3G9H


Conserved Protein Domain Family
muHD

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pfam10291: muHD 
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Muniscin C-terminal mu homology domain
The muniscins are a family of endocytic adaptors that is conserved from yeast to humans.This C-terminal domain is structurally similar to mu homology domains, and is the region of the muniscin proteins involved in the interactions with the endocytic adaptor-scaffold proteins Ede1-eps15. This interaction influences muniscin localization. The muniscins provide a combined adaptor-membrane-tubulation activity that is important for regulating endocytosis.
Statistics
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PSSM-Id: 402075
View PSSM: pfam10291
Aligned: 25 rows
Threshold Bit Score: 236.829
Threshold Setting Gi: 75024761
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
3G9H_A         68 FGLNASIAEVLNASFKDGMLQN--SQLIGEIALNYLPNSVMNsp----lPIGINLRINNGAKFEKVILNQAFI----ERV 137  baker's yeast
Q7RZ47        597 PGLHSSIIETVSALFQDGEAKS--VKVTGEIALSYKSDPHNLq------TDNQIIRLNNFARLESIGPNRLFVt--sDAT 666  Neurospora cr...
Q5K9S2        609 PGLRAHVNESINVIFRNKQVQR--IHITGEIHLSLRAKDASSsspsalpGGPIHIRLAAFEHLEKIAPNPAYLa--qVPD 684  Cryptococcus ...
Q8K285        610 LPVATAFTEYVHAYFRGHSPSc-lARVTGELTMTFPAGIVRVfsg-tppPPVLSFRLVNTAPVEHFQPNADLIfs-dPSQ 686  house mouse
Q8VD37        538 LPVAAAFTETVNAYFKGADPSKciVKITGEMVLSFPAGITRHfan-npsPAALTFRVVNSSRLEHVLPNPQLLcc-dNTQ 615  house mouse
XP_011602967  575 LPIAVAFTESVNAYFKGADPTKciVKITGEMTLSFPMGIIKVftn-npsPAVLTFKLKNTSRLEQILPNQQLLhs-dPSQ 652  torafugu
Q3UQN2        542 LPVAIALTESVNAYFKGADPTKciVKITGDVTISFPSGIIKVfts-npsPAVLCFRVKNISRLEQILPNSQLVfs-dPSQ 619  house mouse
Q6AWD5        927 IPLAVAFHEIIHAYFRGSDESRcqVKVSGDMMLSFPAGIAGLlan-npnPAKLGFRIKHVQNLENLVPNGKLVqi-dRQQ 1004 fruit fly
Q7PUP4        585 IPLAVAFHEIIHAYFKGADESRcqVKMSGDMMISFPAGIVNVltn-npnPAKLGFRIKNLQNLDNVLPNKQLIti-dRLQ 662  Anopheles gam...
KIS69836      657 SPIKASLSERVNAIFVGREIAK--VMVVGELSIAVGSSLAGTv-------KPVHIRIEAFEQLEKAAPNPAFLqavpGGS 727  Ustilago mayd...
3G9H_A        138 APEE---FKVNPSFIDSRT-LGA-------------IKYSIKE--------PIAPIVIHPVWRFESHQASVVLTVKMSPs 192  baker's yeast
Q7RZ47        667 SPDE---FTINTSHLTTIS-TPA-------------FTYRVHAendtalvsSHCPISINPVWKPQGDKLGLLLQYRLNPs 729  Neurospora cr...
Q5K9S2        685 KPGE---YFLNSDVLAAATtARGsaag------pllFKYVVHVqpg--kelATAPLILDPVFQCKSGETRMILHYSANPs 753  Cryptococcus ...
Q8K285        687 SDPEtkdFWLNMAALTEALqHQAeqnptasyynlvlLRYQFSRpg-----pESVPLQMSAHWQCGPTLTRVSVEYSYRAg 761  house mouse
Q8VD37        616 NDANtkeFWVNMPNLMTHLkKVSeqkpqatyynvdmLKYQVSAqg-----iQSTPLNLAVNWRCEPASTDLRIDYKYNTd 690  house mouse
XP_011602967  653 SDSNskdFWFNMQALTSYLrKASdqnpsasyynvdiLKYQVQSdg-----iHSTPLNLTVYWKCTPSTSDLRIDYRYNPe 727  torafugu
Q3UQN2        620 CDSNtkdFWMNMQAVTIYLkKLSeqnpaasyynvdvLKYQVSSng-----iQSTPLNLATYWKCSASTTDLRVDYKYNPe 694  house mouse
Q6AWD5       1005 SSSVstmLEFNMGALTALLrRQAennptasyfnvdiLKYQVRTkp----gaSSCPFQLVSYWKCESSYTALKVDYKYNNh 1080 fruit fly
Q7PUP4        663 STSFsttLEFNMPVLTATLrRQSeqnpnaphinvdiLKYQIKAkp----gaASCPFQLVSYWKCEQRHTDIKIDYKYNCh 738  Anopheles gam...
KIS69836      728 TPGE---YLLDVKSLLEQGvTSGlpssg---sqavvLKYQVHIses--rksEYVPLSLHAQWRCEPHQTSLLMTYTPNSa 799  Ustilago mayd...
3G9H_A        193 lpdEISQ------IVIEDLVVFVNIDGA--NATSALS-KPQ-GSFSKEKKRITWRFKEpVVLTRNGEg-QRLIARFITDG 261  baker's yeast
Q7RZ47        730 --vTLQRp-----IVLHNVTFVATYEGA--RASGVQT-KPS-GTHLKEKHLVYWRIPE-LTLTDDW---AKIICRVIGEQ 794  Neurospora cr...
Q5K9S2        754 splATTG------TQLGSATVVAAFTPGgpSVSNVQA-KPAgGVWSPSTRRMTWKMDS-LLGTTGG----KVIAKFTSEP 821  Cryptococcus ...
Q8K285        762 ---ATAVs-----TPLTNVQILLPVGEP---VTSVRL-QPA-ATWNTEEKRFTWKLPD----VCEAGgsGHLSASWQPQS 824  house mouse
Q8VD37        691 ---AMSTa-----VALNNVQFLVPIDGG---VTKLQAvLPP-AVWNAEQQRILWKIPD-ISQKSENGgvGSLLARFQLSE 757  house mouse
XP_011602967  728 ---SMANp-----RALTNVQILVPVDGG---VTSMQS-LPP-SIWNSEQSKCLWKLSD-ISEKSENEgaGTLRAKFELSN 793  torafugu
Q3UQN2        695 ---AMVAp-----SVLSNIQVVVPVDGG---VTNMQS-LPP-AIWNAEQMKAFWKLSG-ISEKSDSGgsGSLRAKFDLSE 760  house mouse
Q6AWD5       1081 ---AMASa-----SPLLNVTLSVPVNGS---VRNVQS-KPH-SAWLGESNRLVWNFTD-ISQNSQDGgvGTLRARLELND 1146 fruit fly
Q7PUP4        739 ---AMAQp-----SPLLNVSISVPVDGG---VKNVQS-KPH-SAWQGESNRLVWNFTD-ISQHSESGgvDTLRARLEVGT 804  Anopheles gam...
KIS69836      800 crfSTVDagessaTVLQDLQFAVQIQPS--TVNNIMS-KPT-ATFVSETKSLFWKLNDkISLTSPSSevHKLLARCQIEG 875  Ustilago mayd...
3G9H_A        262 LAHe-SAKGVITKFTISETDNVALphsgagSGITLT----------CQeLDENNP--------------FGGEWLDVNTK 316  baker's yeast
Q7RZ47        795 NGEp-QPGHIEVRWEYTAPPAGEVgs---gISVSRLvegkgkekaeEQ-SEEEDPfaddkgpispalgkDGRTWAEVPLS 869  Neurospora cr...
Q5K9S2        822 GQEalVPQVVQVSWAAE-GSLISG------LGLDVVdg-----------------------------elEGNQWVFEEIR 865  Cryptococcus ...
Q8K285        825 GPS--TPSPVAAQFTSE-GATLSG------LDLELL----------------------------------GGGYRMSLVK 861  house mouse
Q8VD37        758 GPS--KPSPLVVQFTSE-GSTLSG------CDIELV----------------------------------GAGYRFSLIK 794  house mouse
XP_011602967  794 GPS--TPSTLAVQFLNE-GTTLSG------ADMELQ----------------------------------GSGYRLSLNK 830  torafugu
Q3UQN2        761 GPS--KPTTLAVQFLSE-GNTLSG------VDIELV----------------------------------GTGYRLSLVK 797  house mouse
Q6AWD5       1147 GPS--TPALLATQFNCE-GTTLSG------IEFELQ----------------------------------GSGYRLSLVK 1183 fruit fly
Q7PUP4        805 GPS--TPAIISTQFNCE-GTTLSG------IEFELA----------------------------------GSGYRLSLVK 841  Anopheles gam...
KIS69836      876 AQT--VPTPVHLKWKII-GKTISS------LGVVTLg-------------------------------eAVDALKIDEVV 915  Ustilago mayd...
3G9H_A        317 RTLTTGNYH 325  baker's yeast
Q7RZ47        870 RKLIGGKYE 878  Neurospora crassa
Q5K9S2        866 KSTTTGKYL 874  Cryptococcus neoformans
Q8K285        862 RRFATGMYL 870  house mouse
Q8VD37        795 KRFAAGKYL 803  house mouse
XP_011602967  831 KRFATGrym 839  torafugu
Q3UQN2        798 KRFATGRYL 806  house mouse
Q6AWD5       1184 RRFVSGKYV 1192 fruit fly
Q7PUP4        842 RRFVSGTYA 850  Anopheles gambiae str. PEST
KIS69836      916 RTCVAGKFI 924  Ustilago maydis 521
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