk--- 76 
XP_001819286   4 LSSKTLIQAHALFLFILAVYLTRSPEVITDSDVVFMLGETLQIDAAPSLSRPQ-SPFALCGILLVADALVDLILVtk--- 79 
XP_001272585   4 LSSKTLIRAHALFLFVLAVYLTKSPEAVTESDFIFMVGEMVQIDAAPTLSRPQ-SPFAMCGILLIADALVDLIILsk--- 79 
XP_045291064   4 LSSKSYINLHALFQFALAVYLTRYQEAIADCDLSYNVNDVIRIDATPTFARPR-SPFAYCGVTLLVFALFDLILAtr--- 79  Histoplasma cap...

EPE04171      78 --SLPEEAGMVHYWGTQ------------------------------------APVRVLLSMVSVFYTFFFSESRWHGkk 119
XP_002560159  83 heALDEALPYIRPLRNGnlpaedlqvlqslpey-----itksltiywsvwiavAACRFAVYAAIAFFIYQ---------- 147
XP_049967852  83 hdALNDALPYIRPLRNSnlpaedlqalarlpey-----itksltmywniwvavSAVRFALYGALSFYIYQ---------- 147
XP_054122419  80 lpQIDDILSTVQHEQRRtedtgfsritlqkpkqninaltiqlatlyneiwtfiACVRFCFFFAVSLFIYTSGGNA----- 154
XP_002485252  80 lpQLDSILTNLQREQRQtedrgfsritlqkpkqtinswtiqlatiyneiwtfiAGARFVFFFAVSLFIYTGDS------- 152
GAD96368      80 vpQINEVLARADVARSRsngstavisnnpfa--------irmaalyseiwtllAASRFCLFFAVSIFIYQSKPVAWGVg- 150
2_pfamImport  77 ipQINEILAMAQAARVQspipvagavrtnpfm-------arltslyseiwtllSAARFCIFFAVSFFIYQSQPSAWGM-- 147
XP_001819286  80 vpRINEIIAMAEIARSAaptsiagamrtnpfl-------arlaslytdiwtllSASRFCLFFAVSFFIYQSKPSDWGV-- 150
XP_001272585  80 vpWINEIIAMAQAARSEsavpvpgamrhnpfl-------arlaslyseiwtllSAVRFCLFFAVSFFIYQSKPDAWGV-- 150
XP_045291064  80 lpLINQLISVMSRLFNArrthdsappssptsstad-kmlqtytslfthicillAITRCLVFSVISIRIYASASEVWVPaa 158 Histoplasma cap...

EPE04171     120 praySSHPTYAQT------GFAGDLLKNRVFFTFMFLEMVSWFWLWVTLREEHTEV 169
XP_002560159 148 ----GKGDHLASSytsaaaIGGLDRLKNRVVFSFAFFEMMFWFWTFSTLREERQER 199
XP_049967852 148 ----ARGSYMVASyaaktaPTGLAQLKSRVVFTFAFMEMMVWFWVFFTCREERQQR 199
XP_054122419 155 ----GKASLEWSDddagqiKLGLEQVKSRVVFTYAFVEMMFWLWTLSNVREERREV 206
XP_002485252 153 ----SGATGKKSWvgqgqvRNGLDQVRNRIVFTFAFVEMMFWLWALSNVREERREV 204
GAD96368     151 ---aSEA------------MSGLDQLKNRVVFTYGFMEMMFWLWILLTLREERQET 191
2_pfamImport 148 ----DAATGMGNYgtagaaTSGLDQLKNRVVFTYGFMEMMFWLWIFITLREERQEA 199
XP_001819286 151 ----DVRHTVDGYgqe--saSGLNQLKNRVVFTYGFMEMMFWLWIFLTLREERHEI 200
XP_001272585 151 ----NVTARGTEYsst-eaLSGLDQLKNRVVFTYGFMEMMFWLWIFITLREERQEI 201
XP_045291064 159 ---aATAGGRGGMldaaalAAKVAHIKNKVVLGYAVAEMMISASTLLSLKDERLqt 211 Histoplasma capsulatum G186AR
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