3G9H,5AWS


Conserved Protein Domain Family
muHD

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pfam10291: muHD (This model is not part of the current CDD release)
Muniscin C-terminal mu homology domain
The muniscins are a family of endocytic adaptors that is conserved from yeast to humans.This C-terminal domain is structurally similar to mu homology domains, and is the region of the muniscin proteins involved in the interactions with the endocytic adaptor-scaffold proteins Ede1-eps15. This interaction influences muniscin localisation. The muniscins provide a combined adaptor-membrane-tubulation activity that is important for regulating endocytosis.
Statistics
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PSSM-Id: 519302
Aligned: 26 rows
Threshold Bit Score: 232.202
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
3G9H_A         68 FGLNASIAEVLNASFKDGMLQN--SQLIGEIALNYLPNSVMNsp----lPIGINLRINNGAKFEKVILNQAFI------- 134  brewer's yeast
Q5K9S2        609 PGLRAHVNESINVIFRNKQVQR--IHITGEIHLSLRAKDASSsspsalpGGPIHIRLAAFEHLEKIAPNPAYLa------ 680  Cryptococcus ...
Q8K285        610 LPVATAFTEYVHAYFRGHSPSc-lARVTGELTMTFPAGIVRVfsg-tppPPVLSFRLVNTAPVEHFQPNADLIfs----- 682  house mouse
Q8VD37        538 LPVAAAFTETVNAYFKGADPSKciVKITGEMVLSFPAGITRHfan-npsPAALTFRVVNSSRLEHVLPNPQLLcc----- 611  house mouse
Q3UQN2        542 LPVAIALTESVNAYFKGADPTKciVKITGDVTISFPSGIIKVfts-npsPAVLCFRVKNISRLEQILPNSQLVfs----- 615  house mouse
Q6AWD5        927 IPLAVAFHEIIHAYFRGSDESRcqVKVSGDMMLSFPAGIAGLlan-npnPAKLGFRIKHVQNLENLVPNGKLVqi----- 1000 fruit fly
XP_011388665  657 SPIKASLSERVNAIFVGREIAK--VMVVGELSIAVGSSLAGTv-------KPVHIRIEAFEQLEKAAPNPAFLqa----- 722 
Q2UCN4        109 PGLNASIIETVNAWFSDGVVTK--SSVIGELALAYNGTPNA----------NTTVRLENFQVLEKVAANPHFVs------ 170  Aspergillus o...
XP_001539081  544 PGLNASIVETVSAWFSDGVVTR--SFVVGELAMTYNSTVNAP-------SDSTLVRLNNFHILEKVAANPVLAtevgnsl 614 
5AWS_A         14 LPVAAAFTETVNAYFKGADPSKciVKITGEMVLSFPAGITRHfan-npsPAALTFRVINFSRLEHVLPNPQLLc------ 86   human
3G9H_A        135 ---E-RVAP-------E---E---FKVNPSFIDSRT-LGA-------------IKYSIKe------PIAPIVIHPVWRFE 177  brewer's yeast
Q5K9S2        681 --qV-PDKP-------G---E---YFLNSDVLAAATtARGsaag------pllFKYVVHvqpgkelATAPLILDPVFQCK 738  Cryptococcus ...
Q8K285        683 --dP-SQSD-------P---EtkdFWLNMAALTEALqHQAeqnptasyynlvlLRYQFSrp---gpESVPLQMSAHWQCG 746  house mouse
Q8VD37        612 --dN-TQND-------A---NtkeFWVNMPNLMTHLkKVSeqkpqatyynvdmLKYQVSaq---giQSTPLNLAVNWRCE 675  house mouse
Q3UQN2        616 --dP-SQCD-------S---NtkdFWMNMQAVTIYLkKLSeqnpaasyynvdvLKYQVSsn---giQSTPLNLATYWKCS 679  house mouse
Q6AWD5       1001 --dR-QQSS-------S---VstmLEFNMGALTALLrRQAennptasyfnvdiLKYQVRtkp--gaSSCPFQLVSYWKCE 1065 fruit fly
XP_011388665  723 -vpG-GSTP-------G---E---YLLDVKSLLEQGvTSGlpssg---sqavvLKYQVHisesrksEYVPLSLHAQWRCE 784 
Q2UCN4        171 --eE-KDKDlsd-ekrG---Q---YSIHIPTIARPSpIVA-------------FKYQLHvdasdssAYCPVIFKPVWNIE 227  Aspergillus o...
XP_001539081  615 kgkE-KEKElgdeerkG---E---YLISLPTIARPTpTVA-------------FKYQVHldpsnlsAYSPVIFNPVWNLE 674 
5AWS_A         87 --cDnTQND-------AntkE---FWVNMPNLMTHLkKVSeqkpqatyynvdmLKYQVSaq---giQSTPLNLAVNWRCE 151  human
3G9H_A        178 SHQASVVLTVKMSPslpdEISQ------IVIEDLVVFVNIDGA--------------NATSALS-KPQ--GSFSKEKKRI 234  brewer's yeast
Q5K9S2        739 SGETRMILHYSANPssplATTG------TQLGSATVVAAFTPGg------------pSVSNVQA-KPAg-GVWSPSTRRM 798  Cryptococcus ...
Q8K285        747 PTLTRVSVEYSYRAg---ATAVs-----TPLTNVQILLPVGEP---------------VTSVRL-QPA--ATWNTEEKRF 800  house mouse
Q8VD37        676 PASTDLRIDYKYNTd---AMSTa-----VALNNVQFLVPIDGG---------------VTKLQAvLPP--AVWNAEQQRI 730  house mouse
Q3UQN2        680 ASTTDLRVDYKYNPe---AMVAp-----SVLSNIQVVVPVDGG---------------VTNMQS-LPP--AIWNAEQMKA 733  house mouse
Q6AWD5       1066 SSYTALKVDYKYNNh---AMASa-----SPLLNVTLSVPVNGS---------------VRNVQS-KPH--SAWLGESNRL 1119 fruit fly
XP_011388665  785 PHQTSLLMTYTPNSacrfSTVDagessaTVLQDLQFAVQIQPS--------------TVNNIMS-KPT--ATFVSETKSL 847 
Q2UCN4        228 EHQASVIVFYSLNP----SFTSsvpresVTLKNLILTVNLDTSpeeg------revaHATSAVM-YPNtgASFRRKHSAV 296  Aspergillus o...
XP_001539081  675 EFQASVIITYSINP----NFVSampstrITLQNLVLTVNLDLSpqedettkqprevaRATGAVM-YPNtgATFRRKISAV 749 
5AWS_A        152 PSSTDLRIDYKYNt---dAMTTa-----VALNNVQFLVPIDGG---------------VTKLQAvLPP--AVWNAEQQRI 206  human
3G9H_A        235 TWRFKEpVVLTRNGEg-QRLIARFITDGLAHe-SAKGVITKFTISETDNvalphsGAGSGITLT-----CQ-ElDENNPf 306  brewer's yeast
Q5K9S2        799 TWKMDS-LLGTTGG----KVIAKFTSEPGQEalVPQVVQVSWAAE-GSL------ISGLGLDVVdgel------------ 854  Cryptococcus ...
Q8K285        801 TWKLPD----VCEAGgsGHLSASWQPQSGPS--TPSPVAAQFTSE-GAT------LSGLDLELLgg-------------- 853  house mouse
Q8VD37        731 LWKIPD-ISQKSENGgvGSLLARFQLSEGPS--KPSPLVVQFTSE-GST------LSGCDIELVga-------------- 786  house mouse
Q3UQN2        734 FWKLSG-ISEKSDSGgsGSLRAKFDLSEGPS--KPTTLAVQFLSE-GNT------LSGVDIELVgt-------------- 789  house mouse
Q6AWD5       1120 VWNFTD-ISQNSQDGgvGTLRARLELNDGPS--TPALLATQFNCE-GTT------LSGIEFELQgs-------------- 1175 fruit fly
XP_011388665  848 FWKLNDkISLTSPSSevHKLLARCQIEGAQT--VPTPVHLKWKII-GKT------ISSLGVVTLgea------------- 905 
Q2UCN4        297 TWKLPE-FEVTAGSD--GKLLVRFSTATSWP--RKGKVEAKFEVHTLDA------GSRLGISAAsp-teEItP-KGSDPf 363  Aspergillus o...
XP_001539081  750 TWKLPE-LEIGSEGD--QRFLARFSTTVSGP--RKGKVDAKFDVTNANN------GERLGISVQnstseQKeK-KADDPf 817 
5AWS_A        207 LWKIPD-ISQKSENGgvGSLLARFQLSEGPS--KPSPLVVQFTSE-GST------LSGCDIELVga-------------- 262  human
3G9H_A        307 g-------------------geWLDVNTKRTLTTGN--------------YH 325  brewer's yeast
Q5K9S2        855 ------------------egnqWVFEEIRKSTTTGK--------------YL 874  Cryptococcus neoformans
Q8K285        854 ---------------------gYRMSLVKRRFATGM--------------YL 870  house mouse
Q8VD37        787 ---------------------gYRFSLIKKRFAAGK--------------YL 803  house mouse
Q3UQN2        790 ---------------------gYRLSLVKKRFATGR--------------YL 806  house mouse
Q6AWD5       1176 ---------------------gYRLSLVKRRFVSGK--------------YV 1192 fruit fly
XP_011388665  906 -------------------vdaLKIDEVVRTCVAGK--------------FI 924 
Q2UCN4        364 adedsgap------ddaqpsltWKEVPTTRKLVGARrtvpvsryhrnclcRI 409  Aspergillus oryzae
XP_001539081  818 adeslvmsngatspehlptsktWEEVPTRRKLAAGR--------------YT 855 
5AWS_A        263 ---------------------gYRFSLIKKRFAAGK--------------YL 279  human
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