Conserved Protein Domain Family
HAD_SAK_1

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pfam10307: HAD_SAK_1 (This model is not part of the current CDD release)
HAD domain family 1 in Swiss Army Knife RNA repair proteins
Family of HAD domain phophoesterases observed in large eukaryotic proteins with predicted role in RNA repair, the so-called 'Swiss Army Knife' repair proteins. May be involved in phosphate group removal during RNA re-ligation.There are two characteristic sequence motifs, GGWW and TGR.
Statistics
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PSSM-Id: 519310
Aligned: 69 rows
Threshold Bit Score: 195.147
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_003686369  45 SPHPNRQLFSKTFIkDVLLKQDLLPSGN-WWSDEKYLrvsfeeskkPSDHGEIRSFWNDKVIKLAKQSCAAEDTITLVLT 123
EPB92231      58 SPLLSPNIWHSSFV-NSITTENLLGPG--WWRDIRSLqlgad---esesSTRWCRYWNEDIVAQVKESMSDPSHLTVLLT 131
XP_067525804  42 SPLLSPTIWHESVL-AQVMCENKFGPG--WWKDIRSLeigpm---eemkEKAWEGFWNENVVLKARQSIDDPDTFTALLT 115
EPB85240      53 SPLLSPTIWHPNLI-RVATAESVYGPG--WWRDIRSLdlgpf---eelkKNAWEGYWNEDIVQQARDCINDADTMTVVLT 126
XP_067518701 214 SPQLSPTIWHSKIR-SLVTAESVYGPG--WWRDVRSLelgpl---ddlkQTAWKGYWNEEIVSKARACIQDPHTMTVVLT 287
XP_006679271  63 SPLPSSDLWTPALK-GKVMADCA------WFSEPRTLetpyiplvpENT------WWHDETIAHALNALSNKNTLTVLLT 129
XP_020432745  72 SPEPNPSLWHPNMI-GKLKAMASEPGGLgWFQDTLTLdhpy-----vpiAPSED-WFNTGVLAAVKESATADNTVTILLT 144
XP_004360461  76 SPEPNPELWTPSMV-GKLKAMPSE-DGLgWFQETATLddpy-----vpsTPSLD-WFNENVLKQAIQSINTPDTITCLLT 147
Q54WC8        17 SPEPNPSTWNPSII-GKIKGMPDE-GGFgWFQDTITLddpy-----vptKPDRDIWFNKNVLDDALNALKHPNNVVCLLT 89  Dictyostelium d...
XP_003292502  16 SPEPNPALWTSQVI-GKIKSMPSENNGFgWFQDTITLdepy-----vpaSPSED-WFNMNVLNDALNSYKDQNNVVCLLT 88 
XP_003686369 124 GRKEEAFSSLIEEMLSskfldS---KFNAVCLKKKFSPYSnntn-------------ksdHTTWSTSNFKLEIFNDFMNY 187
EPB92231     132 GRRYHPFHALMDDILA-----SkglVFDIVGLRPDPESSApdhpvgl-------mfnhepNVFETTMHFKTSFIVNILHN 199
XP_067525804 116 FRPYYPFHSLITTMLE-----SkglQFDMVALCPDPDQAPdylweavdaqrfkinyhpqpAVFGSSIQYKERFILNVLHN 190
EPB85240     127 GRRYHPFHSLVPAMLE-----AkglHFDLVGLRPDPERVSdhqwevksgq-hhltynltsSVFKSTMHFKTSFILNIIHN 200
XP_067518701 288 GRRHNPFSPLVPTMLE-----AkglKFDLIGLRPDPEAVSeyrwkvdgrn-kelnynlsaSVFQSTMHFKQCFLVNILHH 361
XP_006679271 130 GRRHDRFSARIQKLCLskqpePl--AFDLFIMREGHDSTLs-------------------RHYATTLDFKLAVLDKLLQT 188
XP_020432745 145 GRT-TLYADIIHRILG-----SraiEMNHVGLKGTADKQSg-------------------GQVEPTFDFKISYIKSLLSQ 199
XP_004360461 148 GRT-FIYEEIIKRILK-----SvqlNVNYMGLKMI--SEVg-------------------KDRVTTMDFKLGFINHVIDS 200
Q54WC8        90 GRT-VLYEKIIDRILE-----SvelNFHHKGLKPL--NIAn-------------------SQRETTFDFKKRFILNLMHN 142 Dictyostelium d...
XP_003292502  89 GRT-TLYSNIIDRILK-----SanlNFHHKGLKPI--NIPn-------------------VQRESTFDFKKRFILNLINS 141
XP_003686369 188 Y--QdSLQEITVYEDRGSHVRIFEHFFSQTHLYplhlnkrTF-NWYVIPVPPTITYLPPALELQKVKESIEKYNL 259
EPB92231     200 Y--P-SLTDIVMWDDRQSHICVFKEYLIKLEDLg-----lVK-RGEMVCVVPARPKYNPEWEHKTVKSILDTHND 265
XP_067525804 191 V--S-TLKQITWVCNSSAQTKRIKTFLEKLQIAq-----aIL-SFELQIMPKLRPLYRPHWERNVMTNIIHSHNN 256
EPB85240     201 I--P-SIQSVTMWDDRIHHVRKFREYLDIVKSTa-----vIY-SGDVIYVPGIRPKYNPGWEENVIRHIINTHNK 266
XP_067518701 362 V--P-TIKEITMWDDRVPHLKRFKDFLNALHRKr-----lID-RSRIIEVPSLRPKYNPKWEKDVMTRIVETHNL 427
XP_006679271 189 F--P-HIDHIEIHDDRERHLKLFQRQCEAMVAHrr---isTFkMHYVVHERTLNQFIAPHLEKSLVLELVENCNI 257
XP_020432745 200 Y--NnRIKTINVYEDRIKHVEKFRKELAKIV---------DV-TSNVIHVNEPPRYLEEHLEVELVQRLVAKNgt 262
XP_004360461 201 VapG-RIVKIEMYDDRIKHVEQFRAFLQTIP---------NI-ERSVVHIDEKPQYIDEDQETKLVEELISRNgk 264
Q54WC8       143 TykD-EIKRVVVYEDRINHVDLFKSFLASLP---------SLdSYKVKHIEEESKYLEYQTELALVDYLVTKNTS 207 Dictyostelium discoi...
XP_003292502 142 VysN-QIKEVIVYEDRIGHVELFENFLSTLK---------SI-TYKVIHINESPKYLLESDELKLVEYLVKKNTQ 205
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