Conserved Protein Domain Family
DUF2401

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pfam10287: DUF2401 
Putative TOS1-like glycosyl hydrolase (DUF2401)
This family of proteins is conserved in fungi. One member is annotated putatively as OPEL, a house-keeping protein, but this could not be confirmed. It contains 5 highly conserved cysteines two of which form a characteristic CGC sequence motif. It has recently been shown that this family is related to known glycosyl hydrolases.
Statistics
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PSSM-Id: 402072
View PSSM: pfam10287
Aligned: 103 rows
Threshold Bit Score: 182.402
Threshold Setting Gi: 0
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_011121743 196 WKRAGFYdsGKQILEGVTFLNNKGGiG--SGKWTSCFGNSLSHMSADGKDGSATPQILADNTLfGVNEEFSIWTNQTC-- 271 Arthrobotrys ol...
EHY53995     217 WGRQAYYnaEQGVADGLVFLNHHGG-Qg-SGVFDTVWGMSLSYASADNTAGSASPVALADTLI-GDNSEFLIMTDKPCa- 292 Exophiala derma...
XP_002541960 194 WGRQGYYdaEKGVADGLTFLNHHGG-Qg-SGVFDYQLGNSLSYASEDGQSGSASPVVLKDAVL-PDNKEIIIMTDKECk- 269 Uncinocarpus re...
EEQ88880     198 WGRQGYYnaEAGVADGLTFLNHRGG-Dg-SGVFDYDLGNSLSYASEDGCTGSDSPKVLSNKMI-PDNEEIVIMTDKPC-- 272 Blastomyces der...
EGC47378     201 WARQGYYnsAEGQADGLVFLNHHGG-Dk-SGVFDYALGNSLSYASTDGCNGAASPMILADKLL-PDNKEIVIMTDKPC-- 275 Histoplasma cap...
XP_003053785 223 WSRTSYYnaEQQAADNIVFLGNYGG-Dg-SGVFDEIWGNSLSYLNADGSGGSSSPKVLKDVYI-PSNKEFSIWTAEKC-- 297 [Nectria] haema...
CCT62728     219 WKRTSYYnaQRRVADNVVFMGNYGG-Eg-SGVFDNTWGNSLSYLNANGNGGSSSPKILKDVFI-PSNKEFSIFSSEKC-- 293 Fusarium fujiku...
ELR07172     207 YTRSGYYdaASQTLDGLTFLGNYGG-Sg-SGIFDNVFGNSLSYLNSAGTGAAASSSVLADALI-GSNKEFAIFTDKECva 283 Pseudogymnoascu...
EPE32646     300 YQRIGYYnsATQTLKNLVFLGNYGGeSgsSGVFDFHYGASLAYTGTDGCHGATSPQILSDKVI-PSDKEIIVMLGEKCae 378 Glarea lozoyens...
EDN96057     257 YSRIGYYdsAEQTLDNLVFLGNYGG-Qg-SGVFNEAYGASLSFVNSNGTGGASSPQVLADTTL-PSDSEVIVMLDEEC-- 331 Sclerotinia scl...
XP_011121743 272 DGTCGYAYGDDVCYRGWDGDNKVFVFKFTMPPAHTDDSNiygnSNMPAIWSLNSLIGRTQQYpAdkNWSCWDSGCGEFDI 351 Arthrobotrys ol...
EHY53995     293 NGACGTVRDGTVAYHGFDGASKLFLLEFSMPLSGATGFN----SDMPAAWILNAQIPRTIQY-G--SCSCWQSGCGEFDV 365 Exophiala derma...
XP_002541960 270 GDSCGTVRPGTVAYHGFDGASKLFLAEFSMPMTGKTGFN----MDMPAAWILNAAIPRTLQY-GkpECSCWKSGCGEFDV 344 Uncinocarpus re...
EEQ88880     273 NGDCGTVRPGTVAYHGFDGDNKIFLAEFDMPVTGKTGWN----EDMPAAWILNAAIPRTLQYgKa-ECSCWKTGCGEFDV 347 Blastomyces der...
EGC47378     276 NGDCGTVRPGTVAYHGFDGDNKLFLTEFSMPNTGKTGWN----EDMPAAWILNAAIPRTLQY-GkpECSCWISGCGEFDV 350 Histoplasma cap...
XP_003053785 298 DESCGYSRAQDVAYKGFSGGSKIFLFHFNMPMDGDRGFN----GDMPALWALNGRIPRTGQY-S--SCSCWTTGCGEADI 370 [Nectria] haema...
CCT62728     294 DESCGYSRVPDVAYKGFSGSNKIFLFNFKMPFDGNTGFN----GDMPALWALNGRIPRTGQY-S--GCSCWKTGCGEVDI 366 Fusarium fujiku...
ELR07172     284 GDSCGYTRPGSVAYHGFDGADKVFLLEFGMPSDATSGFN----ADMPAVWMLNAQIPRTLQY-GeaSCSCWTTGCGEFDI 358 Pseudogymnoascu...
EPE32646     379 NSACGYTRPGTVAHHGFAGADKLFLMEFSMPADGTSGFN----GDMPAVWLLNAKIPRTLQY-GnpECSCWKSGCGEFDV 453 Glarea lozoyens...
EDN96057     332 NNDCGYVRPGSVAYHGFNGANKVFLLEFSMPIDGSTGFN----ADMPSVWILNAQIPRTIQY-GnpSCSCWESGCGEFDI 406 Sclerotinia scl...
XP_011121743 352 WEVLypqAPACEYMTSTLHSAQgnpgtgkgGGGTCDYFKRPTDTTFTGMVSYLSDG-TITIQKLDDdfDFPEYITTDII 429 Arthrobotrys oli...
EHY53995     366 FEVL---DSGNQKCKSTWHGAH--------SLGDSNWFQRPINGTKKAAVVFDGTSsTAHIIWLSDdtNFDTTISQSTV 433 Exophiala dermat...
XP_002541960 345 LEIL---DSGNTRAKSTLHGHL--------NGGDSHFFERPTEKAIKVAVVFNAAGsSAHIKILDDdvEFSPVMSSDKV 412 Uncinocarpus ree...
EEQ88880     348 FEIL---DAGNMRAKSTLHGNI--------SGGDSHFFERPSGKTVKLAVVFNAAGsSVHIKILDDsfEFKPTLDGEEV 415 Blastomyces derm...
EGC47378     351 FEVL---DAGNPRAKSTLHGNR--------SGGDSHWFPRPISKTLKLAVLFDGAAnSVNIRILDDsfEFKPTLDGSEI 418 Histoplasma caps...
XP_003053785 371 YEVL---ASGDTKCKSTFHLAK--------GAGSSDYFDRPVDSFIRVATIFDERSsSVAIKRVPDdfDFSESLTEDVV 438 [Nectria] haemat...
CCT62728     367 YEVL---ATGDDKCKSTFHLTN--------GAGSSDYFKRPADQYIKVAVVFCERTsSVAIKQLDDafDFGSSLSDETV 434 Fusarium fujikur...
ELR07172     359 AEVL---MSGDKRCKSTLHTNA--------PGGSSDYFARPTSGTVKLAVIFNGADgTANIQKLSDdaTFPASLTANQV 426 Pseudogymnoascus...
EPE32646     454 AEAL---HSGSKFLKSTLHTNK--------PTGDSDYIMRPTDKPLKLAVIFKSANaGIQIEVLPDstEFKTRLTTDEI 521 Glarea lozoyensi...
EDN96057     407 AEAL---NAGSTFLKSTLHTNN--------PGGDSDYFVRPTSSTMKLAVVFSSATsTIHLQKLPAsyEFPTSLTTDDI 474 Sclerotinia scle...
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