Conserved Protein Domain Family
DUF5427

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pfam10310: DUF5427 (This model is not part of the current CDD release)
Family of unknown function (DUF5427)
This is a domain of unknown function. Family members found in Saccharomyces cerevisiae, are synthetic lethal with genes involved in maintenance of telomere capping. However, experimental evidence is yet to verify the exact function of family members and the domain.
Statistics
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PSSM-Id: 519312
Aligned: 70 rows
Threshold Bit Score: 199.491
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
EMR63310      19 EGIG-DDSAVKK--------------PTKAKSTAPKSrggdKHEkDPLAELEnEL-EevpsrphtprvrDAv------sS 76 
XP_003958344  18 ESLPnDG--------------------ANEKVDDGNKkkgnKDE-DIFEFLD-ELeK------------SNlks---kgK 60 
XP_003673909  18 ESLPeTSsn---------------gnQDDKTKDATKKdpqkKDE-DIMDFLD-ELeK------------STadlsekkdK 68 
XP_003980269  18 ESLPsENatd-------------ksiDDTNDNKGKTNeggaGDE-DIMDFLD-ELeK------------SNlsiekpskK 70 
XP_001645983  17 DSLPeAK---------------------KNDQNDQSKdngkKDE-DILDFLD-ELeK------------SNle-----lN 56 
XP_002554470  33 ESLPeSSk------------------TSGGSGAENSGkepkKDT-EILDFLD-ELeQ------------SNlslkkdkkA 80 
XP_022466584  37 GSLPqGK-----------------------AEQGREQekgeGDG-DVFEFLE-ELeK------------SNlsvggkrgG 79 
P47018        17 DSLPeAKNGGKMvntdvkgsqegvkgGSNSVAGKTGNdgkkGDD-DIFEFLE-ELeK------------SNlsltdkkgV 82  Saccharomyces c...
Q6FL79        18 DSLPeDK--------------------KGAEGKSKAKgagkKDEeDVFEFLE-ELeK------------SKmdlgakkgK 64  [Candida] glabrata
XP_004180572  17 DSLPqSGqngdk---------sdsmkDSKDLGSSKAGsntkKDE-DILDFLD-ELeK------------SNlslnkeksE 73 
EMR63310      77 KRT--------------STATPppg----aprQSEDKstn-------------lpRKSveSTR--SFHA-SFTPSATSS- 121
XP_003958344  61 EAKvarkqeqplekegaKQEPEetkpkevepvSNE------------------------------TVSKgTVENPEEneq 110
XP_003673909  69 KQTkkveervktedqpvQKEEKekeeskekitAE-------------------------------TAKTpEQEQEEEQVn 117
XP_003980269  71 KKGltgnsadktgqqsaKEEGKektekvsptiTKEKEeevisg-----------------keeeeNQEQgHEEEEEEEVe 133
XP_001645983  57 KNKtnsgdsannnknkkKASNNtkqeskpqsvGKEETkkapiknneqkpvkeeikEVPldEVT--NKEEsINENQEQDSv 134
XP_002554470  81 Gqae-----------enAQEGEgdsvaqtstaSKEPAaaekpaaa--------ekpvaaeEPA--AVEDpASSKASQPKe 139
XP_022466584  80 EAGgekqvtekgtgkqrLLRRWkgktqrslnkNK------------------------------------GAEAAGEqeg 123
P47018        83 EKKapsesvnnkaqdekVEESKenknseqdahGKEKEp--------------------------qQQEKeEEEEEEEEEe 136 Saccharomyces c...
Q6FL79        65 KVAetkkldpqesndgkAKSETkqe--------------------------------------apAVKKdTEEKSEEASn 106 [Candida] glabrata
XP_004180572  74 GSKvsktktenddkivkNDSSPavienssstsSTQMGk----------------kDQNedSLKkeELKQsDEEKEEEeee 137
EMR63310     122 ELQDAEKKgpveQ----AAPAASGGAG--GGWWGGifatasaTANAAMKQAEAaykeiQKNEEAK----KWAEQVRG--- 188
XP_003958344 111 d-------geplN--------DPITSI--SNWWTS-------SGSTAVSNLWS-----KTTEQAS----KVKDRIQK--- 154
XP_003673909 118 ---------------------DPITSF--SNWWSS-------SGSNTVSSLWN-----KTTEQASthlkKVTERINQ--- 159
XP_003980269 134 qgrd----gtplN--------DPITSI--SNWWSS-------SGQATVSTLWD-----KTTKQATsqikKIGDKIGQ--- 184
XP_001645983 135 pke-----gtplN--------DPITSF--SNWWSS-------SGSAAVTNIWN-----KTQKQAS----ELQKKIVDeqs 183
XP_002554470 140 TAASVSQAdaeiiqsepettsDPITSF--SNWWSS-------SGSATVNSFFS-----KTAEQAT----HLKDRLAQ--- 198
XP_022466584 124 e-------qspaA----PDSASPAGAFslSNWWSA-------SGSATVSQLWN-----RTTEQAT----TLTNKIAQehl 176
P47018       137 eeee----etplH--------DPIASI--SNWWSS-------SGSAKVSSIWN-----KTAEQAS----QIKNRLAQ--- 183 Saccharomyces c...
Q6FL79       107 AKVeane-etskQ----GTNPDPIASI--SSWWSS-------AGSATVSSLWS-----KTTEHAS----QIKNRIQQ--- 160 [Candida] glabrata
XP_004180572 138 a-------deplG--------DPISTF--SNWWSS-------SGSATVSSFWN-----KTTEQAS----QLKNHLSQ--- 181
EMR63310     189 --NVGALKGL-GDDLRHR------------------ALPTIADIMHTLAPPI--SSHERLLIHITHDIVGYPSLDPLIYE 245
XP_003958344 155 --EQQ---TL-TTTLPIKi-----------------NTNTISELAKNLSRIVvgETEEVLRIHLVHDLVNYSNLQYYVES 211
XP_003673909 160 --EQQMEDSI-ASKLTKNl-----------------NPIKISELAKSLSKIVvgDTEEILRIHLVHDLINYSYLQYQIET 219
XP_003980269 185 --DQL------LQQSRGA--------------------IKITELAKNLSKIVvgETDEILRIHLVHDLINYSYLQYQIED 236
XP_001645983 184 qiPIKELTSL-TSKLKTS---------------------TITDLANRLQEIVvgETEEVLRIHLVHDLVNYPLLQYHVEQ 241
XP_002554470 199 --EQH---GI-ASKLQGTslg------------skiNTATLSTLAKNLSRIVvgDTDEVLRIHLVHDLVNYPLLSYHVEQ 260
XP_022466584 177 hdLQG---SL-PIKLDGS---------------------TISELARNLQKIVvgETEEVLRIHLVHDFVNVKYLQRHVEQ 231
P47018       184 --EQL---DL-TSKINTS---------------------TITEIARNLQKIVvgETEEVLRIHLVHDLVNYPSLQYNIES 236 Saccharomyces c...
Q6FL79       161 --EQL---DI-TSKLNTQ---------------------TITDLARNIQKIVvgETDEVLRIHLVHDLVKFPSLQYHIEN 213 [Candida] glabrata
XP_004180572 182 --EQQ---DFiAQSANRVkninmnkvvdmnvvnsvvNKSKITELAKNLQKIVvgETEEVLRIHLVHDLVNYPNLQYIIHE 256
EMR63310     246 VFSRVM-SQVEGGDLLVIQRGQESTA---RRasdvtytkhsSSSSVAGWRDGPWWRqv--dAP-RNL--GAVRG-LPEGT 315
XP_003958344 212 KFDQVLsSQVQGGIRIFVDEWGKPHQddtTTisfi-------------------------ndnrRSL--NLFVGkITDGE 264
XP_003673909 220 KFDQVLsSQVQGGIRIFVDEWGNPNKkmdSSitnefn---------------------dakflkRKL--NLFNGkINDGE 276
XP_003980269 237 KFHQVLsSQVQGGVRIFVDEWGNPNKkdtGRrstitdf-------------------neakflkQKL--NLFRGkTTDGE 295
XP_001645983 242 KFHDVLsSQVQGGIRIFVDEWTNPNErelYEke------vePTSKESKK---------------RQL--NMFNGkVVEGE 298
XP_002554470 261 QFDNVLsSQVQSGVRIFVDEWDHPIEgndRVqd-----------------------------gkRHL--NMFTGkVSDGE 309
XP_022466584 232 KFDQVLsSQVQGGVRIFVDEWGRPGHrdaEDed------seEEQERQDESHS------------ASF--NVFYGkVADGE 291
P47018       237 KFDQVLsSQVEGGIRIFVDEWGHPNNngiTPve------kkPSVADGELGNSK-----------KKLqfNLFDGkVTDGE 299 Saccharomyces c...
Q6FL79       214 RFDQVMsSQVEGGIRIFVDEWGRPNRsnsIStv------vdPEKREHEEKDAIEPK--------IKL--NLFSGkVSDGE 277 [Candida] glabrata
XP_004180572 257 KFNQILnEQVQGGIRIFVDEWGKPNSnsnLNll-------nlANKNINNQLNNIANnininSLpPNF--NVFHGkIIDGE 327
EMR63310     316 KLCRVGAESYAHDYFAGRGGIA-------------EAQRRALEPVSDENPVRTSDIFLAVQAITVDATPalfagstAE-K 381
XP_003958344 265 KLAFANLDNAIKLFNKAQEEISkqqk------eaaDGDDENEKNTNEDTKDNISDIFISILPISIPISG--------SkD 330
XP_003673909 277 KLAFANLDNSIKLFNKAHEEIMkqk--------keNEKQEGKDGKDENDQNKISDIFIAILPIAIPNTG----------- 337
XP_003980269 296 KLALANLENSIKLFNKAHDELLkrkkel-nekddeNSENDDDDEEEEEEQNKISDIFIAILPIAVEEKG--------KtS 366
XP_001645983 299 KLAFANLDNAIKLFHKSRENIIkqqkeaklaetdqDQESKQSDTEAGDEEDNISDIFISILPVSVPGTN-------KD-- 369
XP_002554470 310 KLAFANLNNAIKLFTEAKDELAkqr-------------feTVSAEEGEKELAISDVFISILPISVPEKH--------Kn- 367
XP_022466584 292 KLAFANLDNAVKLFSKAHDEMLrqq-----------reSTDGGSAPAQTPDSISDVFVSLLAIAPPERT----------D 350
P47018       300 KLAFANLENAVKLFNTAHEEYQkqq-------keaDATPDDDRSSISSNSNKISDLFISILPIAIPQKQ----------- 361 Saccharomyces c...
Q6FL79       278 KLAFANIDNSIKLFNKAHDEYIrqq--------keAEGESEEGSSAEKSENRISDIFVSILPVAIPDKN----------- 338 [Candida] glabrata
XP_004180572 328 KLAFANLDNAIELFNKAQKEIQnqqnea-kkeaneATATNDNDEDEDEQIANIIDIFISILPIAPSSSS--------AkM 398
EMR63310     382 AEKESSg----vADDDESsaadAHVCFAVYVLDPVHEIVYSTVSQALPARWIRWLDTPsattttattssgpTPKASG--- 454
XP_003958344 331 VETDDIl----tTDSSQS----GNFNFTIVLRDITNNITTITRSQGFPNKWAEWLEGT-------------KDEDNTkqe 389
XP_003673909 338 -KDDDIi----tTDPSHP----GNFNFTIVLKDITNNITTITRSQGFPLKWVKWLENY-------------NDDEGEdad 395
XP_003980269 367 SDDKDIi----tTDASYP----GNFNFTIVLKDITNNITTITRSQGFPLKWVKWLETE-------------KDKGEEea- 424
XP_001645983 370 ---DPIk----tTDGNAP----GNFSFIIVLKDITNDITSITRSQGYPSKWAGWLEGS-------------YELTSKdda 425
XP_002554470 368 ---PEIa----tTDSSHP----GNFAFTIVLKDISNDFTSITRSQGFPQRWADWLEGT-------------SELKSKqda 423
XP_022466584 351 AENEPVk----tTDAAVG----GNFSFTVVLRDVSNDITTVTRSQGFPLQWLSWLEGS-------------ALPMQ---- 405
P47018       362 ---KDAdgdfqvTDSNTP----GNFNFTLVLKDITNDITTITRSQGFPVKWVNWLEGS-------------VEKTGStas 421 Saccharomyces c...
Q6FL79       339 ---DSTkedmivTDPHHA----GNFSFTVVLKDISNDITAITRSQAFPTSWVEWLEGE-------------TKKNKE--- 395 [Candida] glabrata
XP_004180572 399 DDDKSTi----iTDTTHS----GNFSFTIILKDISNDITSITRSQGFPLKWLKWIENS-------------KDEEDNekd 457
EMR63310     455 --------SGdseeeesseeeeeddddeegnerpppqrqtggarggggaaigvegdglSIPDEIRAIVEGGGVDPREWVA 526
XP_003958344 390 ekskkeeeE-------------------------------------------------EEEEKEPANDEEGEIDPSDWVR 420
XP_003673909 396 adadtnekTN------------------------------------------------RDKEEEEEEEEELGVDPGDWVK 427
XP_003980269 425 ---------------------------------------------------------kEEAADEEAKEEELGVDPGDWVK 447
XP_001645983 426 isqakekdEKkkq------------------------------------------sssNEEDEEDEEDESNNIDPSEWVK 463
XP_002554470 424 iqd--------------------------------------------------reskrDAVERTDSADDAEGIDPSDWVK 453
XP_022466584 406 ----------------------------------------------------------TGEDPTPGADADDDLDPREWVQ 427
P47018       422 eernksydQK------------------------------------------------KQKESEDEDEDDEIIDPSEWVK 453 Saccharomyces c...
Q6FL79       396 ----------------------------------------------------------SKKGDDNEDEEDDIVDPGEWVK 417 [Candida] glabrata
XP_004180572 458 ssksenatLTqktte---------------------------------------nketKGNDETDDEDEDDGVNPAEWVQ 498
EMR63310     527 EWVEETLTLSIGVLAQRYVARRMGV 551
XP_003958344 421 DWIEDGLSLVFGVVAQNYVIDRMGL 445
XP_003673909 428 EWIEDGLNLAFGIVAQNYVIQRMGF 452
XP_003980269 448 DWIEDGLNLSFGIVAQNYVIQRMGF 472
XP_001645983 464 EWIEDGLSLTFGIAAQNYVIERMGF 488
XP_002554470 454 EWVEDGLSLAFGVVAQNYVIDRMGF 478
XP_022466584 428 GWAEDGLALALGVAAQNYVINRMGF 452
P47018       454 EWIEDGLSLSFGVMAQNYVIDRMGL 478 Saccharomyces cerevisiae S288C
Q6FL79       418 DWIEDGLSLSLGILAQTYVIKRMGL 442 [Candida] glabrata
XP_004180572 499 NWVDDGINLAFGTAAQNYVLERMDf 523
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